JP2019523214A5 - - Google Patents
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- Publication number
- JP2019523214A5 JP2019523214A5 JP2018557405A JP2018557405A JP2019523214A5 JP 2019523214 A5 JP2019523214 A5 JP 2019523214A5 JP 2018557405 A JP2018557405 A JP 2018557405A JP 2018557405 A JP2018557405 A JP 2018557405A JP 2019523214 A5 JP2019523214 A5 JP 2019523214A5
- Authority
- JP
- Japan
- Prior art keywords
- ala
- drug conjugate
- iii
- edfyd
- bt17bdc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1607827.1A GB201607827D0 (en) | 2016-05-04 | 2016-05-04 | Bicyclic peptide-toxin conjugates specific for MT1-MMP |
| GB1607827.1 | 2016-05-04 | ||
| PCT/GB2017/051250 WO2017191460A1 (en) | 2016-05-04 | 2017-05-04 | Bicyclic peptide-toxin conjugates specific for mt1-mmp |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019523214A JP2019523214A (ja) | 2019-08-22 |
| JP2019523214A5 true JP2019523214A5 (enExample) | 2020-06-18 |
| JP6942147B2 JP6942147B2 (ja) | 2021-09-29 |
Family
ID=56234400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018557405A Active JP6942147B2 (ja) | 2016-05-04 | 2017-05-04 | Ｍｔ１−ｍｍｐに対して特異的な二環式ペプチド−毒素コンジュゲート |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10994019B2 (enExample) |
| EP (1) | EP3452096B1 (enExample) |
| JP (1) | JP6942147B2 (enExample) |
| CN (1) | CN109414510B (enExample) |
| DK (1) | DK3452096T3 (enExample) |
| ES (1) | ES3010545T3 (enExample) |
| GB (1) | GB201607827D0 (enExample) |
| WO (1) | WO2017191460A1 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS61853B1 (sr) | 2014-10-29 | 2021-06-30 | Bicyclerd Ltd | Biciklični peptidni ligandi specifični za mt1-mmp |
| GB201607827D0 (en) | 2016-05-04 | 2016-06-15 | Bicycle Therapeutics Ltd | Bicyclic peptide-toxin conjugates specific for MT1-MMP |
| WO2018096365A1 (en) * | 2016-11-27 | 2018-05-31 | Bicyclerd Limited | Methods for treating cancer |
| US11730819B2 (en) | 2016-12-23 | 2023-08-22 | Bicycletx Limited | Peptide derivatives having novel linkage structures |
| WO2018127699A1 (en) * | 2017-01-06 | 2018-07-12 | Bicyclerd Limited | Compounds for treating cancer |
| US12410143B2 (en) | 2017-01-17 | 2025-09-09 | Michael David FORREST | Therapeutic inhibitors of the reverse mode of ATP synthase |
| AU2018231832A1 (en) | 2017-03-10 | 2019-08-08 | Quiapeg Pharmaceuticals Ab | Releasable conjugates |
| EP3615550A1 (en) | 2017-04-27 | 2020-03-04 | BicycleTx Limited | Bicyclic peptide ligands and uses thereof |
| EP3645549A1 (en) | 2017-06-26 | 2020-05-06 | BicycleRD Limited | Bicyclic peptide ligands with detectable moieties and uses thereof |
| BR112019028172A2 (pt) | 2017-07-13 | 2020-10-06 | Michael David Forrest | moduladores terapêuticos do modo reverso da atp sintase |
| JP7670481B2 (ja) | 2017-08-04 | 2025-04-30 | バイスクルテクス・リミテッド | Ｃｄ１３７に対して特異的な二環式ペプチドリガンド |
| US20200283482A1 (en) * | 2017-08-14 | 2020-09-10 | Bicyclerd Limited | Bicyclic peptide ligand prr-a conjugates and uses thereof |
| GB201721265D0 (en) | 2017-12-19 | 2018-01-31 | Bicyclerd Ltd | Bicyclic peptide ligands specific for EphA2 |
| TWI825046B (zh) | 2017-12-19 | 2023-12-11 | 英商拜西可泰克斯有限公司 | Epha2特用之雙環胜肽配位基 |
| KR20200128518A (ko) | 2018-02-23 | 2020-11-13 | 바이사이클티엑스 리미티드 | 다량체성 비사이클릭 펩타이드 리간드 |
