JP2019512489A5 - - Google Patents
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- JP2019512489A5 JP2019512489A5 JP2018547943A JP2018547943A JP2019512489A5 JP 2019512489 A5 JP2019512489 A5 JP 2019512489A5 JP 2018547943 A JP2018547943 A JP 2018547943A JP 2018547943 A JP2018547943 A JP 2018547943A JP 2019512489 A5 JP2019512489 A5 JP 2019512489A5
- Authority
- JP
- Japan
- Prior art keywords
- mir
- seq
- nucleic acid
- mimic
- mimetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662304844P | 2016-03-07 | 2016-03-07 | |
| US62/304,844 | 2016-03-07 | ||
| PCT/US2017/021178 WO2017156015A2 (en) | 2016-03-07 | 2017-03-07 | Micrornas and methods of their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019512489A JP2019512489A (ja) | 2019-05-16 |
| JP2019512489A5 true JP2019512489A5 (enExample) | 2020-03-26 |
Family
ID=58361152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018547943A Pending JP2019512489A (ja) | 2016-03-07 | 2017-03-07 | マイクロrnaおよびその使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11655469B2 (enExample) |
| EP (1) | EP3426781B1 (enExample) |
| JP (1) | JP2019512489A (enExample) |
| CN (3) | CN117757795A (enExample) |
| DK (1) | DK3426781T3 (enExample) |
| ES (1) | ES2986046T3 (enExample) |
| WO (1) | WO2017156015A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3492607A3 (en) * | 2017-11-30 | 2019-08-14 | Università Degli Studi Di Torino | Urinary mirnas for the in vitro diagnosis of bladder cancer |
| WO2020227604A1 (en) * | 2019-05-08 | 2020-11-12 | Nova Southeastern University | Regulation of nucleotide excision repair (ner) by microrna for treatment of breast cancer |
| WO2020245822A1 (en) * | 2019-06-03 | 2020-12-10 | Carmel Haifa University Economic Corporation Ltd. | Human head and neck cancer treatment |
| CN111235274A (zh) * | 2020-01-18 | 2020-06-05 | 山西医科大学第一医院 | 喉鳞癌血清外泌体标志物筛选方法和外泌体来源miR-941应用 |
| IL296957A (en) * | 2020-04-02 | 2022-12-01 | Mirecule Inc | Targeted inhibition using engineered oligonucleotides |
| CN112007043B (zh) * | 2020-08-24 | 2021-07-20 | 谢琦 | 抗结直肠癌的药物或组合物 |
| WO2022056454A2 (en) * | 2020-09-14 | 2022-03-17 | President And Fellows Of Harvard College | Methods and compositions for treating hpv-positive cancers |
| CN112294960B (zh) * | 2020-10-30 | 2022-02-08 | 浙江大学 | 微小分子RNA-30b-5p作为靶分子的用途 |
| CN112359115B (zh) * | 2020-11-30 | 2022-08-30 | 河北仁博科技有限公司 | 与肿瘤细胞顺铂耐药性相关的miR-517a-3p及其应用 |
| CN112481273B (zh) * | 2020-12-29 | 2023-11-24 | 南通大学附属医院 | 结直肠癌抑癌基因及其启动子区高dna甲基化的验证方法 |
| EP4124656A1 (en) * | 2021-07-26 | 2023-02-01 | Martin-Luther-Universität Halle-Wittenberg | Pd-l1 micrornas |
| CN113528669A (zh) * | 2021-08-19 | 2021-10-22 | 柳州市工人医院 | 一种利用Small RNA测序技术揭示miRNA对肝癌作用机制的方法 |
| US20250101525A1 (en) * | 2022-01-21 | 2025-03-27 | Griffith University | Biomarkers and uses therefor |
| CN114574596B (zh) * | 2022-03-11 | 2023-06-23 | 浙江省农业科学院 | SNPs分子标记g.43851G>A及其在湖羊分子标记辅助育种中的应用 |
| CN115161321B (zh) * | 2022-06-24 | 2023-04-18 | 天津市农业科学院 | ssc-miR-30c-3p在制备抗PDCoV增殖药物中的应用 |
| CN120035667A (zh) * | 2022-07-10 | 2025-05-23 | 普雷西根公司 | 用于免疫检查点抑制的多顺反子miRNA构建体 |
| WO2024142962A1 (ja) * | 2022-12-28 | 2024-07-04 | 学校法人自治医科大学 | 腹膜播種抑制剤、腹膜播種抑制方法、腹膜播種予防方法、及び腹膜播種治療方法 |
