JP2019510213A - 溶液中の物質の吸光度を測定する装置および方法 - Google Patents
溶液中の物質の吸光度を測定する装置および方法 Download PDFInfo
- Publication number
- JP2019510213A JP2019510213A JP2018544452A JP2018544452A JP2019510213A JP 2019510213 A JP2019510213 A JP 2019510213A JP 2018544452 A JP2018544452 A JP 2018544452A JP 2018544452 A JP2018544452 A JP 2018544452A JP 2019510213 A JP2019510213 A JP 2019510213A
- Authority
- JP
- Japan
- Prior art keywords
- light
- optical
- led
- leds
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000126 substance Substances 0.000 title claims abstract description 33
- 238000002835 absorbance Methods 0.000 title claims abstract description 25
- 238000000034 method Methods 0.000 title claims abstract description 13
- 230000003287 optical effect Effects 0.000 claims abstract description 57
- 239000013307 optical fiber Substances 0.000 claims abstract description 26
- 238000001228 spectrum Methods 0.000 claims abstract description 6
- 239000000835 fiber Substances 0.000 claims description 8
- 230000001902 propagating effect Effects 0.000 claims 4
- 238000003491 array Methods 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 description 9
- 108020004707 nucleic acids Proteins 0.000 description 9
- 150000007523 nucleic acids Chemical class 0.000 description 9
- 102000004169 proteins and genes Human genes 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 9
- 230000008859 change Effects 0.000 description 7
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 6
- 229910052753 mercury Inorganic materials 0.000 description 6
- 230000005540 biological transmission Effects 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000008033 biological extinction Effects 0.000 description 4
- 238000002211 ultraviolet spectrum Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 239000004065 semiconductor Substances 0.000 description 3
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- -1 aromatic amino acid Chemical class 0.000 description 2
- 229910052805 deuterium Inorganic materials 0.000 description 2
- 238000001962 electrophoresis Methods 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 150000002484 inorganic compounds Chemical class 0.000 description 2
- 229910010272 inorganic material Inorganic materials 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 150000002894 organic compounds Chemical class 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 238000004611 spectroscopical analysis Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229910052724 xenon Inorganic materials 0.000 description 2
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 2
- 229910002704 AlGaN Inorganic materials 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 239000011358 absorbing material Substances 0.000 description 1
- 230000032912 absorption of UV light Effects 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 150000001449 anionic compounds Chemical class 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000005251 capillar electrophoresis Methods 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000013592 cell lysate Substances 0.000 description 1
- 150000005829 chemical entities Chemical class 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 229940000406 drug candidate Drugs 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000000295 emission spectrum Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000001917 fluorescence detection Methods 0.000 description 1
- 239000005350 fused silica glass Substances 0.000 description 1
- 230000003760 hair shine Effects 0.000 description 1
- 229910001412 inorganic anion Inorganic materials 0.000 description 1
