JP2019515031A5 - - Google Patents
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- JP2019515031A5 JP2019515031A5 JP2019506612A JP2019506612A JP2019515031A5 JP 2019515031 A5 JP2019515031 A5 JP 2019515031A5 JP 2019506612 A JP2019506612 A JP 2019506612A JP 2019506612 A JP2019506612 A JP 2019506612A JP 2019515031 A5 JP2019515031 A5 JP 2019515031A5
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- 239000000203 mixture Substances 0.000 claims 18
- 241000196324 Embryophyta Species 0.000 claims 17
- 150000001768 cations Chemical class 0.000 claims 8
- QHMBSVQNZZTUGM-ZWKOTPCHSA-N Cannabidiol Chemical compound OC1=CC(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-ZWKOTPCHSA-N 0.000 claims 6
- 229950011318 Cannabidiol Drugs 0.000 claims 6
- QHMBSVQNZZTUGM-MSOLQXFVSA-N Cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1[C@@H]1[C@@H](C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-MSOLQXFVSA-N 0.000 claims 6
- 241000218236 Cannabis Species 0.000 claims 6
- 239000000126 substance Substances 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 239000011734 sodium Substances 0.000 claims 5
- 229910052708 sodium Inorganic materials 0.000 claims 5
- 239000011780 sodium chloride Substances 0.000 claims 5
- UVOLYTDXHDXWJU-NRFANRHFSA-N Cannabichromene Natural products C1=C[C@](C)(CCC=C(C)C)OC2=CC(CCCCC)=CC(O)=C21 UVOLYTDXHDXWJU-NRFANRHFSA-N 0.000 claims 4
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims 4
- CYQFCXCEBYINGO-ZYMOGRSISA-N (6aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydrobenzo[c]chromen-1-ol Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3C21 CYQFCXCEBYINGO-ZYMOGRSISA-N 0.000 claims 3
- QXACEHWTBCFNSA-SFQUDFHCSA-N Cannabigerol Chemical compound CCCCCC1=CC(O)=C(C\C=C(/C)CCC=C(C)C)C(O)=C1 QXACEHWTBCFNSA-SFQUDFHCSA-N 0.000 claims 3
- 229960003453 Cannabinol Drugs 0.000 claims 3
- 235000008697 Cannabis sativa Nutrition 0.000 claims 3
- 240000000218 Cannabis sativa Species 0.000 claims 3
- 241000638023 Cannabis sativa subsp. indica Species 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 3
- 235000005607 chanvre indien Nutrition 0.000 claims 3
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims 3
- 229960004242 dronabinol Drugs 0.000 claims 3
- 229910052751 metal Inorganic materials 0.000 claims 3
- 239000002184 metal Substances 0.000 claims 3
- WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 claims 3
- 150000002892 organic cations Chemical class 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 240000002234 Allium sativum Species 0.000 claims 2
- 241000754798 Calophyllum brasiliense Species 0.000 claims 2
