JP2019522001A - 4−(3−エトキシ−4−ヒドロキシフェニル)ブタン−2−オンとナイアシンアミド化合物とを含有する液体混合物、およびそれを含有する化粧料組成物 - Google Patents
4−(3−エトキシ−4−ヒドロキシフェニル)ブタン−2−オンとナイアシンアミド化合物とを含有する液体混合物、およびそれを含有する化粧料組成物 Download PDFInfo
- Publication number
- JP2019522001A JP2019522001A JP2018568210A JP2018568210A JP2019522001A JP 2019522001 A JP2019522001 A JP 2019522001A JP 2018568210 A JP2018568210 A JP 2018568210A JP 2018568210 A JP2018568210 A JP 2018568210A JP 2019522001 A JP2019522001 A JP 2019522001A
- Authority
- JP
- Japan
- Prior art keywords
- niacinamide
- hydroxyphenyl
- ethoxy
- butan
- mass
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 79
- -1 niacinamide compound Chemical class 0.000 title claims abstract description 35
- 235000005152 nicotinamide Nutrition 0.000 title claims abstract description 30
- 239000011570 nicotinamide Substances 0.000 title claims abstract description 30
- 229960003966 nicotinamide Drugs 0.000 title claims abstract description 30
- MXLOKFOWFPJWCW-UHFFFAOYSA-N ethylzingerone Chemical compound CCOC1=CC(CCC(C)=O)=CC=C1O MXLOKFOWFPJWCW-UHFFFAOYSA-N 0.000 title claims abstract description 19
- 239000007788 liquid Substances 0.000 title claims abstract description 18
- 239000002537 cosmetic Substances 0.000 title claims abstract description 15
- 102000011782 Keratins Human genes 0.000 claims abstract description 7
- 108010076876 Keratins Proteins 0.000 claims abstract description 7
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 9
- 239000004615 ingredient Substances 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 229920005862 polyol Polymers 0.000 claims description 5
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- 150000003077 polyols Chemical class 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 3
- 229920000642 polymer Polymers 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 230000001225 therapeutic effect Effects 0.000 claims description 3
- 239000004480 active ingredient Substances 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 239000000945 filler Substances 0.000 claims description 2
- 239000003205 fragrance Substances 0.000 claims description 2
- 239000003349 gelling agent Substances 0.000 claims description 2
- 239000000419 plant extract Substances 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 238000012216 screening Methods 0.000 claims description 2
- 239000004094 surface-active agent Substances 0.000 claims description 2
- 239000003086 colorant Substances 0.000 claims 1
- 239000000463 material Substances 0.000 abstract description 6
- 239000000499 gel Substances 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- 239000006210 lotion Substances 0.000 description 5
- 238000003860 storage Methods 0.000 description 5
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 description 3
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
- 210000004209 hair Anatomy 0.000 description 3
- 238000009776 industrial production Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 229920000166 polytrimethylene carbonate Polymers 0.000 description 3