- RUTXIHLAWFEWGM-UHFFFAOYSA-H iron(3+) sulfate Chemical compound [Fe+3].[Fe+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O RUTXIHLAWFEWGM-UHFFFAOYSA-H 0.000 description 1
- 229910000360 iron(III) sulfate Inorganic materials 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- KBJMLQFLOWQJNF-UHFFFAOYSA-N nickel(ii) nitrate Chemical compound [Ni+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O KBJMLQFLOWQJNF-UHFFFAOYSA-N 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000003752 polymerase chain reaction Methods 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 150000003212 purines Chemical class 0.000 description 1
- 150000003230 pyrimidines Chemical class 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229910052594 sapphire Inorganic materials 0.000 description 1
- 239000010980 sapphire Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 238000001429 visible spectrum Methods 0.000 description 1
- 239000002676 xenobiotic agent Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/0303—Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/05—Flow-through cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/33—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using ultraviolet light
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N2021/3129—Determining multicomponents by multiwavelength light
- G01N2021/3133—Determining multicomponents by multiwavelength light with selection of wavelengths before the sample
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/062—LED's
- G01N2201/0627—Use of several LED's for spectral resolution
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/066—Modifiable path; multiple paths in one sample
- G01N2201/0668—Multiple paths; optimisable path length
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/08—Optical fibres; light guides
- G01N2201/0826—Fibre array at source, distributing
Landscapes
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Optical Measuring Cells (AREA)
Abstract
Description
ここで、
Aは吸光度、
Eは、Lmol−1cm−1を単位とするモル吸光係数、
bは、cmで定義される試料の光路長、
cは、mol−1で表される溶液中の化合物の濃度である。
20 LED光源配置
21、22、23 発光ダイオード、LED
30、31、32 フローセル、試料セル
41、42 光検出器
50 光学フィルタ、バンドパスフィルタ
51、52、53 光学フィルタ
60 光ファイバ束
70 コントローラ
80 ガラス棒
305 第1の光路
305’ 第2の光路
311 光入口、UV透過窓
312 光出口、UV透過窓
313 入口
314 出口
315 光路
321 光入口、UV透過窓
322 光出口、UV透過窓
323 入口
324 出口
325 光路
F 流れ
S 溶液
Claims (14)
- 溶液中の物質の吸光度を測定する装置であって、
少なくとも部分的に所定の波長スペクトルの光を通す、前記溶液を収容するために配置された、少なくとも1つの試料セル(30、31、32)と、
前記少なくとも1つの試料セル(30、31、32)を通る、少なくとも2本の光路(315、325)であって、前記各光路(315、325)は、既知の路長を有する、少なくとも2本の光路(315、325)と、
少なくとも2つのLED(21、22、23)を含む、LED光源配置(20)であって、前記少なくとも2つのLED(21、22、23)がそれぞれ、前記所定の波長スペクトル以内で、他の1つ以上の前記LED(21、22、23)とは異なる波長の光出力を放射するように配置される、LED光源配置(20)とを備え、
前記装置は、前記少なくとも2つのLED(21、22、23)のそれぞれが、関連する光ファイバ束(60)を備えることを特徴とし、前記束(60)は、複数の光ファイバを含み、前記束(60)は、各LED(21、22、23)から前記各光路(315、325)への光導波路を提供する、装置。 - 前記LED光源配置(20)からの前記光出力を制御するために配置された、コントローラ(70)をさらに備える、請求項1に記載の装置。
- 前記少なくとも1つのフローセル(30)が、前記少なくとも2本の光路(305、305’)を有する、二重路長フローセル(30)であって、前記各光路が、他の前記各光路(315、325)とは路長が異なる、請求項1または2に記載の装置。
- それぞれが少なくとも1本の光路(315、325)を有する、少なくとも2つのフローセル(31、32)をさらに備える、請求項1または2に記載の装置。
- 前記LED光源配置(20)が、各LED(21、22、23)に対し少なくとも1つの光学フィルタ(50、51、52、53)をさらに備え、前記光学フィルタ(50、51、52、53)が、前記LED(21、22、23)と前記光ファイバ束(60)との間に配置される、請求項1乃至3のいずれか1項に記載の装置。
- 前記LED光源配置の各LED(21、22、23)に対し、少なくとも2つの光学フィルタ(50、51、52、53)をさらに備え、前記光学フィルタ(50、51、52、53)が、各光ファイバの出力端と、対応する光路(315、325)の入口(311、312)との間に配置される、請求項1乃至3のいずれか1項に記載の装置。
- 前記LED光源配置の各LED(21、22、23)に対し、少なくとも2つの光学フィルタ(50、51、52、53)をさらに備え、前記光学フィルタ(50、51、52、53)が、各光路(315、325)の出口(321、322)と、対応する検出器(40、41、42)との間に配置される、請求項1乃至3のいずれか1項に記載の装置。
