JP2019509351A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019509351A5 JP2019509351A5 JP2019500746A JP2019500746A JP2019509351A5 JP 2019509351 A5 JP2019509351 A5 JP 2019509351A5 JP 2019500746 A JP2019500746 A JP 2019500746A JP 2019500746 A JP2019500746 A JP 2019500746A JP 2019509351 A5 JP2019509351 A5 JP 2019509351A5
- Authority
- JP
- Japan
- Prior art keywords
- therapy
- administration
- active substance
- administered
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022047991A JP7528143B2 (ja) | 2016-03-22 | 2022-03-24 | 毒性を予防または改善するための早期介入法 |
| JP2024118592A JP2024156736A (ja) | 2016-03-22 | 2024-07-24 | 毒性を予防または改善するための早期介入法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662311906P | 2016-03-22 | 2016-03-22 | |
| US62/311,906 | 2016-03-22 | ||
| US201662417287P | 2016-11-03 | 2016-11-03 | |
| US62/417,287 | 2016-11-03 | ||
| US201662429722P | 2016-12-02 | 2016-12-02 | |
| US62/429,722 | 2016-12-02 | ||
| PCT/US2017/023676 WO2017165571A1 (en) | 2016-03-22 | 2017-03-22 | Early intervention methods to prevent or ameliorate toxicity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022047991A Division JP7528143B2 (ja) | 2016-03-22 | 2022-03-24 | 毒性を予防または改善するための早期介入法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019509351A JP2019509351A (ja) | 2019-04-04 |
| JP2019509351A5 true JP2019509351A5 (https=) | 2020-04-30 |
| JP7048571B2 JP7048571B2 (ja) | 2022-04-05 |
Family
ID=58609964
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019500746A Active JP7048571B2 (ja) | 2016-03-22 | 2017-03-22 | 毒性を予防または改善するための早期介入法 |
| JP2022047991A Active JP7528143B2 (ja) | 2016-03-22 | 2022-03-24 | 毒性を予防または改善するための早期介入法 |
| JP2024118592A Pending JP2024156736A (ja) | 2016-03-22 | 2024-07-24 | 毒性を予防または改善するための早期介入法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022047991A Active JP7528143B2 (ja) | 2016-03-22 | 2022-03-24 | 毒性を予防または改善するための早期介入法 |
| JP2024118592A Pending JP2024156736A (ja) | 2016-03-22 | 2024-07-24 | 毒性を予防または改善するための早期介入法 |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US11518814B2 (https=) |
| EP (3) | EP4545143A3 (https=) |
| JP (3) | JP7048571B2 (https=) |
| KR (1) | KR20190021200A (https=) |
| CN (1) | CN109476743A (https=) |
| AU (2) | AU2017238218B2 (https=) |
| BR (1) | BR112018069251A2 (https=) |
| CA (1) | CA3018588A1 (https=) |
| ES (1) | ES2907557T3 (https=) |
| MA (2) | MA71266A (https=) |
| MX (1) | MX2018011480A (https=) |
| RU (1) | RU2018136877A (https=) |
| WO (1) | WO2017165571A1 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2934532B1 (en) | 2012-12-20 | 2019-10-23 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| BR112017008042A2 (pt) | 2014-10-20 | 2017-12-26 | Juno Therapeutics Inc | métodos e composições para dosagem em terapia de célula adotiva |
| EP4012415A3 (en) | 2015-12-04 | 2022-12-07 | Juno Therapeutics, Inc. | Methods and compositions related to toxicity associated with cell therapy |
| KR20190021200A (ko) | 2016-03-22 | 2019-03-05 | 시애틀 칠드런즈 호스피탈 디/비/에이 시애틀 칠드런즈 리서치 인스티튜트 | 독성을 예방 또는 경감시키기 위한 조기 개재 방법 |
| JP7282521B2 (ja) | 2016-04-08 | 2023-05-29 | パーデュー・リサーチ・ファウンデイション | Car t細胞療法のための方法および組成物 |
| BR112019011065A2 (pt) * | 2016-12-03 | 2019-10-01 | Juno Therapeutics Inc | métodos para determinação da dosagem de células t car |
