JP2019509041A5 - - Google Patents
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- Publication number
- JP2019509041A5 JP2019509041A5 JP2018545838A JP2018545838A JP2019509041A5 JP 2019509041 A5 JP2019509041 A5 JP 2019509041A5 JP 2018545838 A JP2018545838 A JP 2018545838A JP 2018545838 A JP2018545838 A JP 2018545838A JP 2019509041 A5 JP2019509041 A5 JP 2019509041A5
- Authority
- JP
- Japan
- Prior art keywords
- era
- amino acid
- trail
- variant
- fusion protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108020001507 fusion proteins Proteins 0.000 claims 13
- 102000037865 fusion proteins Human genes 0.000 claims 13
- 102000046283 TNF-Related Apoptosis-Inducing Ligand Human genes 0.000 claims 12
- 108700012411 TNFSF10 Proteins 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 108010024976 Asparaginase Proteins 0.000 claims 9
- 102100025573 1-alkyl-2-acetylglycerophosphocholine esterase Human genes 0.000 claims 8
- 125000000539 amino acid group Chemical group 0.000 claims 8
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 235000001014 amino acid Nutrition 0.000 claims 5
- 238000006467 substitution reaction Methods 0.000 claims 5
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 4
- 239000004471 Glycine Substances 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Chemical compound OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 3
- 241000723353 Chrysanthemum Species 0.000 claims 3
- 235000007516 Chrysanthemum Nutrition 0.000 claims 3
- 241000588698 Erwinia Species 0.000 claims 3
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 3
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 3
- 229960001230 asparagine Drugs 0.000 claims 3
- 125000005647 linker group Chemical group 0.000 claims 3
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
- 102000009027 Albumins Human genes 0.000 claims 2
- 108010088751 Albumins Proteins 0.000 claims 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 2
- 208000003950 B-cell lymphoma Diseases 0.000 claims 2
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 2
- 208000011691 Burkitt lymphomas Diseases 0.000 claims 2
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 101000830565 Homo sapiens Tumor necrosis factor ligand superfamily member 10 Proteins 0.000 claims 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 2
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 2
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
- 235000009582 asparagine Nutrition 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 2
- 229940088598 enzyme Drugs 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 2
- 235000004554 glutamine Nutrition 0.000 claims 2
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 2
- 201000009277 hairy cell leukemia Diseases 0.000 claims 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 2
- 102000044949 human TNFSF10 Human genes 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102000015790 Asparaginase Human genes 0.000 claims 1
- 241000588700 Dickeya chrysanthemi Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 102000009127 Glutaminase Human genes 0.000 claims 1
- 108010073324 Glutaminase Proteins 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- 229930182816 L-glutamine Natural products 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 1
- 239000004473 Threonine Substances 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 229960003272 asparaginase Drugs 0.000 claims 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-M asparaginate Chemical compound [O-]C(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-M 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662301806P | 2016-03-01 | 2016-03-01 | |
| US62/301,806 | 2016-03-01 | ||
| US201662347376P | 2016-06-08 | 2016-06-08 | |
| US62/347,376 | 2016-06-08 | ||
| US201762446026P | 2017-01-13 | 2017-01-13 | |
| US62/446,026 | 2017-01-13 | ||
| PCT/US2017/020090 WO2017151707A1 (en) | 2016-03-01 | 2017-03-01 | L-asparaginase variants and fusion proteins with reduced l-glutaminase activity and enhanced stability |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019509041A JP2019509041A (ja) | 2019-04-04 |
| JP2019509041A5 true JP2019509041A5 (enExample) | 2020-03-26 |
| JP7091248B2 JP7091248B2 (ja) | 2022-06-27 |
Family
ID=58314525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018545838A Active JP7091248B2 (ja) | 2016-03-01 | 2017-03-01 | 低減されたｌ－グルタミナーゼ活性および増強された安定性を有するｌ－アスパラギナーゼ変異体および融合タンパク質 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10821160B2 (enExample) |