- 240000005589 Calophyllum inophyllum Species 0.000 claims 2
- 235000009590 Calophyllum inophyllum Nutrition 0.000 claims 2
- IGHTZQUIFGUJTG-UHFFFAOYSA-N Cannabicyclol Chemical compound O1C2=CC(CCCCC)=CC(O)=C2C2C(C)(C)C3C2C1(C)CC3 IGHTZQUIFGUJTG-UHFFFAOYSA-N 0.000 claims 2
- -1 Cannabinodiol (CBDL) Chemical compound 0.000 claims 2
- VBGLYOIFKLUMQG-UHFFFAOYSA-N Cannabinol Chemical compound C1=C(C)C=C2C3=C(O)C=C(CCCCC)C=C3OC(C)(C)C2=C1 VBGLYOIFKLUMQG-UHFFFAOYSA-N 0.000 claims 2
- 244000163122 Curcuma domestica Species 0.000 claims 2
- 240000006223 Matricaria chamomilla Species 0.000 claims 2
- 240000004119 Melissa officinalis Species 0.000 claims 2
- 235000010654 Melissa officinalis Nutrition 0.000 claims 2
- UCONUSSAWGCZMV-HZPDHXFCSA-N Tetrahydrocannabinolic acid Chemical compound C([C@H]1C(C)(C)O2)CC(C)=C[C@H]1C1=C2C=C(CCCCC)C(C(O)=O)=C1O UCONUSSAWGCZMV-HZPDHXFCSA-N 0.000 claims 2
- 240000002657 Thymus vulgaris Species 0.000 claims 2
- 235000007303 Thymus vulgaris Nutrition 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 2
- 239000011575 calcium Substances 0.000 claims 2
- 229910052791 calcium Inorganic materials 0.000 claims 2
- 235000009120 camo Nutrition 0.000 claims 2
- 244000213578 camo Species 0.000 claims 2
- WVOLTBSCXRRQFR-DLBZAZTESA-N cannabidiolic acid Chemical compound OC1=C(C(O)=O)C(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)=C)CCC(C)=C1 WVOLTBSCXRRQFR-DLBZAZTESA-N 0.000 claims 2
- 235000011472 cat’s claw Nutrition 0.000 claims 2
- 235000001544 chamomile Nutrition 0.000 claims 2
- 239000000284 extract Substances 0.000 claims 2
- 235000004611 garlic Nutrition 0.000 claims 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 2
- 239000011777 magnesium Substances 0.000 claims 2
- 229910052749 magnesium Inorganic materials 0.000 claims 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 2
- 239000011591 potassium Substances 0.000 claims 2
- 229910052700 potassium Inorganic materials 0.000 claims 2
- 150000003505 terpenes Chemical class 0.000 claims 2
- 239000001585 thymus vulgaris Substances 0.000 claims 2
- 235000013311 vegetables Nutrition 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 235000007639 Anthemis cotula Nutrition 0.000 claims 1
- 240000002595 Asclepias syriaca Species 0.000 claims 1
- 235000002470 Asclepias syriaca Nutrition 0.000 claims 1
- 244000003240 Caesalpinia gilliesii Species 0.000 claims 1
- 235000014161 Caesalpinia gilliesii Nutrition 0.000 claims 1
- 240000001432 Calendula officinalis Species 0.000 claims 1
- 235000005881 Calendula officinalis Nutrition 0.000 claims 1
- 241001246270 Calophyllum Species 0.000 claims 1