- 前記LED(21、22、23)の少なくとも1つが、交換可能に配置される、請求項1乃至5のいずれか1項に記載の装置。
- 対照検出器、または検出器配列を備え、前記光ファイバ束(60)が、前記検出器(40、41、42)、または前記検出器配列に光路(315、325)を提供する光ファイバを含む、請求項1乃至8のいずれか1項に記載の装置。
- 溶液中の物質の吸光度を測定する方法であって、
少なくとも2つのLED(21、22、23)を有する、LED光源配置(20)を設けるステップであって、前記少なくとも2つのLED(21、22、23)がそれぞれ、所定の波長スペクトル以内で、1つ以上の他の前記LED(21、22、23)とは異なる波長で光出力を放射するように配置される、LED光源配置(20)を設けるステップと、
前記各LED(21、22、23)に、関連するファイバ束(60)を設けるステップであって、前記束(60)は、複数の光ファイバを含み、前記束(60)は、各LED(21、22、23)から、前記少なくとも2本の各光路(315、325)まで、前記溶液中の前記物質を通る光導波路を提供する、ファイバ束(60)を設けるステップと、
前記溶液中の前記物質の前記吸光度の指標を提供するために、前記各光路(315、325)で前記溶液から伝搬する前記光を定量化するステップとを含む、方法。 - 前記光出力を提供するために、前記LED(21、22、23)のうちの1つを選択するように、前記LED光源配置(20)を制御するステップをさらに含む、請求項10に記載の方法。
- 前記LED(21、22、23)と前記光ファイバとの間、または前記光ファイバと前記光路(315、325)との間に配置された光学フィルタ(50)を通る、前記各LED(21、22、23)からの前記光出力を伝送するステップをさらに含む、請求項10または11に記載の方法。
- 前記少なくとも2つのLED(21、22、23)が、所定のサイクルで発光するようにされ、前記定量化するステップが、前記サイクルに対応する間隔で、前記各光路(315、325)において、前記溶液から伝搬する光の強度を記録することを含む、請求項10、11、または12に記載の方法。
- 光ファイバ束(60)を設ける前記ステップが、前記光ファイバの1本以上を対照検出器、または検出器配列のそれぞれに経路指定することを含み、前記溶液から伝搬する前記光を定量化する前記ステップが、前記溶液から伝搬する前記光強度を、前記検出器(40、41、42)、または前記検出器配列のそれぞれにおける前記光強度と比較することを含む、請求項10乃至13のいずれか1項に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1603380.5A GB201603380D0 (en) | 2016-02-26 | 2016-02-26 | Apparatus and method for measuring the light absorbance of a substance in a solution |
GB1603380.5 | 2016-02-26 | ||
PCT/EP2017/054504 WO2017144719A1 (en) | 2016-02-26 | 2017-02-27 | Apparatus and method for measuring the light absorbance of a substance in a solution |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2019510213A true JP2019510213A (ja) | 2019-04-11 |
JP7154540B2 JP7154540B2 (ja) | 2022-10-18 |
Family
ID=55806987
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018544452A Active JP7154540B2 (ja) | 2016-02-26 | 2017-02-27 | 溶液中の物質の吸光度を測定する装置および方法 |
Country Status (6)
Country | Link |
---|---|
US (2) | US11543344B2 (ja) |
EP (1) | EP3420336A1 (ja) |
JP (1) | JP7154540B2 (ja) |
CN (1) | CN109073540B (ja) |
GB (1) | GB201603380D0 (ja) |
WO (1) | WO2017144719A1 (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201603380D0 (en) | 2016-02-26 | 2016-04-13 | Ge Healthcare Bio Sciences Ab | Apparatus and method for measuring the light absorbance of a substance in a solution |
CN114460022B (zh) * | 2022-03-04 | 2024-04-05 | 中国海洋大学 | 一种拖曳式高光谱吸光度传感器系统及其校正方法 |
WO2024126425A1 (en) | 2022-12-13 | 2024-06-20 | Cytiva Sweden Ab | Apparatus for measuring the light absorbance of a substance, computer-implemented method, computer program and non-volatile data carrier |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58193438A (ja) * | 1982-05-07 | 1983-11-11 | Toa Denpa Kogyo Kk | 二波長測光式吸光光度計 |
JPH0712726A (ja) * | 1993-06-24 | 1995-01-17 | Dainippon Screen Mfg Co Ltd | 透過光測定用光学装置 |
US20110188042A1 (en) * | 2007-01-18 | 2011-08-04 | World Precision Instruments, Inc. | Self referencing led detection system for spectroscopy applications |
WO2011093775A1 (en) * | 2010-01-28 | 2011-08-04 | Ge Healthcare Bio-Sciences Ab | Optical flow cell detector |
WO2013178770A1 (en) * | 2012-05-31 | 2013-12-05 | Ge Healthcare Bio-Sciences Ab | Methods and apparatus for measuring the light absorbance of a substance in a solution |
JP2015137983A (ja) * | 2014-01-23 | 2015-07-30 | 株式会社堀場製作所 | 光学分析装置 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5214593A (en) * | 1990-11-07 | 1993-05-25 | Rainin Instrument Co., Inc. | Method and apparatus for extending the linear dynamic range of absorbance detectors including multi-lightpath flow cells |
DE4122925C2 (de) * | 1991-07-11 | 1994-09-22 | Fraunhofer Ges Forschung | Optisches Spektrometer |