| TW202444389A (zh) * | 2023-01-30 | 2024-11-16 | 中央研究院 | 藉由調節mir34治療脊髓性肌肉萎縮症(sma)以及mir34作為sma的預測生物標記的用途 |
| EP4417709A1 (en) * | 2023-02-14 | 2024-08-21 | Gemeinnützige Salzburger Landeskliniken Betriebsges.mbH | Mirna-based diagnostic assay for the detection of a risk to develop skin tumors against the background of severe skin lesions |
| AU2024239300A1 (en) * | 2023-03-23 | 2025-10-23 | Purdue Research Foundation | Fully modified mir-34a and related conjugates, compositions and methods of use |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US5019369A (en) | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| SI1504126T1 (sl) | 2002-05-03 | 2014-08-29 | Duke University Office Of Science And Technology | Postopek regulacije izraĹľanja genov |
| WO2005017145A1 (ja) * | 2003-08-13 | 2005-02-24 | Japan Biological Informatics Consortium | 機能性rnaが制御する被制御遺伝子の同定・予測方法及びその利用方法 |
| EP1768998A2 (en) | 2004-04-27 | 2007-04-04 | Alnylam Pharmaceuticals Inc. | Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety |
| CA2562151C (en) | 2004-04-30 | 2016-09-06 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides comprising a c5-modified pyrimidine |
| EP1789553B1 (en) | 2004-06-30 | 2014-03-26 | Alnylam Pharmaceuticals Inc. | Oligonucleotides comprising a non-phosphate backbone linkage |
| AU2005328382C1 (en) | 2004-07-21 | 2013-01-24 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides comprising a modified or non-natural nucleobase |
| EP1797183B1 (en) * | 2004-09-02 | 2012-08-01 | Yale University | Regulation of oncogenes by micrornas |
| JP2006248978A (ja) | 2005-03-10 | 2006-09-21 | Mebiopharm Co Ltd | 新規なリポソーム製剤 |
| EP1904111A4 (en) | 2005-06-03 | 2009-08-19 | Univ Johns Hopkins | COMPOSITIONS AND METHODS FOR REDUCING MICRORNA EXPRESSION FOR THE TREATMENT OF NEOPLASIA |
| US20070213292A1 (en) | 2005-08-10 | 2007-09-13 | The Rockefeller University | Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof |
| EP2796554A3 (en) | 2005-09-12 | 2014-12-10 | The Ohio State University Research Foundation | Compositions for use in treating BCL2-associated cancers |
| US8603991B2 (en) | 2005-11-18 | 2013-12-10 | Gradalis, Inc. | Individualized cancer therapy |
| BRPI0619755A2 (pt) | 2005-12-12 | 2011-10-18 | Univ North Carolina | micrornas que regulam a proliferação e diferenciação de células musculares |
| CN101389770B (zh) | 2006-01-05 | 2013-11-06 | 俄亥俄州立大学研究基金会 | 用于诊断和治疗实体癌的基于微小rna的方法和组合物 |
| WO2007143752A2 (en) | 2006-06-09 | 2007-12-13 | The Regents Of The University Of California | Targets in breast cancer for prognosis or therapy |
| US20100292299A1 (en) | 2006-06-20 | 2010-11-18 | Mendell Joshua T | Nucleotide Motifs Providing Localization Elements and Methods of Use |
| JP2010503382A (ja) * | 2006-07-17 | 2010-02-04 | サーナ・セラピューティクス・インコーポレイテッド | 低分子干渉核酸(siNA)を用いたプロタンパク質転換酵素サブチリシンケクシン9(PCSK9)遺伝子発現のRNA干渉媒介性阻害 |
| WO2008069940A2 (en) | 2006-12-06 | 2008-06-12 | Albert Einstein College Of Medicine Of Yeshiva University | Multi-microrna methods and compositions |
| CN101627121A (zh) | 2006-12-08 | 2010-01-13 | 奥斯瑞根公司 | 作为治疗干预的靶标的miRNA调控基因和路径 |
