JP2019509268A5 - - Google Patents
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- Publication number
- JP2019509268A5 JP2019509268A5 JP2018542755A JP2018542755A JP2019509268A5 JP 2019509268 A5 JP2019509268 A5 JP 2019509268A5 JP 2018542755 A JP2018542755 A JP 2018542755A JP 2018542755 A JP2018542755 A JP 2018542755A JP 2019509268 A5 JP2019509268 A5 JP 2019509268A5
- Authority
- JP
- Japan
- Prior art keywords
- dihydrophthalazine
- amino
- pharmaceutical composition
- dione
- precipitate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- HWYHZTIRURJOHG-UHFFFAOYSA-N luminol Chemical compound O=C1NNC(=O)C2=C1C(N)=CC=C2 HWYHZTIRURJOHG-UHFFFAOYSA-N 0.000 claims 7
- 239000002244 precipitate Substances 0.000 claims 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 4
- 239000013078 crystal Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000001035 drying Methods 0.000 claims 2
- -1 glidant Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 239000002562 thickening agent Substances 0.000 claims 2
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 235000019568 aromas Nutrition 0.000 claims 1
- 208000037896 autoimmune cutaneous disease Diseases 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 239000008367 deionised water Substances 0.000 claims 1
- 229910021641 deionized water Inorganic materials 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000007884 disintegrant Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003995 emulsifying agent Substances 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 239000000796 flavoring agent Substances 0.000 claims 1
- 235000019634 flavors Nutrition 0.000 claims 1
- 235000003599 food sweetener Nutrition 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000003961 penetration enhancing agent Substances 0.000 claims 1
- 238000000634 powder X-ray diffraction Methods 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 239000013557 residual solvent Substances 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 238000000859 sublimation Methods 0.000 claims 1
- 230000008022 sublimation Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000003765 sweetening agent Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021192808A JP7331067B2 (ja) | 2016-02-16 | 2021-11-29 | ５－アミノ－２，３－ジヒドロフタラジン－１，４－ジオンの結晶形 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16000379 | 2016-02-16 | ||
| EP16000379.4 | 2016-02-16 | ||
| PCT/EP2017/000227 WO2017140430A1 (en) | 2016-02-16 | 2017-02-15 | Crystalline form of 5-amino-2,3-dihydrophthalazine-1,4-dione |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021192808A Division JP7331067B2 (ja) | 2016-02-16 | 2021-11-29 | ５－アミノ－２，３－ジヒドロフタラジン－１，４－ジオンの結晶形 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019509268A JP2019509268A (ja) | 2019-04-04 |
| JP2019509268A5 true JP2019509268A5 (enExample) | 2020-03-26 |
| JP7034079B2 JP7034079B2 (ja) | 2022-03-11 |
Family
ID=55398165
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018542755A Active JP7034079B2 (ja) | 2016-02-16 | 2017-02-15 | ５－アミノ－２，３－ジヒドロフタラジン－１，４－ジオンの結晶形の製造方法 |
| JP2021192808A Active JP7331067B2 (ja) | 2016-02-16 | 2021-11-29 | ５－アミノ－２，３－ジヒドロフタラジン－１，４－ジオンの結晶形 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021192808A Active JP7331067B2 (ja) | 2016-02-16 | 2021-11-29 | ５－アミノ－２，３－ジヒドロフタラジン－１，４－ジオンの結晶形 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11111218B2 (enExample) |
| EP (1) | EP3416951B1 (enExample) |
| JP (2) | JP7034079B2 (enExample) |
| KR (1) | KR102535960B1 (enExample) |
| CN (2) | CN109563052A (enExample) |
| CA (1) | CA3011767C (enExample) |
| ES (1) | ES2797299T3 (enExample) |
| WO (1) | WO2017140430A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3511325A1 (en) * | 2018-01-11 | 2019-07-17 | MetrioPharm AG | Method for solubilizing 5-amino-2,3-dihydro-1,4-phthalazinedione |