| CN110612119B (zh) | 2017-02-07 | 2024-10-29 | 西雅图儿童医院(Dba西雅图儿童研究所) | 磷脂醚(ple)car t细胞肿瘤靶向(ctct)剂 |
| US12163952B2 (en) | 2017-02-27 | 2024-12-10 | Juno Therapeutics, Inc. | Determining toxicity risk in CAR T-cell therapy |
| JP7178355B2 (ja) | 2017-02-28 | 2022-11-25 | エンドサイト・インコーポレイテッド | Car t細胞療法のための組成物および方法 |
| US11564946B2 (en) | 2017-11-01 | 2023-01-31 | Juno Therapeutics, Inc. | Methods associated with tumor burden for assessing response to a cell therapy |
| US20210198372A1 (en) * | 2017-12-01 | 2021-07-01 | Juno Therapeutics, Inc. | Methods for dosing and for modulation of genetically engineered cells |
| JP7549303B2 (ja) | 2018-01-22 | 2024-09-11 | エンドサイト・インコーポレイテッド | Car t細胞の使用方法 |
| SG11202007426XA (en) | 2018-02-06 | 2020-09-29 | Seattle Childrens Hospital Dba Seattle Childrens Res Inst | Fluorescein-specific cars exhibiting optimal t cell function against fl-ple labelled tumors |
| IL311485B1 (en) | 2018-02-16 | 2026-01-01 | Incyte Corp | JAK1 pathway inhibitors for the treatment of cytokine-related disorders |
| CN112105382A (zh) | 2018-02-23 | 2020-12-18 | 恩多塞特公司 | 用于car t细胞疗法的顺序方法 |
| CN111989344A (zh) * | 2018-03-09 | 2020-11-24 | 科济生物医药(上海)有限公司 | 用于治疗肿瘤的方法和组合物 |
| WO2019170845A1 (en) * | 2018-03-09 | 2019-09-12 | Ospedale San Raffaele S.R.L. | Il-1 antagonist and toxicity induced by cell therapy |
| WO2019195823A1 (en) * | 2018-04-06 | 2019-10-10 | The Board Of Regents Of The University Of Texas System | Prediction and treatment of immunotherapeutic toxicity |
| WO2021028469A1 (en) * | 2019-08-12 | 2021-02-18 | Sitokine Limited | Compositions and methods for treating cytokine release syndrome and neurotoxicity |
| ES2970382T3 (es) * | 2019-08-14 | 2024-05-28 | Rigel Pharmaceuticals Inc | Método para bloquear o mejorar el síndrome de liberación de citocinas |
| AU2021217003A1 (en) | 2020-02-04 | 2022-09-15 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Anti-dinitrophenol chimeric antigen receptors |
| US11045546B1 (en) | 2020-03-30 | 2021-06-29 | Cytodyn Inc. | Methods of treating coronavirus infection |
| WO2022072515A1 (en) * | 2020-09-29 | 2022-04-07 | Washington University | Methods to determine risk of neurotoxicity |
| WO2022125670A1 (en) | 2020-12-08 | 2022-06-16 | Incyte Corporation | Jak1 pathway inhibitors for the treatment of vitiligo |
| RS67455B1 (sr) | 2021-05-03 | 2025-12-31 | Incyte Corp | Inhibitori jak1 puta za lečenje prurigo nodularisa |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US265209A (en) | 1882-09-26 | Automatic feeder for perforators | ||
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4452773A (en) | 1982-04-05 | 1984-06-05 | Canadian Patents And Development Limited | Magnetic iron-dextran microspheres |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US5019369A (en) | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
| US4690915A (en) | 1985-08-08 | 1987-09-01 | The United States Of America As Represented By The Department Of Health And Human Services | Adoptive immunotherapy as a treatment modality in humans |
| US4795698A (en) | 1985-10-04 | 1989-01-03 | Immunicon Corporation | Magnetic-polymer particles |
| IN165717B (https=) | 1986-08-07 | 1989-12-23 | Battelle Memorial Institute | |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5219740A (en) | 1987-02-13 | 1993-06-15 | Fred Hutchinson Cancer Research Center | Retroviral gene transfer into diploid fibroblasts for gene therapy |