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000008247 solid mixture Substances 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- 229940043375 1,5-pentanediol Drugs 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- JNJKKAQNKPREFI-UHFFFAOYSA-N 4-butyl-2-ethoxyphenol Chemical compound C(CCC)C1=CC(=C(C=C1)O)OCC JNJKKAQNKPREFI-UHFFFAOYSA-N 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 229930003537 Vitamin B3 Natural products 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 125000005250 alkyl acrylate group Chemical group 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 229920006037 cross link polymer Polymers 0.000 description 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 229940113120 dipropylene glycol Drugs 0.000 description 1
- 210000000720 eyelash Anatomy 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 230000037308 hair color Effects 0.000 description 1
- 208000024963 hair loss Diseases 0.000 description 1
- 230000003676 hair loss Effects 0.000 description 1
- 229940051250 hexylene glycol Drugs 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 210000000282 nail Anatomy 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 235000019160 vitamin B3 Nutrition 0.000 description 1
- 239000011708 vitamin B3 Substances 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
- Detergent Compositions (AREA)
Abstract
Description
− 特に顔、身体もしくは口唇の皮膚または睫毛をメイクアップするためのメイクアップ製品;
− アフターシェーブゲルまたはローション;
− 除毛クリーム;
− シャワージェルまたはシャンプー等の身体を清潔にする組成物;
− 医薬組成物;
− 石鹸または固形洗浄料(cleansing bar)等の固体組成物;
− 加圧された噴射剤も含むエアゾール組成物;
− 整髪ローション、整髪クリームまたはジェル、染毛組成物、毛髪修復用ローション、パーマネントウェーブ用組成物、脱毛を防止するためのローションまたはゲル;あるいは
− 皮膚のケアまたはクレンジングのための組成物
の形態であり得る。
4−(3−エトキシ−4−ヒドロキシフェニル)ブタン−2−オン(ケトン化合物)とナイアシンアミドとの11種類の混合物を、各混合物を75℃±5℃の温度に加熱した後、室温(23℃)に放冷することにより、下表に記載される異なる質量比で生成した。
以下の組成を有するフェイシャルケア用ジェルを調製した(質量百分率としての含有量)。
(アクリレーツ/アクリル酸アルキル(C10〜C30))クロスポリマー(NoveonからのCarbopol(登録商標)Ultrez 20 Polymer) 0.9%
PEG−8 6%
95質量%の4−(3−エトキシ−4−ヒドロキシフェニル)ブタン−2−オンおよび5質量%のナイアシンアミドを含有する混合物M6 0.53%
水酸化ナトリウム 0.35%
水 適量
100%
Claims (8)
- 4−(3−エトキシ−4−ヒドロキシフェニル)ブタン−2−オンと、ナイアシンアミド、N,N−ジエチルナイアシンアミド、N−ピコリルナイアシンアミドおよびN−アリルナイアシンアミドから選択されるナイアシンアミド化合物とから構成される液体混合物。
- 4−(3−エトキシ−4−ヒドロキシフェニル)ブタン−2−オンと、ナイアシンアミドとを、4−(3−エトキシ−4−ヒドロキシフェニル)ブタン−2−オン/ナイアシンアミド化合物の質量比が12〜250の範囲、好ましくは19〜220の範囲であるような量で含むことを特徴とする、請求項1に記載の混合物。
- 前記ナイアシンアミド化合物は、ナイアシンアミドであることを特徴とする、請求項1または2に記載の混合物。
- 4−(3−エトキシ−4−ヒドロキシフェニル)ブタン−2−オンと、ナイアシンアミド、N,N−ジエチルナイアシンアミド、N−ピコリルナイアシンアミドおよびN−アリルナイアシンアミドから選択されるナイアシンアミド化合物とを70〜80℃の温度に加熱して混合するステップ、次いで15〜28℃の温度に冷却するステップを含む、液体混合物を調製するための方法。
- 生理学的に許容される媒体中において、請求項1〜3のいずれか一項に記載の4−(3−エトキシ−4−ヒドロキシフェニル)ブタン−2−オンとナイアシンアミド化合物との液体混合物を含む組成物。
- 水、油、1〜10個の炭素原子を有するポリオール、ゲル化剤、界面活性剤、皮膜形成性高分子、色材、香料、フィラー、UV遮蔽剤、植物抽出物、化粧的および皮膚科学的活性成分ならびに塩から選択される少なくとも1種の追加成分を含むことを特徴とする、請求項5に記載の組成物。
- 前記4−(3−エトキシ−4−ヒドロキシフェニル)ブタン−2−オンは、前記組成物の総質量に対して0.01質量%〜5質量%の範囲、好ましくは0.01質量%〜3質量%の範囲、優先的には0.01質量%〜2.5質量%の範囲の量で存在することを特徴とする、請求項4または5に記載の組成物。
- ケラチン物質をケア、および/またはメイクアップ、および/またはクレンジングするための非治療的な化粧的処置方法であって、請求項5〜7のいずれか一項に記載の組成物を前記ケラチン物質に適用することを含む、非治療的な化粧的処置方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1656175A FR3053333B1 (fr) | 2016-06-30 | 2016-06-30 | Melange liquide contenant du 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one et un com-pose de niacinamide, et composition cosmetique le contenant |
FR1656175 | 2016-06-30 | ||
PCT/EP2017/065547 WO2018001898A1 (en) | 2016-06-30 | 2017-06-23 | Liquid mixture containing 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one, a niacinamide compound, and cosmetic composition containing same |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2019522001A true JP2019522001A (ja) | 2019-08-08 |
JP6855512B2 JP6855512B2 (ja) | 2021-04-07 |