| GB201804132D0 (en) * | 2018-03-15 | 2018-05-02 | Secr Defence | Forensic analysis of an object for chemical and biological agents |
| EP3858358A1 (en) * | 2020-01-31 | 2021-08-04 | MetrioPharm AG | Use of 5-amino-2,3-dihydro-1,4-phthalazinedione in the treatment of rare chronic inflammatory pulmonary diseases |
| EP3858328A1 (en) | 2020-01-31 | 2021-08-04 | MetrioPharm AG | Use of 5-amino-2,3-dihydro-1,4-phthalazinedione in the inhalatory treatment of inflammatory pulmonary diseases |
| ES3057259T3 (en) * | 2020-03-25 | 2026-02-27 | Metriopharm Ag | 5-amino-2,3-dihydro-1,4-phthalazinedione for treatment of acute lung injury |
| EP3981405A1 (en) | 2020-10-08 | 2022-04-13 | MetrioPharm AG | Compound for the treatment of coronaviral infections |
| ES3057264T3 (en) * | 2020-06-10 | 2026-02-27 | Metriopharm Ag | 5-amino-2,3-dihydro-1,4-phthalazinedione for use in the treatment of coronaviral infections |
| WO2022117221A1 (en) | 2020-12-02 | 2022-06-09 | Metriopharm Ag | Luminol for the prophylaxis and the treatment of sequelae of a sars-cov-2 infection |
| US20230087473A1 (en) * | 2021-09-22 | 2023-03-23 | Hemant N. Joshi | Composition of suspoemulsion formulation of anthelmintic drugs with essential oils for naso-pulmonary administration |
| EP4193994A1 (en) | 2021-12-08 | 2023-06-14 | MetrioPharm AG | Combination of 5-amino-2,3-dihydro-1,4-phtalazinedione and a 6'-methoxycinchonan-9-ol for use in the treatment of coronaviral infections |
| CA3240892A1 (en) * | 2022-01-07 | 2023-07-13 | Wolfgang Brysch | Use of 5-amino-2,3-dihydro-1,4-phthalazinedione in the treatment of congenital muscular dystrophies |
| EP4209219A1 (en) | 2022-01-07 | 2023-07-12 | MetrioPharm AG | Combination of budesonide and 5-amino-2,3-dihydro-1,4-phtalazinedione |
| EP4248963A1 (en) | 2022-03-25 | 2023-09-27 | MetrioPharm AG | Combination of 5-amino-2,3-dihydro-1,4-phtalazinedione and a fumaric acid ester |
| EP4483879A1 (en) | 2023-06-29 | 2025-01-01 | MetrioPharm AG | 5-amino-2,3-dihydro-1,4-phthalazinedione for the prophylaxis and treatment of thrombotic disorders |
| WO2025067689A1 (en) | 2023-09-26 | 2025-04-03 | Metriopharm Ag | 5-amino-2,3-dihydro-1,4-phthalazinedione for the treatment of infections with an rna virus |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH683966A5 (it) * | 1993-02-19 | 1994-06-30 | Limad Marketing Exp & Imp | Composti della classe dei ftalidrazidici come sostanze attive in agenti anti-ipossici e di difesa. |
| FR2839155B1 (fr) * | 2002-04-25 | 2005-02-04 | Roc Imp | Procede pour detecter et localiser des traces de sang et compose pour detecter des traces de sang |
| CN102971300B (zh) * | 2010-03-01 | 2016-03-02 | 梅特里奥药品股份公司 | 5-氨基-2,3-二氢-(2,3-二氮杂萘)-1,4-二酮钠盐的晶型、含有它们的药物制剂以及所述晶型的生产方法 |
| WO2011123776A2 (en) * | 2010-04-01 | 2011-10-06 | Guthery B Eugene | Method for detecting occult blood |
| US10258620B2 (en) * | 2014-12-18 | 2019-04-16 | Metriopharm Ag | Crystalline form of 5-amino-2,3-dihydrophthalazine-1,4-dione sodium salt, pharmaceutical preparations containing the same and method for the production of said form |
-
2017
- 2017-02-15 US US15/999,447 patent/US11111218B2/en active Active
- 2017-02-15 CN CN201780023199.1A patent/CN109563052A/zh active Pending
- 2017-02-15 CN CN202211145086.8A patent/CN115536594A/zh active Pending
- 2017-02-15 KR KR1020187026712A patent/KR102535960B1/ko active Active
- 2017-02-15 WO PCT/EP2017/000227 patent/WO2017140430A1/en not_active Ceased
- 2017-02-15 JP JP2018542755A patent/JP7034079B2/ja active Active
- 2017-02-15 EP EP17708969.5A patent/EP3416951B1/en active Active
- 2017-02-15 ES ES17708969T patent/ES2797299T3/es active Active
- 2017-02-15 CA CA3011767A patent/CA3011767C/en active Active
-
2021
- 2021-11-29 JP JP2021192808A patent/JP7331067B2/ja active Active
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