JP2019521312A5 - - Google Patents

Info

Publication number

JP2019521312A5

JP2019521312A5 JP2018554537A JP2018554537A JP2019521312A5 JP 2019521312 A5 JP2019521312 A5 JP 2019521312A5 JP 2018554537 A JP2018554537 A JP 2018554537A JP 2018554537 A JP2018554537 A JP 2018554537A JP 2019521312 A5 JP2019521312 A5 JP 2019521312A5

Authority

JP

Japan

Prior art keywords

seq

clever

patient

tnf

hla

Prior art date

2017-04-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 230000028327 secretion Effects 0.000 claims 4
• 102000006354 HLA-DR Antigens Human genes 0.000 claims 3
• 108010058597 HLA-DR Antigens Proteins 0.000 claims 3
• 101000832225 Homo sapiens Stabilin-1 Proteins 0.000 claims 3
• 239000012634 fragment Substances 0.000 claims 3
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 2
• GOZMBJCYMQQACI-UHFFFAOYSA-N 6,7-dimethyl-3-[[methyl-[2-[methyl-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]amino]ethyl]amino]methyl]chromen-4-one;dihydrochloride Chemical compound Cl.Cl.C=1OC2=CC(C)=C(C)C=C2C(=O)C=1CN(C)CCN(C)CC(C1=CC=CC=C11)=CN1C1=CC=CC(C(F)(F)F)=C1 GOZMBJCYMQQACI-UHFFFAOYSA-N 0.000 claims 2
• 210000004322 M2 macrophage Anatomy 0.000 claims 2
• 102100024471 Stabilin-1 Human genes 0.000 claims 2
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
• 210000003690 classically activated macrophage Anatomy 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
• 239000008280 blood Substances 0.000 claims 1
• 238000011156 evaluation Methods 0.000 claims 1
• 102000058040 human STAB1 Human genes 0.000 claims 1
• 238000005259 measurement Methods 0.000 claims 1
• 210000001616 monocyte Anatomy 0.000 claims 1
• 210000005259 peripheral blood Anatomy 0.000 claims 1
• 239000011886 peripheral blood Substances 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1