JP2019509714A - Ｐｃｓｋ９抗体、その抗原結合フラグメント及び医薬用途 - Google Patents

Ｐｃｓｋ９抗体、その抗原結合フラグメント及び医薬用途 Download PDF

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Publication number
JP2019509714A
JP2019509714A JP2018533864A JP2018533864A JP2019509714A JP 2019509714 A JP2019509714 A JP 2019509714A JP 2018533864 A JP2018533864 A JP 2018533864A JP 2018533864 A JP2018533864 A JP 2018533864A JP 2019509714 A JP2019509714 A JP 2019509714A
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Japan
Prior art keywords
seq
pcsk9
sequence
antibody
amino acid
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Pending
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JP2018533864A
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English (en)
Japanese (ja)
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JP2019509714A5 (cg-RX-API-DMAC7.html
Inventor
チュ、シアンドン
イエ、シン
ジン、ホウホン
ツェイ、ドンビン
フ、チーユエ
タオ、ウェイカン
ジャン、リエンシャン
スン、ピアオヤン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
Original Assignee
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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Application filed by Jiangsu Hengrui Medicine Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd filed Critical Jiangsu Hengrui Medicine Co Ltd
Publication of JP2019509714A publication Critical patent/JP2019509714A/ja
Publication of JP2019509714A5 publication Critical patent/JP2019509714A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2018533864A 2016-01-05 2016-12-26 Ｐｃｓｋ９抗体、その抗原結合フラグメント及び医薬用途 Pending JP2019509714A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610010241 2016-01-05
CN201610010241.3 2016-01-05
PCT/CN2016/112075 WO2017118307A1 (zh) 2016-01-05 2016-12-26 Pcsk9抗体、其抗原结合片段及其医药用途

Publications (2)

Publication Number Publication Date
JP2019509714A true JP2019509714A (ja) 2019-04-11
JP2019509714A5 JP2019509714A5 (cg-RX-API-DMAC7.html) 2020-02-06

Family

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JP2018533864A Pending JP2019509714A (ja) 2016-01-05 2016-12-26 Ｐｃｓｋ９抗体、その抗原結合フラグメント及び医薬用途

Country Status (5)

Country Link
US (1) US20200270365A1 (cg-RX-API-DMAC7.html)
EP (1) EP3401336A4 (cg-RX-API-DMAC7.html)
JP (1) JP2019509714A (cg-RX-API-DMAC7.html)
CN (1) CN107531795B (cg-RX-API-DMAC7.html)
WO (1) WO2017118307A1 (cg-RX-API-DMAC7.html)

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TWI720325B (zh) * 2017-06-30 2021-03-01 大陸商江蘇恒瑞醫藥股份有限公司 一種pcsk-9抗體醫藥組成物及其用途
AU2018304173A1 (en) * 2017-07-17 2020-01-30 Janssen Biotech, Inc. Antigen binding regions against fibronectin type III domains and methods of using the same
US20230108572A1 (en) 2020-03-19 2023-04-06 Suzhou Suncadia Biopharmaceuticals Co., Ltd. Method For Treating Cholesterol-Related Diseases
CN119453139A (zh) * 2024-10-30 2025-02-18 西安交通大学医学院第一附属医院 一种动脉粥样硬化的ob/ob肥胖小鼠模型及其构建方法与应用

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WO2014209384A1 (en) * 2013-06-28 2014-12-31 Amgen Inc. Methods for treating homozygous familial hypercholesterolema
JP2015526440A (ja) * 2012-08-13 2015-09-10 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ｐＨ依存性結合特性を有する抗ＰＣＳＫ９抗体

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Also Published As

Publication number Publication date
CN107531795B (zh) 2021-01-19
US20200270365A1 (en) 2020-08-27
EP3401336A4 (en) 2020-01-22
WO2017118307A1 (zh) 2017-07-13
EP3401336A1 (en) 2018-11-14
CN107531795A (zh) 2018-01-02
HK1243439A1 (zh) 2018-07-13

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