JP2019509714A - Ｐｃｓｋ９抗体、その抗原結合フラグメント及び医薬用途 - Google Patents

Ｐｃｓｋ９抗体、その抗原結合フラグメント及び医薬用途 Download PDF

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Publication number
JP2019509714A
JP2019509714A JP2018533864A JP2018533864A JP2019509714A JP 2019509714 A JP2019509714 A JP 2019509714A JP 2018533864 A JP2018533864 A JP 2018533864A JP 2018533864 A JP2018533864 A JP 2018533864A JP 2019509714 A JP2019509714 A JP 2019509714A
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Japan
Prior art keywords
seq
pcsk9
sequence
antibody
amino acid
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Pending
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JP2018533864A
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English (en)
Japanese (ja)
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JP2019509714A5 (https=
Inventor
チュ、シアンドン
イエ、シン
ジン、ホウホン
ツェイ、ドンビン
フ、チーユエ
タオ、ウェイカン
ジャン、リエンシャン
スン、ピアオヤン
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Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
Original Assignee
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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Application filed by Jiangsu Hengrui Medicine Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd filed Critical Jiangsu Hengrui Medicine Co Ltd
Publication of JP2019509714A publication Critical patent/JP2019509714A/ja
Publication of JP2019509714A5 publication Critical patent/JP2019509714A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2018533864A 2016-01-05 2016-12-26 Ｐｃｓｋ９抗体、その抗原結合フラグメント及び医薬用途 Pending JP2019509714A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610010241 2016-01-05
CN201610010241.3 2016-01-05
PCT/CN2016/112075 WO2017118307A1 (zh) 2016-01-05 2016-12-26 Pcsk9抗体、其抗原结合片段及其医药用途

Publications (2)

Publication Number Publication Date
JP2019509714A true JP2019509714A (ja) 2019-04-11
JP2019509714A5 JP2019509714A5 (https=) 2020-02-06

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018533864A Pending JP2019509714A (ja) 2016-01-05 2016-12-26 Ｐｃｓｋ９抗体、その抗原結合フラグメント及び医薬用途

Country Status (5)

Country Link
US (1) US20200270365A1 (https=)
EP (1) EP3401336A4 (https=)
JP (1) JP2019509714A (https=)
CN (1) CN107531795B (https=)
WO (1) WO2017118307A1 (https=)

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EP3647325A4 (en) * 2017-06-30 2021-03-17 Shanghai Hengrui Pharmaceutical Co., Ltd PHARMACEUTICAL COMPOSITION OF PCSK-9 ANTIBODIES AND USES THEREOF
WO2019018402A2 (en) * 2017-07-17 2019-01-24 Janssen Biotech, Inc. ANTIGEN-BINDING REGIONS DIRECTED AGAINST FIBRONECTIN TYPE III DOMAINS AND METHODS OF USING THE SAME
TW202144436A (zh) 2020-03-19 2021-12-01 大陸商江蘇恒瑞醫藥股份有限公司 膽固醇相關疾病的治療方法
CN119453139A (zh) * 2024-10-30 2025-02-18 西安交通大学医学院第一附属医院 一种动脉粥样硬化的ob/ob肥胖小鼠模型及其构建方法与应用

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Also Published As

Publication number Publication date
US20200270365A1 (en) 2020-08-27
EP3401336A1 (en) 2018-11-14
WO2017118307A1 (zh) 2017-07-13
CN107531795B (zh) 2021-01-19
HK1243439A1 (zh) 2018-07-13
EP3401336A4 (en) 2020-01-22
CN107531795A (zh) 2018-01-02

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