US5408326A (en) * | 1993-04-28 | 1995-04-18 | Shell Oil Company | Dual-wavelength absorption detector adapted for continuous-flow detection |
US6342948B1 (en) * | 1998-11-20 | 2002-01-29 | Waters Investments Limited | Dual pathlength system for light absorbance detection |
JP2004354068A (ja) * | 2003-05-27 | 2004-12-16 | Hitachi Ltd | 光導波路を用いた化学物質計測装置 |
US7122799B2 (en) * | 2003-12-18 | 2006-10-17 | Palo Alto Research Center Incorporated | LED or laser enabled real-time PCR system and spectrophotometer |
EP1889034A1 (en) * | 2005-05-24 | 2008-02-20 | Agilent Technologies, Inc. | Multi-path flow cell correction |
CN100575926C (zh) | 2005-12-01 | 2009-12-30 | 中国科学院电子学研究所 | 反射式光纤生化传感装置 |
US7570360B1 (en) * | 2007-02-01 | 2009-08-04 | Bah Holdings, Llc | Optical absorption spectrometer and method for measuring concentration of a substance |
EP1962084A1 (en) * | 2007-02-21 | 2008-08-27 | Roche Diagnostics GmbH | Apparatus for emitting and detecting beams of light |
DE102010062268B4 (de) * | 2010-12-01 | 2024-01-11 | Endress+Hauser Conducta Gmbh+Co. Kg | Absorptionsmesseinrichtung |
JP6155684B2 (ja) | 2013-02-15 | 2017-07-05 | セイコーエプソン株式会社 | 照明装置、及びプロジェクター |
DE102013101523A1 (de) | 2013-02-15 | 2014-08-21 | B. Braun Avitum Ag | Fotometrische Messvorrichtung und Verfahren zum Messen einer optischen Absorbanz eines Fluids mit einer variablen Konzentration von mindestens einer Licht absorbierenden Substanz, sowie Blutbehandlungsvorrichtung mit einer derartigen Messvorrichtung |
CN104062235B (zh) * | 2014-07-16 | 2016-06-08 | 北京佰纯润宇生物科技有限公司 | 基于光纤的单流通池的多波长在线检测设备 |
GB201603380D0 (en) | 2016-02-26 | 2016-04-13 | Ge Healthcare Bio Sciences Ab | Apparatus and method for measuring the light absorbance of a substance in a solution |
-
2016
- 2016-02-26 GB GBGB1603380.5A patent/GB201603380D0/en not_active Ceased
-
2017
- 2017-02-27 CN CN201780025261.0A patent/CN109073540B/zh active Active
- 2017-02-27 WO PCT/EP2017/054504 patent/WO2017144719A1/en active Application Filing
- 2017-02-27 US US16/078,727 patent/US11543344B2/en active Active
- 2017-02-27 EP EP17707830.0A patent/EP3420336A1/en active Pending
- 2017-02-27 JP JP2018544452A patent/JP7154540B2/ja active Active
-
2022
- 2022-12-05 US US18/061,854 patent/US20230101434A1/en active Pending
Patent Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58193438A (ja) * | 1982-05-07 | 1983-11-11 | Toa Denpa Kogyo Kk | 二波長測光式吸光光度計 |
JPH0712726A (ja) * | 1993-06-24 | 1995-01-17 | Dainippon Screen Mfg Co Ltd | 透過光測定用光学装置 |
US20110188042A1 (en) * | 2007-01-18 | 2011-08-04 | World Precision Instruments, Inc. | Self referencing led detection system for spectroscopy applications |
WO2011093775A1 (en) * | 2010-01-28 | 2011-08-04 | Ge Healthcare Bio-Sciences Ab | Optical flow cell detector |
EP2529198A1 (en) * | 2010-01-28 | 2012-12-05 | GE Healthcare Bio-Sciences AB | Optical flow cell detector |
US20120327397A1 (en) * | 2010-01-28 | 2012-12-27 | Ge Healthcare Bio-Sciences Ab | Optical flow cell detector |
JP2013518278A (ja) * | 2010-01-28 | 2013-05-20 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | 光学フローセル検出器 |
WO2013178770A1 (en) * | 2012-05-31 | 2013-12-05 | Ge Healthcare Bio-Sciences Ab | Methods and apparatus for measuring the light absorbance of a substance in a solution |
EP2856111A1 (en) * | 2012-05-31 | 2015-04-08 | GE Healthcare Bio-Sciences AB | Methods and apparatus for measuring the light absorbance of a substance in a solution |
US20150153272A1 (en) * | 2012-05-31 | 2015-06-04 | Ge Healthcare Bio-Sciences Ab | Methods and apparatus for measuring the light absorbance of a substance in a solution |
