CN109475662A - 支架材料、方法和用途 - Google Patents

支架材料、方法和用途 Download PDF

Info

Publication number
CN109475662A
CN109475662A CN201780025424.5A CN201780025424A CN109475662A CN 109475662 A CN109475662 A CN 109475662A CN 201780025424 A CN201780025424 A CN 201780025424A CN 109475662 A CN109475662 A CN 109475662A
Authority
CN
China
Prior art keywords
scaffold
polymer
carrier
plasticizer
polymer particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780025424.5A
Other languages
English (en)
Chinese (zh)
Inventor
A·伦纳迪
H·C·考克斯
S·凯里
C·马修斯
A·洛马斯
K·M·莎士舍夫
R·A·奎克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Location Therapy Co Ltd
Original Assignee
Location Therapy Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1605122.9A external-priority patent/GB201605122D0/en
Application filed by Location Therapy Co Ltd filed Critical Location Therapy Co Ltd
Publication of CN109475662A publication Critical patent/CN109475662A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/10—Ceramics or glasses
    • A61L27/105—Ceramics or glasses containing Al2O3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/502—Plasticizers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Ceramic Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
CN201780025424.5A 2016-03-24 2017-03-23 支架材料、方法和用途 Pending CN109475662A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1605122.9A GB201605122D0 (en) 2016-03-24 2016-03-24 Scaffolding material, methods and uses
GB1605122.9 2016-03-24
GB201606395 2016-04-13
GB1606395.0 2016-04-13
PCT/GB2017/050815 WO2017163072A1 (en) 2016-03-24 2017-03-23 Scaffolding material, methods and uses

Publications (1)

Publication Number Publication Date
CN109475662A true CN109475662A (zh) 2019-03-15

Family

ID=58464594

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780025424.5A Pending CN109475662A (zh) 2016-03-24 2017-03-23 支架材料、方法和用途

Country Status (8)

Country Link
US (2) US20200093956A1 (https=)
EP (1) EP3432939B1 (https=)
JP (2) JP7021182B2 (https=)
KR (1) KR20190003945A (https=)
CN (1) CN109475662A (https=)
AU (1) AU2017236423A1 (https=)
CA (1) CA3018629A1 (https=)
WO (1) WO2017163072A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110564123A (zh) * 2019-10-29 2019-12-13 吉林大学 一种聚乳酸/生物玻璃复合材料及制备方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102266384B1 (ko) * 2021-01-25 2021-06-21 주식회사 울트라브이 필러용 생분해성 고분자 미세입자, 이를 포함한 필러용 동결건조체, 그 제조방법 및 상기 동결건조체를 포함하는 필러용 주사제
GB202306382D0 (en) 2023-04-28 2023-06-14 Locate Bio Ltd Osteoinstructive calcium phosphate ceramic material

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1575188A (zh) * 2001-10-25 2005-02-02 康涅狄格大学 生物活性物质,制备生物活性物质的方法及其使用方法
CN101237856A (zh) * 2005-06-07 2008-08-06 雷迪博士实验室有限公司 用于药物递送的组合物
WO2008093094A2 (en) * 2007-02-01 2008-08-07 Regentec Limited Composition
CN101264340A (zh) * 2007-03-15 2008-09-17 肌骨胳移植基金会 用于填充骨缺损的陶瓷组合物
CN101478997A (zh) * 2006-06-30 2009-07-08 Scil技术有限公司 含有可降解性稳定化聚合物的生物材料
CN100566763C (zh) * 2003-03-27 2009-12-09 瑞根泰克有限公司 组织支架以及该组织支架的生产工艺
CN102421415A (zh) * 2009-03-05 2012-04-18 瑞根泰克有限公司 具有支架的输送系统
CN102573938A (zh) * 2009-07-23 2012-07-11 布若贞提克斯骨生物学有限公司 可注射和可模塑的骨诱导性陶瓷材料
CN103313733A (zh) * 2010-11-15 2013-09-18 捷迈整形外科生物材料有限公司 骨空隙填充剂
WO2015019109A1 (en) * 2013-08-09 2015-02-12 Locate Therapeutics Limited Composition and delivery system