Family
ID=56855695
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018568210A Active JP6855512B2 (ja) | 2016-06-30 | 2017-06-23 | 4−(3−エトキシ−4−ヒドロキシフェニル)ブタン−2−オンとナイアシンアミド化合物とを含有する液体混合物、およびそれを含有する化粧料組成物 |
Country Status (10)
Country | Link |
---|---|
US (1) | US10918582B2 (ja) |
EP (1) | EP3478253B1 (ja) |
JP (1) | JP6855512B2 (ja) |
KR (1) | KR102257407B1 (ja) |
CN (1) | CN109414382B (ja) |
BR (1) | BR112018076636B1 (ja) |
ES (1) | ES2784947T3 (ja) |
FR (1) | FR3053333B1 (ja) |
RU (1) | RU2748269C2 (ja) |
WO (1) | WO2018001898A1 (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR3090273A1 (fr) | 2018-12-21 | 2020-06-26 | L'oreal | Mélange antimicrobien contenant du 4-(3-éthoxy-4-hydroxyphényl)butan-2-one et du niacinamide, et composition le contenant |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1152742A1 (en) * | 1999-02-12 | 2001-11-14 | The Procter & Gamble Company | Cosmetic compositions containing vitamin b3 compounds |
US20030082219A1 (en) * | 2001-10-01 | 2003-05-01 | The Procter & Gamble Company | Skin care compositions comprising low concentrations of skin treatment agents |
DE10342856A1 (de) * | 2003-09-15 | 2005-04-21 | Basf Ag | Pulverförmige Zubereitungen, enthaltend 2,4,6-Trianilino-p-(carbo-2'-ethylhexyl-1'-oxi)-1,3,5-triazin |
US20100099766A1 (en) * | 2008-10-16 | 2010-04-22 | Novartis Ag | Topical NSAID compositions having sensate component |
GB0915964D0 (en) * | 2009-09-11 | 2009-10-28 | Reckitt Benckiser Healthcare I | Cosmetic composition |
FR2950884B1 (fr) * | 2009-10-01 | 2011-11-11 | Oreal | Utilisation de derives de vanilline comme conservateur, procede de conservation, composes et composition |
FR2973228B1 (fr) * | 2011-04-01 | 2014-08-01 | Oreal | Composition cosmetique comprenant du 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one |
FR2973227B1 (fr) * | 2011-04-01 | 2014-08-08 | Oreal | Composition cosmetique comprenant du 4-(3-ethoxy-4-hydroxyphenyl)butan-2-one |
-
2016
- 2016-06-30 FR FR1656175A patent/FR3053333B1/fr not_active Expired - Fee Related
-
2017
- 2017-06-23 EP EP17735414.9A patent/EP3478253B1/en active Active
- 2017-06-23 BR BR112018076636-4A patent/BR112018076636B1/pt active IP Right Grant
- 2017-06-23 WO PCT/EP2017/065547 patent/WO2018001898A1/en unknown
- 2017-06-23 US US16/311,906 patent/US10918582B2/en active Active
- 2017-06-23 KR KR1020197002124A patent/KR102257407B1/ko active IP Right Grant
- 2017-06-23 ES ES17735414T patent/ES2784947T3/es active Active
- 2017-06-23 CN CN201780039213.7A patent/CN109414382B/zh active Active
- 2017-06-23 RU RU2019102402A patent/RU2748269C2/ru active
- 2017-06-23 JP JP2018568210A patent/JP6855512B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
ES2784947T3 (es) | 2020-10-02 |
WO2018001898A1 (en) | 2018-01-04 |
US20190201303A1 (en) | 2019-07-04 |
FR3053333B1 (fr) | 2018-07-27 |
KR20190021387A (ko) | 2019-03-05 |
RU2748269C2 (ru) | 2021-05-21 |
JP6855512B2 (ja) | 2021-04-07 |
RU2019102402A3 (ja) | 2020-07-30 |
FR3053333A1 (fr) | 2018-01-05 |
CN109414382A (zh) | 2019-03-01 |
RU2019102402A (ru) | 2020-07-30 |
KR102257407B1 (ko) | 2021-05-31 |
BR112018076636A2 (pt) | 2019-04-02 |
CN109414382B (zh) | 2021-12-10 |
EP3478253B1 (en) | 2020-02-12 |
BR112018076636B1 (pt) | 2022-04-12 |
US10918582B2 (en) | 2021-02-16 |
EP3478253A1 (en) | 2019-05-08 |
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