- 241001404094 Calophyllum soulattri Species 0.000 claims 1
- 240000001548 Camellia japonica Species 0.000 claims 1
- 240000000363 Cantharellus cibarius Species 0.000 claims 1
- 235000015722 Cantharellus cibarius Nutrition 0.000 claims 1
- 241000282994 Cervidae Species 0.000 claims 1
- 235000007866 Chamaemelum nobile Nutrition 0.000 claims 1
- 235000014375 Curcuma Nutrition 0.000 claims 1
- 235000003392 Curcuma domestica Nutrition 0.000 claims 1
- 241000088853 Duboisia hopwoodii Species 0.000 claims 1
- 240000003276 Euphorbia heterophylla Species 0.000 claims 1
- 240000002883 Ginkgo biloba Species 0.000 claims 1
- 235000008100 Ginkgo biloba Nutrition 0.000 claims 1
- 240000008526 Hypericum perforatum Species 0.000 claims 1
- 235000017309 Hypericum perforatum Nutrition 0.000 claims 1
- 241000934806 Krameria Species 0.000 claims 1
- 241000244355 Ligusticum Species 0.000 claims 1
- 235000007232 Matricaria chamomilla Nutrition 0.000 claims 1
- 235000004429 Matricaria chamomilla var recutita Nutrition 0.000 claims 1
- 230000035536 Oral bioavailability Effects 0.000 claims 1
- 240000006764 Punica granatum Species 0.000 claims 1
- 235000014360 Punica granatum Nutrition 0.000 claims 1
- 241001278097 Salix alba Species 0.000 claims 1
- 235000002197 St. John’s wort Nutrition 0.000 claims 1
- 241000607122 Uncaria tomentosa Species 0.000 claims 1
- 241001441361 Usnea barbata Species 0.000 claims 1
- 235000012511 Vaccinium Nutrition 0.000 claims 1
- 241000736767 Vaccinium Species 0.000 claims 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 1
- 235000018597 common camellia Nutrition 0.000 claims 1
- 235000003373 curcuma longa Nutrition 0.000 claims 1
- LCGLNKUTAGEVQW-UHFFFAOYSA-N dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 claims 1
- 235000021285 flavonoid Nutrition 0.000 claims 1
- 229930003935 flavonoids Natural products 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 235000000381 ginkgo Nutrition 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 230000036220 oral bioavailability Effects 0.000 claims 1
- 150000003385 sodium Chemical group 0.000 claims 1
- 235000007586 terpenes Nutrition 0.000 claims 1
- QEMXHQIAXOOASZ-UHFFFAOYSA-N tetramethylammonium Chemical compound C[N+](C)(C)C QEMXHQIAXOOASZ-UHFFFAOYSA-N 0.000 claims 1
- 235000013976 turmeric Nutrition 0.000 claims 1
Claims (20)
- （ｉ）０．１ｍｇ／ｍｌ未満の水溶解度をもつ植物性物質及び
（ｉｉ）Ｎ−アシル化脂肪アミノ酸又はその塩を含む、
経口送達用に処方された植物由来組成物であって、
Ｎ−アシル化脂肪アミノ酸又はその塩が、
- ＸがＨであり、ＺがＨである、請求項１に記載の植物由来組成物。
- ＸがＨであり、Ｚがナトリウムである、請求項１に記載の植物由来組成物。
- Ｘがナトリウムであり、Ｚがナトリウムである、請求項１に記載の植物由来組成物。
- ＺがＨであり、一価のカチオンがナトリウム又はカリウムを含み、二価のカチオンがカルシウム又はマグネシウムを含む、請求項１に記載の植物由来組成物。
