JP2019510826A5 - - Google Patents
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- Publication number
- JP2019510826A5 JP2019510826A5 JP2019502544A JP2019502544A JP2019510826A5 JP 2019510826 A5 JP2019510826 A5 JP 2019510826A5 JP 2019502544 A JP2019502544 A JP 2019502544A JP 2019502544 A JP2019502544 A JP 2019502544A JP 2019510826 A5 JP2019510826 A5 JP 2019510826A5
- Authority
- JP
- Japan
- Prior art keywords
- trapidil
- composition
- compound
- levodopa
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 trapidil compound Chemical class 0.000 claims 15
- 229960000363 trapidil Drugs 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 13
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims 12
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims 12
- 229960004502 levodopa Drugs 0.000 claims 12
- GSNOZLZNQMLSKJ-UHFFFAOYSA-N Trapidil Chemical class CCN(CC)C1=CC(C)=NC2=NC=NN12 GSNOZLZNQMLSKJ-UHFFFAOYSA-N 0.000 claims 4
- 208000016285 Movement disease Diseases 0.000 claims 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 238000007911 parenteral administration Methods 0.000 claims 2
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 claims 1
- 206010061623 Adverse drug reaction Diseases 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 claims 1
- 208000012661 Dyskinesia Diseases 0.000 claims 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims 1
- 229940071870 hydroiodic acid Drugs 0.000 claims 1
- 229910017604 nitric acid Inorganic materials 0.000 claims 1
- 235000006408 oxalic acid Nutrition 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 235000002906 tartaric acid Nutrition 0.000 claims 1
- 239000011975 tartaric acid Substances 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022044284A JP7794668B2 (ja) | 2016-04-04 | 2022-03-18 | トラピジルを使用する錐体外路症候群の処置 |
| JP2024041690A JP2024095682A (ja) | 2016-04-04 | 2024-03-15 | トラピジルを使用する錐体外路症候群の処置 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662317983P | 2016-04-04 | 2016-04-04 | |
| US62/317,983 | 2016-04-04 | ||
| PCT/US2017/025788 WO2017176652A2 (en) | 2016-04-04 | 2017-04-03 | Treating extrapyramidal syndrome using trapidil |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022044284A Division JP7794668B2 (ja) | 2016-04-04 | 2022-03-18 | トラピジルを使用する錐体外路症候群の処置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019510826A JP2019510826A (ja) | 2019-04-18 |
| JP2019510826A5 true JP2019510826A5 (https=) | 2020-05-14 |
| JP7049683B2 JP7049683B2 (ja) | 2022-04-07 |
Family
ID=60001402
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019502544A Active JP7049683B2 (ja) | 2016-04-04 | 2017-04-03 | トラピジルを使用する錐体外路症候群の処置 |
| JP2022044284A Active JP7794668B2 (ja) | 2016-04-04 | 2022-03-18 | トラピジルを使用する錐体外路症候群の処置 |
| JP2024041690A Pending JP2024095682A (ja) | 2016-04-04 | 2024-03-15 | トラピジルを使用する錐体外路症候群の処置 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022044284A Active JP7794668B2 (ja) | 2016-04-04 | 2022-03-18 | トラピジルを使用する錐体外路症候群の処置 |
| JP2024041690A Pending JP2024095682A (ja) | 2016-04-04 | 2024-03-15 | トラピジルを使用する錐体外路症候群の処置 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US10350212B2 (https=) |
| EP (1) | EP3442538B1 (https=) |
| JP (3) | JP7049683B2 (https=) |
| CN (2) | CN116509869A (https=) |
| AU (1) | AU2017246334C1 (https=) |
| CA (1) | CA3054674A1 (https=) |
| DK (1) | DK3442538T3 (https=) |
| ES (1) | ES3039958T3 (https=) |
| FI (1) | FI3442538T3 (https=) |
| WO (1) | WO2017176652A2 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7049683B2 (ja) | 2016-04-04 | 2022-04-07 | シノピア バイオサイエンシーズ，インク． | トラピジルを使用する錐体外路症候群の処置 |
| US11517548B2 (en) | 2018-07-19 | 2022-12-06 | Impel Pharmaceuticals Inc. | Respiratory tract delivery of levodopa and DOPA decarboxylase inhibitor for treatment of Parkinson's Disease |
| CA3163242A1 (en) * | 2019-12-02 | 2021-06-10 | Aarash BORDBAR | Treating cognitive disorders using trapidil |
| MX2022011879A (es) * | 2020-03-26 | 2023-01-11 | Sinopia Biosciences Inc | Derivados de trapidilo marcados isotopicamente. |
| WO2024053728A1 (ja) * | 2022-09-09 | 2024-03-14 | 住友ファーマ株式会社 | 対象の状態の予測およびその応用 |
| CN116754348B (zh) * | 2023-06-06 | 2024-03-08 | 华北理工大学 | 基于zif-8-90材料的泡腾片、其制备方法及其应用 |
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| JP7049683B2 (ja) | 2016-04-04 | 2022-04-07 | シノピア バイオサイエンシーズ，インク． | トラピジルを使用する錐体外路症候群の処置 |
| MX2022011879A (es) | 2020-03-26 | 2023-01-11 | Sinopia Biosciences Inc | Derivados de trapidilo marcados isotopicamente. |
-
2017
- 2017-04-03 JP JP2019502544A patent/JP7049683B2/ja active Active
- 2017-04-03 ES ES17779608T patent/ES3039958T3/es active Active
- 2017-04-03 WO PCT/US2017/025788 patent/WO2017176652A2/en not_active Ceased
- 2017-04-03 CN CN202310643240.2A patent/CN116509869A/zh active Pending
- 2017-04-03 CA CA3054674A patent/CA3054674A1/en active Pending
- 2017-04-03 AU AU2017246334A patent/AU2017246334C1/en active Active
- 2017-04-03 DK DK17779608.3T patent/DK3442538T3/da active
- 2017-04-03 FI FIEP17779608.3T patent/FI3442538T3/fi active
- 2017-04-03 CN CN201780034722.0A patent/CN109310700A/zh active Pending
- 2017-04-03 EP EP17779608.3A patent/EP3442538B1/en active Active
-
2018
- 2018-04-25 US US15/962,999 patent/US10350212B2/en active Active
-
2019
- 2019-07-03 US US16/503,128 patent/US11628170B2/en active Active
-
2022
- 2022-03-18 JP JP2022044284A patent/JP7794668B2/ja active Active
-
2023
- 2023-03-01 US US18/176,962 patent/US12268691B2/en active Active
-
2024
- 2024-03-15 JP JP2024041690A patent/JP2024095682A/ja active Pending
-
2025
- 2025-01-16 US US19/025,296 patent/US20250387396A1/en active Pending
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