JP2019516524A5 - - Google Patents
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- Publication number
- JP2019516524A5 JP2019516524A5 JP2019501766A JP2019501766A JP2019516524A5 JP 2019516524 A5 JP2019516524 A5 JP 2019516524A5 JP 2019501766 A JP2019501766 A JP 2019501766A JP 2019501766 A JP2019501766 A JP 2019501766A JP 2019516524 A5 JP2019516524 A5 JP 2019516524A5
- Authority
- JP
- Japan
- Prior art keywords
- plasticizer
- scaffold
- scaffolding material
- scaffolding
- polymer particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000463 material Substances 0.000 claims 39
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims 26
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 24
- 239000004014 plasticizer Substances 0.000 claims 23
- 229920000642 polymer Polymers 0.000 claims 22
- 238000000034 method Methods 0.000 claims 18
- 239000002245 particle Substances 0.000 claims 17
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims 16
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 16
- 239000002202 Polyethylene glycol Substances 0.000 claims 15
- 229920001223 polyethylene glycol Polymers 0.000 claims 15
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims 14
- 239000001069 triethyl citrate Substances 0.000 claims 14
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims 14
- 235000013769 triethyl citrate Nutrition 0.000 claims 14
- 239000001087 glyceryl triacetate Substances 0.000 claims 13
- 235000013773 glyceryl triacetate Nutrition 0.000 claims 13
- 229960002622 triacetin Drugs 0.000 claims 13
- 235000019441 ethanol Nutrition 0.000 claims 10
- 239000007788 liquid Substances 0.000 claims 10
- 239000005711 Benzoic acid Substances 0.000 claims 8
- AHVYPIQETPWLSZ-UHFFFAOYSA-N N-methyl-pyrrolidine Natural products CN1CC=CC1 AHVYPIQETPWLSZ-UHFFFAOYSA-N 0.000 claims 8
- 235000010233 benzoic acid Nutrition 0.000 claims 8
- 239000011859 microparticle Substances 0.000 claims 8
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 4
- ZFOZVQLOBQUTQQ-UHFFFAOYSA-N Tributyl citrate Chemical compound CCCCOC(=O)CC(O)(C(=O)OCCCC)CC(=O)OCCCC ZFOZVQLOBQUTQQ-UHFFFAOYSA-N 0.000 claims 4
- FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 claims 4
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims 2
- QZCLKYGREBVARF-UHFFFAOYSA-N Acetyl tributyl citrate Chemical compound CCCCOC(=O)CC(C(=O)OCCCC)(OC(C)=O)CC(=O)OCCCC QZCLKYGREBVARF-UHFFFAOYSA-N 0.000 claims 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 2
- PYGXAGIECVVIOZ-UHFFFAOYSA-N Dibutyl decanedioate Chemical compound CCCCOC(=O)CCCCCCCCC(=O)OCCCC PYGXAGIECVVIOZ-UHFFFAOYSA-N 0.000 claims 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical class OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims 2
- 150000001298 alcohols Chemical class 0.000 claims 2
- 239000004359 castor oil Substances 0.000 claims 2
- 235000019438 castor oil Nutrition 0.000 claims 2
- 239000000919 ceramic Substances 0.000 claims 2
- 150000001860 citric acid derivatives Chemical class 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- -1 diacetyl monoglyceride Chemical compound 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 235000011187 glycerol Nutrition 0.000 claims 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 2
- 239000000178 monomer Substances 0.000 claims 2
- 229920005615 natural polymer Polymers 0.000 claims 2
- 235000021317 phosphate Nutrition 0.000 claims 2
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims 2
- 125000005498 phthalate group Chemical class 0.000 claims 2
- 229920000747 poly(lactic acid) Polymers 0.000 claims 2
- 229920001610 polycaprolactone Polymers 0.000 claims 2
- 239000004632 polycaprolactone Substances 0.000 claims 2
- 229920001451 polypropylene glycol Polymers 0.000 claims 2
- 239000011148 porous material Substances 0.000 claims 2
- 239000000600 sorbitol Substances 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- WEAPVABOECTMGR-UHFFFAOYSA-N triethyl 2-acetyloxypropane-1,2,3-tricarboxylate Chemical compound CCOC(=O)CC(C(=O)OCC)(OC(C)=O)CC(=O)OCC WEAPVABOECTMGR-UHFFFAOYSA-N 0.000 claims 2
- 229920000954 Polyglycolide Polymers 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000011066 ex-situ storage Methods 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022015471A JP2022068212A (ja) | 2016-03-24 | 2022-02-03 | 足場材料、方法および使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1605122.9A GB201605122D0 (en) | 2016-03-24 | 2016-03-24 | Scaffolding material, methods and uses |
| GB1605122.9 | 2016-03-24 | ||
| GB201606395 | 2016-04-13 | ||
| GB1606395.0 | 2016-04-13 | ||
