CN109562123A - 磷酸二酰胺吗啉代寡聚物药物组合物 - Google Patents

磷酸二酰胺吗啉代寡聚物药物组合物 Download PDF

Info

Publication number
CN109562123A
CN109562123A CN201780030581.5A CN201780030581A CN109562123A CN 109562123 A CN109562123 A CN 109562123A CN 201780030581 A CN201780030581 A CN 201780030581A CN 109562123 A CN109562123 A CN 109562123A
Authority
CN
China
Prior art keywords
pharmaceutical composition
eteplirsen
sodium chloride
total volume
another embodiment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780030581.5A
Other languages
English (en)
Chinese (zh)
Inventor
T.霍尔特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SA Leputa Medical Co
Original Assignee
SA Leputa Medical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SA Leputa Medical Co filed Critical SA Leputa Medical Co
Publication of CN109562123A publication Critical patent/CN109562123A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201780030581.5A 2016-05-24 2017-05-24 磷酸二酰胺吗啉代寡聚物药物组合物 Pending CN109562123A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662340947P 2016-05-24 2016-05-24
US62/340947 2016-05-24
US201662429160P 2016-12-02 2016-12-02
US62/429160 2016-12-02
PCT/US2017/034265 WO2017213854A1 (en) 2016-05-24 2017-05-24 Pharmaceutical composition comprising eteplirsen

Publications (1)

Publication Number Publication Date
CN109562123A true CN109562123A (zh) 2019-04-02

Family

ID=59093599

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780030581.5A Pending CN109562123A (zh) 2016-05-24 2017-05-24 磷酸二酰胺吗啉代寡聚物药物组合物

Country Status (15)

Country Link
US (1) US20190275072A1 (https=)
EP (1) EP3463390A1 (https=)
JP (1) JP2019516730A (https=)
KR (1) KR20190009343A (https=)
CN (1) CN109562123A (https=)
AU (1) AU2017278699A1 (https=)
BR (1) BR112018074299A2 (https=)
CA (1) CA3024178A1 (https=)
CO (1) CO2018013828A2 (https=)
IL (1) IL263040A (https=)
MA (1) MA45158A (https=)
MX (1) MX2018014129A (https=)
SG (1) SG11201809494VA (https=)
TW (1) TW201805002A (https=)
WO (1) WO2017213854A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI541024B (zh) 2010-09-01 2016-07-11 日本新藥股份有限公司 反義核酸
EP3806868A4 (en) * 2018-06-13 2022-06-22 Sarepta Therapeutics, Inc. EXON SKIPPING OLIGOMERS FOR MUSCULAR DYSTROPHY
WO2019241385A2 (en) * 2018-06-13 2019-12-19 Sarepta Therapeutics, Inc. Exon skipping oligomers for muscular dystropy
JP7579147B2 (ja) * 2018-06-14 2024-11-07 サレプタ セラピューティクス， インコーポレイテッド 筋ジストロフィーに対するエクソンスキッピングオリゴマーおよびオリゴマーコンジュゲート
EP4671372A3 (en) 2024-01-29 2026-03-11 Arnatar Therapeutics, Inc Translation enhancing nucleic acid compounds: aso coupled translation - upregulation 1 (act-up1) and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103933549A (zh) * 2013-01-17 2014-07-23 刘海俊 一种新的血管抑素滴眼剂及其制备方法
CN105307723A (zh) * 2013-03-15 2016-02-03 萨勒普塔医疗公司 改进的用于治疗肌营养不良的组合物

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521063A (en) 1985-03-15 1996-05-28 Antivirals Inc. Polynucleotide reagent containing chiral subunits and methods of use
US5185444A (en) 1985-03-15 1993-02-09 Anti-Gene Deveopment Group Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
US5217866A (en) 1985-03-15 1993-06-08 Anti-Gene Development Group Polynucleotide assay reagent and method
US5506337A (en) 1985-03-15 1996-04-09 Antivirals Inc. Morpholino-subunit combinatorial library and method
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US5166315A (en) 1989-12-20 1992-11-24 Anti-Gene Development Group Sequence-specific binding polymers for duplex nucleic acids
JP3022967B2 (ja) 1985-03-15 2000-03-21 アンチバイラルズ インコーポレイテッド 立体規則性ポリヌクレオチド結合ポリマー
EP0433345B1 (en) 1988-09-01 1994-04-20 Forskningscenter Riso Peptide synthesis method and solid support for use in the method
ATE498685T1 (de) 2004-06-28 2011-03-15 Univ Western Australia Antisense-oligonukleotide zur induktion von exon- skipping sowie verfahren zur verwendung davon
US8067571B2 (en) 2005-07-13 2011-11-29 Avi Biopharma, Inc. Antibacterial antisense oligonucleotide and method
US8299206B2 (en) 2007-11-15 2012-10-30 Avi Biopharma, Inc. Method of synthesis of morpholino oligomers
MX2010004955A (es) 2007-11-15 2010-06-30 Avi Biopharma Inc Metodo de sintesis de oligomeros de morfolina.
US8076476B2 (en) 2007-11-15 2011-12-13 Avi Biopharma, Inc. Synthesis of morpholino oligomers using doubly protected guanine morpholino subunits
RS55610B1 (sr) 2010-09-30 2017-06-30 Nippon Shinyaku Co Ltd Derivat morfolino nukleinske kiseline
ES2727481T3 (es) 2011-11-30 2019-10-16 Sarepta Therapeutics Inc Inclusión inducida de exón en atrofia muscular espinal