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3107573A (en) * 1960-10-28 1963-10-22 Standard Oil Co Method of restricting a solid propellant
IT1268621B1 (it) * 1994-10-07 1997-03-06 P & G Spa Composizione adesiva e relativo procedimento di preparazione.
JP3503045B2 (ja) * 1997-05-13 2004-03-02 タキロン株式会社 形状記憶生体内分解吸収性材料
CA2285149A1 (en) * 1998-10-07 2000-04-07 Isotis B.V. Device for tissue engineering a bone equivalent
ATE419834T1 (de) * 2000-11-20 2009-01-15 Elan Pharma Int Ltd Nanopartikel bestehend aus einem arzneistoff und copolymeren von vinyl pyrrolidon und vinyl acetat als oberflächenstabilisatoren
US8163030B2 (en) * 2004-05-06 2012-04-24 Degradable Solutions Ag Biocompatible bone implant compositions and methods for repairing a bone defect
JP2007236802A (ja) * 2006-03-10 2007-09-20 Takiron Co Ltd インプラント傾斜材料
RU2454220C2 (ru) * 2006-08-16 2012-06-27 Новартис Аг Способ получения твердых дисперсий высококристаллических терапевтических соединений
EP2207577B1 (en) * 2007-10-26 2015-01-14 National Institute Of Immunology Biodegradable polymer scaffold and process for preparation thereof
GB201317005D0 (en) * 2013-09-25 2013-11-06 Blueberry Therapeutics Ltd Composition and methods of treatment
JP6460540B2 (ja) * 2014-04-08 2019-01-30 ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． 関節障害の処置のために使用される生分解性ポリエステルアミド

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1575188A (zh) * 2001-10-25 2005-02-02 康涅狄格大学 生物活性物质,制备生物活性物质的方法及其使用方法
CN100566763C (zh) * 2003-03-27 2009-12-09 瑞根泰克有限公司 组织支架以及该组织支架的生产工艺
CN101237856A (zh) * 2005-06-07 2008-08-06 雷迪博士实验室有限公司 用于药物递送的组合物
CN101478997A (zh) * 2006-06-30 2009-07-08 Scil技术有限公司 含有可降解性稳定化聚合物的生物材料
WO2008093094A2 (en) * 2007-02-01 2008-08-07 Regentec Limited Composition
CN101264340A (zh) * 2007-03-15 2008-09-17 肌骨胳移植基金会 用于填充骨缺损的陶瓷组合物
CN102421415A (zh) * 2009-03-05 2012-04-18 瑞根泰克有限公司 具有支架的输送系统
CN102573938A (zh) * 2009-07-23 2012-07-11 布若贞提克斯骨生物学有限公司 可注射和可模塑的骨诱导性陶瓷材料
CN103313733A (zh) * 2010-11-15 2013-09-18 捷迈整形外科生物材料有限公司 骨空隙填充剂
WO2015019109A1 (en) * 2013-08-09 2015-02-12 Locate Therapeutics Limited Composition and delivery system

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110564123A (zh) * 2019-10-29 2019-12-13 吉林大学 一种聚乳酸/生物玻璃复合材料及制备方法
CN110564123B (zh) * 2019-10-29 2021-07-20 吉林大学 一种聚乳酸/生物玻璃复合材料及制备方法

Also Published As

Publication number Publication date
EP3432939A1 (en) 2019-01-30
KR20190003945A (ko) 2019-01-10
WO2017163072A1 (en) 2017-09-28
JP2022068212A (ja) 2022-05-09
JP2019516524A (ja) 2019-06-20
AU2017236423A1 (en) 2018-11-15
US20200093956A1 (en) 2020-03-26
CA3018629A1 (en) 2017-09-28
JP7021182B2 (ja) 2022-02-16
EP3432939B1 (en) 2024-05-01
US20210290818A1 (en) 2021-09-23

Similar Documents

Publication Publication Date Title
US20120063997A1 (en) Delivery system with scaffolds
CA2520398C (en) Two phase porous matrix for use as a tissue scaffold
CN105658251A (zh) 组合物和递送系统
JPH05305135A (ja) 生物分解性のある重合体組成物
US20240350707A1 (en) Tissue scaffold and scaffold composition
JP2022068212A (ja) 足場材料、方法および使用
CN111166940B (zh) 可吸收的人工骨复合材料及其制备方法
Nairon et al. Tunable hydrogel systems for delivery and release of cell-secreted and synthetic therapeutic products
CN113041400B (zh) 可诱导骨生长的人工骨复合材料
Nairon et al. 3 Tunable Hydrogel Systems

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
CB02 Change of applicant information

Address after: The British county of Northampton

Applicant after: Lecott Biology Co.,Ltd.

Address before: The British county of Northampton

Applicant before: LOCATE THERAPEUTICS Ltd.

CB02 Change of applicant information
RJ01 Rejection of invention patent application after publication

Application publication date: 20190315

RJ01 Rejection of invention patent application after publication