JP2019512528A - 抑うつ、不安症、快感消失症、疲労、自殺念慮、および外傷後ストレス障害の治療における（２ｒ，６ｒ）−ヒドロキシノルケタミンおよび（２ｓ，６ｓ）−ヒドロキシノルケタミンの使用方法 - Google Patents

抑うつ、不安症、快感消失症、疲労、自殺念慮、および外傷後ストレス障害の治療における（２ｒ，６ｒ）−ヒドロキシノルケタミンおよび（２ｓ，６ｓ）−ヒドロキシノルケタミンの使用方法 Download PDF

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JP2019512528A
JP2019512528A JP2018550327A JP2018550327A JP2019512528A JP 2019512528 A JP2019512528 A JP 2019512528A JP 2018550327 A JP2018550327 A JP 2018550327A JP 2018550327 A JP2018550327 A JP 2018550327A JP 2019512528 A JP2019512528 A JP 2019512528A
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Japan
Prior art keywords
disorder
hnk
ketamine
anxiety
hydroxynorketamine
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JP2019512528A5 (cg-RX-API-DMAC10.html
Inventor
アービング ワイナー
アービング ワイナー
カルロス ザラテ
カルロス ザラテ
ルイン モアデル
ルイン モアデル
トッド ゴウルド
トッド ゴウルド
パノス ザノス
パノス ザノス
クレイグ トーマス
クレイグ トーマス
パトリック モリス
パトリック モリス
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United States Department of Health and Human Services
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United States Department of Health and Human Services
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Publication of JP2019512528A publication Critical patent/JP2019512528A/ja
Publication of JP2019512528A5 publication Critical patent/JP2019512528A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2018550327A 2016-03-25 2017-03-27 抑うつ、不安症、快感消失症、疲労、自殺念慮、および外傷後ストレス障害の治療における（２ｒ，６ｒ）−ヒドロキシノルケタミンおよび（２ｓ，６ｓ）−ヒドロキシノルケタミンの使用方法 Pending JP2019512528A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662313317P 2016-03-25 2016-03-25
US62/313,317 2016-03-25
PCT/US2017/024238 WO2017165877A1 (en) 2016-03-25 2017-03-27 Methods of using (2r, 6r)-hydroxynorketamine and (2s, 6s)-hydroxynorketamine in the treatment of depression, anxiety, anhedonia, suicidal ideation, and post traumatic stress disorders

Publications (2)

Publication Number Publication Date
JP2019512528A true JP2019512528A (ja) 2019-05-16
JP2019512528A5 JP2019512528A5 (cg-RX-API-DMAC10.html) 2020-05-07

Family

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Application Number Title Priority Date Filing Date
JP2018550327A Pending JP2019512528A (ja) 2016-03-25 2017-03-27 抑うつ、不安症、快感消失症、疲労、自殺念慮、および外傷後ストレス障害の治療における（２ｒ，６ｒ）−ヒドロキシノルケタミンおよび（２ｓ，６ｓ）−ヒドロキシノルケタミンの使用方法

Country Status (7)

Country Link
US (1) US20190083420A1 (cg-RX-API-DMAC10.html)
EP (1) EP3432869A1 (cg-RX-API-DMAC10.html)
JP (1) JP2019512528A (cg-RX-API-DMAC10.html)
CN (1) CN109475514A (cg-RX-API-DMAC10.html)
AU (1) AU2017238858A1 (cg-RX-API-DMAC10.html)
CA (1) CA3019012A1 (cg-RX-API-DMAC10.html)
WO (1) WO2017165877A1 (cg-RX-API-DMAC10.html)