| KR20200103780A (ko) | 2018-03-09 | 2020-09-02 | 퀴아펙 파마슈티칼스 에이비 | 방출가능한 항체 접합체 |
| US11180531B2 (en) | 2018-06-22 | 2021-11-23 | Bicycletx Limited | Bicyclic peptide ligands specific for Nectin-4 |
| GB201810327D0 (en) | 2018-06-22 | 2018-08-08 | Bicycletx Ltd | Peptide ligands for binding to IL-17 |
| GB201810320D0 (en) | 2018-06-22 | 2018-08-08 | Bicycletx Ltd | Peptide ligands for binding to CD38 |
| GB201810316D0 (en) | 2018-06-22 | 2018-08-08 | Bicyclerd Ltd | Peptide ligands for binding to EphA2 |
| GB201810329D0 (en) | 2018-06-22 | 2018-08-08 | Bicycletx Ltd | Peptide ligands for binding to integrin avB3 |
| EP3849660A1 (en) | 2018-09-12 | 2021-07-21 | QuiaPEG Pharmaceuticals AB | Releasable glp-1 conjugates |
| CN112955459A (zh) | 2018-10-23 | 2021-06-11 | 拜斯科技术开发有限公司 | 双环肽配体和其用途 |
| US20220024982A1 (en) * | 2018-12-13 | 2022-01-27 | Bicycletx Limited | Bicyclic peptide ligands specific for mt1-mmp |
| GB201820325D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for psma |
| GB201820288D0 (en) | 2018-12-13 | 2019-01-30 | Bicycle Tx Ltd | Bicycle peptide ligaands specific for MT1-MMP |
| GB201820295D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for MT1-MMP |
| CN113474045A (zh) | 2018-12-21 | 2021-10-01 | 拜斯科技术开发有限公司 | Pd-l1特异性的双环肽配体 |
| WO2020128527A1 (en) * | 2018-12-21 | 2020-06-25 | Bicyclerd Limited | Bicyclic peptide ligands specific for pd-l1 |
| GB201900526D0 (en) * | 2019-01-15 | 2019-03-06 | Bicyclerd Ltd | Bicyclic peptide ligands specific for caix |
| GB201900529D0 (en) | 2019-01-15 | 2019-03-06 | Bicycletx Ltd | Bicyclic peptide ligands specific for CD38 |
| WO2020225577A1 (en) * | 2019-05-09 | 2020-11-12 | Bicycletx Limited | Bicyclic peptide ligands specific for ox40 |
| TWI869398B (zh) | 2019-05-10 | 2025-01-11 | 英商拜西克爾德有限公司 | 治療癌症之方法 |
| CN112048013B (zh) * | 2019-06-05 | 2021-11-05 | 深圳先进技术研究院 | 靶向脑胶质瘤的多肽化合物及其合成方法与应用 |
| TWI862640B (zh) | 2019-07-30 | 2024-11-21 | 英商拜西可泰克斯有限公司 | 異質雙環肽複合物 |
| PT4464721T (pt) | 2019-10-03 | 2025-06-24 | Bicycletx Ltd | Complexos peptídicos bicíclicos heterotandem |
| KR20230074119A (ko) | 2020-08-03 | 2023-05-26 | 바이사이클티엑스 리미티드 | 펩타이드 기반 링커 |
| US20250186539A2 (en) | 2021-01-11 | 2025-06-12 | Bicycletx Limited | Methods for treating cancer |
| WO2022157548A1 (en) | 2021-01-24 | 2022-07-28 | Forrest Michael David | Inhibitors of atp synthase - cosmetic and therapeutic uses |
| GB202114282D0 (en) | 2021-10-06 | 2021-11-17 | Bicyclerd Ltd | Bicyclic peptide ligand drug conjugates |
| JP2024537396A (ja) * | 2021-10-14 | 2024-10-10 | シーザン ハイスーク ファーマシューティカル カンパニー リミテッド | ＥｐｈＡ２の二環式ペプチドリガンド及びそのコンジュゲート |
| WO2023088236A1 (zh) * | 2021-11-16 | 2023-05-25 | 海思科医药集团股份有限公司 | Mt1-mmp的双环肽配体及其缀合物 |
| GB202214528D0 (en) | 2022-10-03 | 2022-11-16 | Owlstone Med Ltd | A compound |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60336149D1 (de) * | 2002-08-16 | 2011-04-07 | Immunogen Inc | Vernetzer mit hoher reaktivität und löslichkeit und ihre verwendung bei der herstellung von konjugaten für die gezielte abgabe von kleinmolekularen arzneimitteln |
| EP1452868A2 (en) | 2003-02-27 | 2004-09-01 | Pepscan Systems B.V. | Method for selecting a candidate drug compound |
