ES2797299T3 - Forma cristalina de 5-amino-2,3-dihidroftalazina-1,4-diona - Google Patents
Forma cristalina de 5-amino-2,3-dihidroftalazina-1,4-diona Download PDFInfo
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- ES2797299T3 ES2797299T3 ES17708969T ES17708969T ES2797299T3 ES 2797299 T3 ES2797299 T3 ES 2797299T3 ES 17708969 T ES17708969 T ES 17708969T ES 17708969 T ES17708969 T ES 17708969T ES 2797299 T3 ES2797299 T3 ES 2797299T3
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- crystalline form
- acid
- dihydrophthalazine
- pharmaceutical composition
- dione
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- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
- C09K11/06—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
- C09K2211/10—Non-macromolecular compounds
- C09K2211/1018—Heterocyclic compounds
- C09K2211/1025—Heterocyclic compounds characterised by ligands
- C09K2211/1044—Heterocyclic compounds characterised by ligands containing two nitrogen atoms as heteroatoms
Landscapes
- Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
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- Heart & Thoracic Surgery (AREA)
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- Physical Education & Sports Medicine (AREA)
- Optics & Photonics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16000379 | 2016-02-16 | ||
| PCT/EP2017/000227 WO2017140430A1 (en) | 2016-02-16 | 2017-02-15 | Crystalline form of 5-amino-2,3-dihydrophthalazine-1,4-dione |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2797299T3 true ES2797299T3 (es) | 2020-12-01 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES17708969T Active ES2797299T3 (es) | 2016-02-16 | 2017-02-15 | Forma cristalina de 5-amino-2,3-dihidroftalazina-1,4-diona |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11111218B2 (enExample) |
| EP (1) | EP3416951B1 (enExample) |
| JP (2) | JP7034079B2 (enExample) |
| KR (1) | KR102535960B1 (enExample) |
| CN (2) | CN109563052A (enExample) |
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| ES (1) | ES2797299T3 (enExample) |
| WO (1) | WO2017140430A1 (enExample) |
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| EP3511325A1 (en) | 2018-01-11 | 2019-07-17 | MetrioPharm AG | Method for solubilizing 5-amino-2,3-dihydro-1,4-phthalazinedione |
| GB201804132D0 (en) * | 2018-03-15 | 2018-05-02 | Secr Defence | Forensic analysis of an object for chemical and biological agents |
| EP3858358A1 (en) * | 2020-01-31 | 2021-08-04 | MetrioPharm AG | Use of 5-amino-2,3-dihydro-1,4-phthalazinedione in the treatment of rare chronic inflammatory pulmonary diseases |
| EP3858328A1 (en) * | 2020-01-31 | 2021-08-04 | MetrioPharm AG | Use of 5-amino-2,3-dihydro-1,4-phthalazinedione in the inhalatory treatment of inflammatory pulmonary diseases |
| CA3168777A1 (en) * | 2020-03-25 | 2021-09-30 | Wolfgang Brysch | 5-amino-2,3-dihydro-1,4-phthalazinedione for treatment of acute lung injury |
| EP3981405A1 (en) | 2020-10-08 | 2022-04-13 | MetrioPharm AG | Compound for the treatment of coronaviral infections |
| IL298899A (en) | 2020-06-10 | 2023-02-01 | Metriopharm Ag | A compound for the treatment of corona virus infections |
| US20240075029A1 (en) | 2020-12-02 | 2024-03-07 | Metriopharm Ag | Luminol for the prophylaxis and the treatment of sequelae of a sars-cov-2 infection |
| US20230087473A1 (en) * | 2021-09-22 | 2023-03-23 | Hemant N. Joshi | Composition of suspoemulsion formulation of anthelmintic drugs with essential oils for naso-pulmonary administration |
| EP4193994A1 (en) | 2021-12-08 | 2023-06-14 | MetrioPharm AG | Combination of 5-amino-2,3-dihydro-1,4-phtalazinedione and a 6'-methoxycinchonan-9-ol for use in the treatment of coronaviral infections |
| WO2023131579A1 (en) * | 2022-01-07 | 2023-07-13 | Metriopharm Ag | Use of 5-amino-2,3-dihydro-1,4-phthalazinedione in the treatment of congenital muscular dystrophies |
| EP4209219A1 (en) * | 2022-01-07 | 2023-07-12 | MetrioPharm AG | Combination of budesonide and 5-amino-2,3-dihydro-1,4-phtalazinedione |
| EP4248963A1 (en) | 2022-03-25 | 2023-09-27 | MetrioPharm AG | Combination of 5-amino-2,3-dihydro-1,4-phtalazinedione and a fumaric acid ester |
| EP4483879A1 (en) | 2023-06-29 | 2025-01-01 | MetrioPharm AG | 5-amino-2,3-dihydro-1,4-phthalazinedione for the prophylaxis and treatment of thrombotic disorders |
| WO2025067689A1 (en) | 2023-09-26 | 2025-04-03 | Metriopharm Ag | 5-amino-2,3-dihydro-1,4-phthalazinedione for the treatment of infections with an rna virus |
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| CH683966A5 (it) * | 1993-02-19 | 1994-06-30 | Limad Marketing Exp & Imp | Composti della classe dei ftalidrazidici come sostanze attive in agenti anti-ipossici e di difesa. |
| FR2839155B1 (fr) * | 2002-04-25 | 2005-02-04 | Roc Imp | Procede pour detecter et localiser des traces de sang et compose pour detecter des traces de sang |
| RU2585677C2 (ru) | 2010-03-01 | 2016-06-10 | Метриофарм Аг | Кристаллические формы натриевой соли 5-амино-2,3-дигидрофталазин-1,4-диона, содержащие их фармацевтические препараты и способы получения указанных форм |
| WO2011123776A2 (en) * | 2010-04-01 | 2011-10-06 | Guthery B Eugene | Method for detecting occult blood |
| WO2016096143A1 (de) | 2014-12-18 | 2016-06-23 | Metriopharm Ag | Kristalline form von 5-amino-2,3-dihydrophthalazin-1,4-dion natriumsalz, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung |
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Also Published As
| Publication number | Publication date |
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| CA3011767A1 (en) | 2017-08-24 |
| JP2019509268A (ja) | 2019-04-04 |
| US20200369624A1 (en) | 2020-11-26 |
| JP7331067B2 (ja) | 2023-08-22 |
| WO2017140430A1 (en) | 2017-08-24 |
| KR102535960B1 (ko) | 2023-05-23 |
| KR20180107277A (ko) | 2018-10-01 |
| JP2022037005A (ja) | 2022-03-08 |
| JP7034079B2 (ja) | 2022-03-11 |
| EP3416951A1 (en) | 2018-12-26 |
| US11111218B2 (en) | 2021-09-07 |
| CN109563052A (zh) | 2019-04-02 |
| EP3416951B1 (en) | 2020-04-08 |
| CA3011767C (en) | 2024-02-06 |
| CN115536594A (zh) | 2022-12-30 |
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