| EP2111408A4 (en) | 2007-01-17 | 2010-02-03 | Univ Johns Hopkins | COMPOSITIONS AND METHODS OF microRNA FOR THE TREATMENT OF NEOPLASIA |
| AU2008283794B2 (en) | 2007-07-31 | 2014-03-20 | Board Of Regents, The University Of Texas System | Micro-RNAs that control myosin expression and myofiber identity |
| US20090148535A1 (en) * | 2007-12-06 | 2009-06-11 | Minerva Biotechnologies Corporation | Method for treating cancer using interference rna |
| EP2306978A2 (en) | 2008-06-06 | 2011-04-13 | Mirna Therapeutics, Inc. | Compositions for the in vivo delivery of rnai agents |
| JP2010094122A (ja) * | 2008-06-12 | 2010-04-30 | Keio Gijuku | バイオマーカーとしてのマイクロrnaを用いた頭頸部腫瘍の診断・治療選択 |
| WO2010065630A2 (en) * | 2008-12-03 | 2010-06-10 | The Johns Hopkins University | Compositions and methods for treating hepatic neoplasia |
| GEP20156329B (en) | 2009-06-08 | 2015-07-27 | Miragen Therapeutics | CHEMICAL MODIFICATIONS OF miRNA INHIBITORS AND MIMETICS |
| WO2011034811A1 (en) | 2009-09-17 | 2011-03-24 | Sigma-Aldrich Co. | Short rna mimetics |
| US8754059B2 (en) * | 2010-02-16 | 2014-06-17 | University Of Miami | Use of miR-30e to treat vascular lesions |
| WO2011143660A2 (en) * | 2010-05-14 | 2011-11-17 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating leukemia |
| CN103459598B (zh) | 2011-02-03 | 2016-08-10 | 米尔纳医疗股份有限公司 | Mir-124的合成模拟物 |
| SG10201600836PA (en) | 2011-02-03 | 2016-03-30 | Mirna Therapeutics Inc | Synthetic mimics of mir-34 |
| GB201102283D0 (en) * | 2011-02-09 | 2011-03-23 | Ucl Business Plc | Treatment |
| AU2013201303C1 (en) | 2011-10-06 | 2016-06-23 | MiRagen Therapeutics, Inc. | Control of whole body energy homeostasis by microRNA regulation |
| US8846633B2 (en) * | 2011-11-07 | 2014-09-30 | Taipei Veterans General Hospital | Method for inhibiting cancer stem cell like properties and chemoradioresistant properties of cancer or tumor cells with microRNA145 |
| WO2014117050A2 (en) * | 2013-01-26 | 2014-07-31 | Mirimus, Inc. | Modified mirna as a scaffold for shrna |
| DK2963125T3 (da) * | 2013-02-15 | 2020-10-12 | Univ Nat Corp Tokyo Medical & Dental | Terapeutisk middel til behandling af en cancer, hvor NRF2 er stabiliseret |
| US9518300B2 (en) * | 2014-04-14 | 2016-12-13 | Dana-Farber Cancer Institute, Inc. | Composition and method for treating a hematological malignancy |
| DK3134130T3 (da) * | 2014-04-25 | 2019-08-26 | Childrens Medical Center | Sammensætninger og fremgangsmåder til behandling af hæmoglobinopatier |
-
2017
- 2017-03-07 ES ES17712348T patent/ES2986046T3/es active Active
- 2017-03-07 EP EP17712348.6A patent/EP3426781B1/en active Active
- 2017-03-07 DK DK17712348.6T patent/DK3426781T3/da active
- 2017-03-07 JP JP2018547943A patent/JP2019512489A/ja active Pending
- 2017-03-07 WO PCT/US2017/021178 patent/WO2017156015A2/en not_active Ceased
- 2017-03-07 CN CN202410174429.6A patent/CN117757795A/zh active Pending
- 2017-03-07 US US16/082,852 patent/US11655469B2/en active Active
- 2017-03-07 CN CN202410174426.2A patent/CN117757794A/zh active Pending
- 2017-03-07 CN CN201780027750.XA patent/CN109312341B/zh active Active
-
2023
- 2023-04-14 US US18/301,040 patent/US20230295631A1/en not_active Abandoned
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