| US20070112176A1 (en) * | 2003-04-04 | 2007-05-17 | Daiichi Pharmaceutical Co., Ltd. | Lipid membrane structure containing anti-mt-mmp monoclonal antibody |
| WO2006078161A1 (en) | 2005-01-24 | 2006-07-27 | Pepscan Systems B.V. | Binding compounds, immunogenic compounds and peptidomimetics |
| DK2257624T5 (da) | 2008-02-05 | 2012-09-10 | Medical Res Council | Fremgangsmåder og sammensætninger |
| GB0913775D0 (en) | 2009-08-06 | 2009-09-16 | Medical Res Council | Multispecific peptides |
| GB0914110D0 (en) | 2009-08-12 | 2009-09-16 | Medical Res Council | Peptide libraries |
| JP2013518558A (ja) * | 2010-02-04 | 2013-05-23 | メディカル リサーチ カウンシル | 構造化されたペプチドプロセシング |
| US10800813B2 (en) * | 2011-10-07 | 2020-10-13 | Bicyclerd Limited | Modulation of structured polypeptide specificity |
| US20140274759A1 (en) | 2013-03-15 | 2014-09-18 | Bicycle Therapeutics Limited | Modification of polypeptides |
| GB201306623D0 (en) | 2013-04-11 | 2013-05-29 | Bicycle Therapeutics Ltd | Modulation of structured polypeptide specificity |
| EP3062823B1 (en) | 2013-10-28 | 2018-12-12 | BicycleRD Limited | Novel polypeptides |
| RS61853B1 (sr) * | 2014-10-29 | 2021-06-30 | Bicyclerd Ltd | Biciklični peptidni ligandi specifični za mt1-mmp |
| GB201600911D0 (en) * | 2016-01-18 | 2016-03-02 | Bicycle Therapeutics Ltd | Stabilized peptide derivatives |
| GB201607827D0 (en) | 2016-05-04 | 2016-06-15 | Bicycle Therapeutics Ltd | Bicyclic peptide-toxin conjugates specific for MT1-MMP |
| WO2018096365A1 (en) | 2016-11-27 | 2018-05-31 | Bicyclerd Limited | Methods for treating cancer |
| US11730819B2 (en) | 2016-12-23 | 2023-08-22 | Bicycletx Limited | Peptide derivatives having novel linkage structures |
| CN110506049B (zh) | 2016-12-23 | 2024-08-16 | 拜斯科技术开发有限公司 | 用于结合mt1-mmp的肽配体 |
| WO2018127699A1 (en) | 2017-01-06 | 2018-07-12 | Bicyclerd Limited | Compounds for treating cancer |
| GB201706477D0 (en) | 2017-04-24 | 2017-06-07 | Bicycle Therapeutics Ltd | Modification of polypeptides |
| EP3615550A1 (en) | 2017-04-27 | 2020-03-04 | BicycleTx Limited | Bicyclic peptide ligands and uses thereof |
| EP3645549A1 (en) | 2017-06-26 | 2020-05-06 | BicycleRD Limited | Bicyclic peptide ligands with detectable moieties and uses thereof |
| TWI825046B (zh) | 2017-12-19 | 2023-12-11 | 英商拜西可泰克斯有限公司 | Epha2特用之雙環胜肽配位基 |
| KR20200128518A (ko) | 2018-02-23 | 2020-11-13 | 바이사이클티엑스 리미티드 | 다량체성 비사이클릭 펩타이드 리간드 |
| KR20200139236A (ko) | 2018-04-04 | 2020-12-11 | 바이사이클티엑스 리미티드 | 헤테로탠덤 비사이클릭 펩티드 복합체 |
| CN112955459A (zh) | 2018-10-23 | 2021-06-11 | 拜斯科技术开发有限公司 | 双环肽配体和其用途 |
| SG11202104356VA (en) | 2018-10-30 | 2021-05-28 | Bicyclerd Ltd | Bt1718 for use in treating cancer |
-
2016
- 2016-05-04 GB GBGB1607827.1A patent/GB201607827D0/en not_active Ceased
-
2017
- 2017-05-04 EP EP17723745.0A patent/EP3452096B1/en active Active
- 2017-05-04 WO PCT/GB2017/051250 patent/WO2017191460A1/en not_active Ceased
- 2017-05-04 ES ES17723745T patent/ES3010545T3/es active Active
- 2017-05-04 JP JP2018557405A patent/JP6942147B2/ja active Active
- 2017-05-04 US US16/097,305 patent/US10994019B2/en active Active
- 2017-05-04 DK DK17723745.0T patent/DK3452096T3/da active
- 2017-05-04 CN CN201780031804.XA patent/CN109414510B/zh active Active
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