| PCT/GB2017/050815 WO2017163072A1 (en) | 2016-03-24 | 2017-03-23 | Scaffolding material, methods and uses |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022015471A Division JP2022068212A (ja) | 2016-03-24 | 2022-02-03 | 足場材料、方法および使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019516524A JP2019516524A (ja) | 2019-06-20 |
| JP2019516524A5 true JP2019516524A5 (https=) | 2020-04-30 |
| JP7021182B2 JP7021182B2 (ja) | 2022-02-16 |
Family
ID=58464594
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019501766A Active JP7021182B2 (ja) | 2016-03-24 | 2017-03-23 | 足場材料、方法および使用 |
| JP2022015471A Pending JP2022068212A (ja) | 2016-03-24 | 2022-02-03 | 足場材料、方法および使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022015471A Pending JP2022068212A (ja) | 2016-03-24 | 2022-02-03 | 足場材料、方法および使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20200093956A1 (https=) |
| EP (1) | EP3432939B1 (https=) |
| JP (2) | JP7021182B2 (https=) |
| KR (1) | KR20190003945A (https=) |
| CN (1) | CN109475662A (https=) |
| AU (1) | AU2017236423A1 (https=) |
| CA (1) | CA3018629A1 (https=) |
| WO (1) | WO2017163072A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110564123B (zh) * | 2019-10-29 | 2021-07-20 | 吉林大学 | 一种聚乳酸/生物玻璃复合材料及制备方法 |
| KR102266384B1 (ko) * | 2021-01-25 | 2021-06-21 | 주식회사 울트라브이 | 필러용 생분해성 고분자 미세입자, 이를 포함한 필러용 동결건조체, 그 제조방법 및 상기 동결건조체를 포함하는 필러용 주사제 |
| GB202306382D0 (en) | 2023-04-28 | 2023-06-14 | Locate Bio Ltd | Osteoinstructive calcium phosphate ceramic material |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3107573A (en) * | 1960-10-28 | 1963-10-22 | Standard Oil Co | Method of restricting a solid propellant |
| IT1268621B1 (it) * | 1994-10-07 | 1997-03-06 | P & G Spa | Composizione adesiva e relativo procedimento di preparazione. |
| JP3503045B2 (ja) * | 1997-05-13 | 2004-03-02 | タキロン株式会社 | 形状記憶生体内分解吸収性材料 |
| CA2285149A1 (en) * | 1998-10-07 | 2000-04-07 | Isotis B.V. | Device for tissue engineering a bone equivalent |
| ATE419834T1 (de) * | 2000-11-20 | 2009-01-15 | Elan Pharma Int Ltd | Nanopartikel bestehend aus einem arzneistoff und copolymeren von vinyl pyrrolidon und vinyl acetat als oberflächenstabilisatoren |
| JP4669662B2 (ja) * | 2001-10-25 | 2011-04-13 | ユニヴァーシティー オブ コネティカット | 生物活性材料、生物活性材料の製法およびその使用方法 |
| GB0307011D0 (en) | 2003-03-27 | 2003-04-30 | Regentec Ltd | Porous matrix |
| US8163030B2 (en) * | 2004-05-06 | 2012-04-24 | Degradable Solutions Ag | Biocompatible bone implant compositions and methods for repairing a bone defect |
| US8053000B2 (en) * | 2005-06-07 | 2011-11-08 | Dr. Reddy's Laboratories Limited | Compositions for drug delivery |
| JP2007236802A (ja) * | 2006-03-10 | 2007-09-20 | Takiron Co Ltd | インプラント傾斜材料 |
| EP1872807A1 (en) * | 2006-06-30 | 2008-01-02 | Scil Technology GmbH | Biomaterial containing degradation stabilized polymer |
| RU2454220C2 (ru) * | 2006-08-16 | 2012-06-27 | Новартис Аг | Способ получения твердых дисперсий высококристаллических терапевтических соединений |
| GB0701896D0 (en) * | 2007-02-01 | 2007-03-14 | Regentec Ltd | Composition |
| US8288344B2 (en) * | 2007-03-15 | 2012-10-16 | Musculoskeletal Transplant Foundation | Ceramic composition for filling bone defects |
| EP2207577B1 (en) * | 2007-10-26 | 2015-01-14 | National Institute Of Immunology | Biodegradable polymer scaffold and process for preparation thereof |
| GB0903810D0 (en) * | 2009-03-05 | 2009-04-22 | Regentec Ltd | Delivery system |
| AU2010275697B2 (en) * | 2009-07-23 | 2014-01-30 | Progentix Orthobiology B.V. | Injectable and moldable osteoinductive ceramic materials |
| AU2011329054B2 (en) * | 2010-11-15 | 2015-05-28 | Zimmer Orthobiologics, Inc. | Bone void fillers |
| GB201314312D0 (en) * | 2013-08-09 | 2013-09-25 | Regentec Ltd | Composition and delivery system |
| GB201317005D0 (en) * | 2013-09-25 | 2013-11-06 | Blueberry Therapeutics Ltd | Composition and methods of treatment |
| JP6460540B2 (ja) * | 2014-04-08 | 2019-01-30 | ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． | 関節障害の処置のために使用される生分解性ポリエステルアミド |
-
2017
- 2017-03-23 JP JP2019501766A patent/JP7021182B2/ja active Active
- 2017-03-23 EP EP17715260.0A patent/EP3432939B1/en active Active
- 2017-03-23 KR KR1020187030561A patent/KR20190003945A/ko not_active Withdrawn
- 2017-03-23 AU AU2017236423A patent/AU2017236423A1/en not_active Abandoned
- 2017-03-23 CN CN201780025424.5A patent/CN109475662A/zh active Pending
- 2017-03-23 CA CA3018629A patent/CA3018629A1/en not_active Abandoned
- 2017-03-23 WO PCT/GB2017/050815 patent/WO2017163072A1/en not_active Ceased
- 2017-03-23 US US16/087,772 patent/US20200093956A1/en not_active Abandoned
-
2020
- 2020-11-13 US US17/097,894 patent/US20210290818A1/en not_active Abandoned
-
2022
- 2022-02-03 JP JP2022015471A patent/JP2022068212A/ja active Pending
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