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DK3043785T3 (da) 2013-09-13 2021-11-15 Univ Chiba Nat Univ Corp Anvendelse af r-ketamin og salt deraf som lægemidler
CN107847469A (zh) 2015-06-27 2018-03-27 美国神农制药责任有限公司 氯胺酮透皮递送系统
AU2017238859B2 (en) 2016-03-25 2021-02-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Crystal forms and methods of synthesis of (2R, 6R)-hydroxynorketamine and (2S, 6S)-hydroxynorketamine
AU2017250086A1 (en) * 2016-04-11 2018-09-20 Clexio Biosciences Ltd. Deuterated ketamine derivatives
WO2018102488A1 (en) * 2016-11-30 2018-06-07 Wolfson Philip E Ketamine for the treatment of menstrually related symptoms
DK3505157T3 (da) 2017-12-29 2022-02-28 Celon Pharma Sa Tørpulver-ketaminsammensætning til pulmonal indgivelse ved behandlingsresistent depression
WO2019160057A1 (ja) 2018-02-15 2019-08-22 国立大学法人千葉大学 炎症性疾患若しくは骨疾患の予防又は治療剤及び医薬組成物
CN110343050B (zh) * 2018-04-04 2021-09-24 上海键合医药科技有限公司 芳香类化合物及其制备方法和用途
CN118121577A (zh) 2018-05-04 2024-06-04 感知神经科学公司 治疗物质滥用的方法
WO2020237748A1 (zh) * 2019-05-24 2020-12-03 北京大学深圳研究生院 一种长效化合物的制备方法
EP4007575B1 (en) * 2019-11-05 2023-09-27 Claes THULIN 4-[5-[(rac)-1-[5-(3-chlorophenyl)-3-isoxazolyl]ethoxy]-4-methyl-4h-1,2,4-triazol-3-yl]pyridine for use in prevention and/or treatment of stress
CN113125586B (zh) * 2019-12-31 2022-05-24 成都百裕制药股份有限公司 一种1-[2-(2，4-二甲基-苯硫基)-苯基]哌嗪及其异构体的检测方法
EP4168385A4 (en) 2020-06-17 2024-07-17 Spirify Pharma Inc. HYDROXYNORKETAMINE ANALOGS, COMPOSITIONS COMPRISING THEM AND METHODS OF USE THEREOF
US12466785B2 (en) 2020-08-31 2025-11-11 Shenzhen Ruijian Biotechnology Co., Ltd Long-acting low-addiction HNK derivative and preparation method therefor
CN112516130B (zh) * 2020-08-31 2022-01-04 深圳瑞健生物科技有限公司 一种长效低成瘾性化合物在制备药物中的应用
KR102906446B1 (ko) 2020-08-31 2026-01-02 선전 루이지엔 바이오테크놀로지 컴퍼니 리미티드 장기 작용성 및 저중독성 hnk 유도체 및 그의 제조 방법
CN112521357B (zh) * 2020-08-31 2021-10-08 深圳瑞健生物科技有限公司 一种长效低成瘾性hnk衍生物及其制备方法
CN114524737B (zh) * 2020-11-23 2024-10-22 江苏恒瑞医药股份有限公司 一种取代的环己酮类化合物
CN114947839B (zh) * 2022-05-27 2025-12-02 华东师范大学 大脑调控的训练方法、装置及电子设备
CN120736994B (zh) * 2025-01-26 2025-11-18 上海东西智荟生物医药有限公司 氯胺酮衍生物及其在精神疾病的治疗中的用途
CN121313626A (zh) * 2025-10-27 2026-01-13 北京大学深圳研究生院 治疗胶质母细胞瘤的化合物和方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015501302A (ja) * 2011-10-14 2015-01-15 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ うつ病及び神経障害性疼痛の治療における（２ｒ，６ｒ）−ヒドロキシノルケタミン、（ｓ）−デヒドロノルケタミン及び他の（ｒ，ｓ）−ケタミンの立体異性デヒドロ及びヒドロキシル化代謝生成物の使用

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US20140079740A1 (en) * 2012-08-02 2014-03-20 ClinPharm Support GmbH Oral transmucosal adminstration forms of s-ketamine

Patent Citations (1)

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JP2015501302A (ja) * 2011-10-14 2015-01-15 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ うつ病及び神経障害性疼痛の治療における（２ｒ，６ｒ）−ヒドロキシノルケタミン、（ｓ）−デヒドロノルケタミン及び他の（ｒ，ｓ）−ケタミンの立体異性デヒドロ及びヒドロキシル化代謝生成物の使用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ANN. N.Y. ACAD. SCI., vol. Vol. 1345, Issue 1, JPN6021006831, 2015, pages 47 - 58, ISSN: 0004614797 *
BIOL. PSYCHIATRY, vol. Vol. 76, Issue 12, JPN6021006832, 2014, pages 970 - 976, ISSN: 0004614798 *

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AU2017238858A1 (en) 2018-10-18
US20190083420A1 (en) 2019-03-21
CA3019012A1 (en) 2017-09-28
CN109475514A (zh) 2019-03-15
EP3432869A1 (en) 2019-01-30
WO2017165877A1 (en) 2017-09-28
WO2017165877A8 (en) 2018-10-18

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