JP2019513752A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019513752A5 JP2019513752A5 JP2018552826A JP2018552826A JP2019513752A5 JP 2019513752 A5 JP2019513752 A5 JP 2019513752A5 JP 2018552826 A JP2018552826 A JP 2018552826A JP 2018552826 A JP2018552826 A JP 2018552826A JP 2019513752 A5 JP2019513752 A5 JP 2019513752A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- composition
- therapeutic
- disease
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 9
- 230000001225 therapeutic Effects 0.000 claims 6
- 206010053643 Neurodegenerative disease Diseases 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 201000011240 frontotemporal dementia Diseases 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 206010001897 Alzheimer's disease Diseases 0.000 claims 1
- 206010002026 Amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 108009000433 Amyotrophic lateral sclerosis (ALS) Proteins 0.000 claims 1
- 201000001971 Huntington's disease Diseases 0.000 claims 1
- 206010061536 Parkinson's disease Diseases 0.000 claims 1
- 102100002435 TARDBP Human genes 0.000 claims 1
- 101710036241 TARDBP Proteins 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 230000004059 degradation Effects 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 230000001404 mediated Effects 0.000 claims 1
- 230000002438 mitochondrial Effects 0.000 claims 1
- 108010091748 peptide A Proteins 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000035806 respiratory chain Effects 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
Claims (10)
- 配列番号１、配列番号３または配列番号５と少なくとも７５％同一であるアミノ酸配列を有する５〜１０アミノ酸の合成治療ペプチドと、前記治療ペプチドに連結されており且つ細胞による前記治療ペプチドの取り込みを促進する輸送部分と、を含む治療剤を含む、医薬組成物。
- 前記治療ペプチドが、ミトコンドリアの呼吸鎖複合体１の、ＴＤＰ−４３によって媒介される分解を阻害する、請求項１に記載の組成物。
- 前記治療ペプチドが、配列番号１、配列番号３、配列番号５、配列番号７、配列番号８および配列番号９からなる群から選択されるアミノ酸配列を有する、請求項１に記載の組成物。
- 前記輸送部分がＴＡＴペプチドを含む、請求項１に記載の組成物。
- 前記治療剤が、配列番号１２〜１７からなる群から選択されるアミノ酸配列を有する、請求項１に記載の組成物。
- 神経変性疾患の治療における使用のための請求項１に記載の組成物。
- 前記神経変性疾患が、筋萎縮性側索硬化症（ＡＬＳ）、前頭側頭型認知症、アルツハイマー病、パーキンソン病、およびハンチントン病からなる群から選択される、請求項６に記載の組成物。
- 前記神経変性疾患が、前頭側頭型認知症である、請求項７に記載の組成物。
- 前記神経変性疾患が、筋萎縮性側索硬化症である、請求項７に記載の組成物。
- 連続的皮下注入用に製剤化されている、請求項７に記載の組成物。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662319580P | 2016-04-07 | 2016-04-07 | |
| US62/319,580 | 2016-04-07 | ||
| US201662328484P | 2016-04-27 | 2016-04-27 | |
| US62/328,484 | 2016-04-27 | ||
| PCT/US2017/026675 WO2017177178A1 (en) | 2016-04-07 | 2017-04-07 | Tdp-43 mitochondrial localization inhibitor for the treatment of neurodegenerative disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019513752A JP2019513752A (ja) | 2019-05-30 |
| JP2019513752A5 true JP2019513752A5 (ja) | 2020-05-21 |
Family
ID=60000683
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018552826A Pending JP2019513752A (ja) | 2016-04-07 | 2017-04-07 | 神経変性疾患を治療するためのｔｄｐ−４３のミトコンドリア局在化阻害剤 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11124553B2 (ja) |
| EP (1) | EP3440094B1 (ja) |
| JP (1) | JP2019513752A (ja) |
| KR (1) | KR20180132807A (ja) |
| CN (1) | CN109563130A (ja) |
| AU (1) | AU2017248353A1 (ja) |
| CA (1) | CA3020344A1 (ja) |
| SG (1) | SG11201808829VA (ja) |
| WO (1) | WO2017177178A1 (ja) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10906949B2 (en) * | 2017-06-28 | 2021-02-02 | The Cleveland Clinic Foundation | Methods of treating spinal cord injury using a chondroitin sulfate proteoglycan (CSPG) reduction peptide (CRP) comprising a cell membrane penetrating domain, a CSPG binding domain, and a lysosome targeting domain |
| CN113683703B (zh) * | 2020-05-18 | 2023-08-15 | 中国人民解放军陆军军医大学第二附属医院 | 一种hTERT靶向物及其用途 |
| WO2021247893A1 (en) * | 2020-06-03 | 2021-12-09 | Yumanity Therapeutics, Inc. | Bicyclic heteroaromatic amide compounds and uses thereof |
| CN114057858B (zh) | 2020-08-10 | 2023-03-21 | 上海瑞吉康生物医药有限公司 | 对引起神经变性和神经退行性疾病的蛋白聚集具有解聚作用的多肽 |
| KR102488166B1 (ko) | 2020-09-24 | 2023-01-13 | 재단법인대구경북과학기술원 | Ｈｄａｃ６의 ｔｄｐ－４３ 단백질병증 예방 또는 치료제로서의 용도 |
| JP6961278B1 (ja) * | 2021-03-10 | 2021-11-05 | 国立研究開発法人量子科学技術研究開発機構 | 生体試料中のｔｄｐ−４３を測定する方法及び装置 |
| CN113450336B (zh) * | 2021-07-01 | 2022-10-25 | 维柯基科技(上海)有限公司 | 一种多孔荧光微阵列图像的处理方法、装置、计算机设备及计算机可读存储介质 |