| ES2067018T3 (es) | 1988-12-28 | 1995-03-16 | Stefan Miltenyi | Procedimiento y materiales para la separacion en alto gradiente magnetico de materiales biologicos. |
| US5200084A (en) | 1990-09-26 | 1993-04-06 | Immunicon Corporation | Apparatus and methods for magnetic separation |
| CA2096222C (en) | 1990-11-13 | 1998-12-29 | Stephen D. Lupton | Bifunctional selectable fusion genes |
| CA2147466A1 (en) | 1992-10-20 | 1994-04-28 | Just P. J. Brakenhoff | Interleukin-6 receptor antagonists |
| US6645493B1 (en) * | 1993-05-17 | 2003-11-11 | The Picower Institute For Medical Research | Composition containing anti-MIF antibody |
| WO1994028143A1 (en) | 1993-05-21 | 1994-12-08 | Targeted Genetics Corporation | Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene |
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| DE19608753C1 (de) | 1996-03-06 | 1997-06-26 | Medigene Gmbh | Transduktionssystem und seine Verwendung |
| WO1997034634A1 (en) | 1996-03-20 | 1997-09-25 | Sloan-Kettering Institute For Cancer Research | Single chain fv constructs of anti-ganglioside gd2 antibodies |
| JP2002524081A (ja) | 1998-09-04 | 2002-08-06 | スローン − ケッタリング インスティチュート フォー キャンサー リサーチ | 前立腺−特異的膜抗原に特異的な融合受容体およびその使用 |
| WO2000023573A2 (en) | 1998-10-20 | 2000-04-27 | City Of Hope | Cd20-specific redirected t cells and their use in cellular immunotherapy of cd20+ malignancies |
| US20020131960A1 (en) | 2000-06-02 | 2002-09-19 | Michel Sadelain | Artificial antigen presenting cells and methods of use thereof |
| AU2001297703B2 (en) | 2000-11-07 | 2006-10-19 | City Of Hope | CD19-specific redirected immune cells |
| US7070995B2 (en) | 2001-04-11 | 2006-07-04 | City Of Hope | CE7-specific redirected immune cells |
| US20090257994A1 (en) | 2001-04-30 | 2009-10-15 | City Of Hope | Chimeric immunoreceptor useful in treating human cancers |
| US20030170238A1 (en) | 2002-03-07 | 2003-09-11 | Gruenberg Micheal L. | Re-activated T-cells for adoptive immunotherapy |
| US7446190B2 (en) | 2002-05-28 | 2008-11-04 | Sloan-Kettering Institute For Cancer Research | Nucleic acids encoding chimeric T cell receptors |
| US20050129671A1 (en) | 2003-03-11 | 2005-06-16 | City Of Hope | Mammalian antigen-presenting T cells and bi-specific T cells |
| WO2007147623A2 (en) * | 2006-06-22 | 2007-12-27 | Cellact Pharma Gmbh | A novel target in the treatment of cytokine release syndrome |
| CA2682527C (en) | 2007-03-30 | 2017-07-11 | Memorial Sloan-Kettering Cancer Center | Constitutive expression of costimulatory ligands on adoptively transferred t lymphocytes |
| WO2009072003A2 (en) | 2007-12-07 | 2009-06-11 | Miltenyi Biotec Gmbh | Sample processing system and methods |
| US8479118B2 (en) | 2007-12-10 | 2013-07-02 | Microsoft Corporation | Switching search providers within a browser search box |
| US20120164718A1 (en) | 2008-05-06 | 2012-06-28 | Innovative Micro Technology | Removable/disposable apparatus for MEMS particle sorting device |
| JP5173594B2 (ja) | 2008-05-27 | 2013-04-03 | キヤノン株式会社 | 管理装置、画像形成装置及びそれらの処理方法 |
| EP4032552B1 (en) | 2008-08-26 | 2023-10-04 | City of Hope | Method and compositions for enhanced anti-tumor effector functioning of t cells |
| TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
