JP2019516730A5 - - Google Patents
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- Publication number
- JP2019516730A5 JP2019516730A5 JP2018560674A JP2018560674A JP2019516730A5 JP 2019516730 A5 JP2019516730 A5 JP 2019516730A5 JP 2018560674 A JP2018560674 A JP 2018560674A JP 2018560674 A JP2018560674 A JP 2018560674A JP 2019516730 A5 JP2019516730 A5 JP 2019516730A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- eteprilsen
- potassium
- composition according
- chloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims description 50
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 36
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 36
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 18
- 239000001103 potassium chloride Substances 0.000 claims description 18
- 235000011164 potassium chloride Nutrition 0.000 claims description 18
- 239000011780 sodium chloride Substances 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 229940061607 dibasic sodium phosphate Drugs 0.000 claims description 17
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims description 12
- 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 claims description 8
- 235000019796 monopotassium phosphate Nutrition 0.000 claims description 6
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 claims description 6
- 108010069091 Dystrophin Proteins 0.000 claims description 4
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims description 4
- 230000035772 mutation Effects 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 229940111688 monobasic potassium phosphate Drugs 0.000 claims description 2
- 229910000397 disodium phosphate Inorganic materials 0.000 claims 1
- 235000019800 disodium phosphate Nutrition 0.000 claims 1
- 238000000034 method Methods 0.000 description 3
- 208000029578 Muscle disease Diseases 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662340947P | 2016-05-24 | 2016-05-24 | |
| US62/340,947 | 2016-05-24 | ||
| US201662429160P | 2016-12-02 | 2016-12-02 | |
| US62/429,160 | 2016-12-02 | ||
| PCT/US2017/034265 WO2017213854A1 (en) | 2016-05-24 | 2017-05-24 | Pharmaceutical composition comprising eteplirsen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019516730A JP2019516730A (ja) | 2019-06-20 |
| JP2019516730A5 true JP2019516730A5 (https=) | 2020-06-25 |
Family
ID=59093599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018560674A Pending JP2019516730A (ja) | 2016-05-24 | 2017-05-24 | エテプリルセンを含む医薬組成物 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20190275072A1 (https=) |
| EP (1) | EP3463390A1 (https=) |
| JP (1) | JP2019516730A (https=) |
| KR (1) | KR20190009343A (https=) |
| CN (1) | CN109562123A (https=) |
| AU (1) | AU2017278699A1 (https=) |
| BR (1) | BR112018074299A2 (https=) |
| CA (1) | CA3024178A1 (https=) |
| CO (1) | CO2018013828A2 (https=) |
| IL (1) | IL263040A (https=) |
| MA (1) | MA45158A (https=) |
| MX (1) | MX2018014129A (https=) |
| SG (1) | SG11201809494VA (https=) |
| TW (1) | TW201805002A (https=) |
| WO (1) | WO2017213854A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI541024B (zh) | 2010-09-01 | 2016-07-11 | 日本新藥股份有限公司 | 反義核酸 |
| EP3806868A4 (en) * | 2018-06-13 | 2022-06-22 | Sarepta Therapeutics, Inc. | EXON SKIPPING OLIGOMERS FOR MUSCULAR DYSTROPHY |
| WO2019241385A2 (en) * | 2018-06-13 | 2019-12-19 | Sarepta Therapeutics, Inc. | Exon skipping oligomers for muscular dystropy |