- ＸがＨであり、一価のカチオンがナトリウム又はカリウムを含み、二価の金属カチオンがカルシウム又はマグネシウムを含み、及び有機のカチオンがアンモニウム又はテトラメチルアンモニウムを含む、請求項１に記載の植物由来組成物。
- Ｎ−アシル化脂肪アミノ酸又はその塩が、Ｎ−［８−（２−ヒドロキシベンゾイル）アミノ］カプリレートを含む、請求項１〜６のいずれか一項に記載の植物由来組成物。
- １００〜２００ｍｇのＮ−［８−（２−ヒドロキシベンゾイル）アミノ］カプリレートを含む、請求項７に記載の植物由来組成物。
- 植物性物質が大麻に由来する、請求項１〜８のいずれか一項に記載の植物由来組成物。
- 大麻が、アサ（Ｃａｎｎａｂｉｓ ｓａｔｉｖａ）、カンナビス・ルデラリス（Ｃａｎｎａｂｉｓ ｒｕｄｅｒａｌｉｓ）、及び／又はインド大麻（Ｃａｎｎａｂｉｓ ｉｎｄｉｃａ）から選択される、請求項９に記載の植物由来組成物。
- 大麻抽出物を含む、請求項１０に記載の植物由来組成物。
- Δ９−テトラヒドロカンナビノール（ＴＨＣ）及びカンナビジオール（ＣＢＤ）、カンナビゲロール（ＣＢＧ）、カンナビクロメン（ＣＢＣ）、カンナビノール（ＣＢＮ）、カンナビノジオール（ＣＢＤＬ）、カンナビシクロール（ＣＢＬ）、カンナビバリン（ＣＢＶ）、テトラヒドロカンナビバリン（ＴＨＣＶ）、カンナビジバリン（ＣＢＤＶ）、カンナビクロメバリン（ＣＢＣＶ）、カンナビゲロバリン（ＣＢＧＶ）、カンナビゲロールモノメチルエーテル（ＣＢＧＭ）、カンナビネロール酸、カンナビジオール酸（ＣＢＤＡ）、カンナビノールプロピル変異体（ＣＢＮＶ）、カンナビトリオール（ＣＢＯ）、テトラヒドロカンナビノール酸（ＴＨＣＡ）、テトラヒドロカンナビバリン酸（ＴＨＣＶＡ）及び／又はこれらの混合物を含む、請求項１〜１１のいずれか一項に記載の植物由来組成物。
- 植物性物質が、Δ９−テトラヒドロカンナビノール（ＴＨＣ）及び／又はカンナビジオール（ＣＢＤ）を含む、請求項１２に記載の植物由来組成物。
- フラボノイド化合物、テルペン、又はテルペノイドを含む、請求項１〜１３のいずれか一項に記載の植物由来組成物。
- 植物性物質が、サンタマリア（Ｃａｌｏｐｈｙｌｌｕｍ ｂｒａｓｉｌｉｅｎｓｅ）、カロフィラム・カレドニクルン（Ｃａｌｏｐｈｙｌｌｕｍ ｃａｌｅｄｏｎｉｃｕｒｎ）、テリハボク（Ｃａｌｏｐｈｙｌｌｕｍ ｉｎｏｐｈｙｌｌｕｍ）、オトギリソウ（Ｃａｌｏｐｈｙｌｌｕｍ ｓｏｕｌａｔｔｒｉ）、キャッツクロー（Ｕｎｃａｒｉａ ｔｏｍｅｎｔｏｓａ）、タチジャコウソウ（Ｔｈｙｍｕｓ ｖｕｌｇａｒｉｓ）、カモミール（Ｍａｔｒｉｃａｒｉａ ｒｅｃｕｔｉｔａ）、サリックス・アルバ（Ｓａｌｉｘ ａｌｂａ）、キンセンカ（Ｃａｌｅｎｄｕｌａ ｏｆｆｉｃｉｎａｌｉｓ）、ウスニア・バルバタ（Ｕｓｎｅａ ｂａｒｂａｔａ）、リグスティカム・ポルテリーオシャ（Ｌｉｇｕｓｔｉｃｕｍ ｐｏｒｔｅｒｉｉ−ｏｓｈａ）、ヒメコウジ（Ｇａｕｌｔｈｅｒｉａ ｐｒｏｃｕｍｂｅｎｓ）、チャノキ（Ｃａｍｅｌｌｉａ ｓｉｎｅｎｓｉｓ）、セイヨウスノキ（Ｖａｃｃｉｎｉｕｍ ｍｙｒｔｉｌｌｕｓ）、レモンバーム（Ｍｅｌｉｓｓａ ｏｆｆｉｃｉｎａｌｉｓ）、ニンニク（Ａｌｌｉｕｍ ｓａｔｉｖｕｍ）、チャノキ（Ｃａｍｅｌｌｉａ ｓｉｎｅｎｓｉｓ）、クラメリア・トリアンドラ（Ｋｒａｍｅｒｉａ ｔｒｉａｎｄｒａ）、ザクロ（Ｐｕｎｉｃａ ｇｒａｎａｔｕｍ）、ヤブデマリ（Ｖｉｂｕｒｎｕｍ ｐｌｉｃａｔｕｍ）、タバコ（Ｎｉｃｏｔｉａｎａ ｔａｂａｃｕｍ）、ピチュリ（Ｄｕｂｏｉｓｉａ ｈｏｐｗｏｏｄｉｉ）、オオトウワタ（Ａｓｃｌｅｐｉａｓ ｓｙｒｉａｃａ）、ウコン（Ｃｕｒｃｕｍａ ｌｏｎｇａ）、アサ（Ｃａｎｎａｂｉｓ ｓａｔｉｖａ）、インド大麻（Ｃａｎｎａｂｉｓ ｉｎｄｉｃａ）、カンナビス・ルデラリス（Ｃａｎｎａｂｉｓ ｒｕｄｅｒａｌｉｓ）及び／又はカエデ属の種（Ａｃｅｒ ｓｐｐ）、又はこれらの抽出物に由来する、請求項１に記載の植物由来組成物。
- Ｎ−アシル化脂肪アミノ酸又はその塩を、植物性物質を含む経口製剤に添加することを含む、０．１ｍｇ／ｍｌ未満の水溶解度をもつ植物性物質における有効成分の経口におけるバイオアベイラビリティーを増大させる方法であって、
Ｎ−アシル化脂肪アミノ酸又はその塩が、式、
- １００〜２００ｍｇのＮ−［８−（２−ヒドロキシベンゾイル）アミノ］カプリレートを製剤に添加することを含む、請求項１６に記載の方法。
- 添加が、有効成分の作用の開始を短くする、請求項１６に記載の方法。
- 植物性物質が、アサ（Ｃａｎｎａｂｉｓ ｓａｔｉｖａ）、カンナビス・ルデラリス（Ｃａｎｎａｂｉｓ ｒｕｄｅｒａｌｉｓ）、及び／又はインド大麻（Ｃａｎｎａｂｉｓ ｉｎｄｉｃａ）に由来する請求項１８に記載の方法。
- 有効成分が、Δ９−テトラヒドロカンナビノール（ＴＨＣ）及び／又はカンナビジオール（ＣＢＤ）である、請求項１９に記載の方法。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021189167A JP7284241B2 (ja) | 2016-04-22 | 2021-11-22 | 即効性の植物由来医薬化合物及び栄養補給剤 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662326490P | 2016-04-22 | 2016-04-22 | |
| US62/326,490 | 2016-04-22 | ||
| US201662429544P | 2016-12-02 | 2016-12-02 | |
| US62/429,544 | 2016-12-02 | ||
| PCT/US2017/028953 WO2017185038A1 (en) | 2016-04-22 | 2017-04-21 | Fast-acting plant-based medicinal compounds and nutritional supplements |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021189167A Division JP7284241B2 (ja) | 2016-04-22 | 2021-11-22 | 即効性の植物由来医薬化合物及び栄養補給剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019515031A JP2019515031A (ja) | 2019-06-06 |