| DK2496698T3 (en) | 2009-11-03 | 2019-04-15 | Hope City | TRUNCATED EPIDERIMAL GROWTH FACTOR RECEPTOR (EGFRt) FOR TRUNCATED T-CELL SELECTION |
| CN103249742B (zh) * | 2010-09-16 | 2017-04-12 | 巴利奥医药股份公司 | 抗人肿瘤坏死因子1型受体抗体 |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| CN110200997A (zh) | 2011-03-23 | 2019-09-06 | 弗雷德哈钦森癌症研究中心 | 用于细胞免疫治疗的方法和组合物 |
| US8398282B2 (en) | 2011-05-12 | 2013-03-19 | Delphi Technologies, Inc. | Vehicle front lighting assembly and systems having a variable tint electrowetting element |
| KR102134932B1 (ko) | 2011-11-11 | 2020-07-17 | 프레드 헛친슨 켄서 리서치 센터 | 암을 위한 사이클린 a1―표적화된 t―세포 면역요법 |
| JP6850528B2 (ja) | 2012-02-13 | 2021-03-31 | シアトル チルドレンズ ホスピタル ドゥーイング ビジネス アズ シアトル チルドレンズ リサーチ インスティテュート | 二重特異性キメラ抗原受容体およびその治療的使用 |
| WO2013126726A1 (en) | 2012-02-22 | 2013-08-29 | The Trustees Of The University Of Pennsylvania | Double transgenic t cells comprising a car and a tcr and their methods of use |
| SG10201609210SA (en) | 2012-05-03 | 2016-12-29 | Hutchinson Fred Cancer Res | Enhanced affinity t cell receptors and methods for making the same |
| LT4461308T (lt) * | 2012-07-13 | 2025-06-10 | The Trustees Of The University Of Pennsylvania | Car priešnavikinio aktyvumo toksiškumo valdymas |
| CA2881981A1 (en) | 2012-08-20 | 2014-02-27 | Fred Hutchinson Cancer Research Center | Method and compositions for cellular immunotherapy |
| AU2013327136A1 (en) | 2012-10-02 | 2015-04-16 | Memorial Sloan-Kettering Cancer Center | Compositions and methods for immunotherapy |
| DE112012007250B4 (de) | 2012-12-20 | 2024-10-24 | Mitsubishi Electric Corp. | Fahrzeuginterne Vorrichtung und Programm |
| UY35468A (es) | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| US9108442B2 (en) | 2013-08-20 | 2015-08-18 | Ricoh Company, Ltd. | Image forming apparatus |
| US11512289B2 (en) * | 2015-02-18 | 2022-11-29 | Enlivex Therapeutics Rdo Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| WO2017035362A1 (en) * | 2015-08-26 | 2017-03-02 | Achillion Pharmaceuticals, Inc. | Use of complement pathway inhibitor compounds to mitigate adoptive t-cell therapy associated adverse immune responses |
| JP6905163B2 (ja) | 2015-09-03 | 2021-07-21 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | サイトカイン放出症候群を予測するバイオマーカー |
| KR20190021200A (ko) | 2016-03-22 | 2019-03-05 | 시애틀 칠드런즈 호스피탈 디/비/에이 시애틀 칠드런즈 리서치 인스티튜트 | 독성을 예방 또는 경감시키기 위한 조기 개재 방법 |
| US20190336504A1 (en) | 2016-07-15 | 2019-11-07 | Novartis Ag | Treatment and prevention of cytokine release syndrome using a chimeric antigen receptor in combination with a kinase inhibitor |
-
2017
- 2017-03-22 KR KR1020187030514A patent/KR20190021200A/ko not_active Withdrawn
- 2017-03-22 ES ES17719044T patent/ES2907557T3/es active Active
- 2017-03-22 EP EP24221056.5A patent/EP4545143A3/en active Pending
- 2017-03-22 EP EP17719044.4A patent/EP3433276B1/en not_active Revoked
- 2017-03-22 EP EP21207779.6A patent/EP4015536A1/en active Pending
- 2017-03-22 CA CA3018588A patent/CA3018588A1/en active Pending
- 2017-03-22 JP JP2019500746A patent/JP7048571B2/ja active Active
- 2017-03-22 US US16/087,488 patent/US11518814B2/en active Active
- 2017-03-22 BR BR112018069251A patent/BR112018069251A2/pt not_active IP Right Cessation
- 2017-03-22 WO PCT/US2017/023676 patent/WO2017165571A1/en not_active Ceased