| JP7579147B2 (ja) * | 2018-06-14 | 2024-11-07 | サレプタ セラピューティクス， インコーポレイテッド | 筋ジストロフィーに対するエクソンスキッピングオリゴマーおよびオリゴマーコンジュゲート |
| EP4671372A3 (en) | 2024-01-29 | 2026-03-11 | Arnatar Therapeutics, Inc | Translation enhancing nucleic acid compounds: aso coupled translation - upregulation 1 (act-up1) and uses thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5521063A (en) | 1985-03-15 | 1996-05-28 | Antivirals Inc. | Polynucleotide reagent containing chiral subunits and methods of use |
| US5185444A (en) | 1985-03-15 | 1993-02-09 | Anti-Gene Deveopment Group | Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages |
| US5217866A (en) | 1985-03-15 | 1993-06-08 | Anti-Gene Development Group | Polynucleotide assay reagent and method |
| US5506337A (en) | 1985-03-15 | 1996-04-09 | Antivirals Inc. | Morpholino-subunit combinatorial library and method |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5166315A (en) | 1989-12-20 | 1992-11-24 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
| JP3022967B2 (ja) | 1985-03-15 | 2000-03-21 | アンチバイラルズ インコーポレイテッド | 立体規則性ポリヌクレオチド結合ポリマー |
| EP0433345B1 (en) | 1988-09-01 | 1994-04-20 | Forskningscenter Riso | Peptide synthesis method and solid support for use in the method |
| ATE498685T1 (de) | 2004-06-28 | 2011-03-15 | Univ Western Australia | Antisense-oligonukleotide zur induktion von exon- skipping sowie verfahren zur verwendung davon |
| US8067571B2 (en) | 2005-07-13 | 2011-11-29 | Avi Biopharma, Inc. | Antibacterial antisense oligonucleotide and method |
| US8299206B2 (en) | 2007-11-15 | 2012-10-30 | Avi Biopharma, Inc. | Method of synthesis of morpholino oligomers |
| MX2010004955A (es) | 2007-11-15 | 2010-06-30 | Avi Biopharma Inc | Metodo de sintesis de oligomeros de morfolina. |
| US8076476B2 (en) | 2007-11-15 | 2011-12-13 | Avi Biopharma, Inc. | Synthesis of morpholino oligomers using doubly protected guanine morpholino subunits |
| RS55610B1 (sr) | 2010-09-30 | 2017-06-30 | Nippon Shinyaku Co Ltd | Derivat morfolino nukleinske kiseline |
| ES2727481T3 (es) | 2011-11-30 | 2019-10-16 | Sarepta Therapeutics Inc | Inclusión inducida de exón en atrofia muscular espinal |
| CN103933549A (zh) * | 2013-01-17 | 2014-07-23 | 刘海俊 | 一种新的血管抑素滴眼剂及其制备方法 |
| CA2906812A1 (en) * | 2013-03-15 | 2014-09-18 | Sarepta Therapeutics, Inc. | Improved compositions for treating muscular dystrophy |
-
2017
- 2017-05-24 US US16/302,484 patent/US20190275072A1/en not_active Abandoned
- 2017-05-24 TW TW106117190A patent/TW201805002A/zh unknown
- 2017-05-24 MX MX2018014129A patent/MX2018014129A/es unknown
- 2017-05-24 JP JP2018560674A patent/JP2019516730A/ja active Pending
- 2017-05-24 AU AU2017278699A patent/AU2017278699A1/en not_active Abandoned
- 2017-05-24 WO PCT/US2017/034265 patent/WO2017213854A1/en not_active Ceased
- 2017-05-24 SG SG11201809494VA patent/SG11201809494VA/en unknown
- 2017-05-24 CA CA3024178A patent/CA3024178A1/en not_active Abandoned
- 2017-05-24 KR KR1020187036635A patent/KR20190009343A/ko not_active Ceased
- 2017-05-24 MA MA045158A patent/MA45158A/fr unknown
- 2017-05-24 BR BR112018074299-6A patent/BR112018074299A2/pt not_active Application Discontinuation
- 2017-05-24 EP EP17731957.1A patent/EP3463390A1/en not_active Withdrawn
- 2017-05-24 CN CN201780030581.5A patent/CN109562123A/zh active Pending
-
2018
- 2018-11-15 IL IL263040A patent/IL263040A/en unknown
- 2018-12-19 CO CONC2018/0013828A patent/CO2018013828A2/es unknown