| EP (1) | EP3423480A1 (enExample) |
| JP (1) | JP7091248B2 (enExample) |
| CN (1) | CN109153711B (enExample) |
| CA (1) | CA3054286A1 (enExample) |
| WO (1) | WO2017151707A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3781197B1 (en) * | 2018-04-19 | 2025-09-10 | Elanco US Inc. | Variant asparaginase polypeptides for medical use |
| US20220362357A1 (en) | 2018-08-31 | 2022-11-17 | Stichting Radboud Universitair Medisch Centrum | Synergistic Combinations of Amino Acid Depletion Agent Sensitizers (AADAS) and Amino Acid Depletion Agents (AADA), and Therapeutic Methods of Use Thereof |
| KR102269634B1 (ko) * | 2019-10-31 | 2021-06-25 | 대상 주식회사 | ansB 유전자 불활성화에 의해 아미노산 생산능력이 향상된 균주 |
| KR102283626B1 (ko) * | 2019-10-31 | 2021-08-02 | 대상 주식회사 | glsB 유전자 불활성화에 의해 아미노산 생산능력이 향상된 균주 및 이의 제조방법 |
| WO2025026424A1 (en) * | 2023-08-02 | 2025-02-06 | The Hong Kong Polytechnic University | Bioengineered asparaginase fusion proteins |
| CN117165564B (zh) * | 2023-08-16 | 2025-01-28 | 云南师范大学 | 一种ii型l-天冬酰胺酶及其应用 |
| CN118460485B (zh) * | 2024-05-07 | 2025-06-17 | 山东凯密斯新材料科技有限公司 | 一种用于合成l-天冬酰胺的天冬酰胺合成酶a突变体及应用 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US6267964B1 (en) | 1989-08-01 | 2001-07-31 | Affibody Technology Sweden Ab | Stabilized protein or peptide conjugates able to bond albumin having extended biological half-lives |
| SE9002213D0 (sv) | 1990-06-21 | 1990-06-21 | Hightech Receptor Ab | Albumin binding proteins |
| US5766897A (en) | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
| US6565841B1 (en) | 1991-03-15 | 2003-05-20 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| US20050287153A1 (en) | 2002-06-28 | 2005-12-29 | Genentech, Inc. | Serum albumin binding peptides for tumor targeting |
| US20040001827A1 (en) | 2002-06-28 | 2004-01-01 | Dennis Mark S. | Serum albumin binding peptides for tumor targeting |
| DE60041564D1 (de) | 1999-12-24 | 2009-03-26 | Genentech Inc | Verfahren und Zusammensetzungen zur Verlängerung der Entsorgungshalbwertszeit von biowirksamen Verbindungen |
| US20020065397A1 (en) | 2000-10-12 | 2002-05-30 | Joseph Roberts | Protecting therapeutic compositions from host-mediated inactivation |
| EP1654379A4 (en) | 2003-06-26 | 2007-01-17 | Lifesensors Inc | METHOD AND COMPOSITIONS FOR IMPROVED PROTEIN EXPRESSION AND CLEANING |
| US8642743B2 (en) | 2004-04-06 | 2014-02-04 | Affibody Ab | Method for reducing the immune response to a biologically active protein |
| WO2007103290A2 (en) | 2006-03-03 | 2007-09-13 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Materials and methods directed to asparagine synthetase and asparaginase therapies |
| FI20070455A0 (fi) | 2007-06-08 | 2007-06-08 | Reagena Ltd Oy | Menetelmä syöpäsairauksien tai tulehdussairauksien hoitoon |
| US20090131317A1 (en) | 2007-06-22 | 2009-05-21 | Affymax, Inc. | Compounds and peptides that bind the trail receptor |
| US8969626B2 (en) | 2008-07-21 | 2015-03-03 | Polytherics Limited | Reagents and method for conjugating biological molecules |
| WO2010065950A2 (en) | 2008-12-05 | 2010-06-10 | Abraxis Bioscience, Llc | Albumin binding peptide-mediated disease targeting |
| WO2011003633A1 (en) | 2009-07-06 | 2011-01-13 | Alize Pharma Ii | Pegylated l-asparaginase |
| US9322008B2 (en) | 2010-09-01 | 2016-04-26 | Indian Institute Of Technology | Mutants of L-asparaginase |
| WO2012170640A1 (en) | 2011-06-07 | 2012-12-13 | The Trustees Of Columbia University In The City Of New York | Methods and compositions for trail-drug combination therapy |
| CA2849705A1 (en) | 2011-09-23 | 2013-03-28 | Technophage, Investigacao E Desenvolvimento Em Biotecnologia, Sa | Modified albumin-binding domains and uses thereof to improve pharmacokinetics |
| ES2670442T3 (es) | 2012-05-25 | 2018-05-30 | Janssen Biotech, Inc. | Dominios de unión a albúmina de consenso no naturales |
| US20160213759A1 (en) | 2013-09-10 | 2016-07-28 | Board Of Regents, The University Of Texas System | Therapeutic asparaginases |
| NO2776305T3 (enExample) | 2014-04-23 | 2018-01-27 | ||
| CN104371993B (zh) | 2014-10-22 | 2016-10-19 | 江南大学 | 一种酶活提高的天冬酰胺酶突变体 |
-
2017
- 2017-03-01 CN CN201780014261.0A patent/CN109153711B/zh active Active
- 2017-03-01 WO PCT/US2017/020090 patent/WO2017151707A1/en not_active Ceased
- 2017-03-01 US US16/080,435 patent/US10821160B2/en active Active
- 2017-03-01 EP EP17711054.1A patent/EP3423480A1/en active Pending
- 2017-03-01 JP JP2018545838A patent/JP7091248B2/ja active Active
- 2017-03-01 CA CA3054286A patent/CA3054286A1/en active Pending