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103933549A (zh) * 2013-01-17 2014-07-23 刘海俊 一种新的血管抑素滴眼剂及其制备方法
CN105307723A (zh) * 2013-03-15 2016-02-03 萨勒普塔医疗公司 改进的用于治疗肌营养不良的组合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
李凌等: "《生物化学与分子生物学实验指导》", 31 August 2015, 人民军医出版社 *

Also Published As

Publication number Publication date
CA3024178A1 (en) 2017-12-14
IL263040A (en) 2018-12-31
AU2017278699A1 (en) 2018-11-15
US20190275072A1 (en) 2019-09-12
BR112018074299A2 (pt) 2019-03-12
WO2017213854A1 (en) 2017-12-14
MA45158A (fr) 2019-04-10
SG11201809494VA (en) 2018-12-28
CO2018013828A2 (es) 2018-12-28
KR20190009343A (ko) 2019-01-28
EP3463390A1 (en) 2019-04-10
MX2018014129A (es) 2019-04-29
TW201805002A (zh) 2018-02-16
JP2019516730A (ja) 2019-06-20

Similar Documents

Publication Publication Date Title
CN109562123A (zh) 磷酸二酰胺吗啉代寡聚物药物组合物
CN109153703A (zh) 免疫调节剂
Nishikawa et al. A multivalent peptide library approach identifies a novel Shiga toxin inhibitor that induces aberrant cellular transport of the toxin
ES2547827T3 (es) Procedimiento para la purificación de la micafungina
CN107002081A (zh) 抗tnf化合物
CN109415731A (zh) 呈递用于特异性敲低白介素17受体mRNA的反义寡核苷酸(ASO)的脂质体球形核酸(SNA)构建体
EP4710942A1 (en) Preparation for sirna and drug co-delivery system for efficiently targeting glioma initiating cells, and use
CN113774027A (zh) 一种蜂巢状GelMA微球在构建肿瘤模型中的应用
Srinatha et al. Microsponges: a promising frontier for prolonged release-current perspectives and patents
ES2324525T3 (es) Metodo para promover transferencia de acidos nucleicos.
Yu et al. Study on glyco-modification of endostatin-derived synthetic peptide endostatin2 (ES2) by soluble chitooligosaccharide
Kranjec et al. A bacteriocin-based coating strategy to prevent vancomycin-resistant Enterococcus faecium biofilm formation on materials of interest for indwelling medical devices
ES2386437T3 (es) Procedimiento de preparación de complejos moleculares
EP2322608B1 (en) Transfection agent
AU2022366465A1 (en) AUTOIMMUNE DISEASE THERAPEUTIC AGENT INCLUDING OLIGONUCLEOTIDE THAT SELECTIVELY BINDS TO IFN-γ, AND SAID OLIGONUCLEOTIDE
Dorchei et al. Postmodification with polycations enhances key properties of alginate-based multicomponent microcapsules
CN107124883A (zh) 具有破骨细胞分化及活性抑制能力的肽及其用途
CN110897998A (zh) 一种同时载有疏水性药物和亲水性药物的基因工程多肽纳米水凝胶及其制备方法
WO2021025899A1 (en) Phosphorodiamidate morpholino oligomer pharmaceutical compositions
Podkościelna et al. Polymer microspheres modified with pyrazole derivatives as potential agents in anticancer therapy–Preliminary studies
CN105693699B (zh) 托吡司他的晶型及其制备方法
Lee et al. Multifunctional nanodelivery platform for maximizing nucleic acids combination therapy
AU2016200507A1 (en) Treatment of cancer
CN115944597B (zh) 硫代寡核苷酸注射剂及其制备方法
CN117069799B (zh) 细胞穿膜肽及其应用

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20190402