JP2019519568A5 - - Google Patents
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- Publication number
- JP2019519568A5 JP2019519568A5 JP2018567951A JP2018567951A JP2019519568A5 JP 2019519568 A5 JP2019519568 A5 JP 2019519568A5 JP 2018567951 A JP2018567951 A JP 2018567951A JP 2018567951 A JP2018567951 A JP 2018567951A JP 2019519568 A5 JP2019519568 A5 JP 2019519568A5
- Authority
- JP
- Japan
- Prior art keywords
- lipid
- population
- nanoparticles
- peg
- conjugate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000002632 lipids Chemical class 0.000 claims 65
- 239000002105 nanoparticle Substances 0.000 claims 55
- -1 cationic lipid Chemical class 0.000 claims 17
- 108020004999 messenger RNA Proteins 0.000 claims 14
- 239000000203 mixture Substances 0.000 claims 14
- 239000002245 particle Substances 0.000 claims 10
- 238000009472 formulation Methods 0.000 claims 8
- 239000003246 corticosteroid Substances 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims 5
- 239000002953 phosphate buffered saline Substances 0.000 claims 5
- 150000003904 phospholipids Chemical class 0.000 claims 5
- 238000000034 method Methods 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 2
- NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 229940106189 ceramide Drugs 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 229960002842 clobetasol Drugs 0.000 claims 1
- CBGUOGMQLZIXBE-XGQKBEPLSA-N clobetasol propionate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CCl)(OC(=O)CC)[C@@]1(C)C[C@@H]2O CBGUOGMQLZIXBE-XGQKBEPLSA-N 0.000 claims 1
- 229960001334 corticosteroids Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000003862 glucocorticoid Substances 0.000 claims 1
- 230000001771 impaired effect Effects 0.000 claims 1
- 239000002395 mineralocorticoid Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022092262A JP2022111231A (ja) | 2016-06-30 | 2022-06-07 | メッセンジャーｒｎａを送達するための組成物及び方法 |
| JP2025019358A JP2025065390A (ja) | 2016-06-30 | 2025-02-07 | メッセンジャーｒｎａを送達するための組成物及び方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662357189P | 2016-06-30 | 2016-06-30 | |
| US62/357,189 | 2016-06-30 | ||
| US201662375292P | 2016-08-15 | 2016-08-15 | |
| US62/375,292 | 2016-08-15 | ||
| PCT/US2017/040446 WO2018006052A1 (en) | 2016-06-30 | 2017-06-30 | Compositions and methods for delivering messenger rna |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022092262A Division JP2022111231A (ja) | 2016-06-30 | 2022-06-07 | メッセンジャーｒｎａを送達するための組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019519568A JP2019519568A (ja) | 2019-07-11 |
| JP2019519568A5 true JP2019519568A5 (https=) | 2020-08-06 |
| JP7086870B2 JP7086870B2 (ja) | 2022-06-20 |
Family
ID=59363246
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018567951A Active JP7086870B2 (ja) | 2016-06-30 | 2017-06-30 | メッセンジャーｒｎａを送達するための組成物及び方法 |
| JP2022092262A Pending JP2022111231A (ja) | 2016-06-30 | 2022-06-07 | メッセンジャーｒｎａを送達するための組成物及び方法 |
| JP2025019358A Pending JP2025065390A (ja) | 2016-06-30 | 2025-02-07 | メッセンジャーｒｎａを送達するための組成物及び方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022092262A Pending JP2022111231A (ja) | 2016-06-30 | 2022-06-07 | メッセンジャーｒｎａを送達するための組成物及び方法 |
| JP2025019358A Pending JP2025065390A (ja) | 2016-06-30 | 2025-02-07 | メッセンジャーｒｎａを送達するための組成物及び方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11191849B2 (https=) |
| EP (1) | EP3478838A1 (https=) |
| JP (3) | JP7086870B2 (https=) |
| CN (1) | CN109563511A (https=) |
| AU (2) | AU2017286980B2 (https=) |
| CA (1) | CA3034681A1 (https=) |
| MX (2) | MX2018016389A (https=) |
| WO (1) | WO2018006052A1 (https=) |
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2017
- 2017-06-30 CN CN201780049850.2A patent/CN109563511A/zh active Pending
- 2017-06-30 AU AU2017286980A patent/AU2017286980B2/en active Active
- 2017-06-30 MX MX2018016389A patent/MX2018016389A/es unknown
- 2017-06-30 WO PCT/US2017/040446 patent/WO2018006052A1/en not_active Ceased
- 2017-06-30 JP JP2018567951A patent/JP7086870B2/ja active Active
- 2017-06-30 CA CA3034681A patent/CA3034681A1/en active Pending
- 2017-06-30 EP EP17740546.1A patent/EP3478838A1/en active Pending
- 2017-06-30 US US16/312,162 patent/US11191849B2/en active Active
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2018
- 2018-12-19 MX MX2024000327A patent/MX2024000327A/es unknown
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2021
- 2021-11-01 US US17/515,859 patent/US20220160899A1/en not_active Abandoned
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2022
- 2022-06-07 JP JP2022092262A patent/JP2022111231A/ja active Pending
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2024
- 2024-01-22 AU AU2024200392A patent/AU2024200392A1/en not_active Abandoned
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- 2025-02-07 JP JP2025019358A patent/JP2025065390A/ja active Pending
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