| JP2019515031A5 true JP2019515031A5 (ja) | 2020-05-28 |
| JP6983868B2 JP6983868B2 (ja) | 2021-12-17 |
Family
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019506612A Active JP6983868B2 (ja) | 2016-04-22 | 2017-04-21 | 即効性の植物由来医薬化合物及び栄養補給剤 |
| JP2021189167A Active JP7284241B2 (ja) | 2016-04-22 | 2021-11-22 | 即効性の植物由来医薬化合物及び栄養補給剤 |
| JP2023081364A Pending JP2023103393A (ja) | 2016-04-22 | 2023-05-17 | 即効性の植物由来医薬化合物及び栄養補給剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
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| JP2021189167A Active JP7284241B2 (ja) | 2016-04-22 | 2021-11-22 | 即効性の植物由来医薬化合物及び栄養補給剤 |
| JP2023081364A Pending JP2023103393A (ja) | 2016-04-22 | 2023-05-17 | 即効性の植物由来医薬化合物及び栄養補給剤 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10588974B2 (ja) |
| EP (2) | EP3445356B1 (ja) |
| JP (3) | JP6983868B2 (ja) |
| KR (1) | KR102393596B1 (ja) |
| CN (1) | CN109069475B (ja) |
| AU (3) | AU2017252575B2 (ja) |
| BR (1) | BR112018071518A2 (ja) |
| CA (1) | CA3021660A1 (ja) |
| CL (1) | CL2018002997A1 (ja) |
| CO (1) | CO2018011299A2 (ja) |
| IL (2) | IL262505B (ja) |
| MX (2) | MX2018012913A (ja) |
| WO (1) | WO2017185038A1 (ja) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102393596B1 (ko) | 2016-04-22 | 2022-05-04 | 리셉터 홀딩스, 인크. | 속효성 식물-계 의약 화합물 및 영양 보충제 |
| EA201892396A1 (ru) | 2016-12-02 | 2019-04-30 | Ресептор Лайф Сайенсиз, Инк. | Быстродействующие растительные лекарственные соединения и биологически активные добавки |
| US10239808B1 (en) | 2016-12-07 | 2019-03-26 | Canopy Holdings, LLC | Cannabis extracts |
| CN110121337A (zh) * | 2017-01-03 | 2019-08-13 | 受体控股公司 | 药用化合物和营养补充剂 |
| WO2018175992A1 (en) * | 2017-03-23 | 2018-09-27 | Receptor Life Sciences | Rapid and controlled delivery of compositions with restored entourage effects |
| EP3745884A1 (en) | 2018-01-31 | 2020-12-09 | Canopy Holdings, Llc | Hemp powder |
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2017
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- 2017-04-21 EP EP17786760.3A patent/EP3445356B1/en active Active
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- 2017-04-21 BR BR112018071518-2A patent/BR112018071518A2/pt not_active Application Discontinuation
- 2017-04-21 AU AU2017252575A patent/AU2017252575B2/en active Active
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- 2017-04-21 CN CN201780024997.6A patent/CN109069475B/zh active Active
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