| KR20240133923A (ko) * | 2023-02-28 | 2024-09-05 | (주)케어젠 | 펩타이드 복합체를 유효성분으로 포함하는 항노화용 조성물 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US5670617A (en) | 1989-12-21 | 1997-09-23 | Biogen Inc | Nucleic acid conjugates of tat-derived transport polypeptides |
| US5804604A (en) | 1989-12-21 | 1998-09-08 | Biogen, Inc. | Tat-derived transport polypeptides and fusion proteins |
| JP3150340B2 (ja) | 1990-11-13 | 2001-03-26 | イムネクス コーポレイション | 二機能選択可能融合遺伝子 |
| JPH09500783A (ja) | 1993-05-21 | 1997-01-28 | ターゲッティッド ジェネティクス コーポレイション | シトシンデアミナーゼ（ｃｄ）遺伝子に基づく二機能性選択融合遺伝子 |
| US5858683A (en) * | 1996-08-30 | 1999-01-12 | Matritech, Inc. | Methods and compositions for the detection of cervical cancer |
| GB9718609D0 (en) | 1997-09-02 | 1997-11-05 | Imp College Innovations Ltd | Fusion protein |
| GB9723824D0 (en) * | 1997-11-11 | 1998-01-07 | Actinova Ltd | Cytostatic agents |
| WO2002010201A2 (en) | 2000-07-31 | 2002-02-07 | Active Motif | Peptide-mediated delivery of molecules into cells |
| US20040229837A1 (en) * | 2003-05-15 | 2004-11-18 | Yijuang Chern | Treatment of neurodegenerative diseases |
| CN101287988B (zh) * | 2005-07-01 | 2012-10-10 | 阿波维塔公司 | 用于流感诊断和治疗的方法和组合物 |
| EP2097090B1 (en) | 2006-12-06 | 2014-10-29 | Thomas Jefferson University | Peptide and treatment for hiv-1 infection |
| US8889597B2 (en) * | 2008-02-01 | 2014-11-18 | Washington University | Sequences associated with TDP-43 proteinopathies and methods of using the same |
| WO2010072228A1 (en) * | 2008-12-22 | 2010-07-01 | Xigen S.A. | Novel transporter constructs and transporter cargo conjugate molecules |
| WO2013012811A2 (en) * | 2011-07-19 | 2013-01-24 | New York University | Immunotherapeutic modulation of amyloidogenic disease using non-fibrillogenic, non-amyloidogenic polymerized proteins and peptides |
| WO2013129603A1 (ja) | 2012-02-28 | 2013-09-06 | 国立大学法人東京農工大学 | Tdp-43細胞内存在量関連疾患の認定方法 |
| US9017672B2 (en) * | 2012-05-11 | 2015-04-28 | Immunicum Aktiebolag | Hexon Tat-PTD modified adenovirus and uses thereof |
| WO2013192298A1 (en) * | 2012-06-22 | 2013-12-27 | The Scripps Research Institute | Apoptosis biomarkers |
| GB201408255D0 (en) * | 2014-05-09 | 2014-06-25 | Immatics Biotechnologies Gmbh | Novel immunotherapy against several tumours of the blood, such as acute myeloid leukemia (AML) |
-
2017
- 2017-04-07 JP JP2018552826A patent/JP2019513752A/ja active Pending
- 2017-04-07 CN CN201780028382.0A patent/CN109563130A/zh active Pending
- 2017-04-07 WO PCT/US2017/026675 patent/WO2017177178A1/en active Application Filing
- 2017-04-07 US US16/090,786 patent/US11124553B2/en active Active
- 2017-04-07 AU AU2017248353A patent/AU2017248353A1/en not_active Abandoned
- 2017-04-07 EP EP17779936.8A patent/EP3440094B1/en active Active
- 2017-04-07 KR KR1020187031919A patent/KR20180132807A/ko not_active Application Discontinuation
- 2017-04-07 SG SG11201808829VA patent/SG11201808829VA/en unknown
- 2017-04-07 CA CA3020344A patent/CA3020344A1/en not_active Abandoned
-
2021
- 2021-09-21 US US17/480,884 patent/US12129285B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019513752A5 (ja) | ||
| JP2016222689A5 (ja) | 合成ペプチド及び乾燥粉末薬剤輸送システム | |
| JP2017158561A5 (ja) | ||
| JP2013172743A5 (ja) | ||
| JP2015517489A5 (ja) | ||
| JP2012176978A5 (ja) | ||
| JP2015529685A5 (ja) | ||
| JP2015517488A5 (ja) | ||
| JPWO2019156137A5 (ja) | ||
| JP2017502024A5 (ja) | ||
| JP2016525095A5 (ja) | 環状ポリペプチド | |
| JP2014510101A5 (ja) | ||
| MX2012012225A (es) | Profármacos de agentes tearapéuticos de liberación de óxido nítrico. | |
| JP2012501973A5 (ja) | ||
| WO2017009843A3 (en) | Compositions, articles of manufacture and methods for treating cancer | |
| NZ611620A (en) | Cyclosporine analogue molecules modified at amino acid 1 and 3 | |
| JPWO2019107530A5 (ja) | ||
| JP2013533273A5 (ja) | ||
| JP2014514365A5 (ja) | ||
| FI3511004T3 (fi) | Yhdistelmävalmisteita syövän hoitoon | |
| JP2012102105A5 (ja) | ||
| JP2013523718A5 (ja) | ||
| JP2019531293A5 (ja) | ||
| EA201391387A1 (ru) | Нейропротекторные пептиды | |
| JP2019505567A5 (ja) |