- 2017-03-22 CN CN201780031706.6A patent/CN109476743A/zh active Pending
- 2017-03-22 MX MX2018011480A patent/MX2018011480A/es unknown
- 2017-03-22 AU AU2017238218A patent/AU2017238218B2/en active Active
- 2017-03-22 RU RU2018136877A patent/RU2018136877A/ru not_active Application Discontinuation
- 2017-03-22 MA MA71266A patent/MA71266A/fr unknown
- 2017-03-22 MA MA044486A patent/MA44486A/fr unknown
-
2022
- 2022-03-24 JP JP2022047991A patent/JP7528143B2/ja active Active
- 2022-12-02 US US18/061,196 patent/US11760804B2/en active Active
- 2022-12-05 US US18/061,939 patent/US20230212298A1/en active Pending
-
2023
- 2023-06-06 US US18/329,987 patent/US12098208B2/en active Active
-
2024
- 2024-07-24 JP JP2024118592A patent/JP2024156736A/ja active Pending
- 2024-07-24 AU AU2024205049A patent/AU2024205049A1/en active Pending
- 2024-09-09 US US18/828,243 patent/US20240425608A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019509351A5 (https=) | ||
| Shimba et al. | Pleiotropic effects of glucocorticoids on the immune system in circadian rhythm and stress | |
| De Waele et al. | A systematic review on poly (I: C) and poly-ICLC in glioblastoma: adjuvants coordinating the unlocking of immunotherapy | |
| JP2024156736A5 (https=) | ||
| Silverman et al. | Immune modulation of the hypothalamic-pituitary-adrenal (HPA) axis during viral infection | |
| Canna et al. | Life-threatening NLRC4-associated hyperinflammation successfully treated with IL-18 inhibition | |
| Shoenfeld et al. | The mosaic of autoimmunity: hormonal and environmental factors involved in autoimmune diseases--2008 | |
| Mesquida et al. | Interleukin-6 blockade in ocular inflammatory diseases | |
| JP2021102644A5 (https=) | ||
| AU2017238218A1 (en) | Early intervention methods to prevent or ameliorate toxicity | |
| Piccinni et al. | Medroxyprogesterone acetate decreases Th1, Th17, and increases Th22 responses via AHR signaling which could affect susceptibility to infections and inflammatory disease | |
| JP2019504892A5 (https=) | ||
| Kasapçopur et al. | Treatment in juvenile rheumatoid arthritis and new treatment options | |
| JP2020530831A5 (https=) | ||
| Stallmach et al. | An interleukin 12 p40-IgG2b fusion protein abrogates T cell mediated inflammation: anti-inflammatory activity in Crohn’s disease and experimental colitis in vivo | |
| JP2017523187A5 (https=) | ||
| EP3193894A1 (en) | Use of cord blood plasma to treat nk cell-mediated diseases and ifn- mediated diseases | |
| Bellmann et al. | A TLR7 agonist strengthens T and NK cell function during BRAF‐targeted therapy in a preclinical melanoma model | |
| Everaerdt et al. | Recombinant IL-1 receptor antagonist protects against TNF-induced lethality in mice. | |
| Khan et al. | Interleukin inhibitors and the associated risk of candidiasis | |
| JPWO2020250915A5 (https=) | ||
| Spies et al. | Prednisone chronotherapy | |
| Jain et al. | Radiation therapy as a bridging strategy for refractory diffuse large B cell lymphoma patients awaiting CAR T manufacturing of axicabtagene ciloleucel | |
| IL321878A (en) | Medicinal products and methods for the alleviation of cancer immunotherapy-associated cytokine release syndrome | |
| Schuler et al. | Lack of efficacy of recombinant human interleukin-6 in patients with advanced renal cell cancer: results of a phase II study |