JP2015518157A (ja) * | 2012-05-31 | 2015-06-25 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | 溶液中の物質の吸光度を測定する方法並びに装置 |
JP2015137983A (ja) * | 2014-01-23 | 2015-07-30 | 株式会社堀場製作所 | 光学分析装置 |
Also Published As
Publication number | Publication date |
---|---|
CN109073540A (zh) | 2018-12-21 |
US20230101434A1 (en) | 2023-03-30 |
JP7154540B2 (ja) | 2022-10-18 |
EP3420336A1 (en) | 2019-01-02 |
US20210096059A1 (en) | 2021-04-01 |
GB201603380D0 (en) | 2016-04-13 |
CN109073540B (zh) | 2022-11-01 |
WO2017144719A1 (en) | 2017-08-31 |
US11543344B2 (en) | 2023-01-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6248098B2 (ja) | 溶液中の物質の吸光度を測定する方法並びに装置 | |
JP5814499B2 (ja) | 溶液中の物質の濃度の測定方法及び装置 | |
US20230101434A1 (en) | Apparatus and Method for Measuring the Light Absorbance of a Substance in a Solution | |
WO2016124083A1 (zh) | 一种超小型化多通道实时荧光光谱检测装置 | |
JP6595204B2 (ja) | 光学分析装置 | |
JP6804445B2 (ja) | 吸光度測定装置への蛍光検出機能の統合 | |
JP6413759B2 (ja) | 光学分析装置 | |
JP2009008554A (ja) | 分光光度計及び液体クロマトグラフィ | |
ES2690570T3 (es) | Procedimiento y dispositivo para la determinación de la fluorescencia de una muestra así como uso de los mismos | |
KR101029084B1 (ko) | 냉증기원자흡광광도부와 냉증기원자형광광도부가 결합되어 있는 수은분석장치 | |
US20130320223A1 (en) | Quantifying nucleic acid in samples | |
CN107003182B (zh) | 用于测量光吸收或确定物质的浓度的系统的光纤布置 | |
CN110383041B (zh) | 光学测定系统、光学单元以及光学测定方法 | |
KR20190014158A (ko) | 광 필터를 이용한 가스 검출기 | |
JP2000074820A (ja) | 液体クロマトグラフ | |
JP2016180608A (ja) | 紫外光吸収による検出装置 | |
JPH11183385A (ja) | 蛍光分析計 | |
KR20190021648A (ko) | 다중 광원을 구비한 광특성 계측 장치 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7423 Effective date: 20190521 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20200127 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20201102 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20201030 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210201 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20210628 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20211008 |
|
C60 | Trial request (containing other claim documents, opposition documents) |
Free format text: JAPANESE INTERMEDIATE CODE: C60 Effective date: 20211008 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20211018 |
|
C21 | Notice of transfer of a case for reconsideration by examiners before appeal proceedings |
Free format text: JAPANESE INTERMEDIATE CODE: C21 Effective date: 20211025 |
|
A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20211119 |
|
C211 | Notice of termination of reconsideration by examiners before appeal proceedings |
Free format text: JAPANESE INTERMEDIATE CODE: C211 Effective date: 20211129 |
|
C22 | Notice of designation (change) of administrative judge |
Free format text: JAPANESE INTERMEDIATE CODE: C22 Effective date: 20220111 |
|
C13 | Notice of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: C13 Effective date: 20220404 |
|
C22 | Notice of designation (change) of administrative judge |
Free format text: JAPANESE INTERMEDIATE CODE: C22 Effective date: 20220418 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220701 |
|
C23 | Notice of termination of proceedings |
Free format text: JAPANESE INTERMEDIATE CODE: C23 Effective date: 20220801 |
|
C03 | Trial/appeal decision taken |
Free format text: JAPANESE INTERMEDIATE CODE: C03 Effective date: 20220905 |
|
C30A | Notification sent |
Free format text: JAPANESE INTERMEDIATE CODE: C3012 Effective date: 20220905 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20220927 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 7154540 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |