JP2019509034A5 - - Google Patents

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Publication number
JP2019509034A5
JP2019509034A5 JP2018543719A JP2018543719A JP2019509034A5 JP 2019509034 A5 JP2019509034 A5 JP 2019509034A5 JP 2018543719 A JP2018543719 A JP 2018543719A JP 2018543719 A JP2018543719 A JP 2018543719A JP 2019509034 A5 JP2019509034 A5 JP 2019509034A5
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JP
Japan
Prior art keywords
cells
polynucleotide
cell
genetically modified
seq
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JP2018543719A
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English (en)
Japanese (ja)
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JP2019509034A (ja
JP6975465B2 (ja
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Priority claimed from PCT/US2017/018483 external-priority patent/WO2017143266A1/en
Publication of JP2019509034A publication Critical patent/JP2019509034A/ja
Publication of JP2019509034A5 publication Critical patent/JP2019509034A5/ja
Priority to JP2021177252A priority Critical patent/JP7350361B2/ja
Application granted granted Critical
Publication of JP6975465B2 publication Critical patent/JP6975465B2/ja
Expired - Fee Related legal-status Critical Current
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JP2018543719A 2016-02-19 2017-02-17 遺伝子改変細胞をポジティブに選択して、排除するための短ヘアピンｒｎａ（ｓｈｒｎａ７３４）およびその使用 Expired - Fee Related JP6975465B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021177252A JP7350361B2 (ja) 2016-02-19 2021-10-29 遺伝子改変細胞をポジティブに選択して、排除するための短ヘアピンｒｎａ（ｓｈｒｎａ７３４）およびその使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662297432P 2016-02-19 2016-02-19
US62/297,432 2016-02-19
PCT/US2017/018483 WO2017143266A1 (en) 2016-02-19 2017-02-17 Short hairpin rna (shrna734) and use of same to positively select and eliminate genetically modified cells

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021177252A Division JP7350361B2 (ja) 2016-02-19 2021-10-29 遺伝子改変細胞をポジティブに選択して、排除するための短ヘアピンｒｎａ（ｓｈｒｎａ７３４）およびその使用

Publications (3)

Publication Number Publication Date
JP2019509034A JP2019509034A (ja) 2019-04-04
JP2019509034A5 true JP2019509034A5 (enExample) 2020-03-19
JP6975465B2 JP6975465B2 (ja) 2021-12-08

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Application Number Title Priority Date Filing Date
JP2018543719A Expired - Fee Related JP6975465B2 (ja) 2016-02-19 2017-02-17 遺伝子改変細胞をポジティブに選択して、排除するための短ヘアピンｒｎａ（ｓｈｒｎａ７３４）およびその使用
JP2021177252A Active JP7350361B2 (ja) 2016-02-19 2021-10-29 遺伝子改変細胞をポジティブに選択して、排除するための短ヘアピンｒｎａ（ｓｈｒｎａ７３４）およびその使用

Family Applications After (1)

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JP2021177252A Active JP7350361B2 (ja) 2016-02-19 2021-10-29 遺伝子改変細胞をポジティブに選択して、排除するための短ヘアピンｒｎａ（ｓｈｒｎａ７３４）およびその使用

Country Status (8)

Country Link
US (2) US11377659B2 (enExample)
EP (1) EP3416660A4 (enExample)
JP (2) JP6975465B2 (enExample)
KR (1) KR20180114008A (enExample)
CN (1) CN108495640B (enExample)
AU (1) AU2017221456B2 (enExample)
HK (1) HK1257668A1 (enExample)
WO (1) WO2017143266A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3070242A1 (en) 2017-07-18 2019-01-24 Calimmune, Inc. Compositions and methods for treating beta-hemoglobinopathies
EP3654994B1 (en) 2017-07-18 2022-12-28 CSL Behring Gene Therapy, Inc. A modulatable switch for selection of donor modified cells
EP3897831A1 (en) * 2018-12-23 2021-10-27 CSL Behring LLC Donor t-cells with kill switch
CN113518825A (zh) * 2018-12-23 2021-10-19 美国杰特贝林生物制品有限公司 Wiskott-aldrich综合征的造血干细胞基因疗法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997043900A1 (en) 1996-05-24 1997-11-27 The President And Fellows Of Harvard College In vivo selection
AU7605796A (en) 1996-11-04 1998-05-29 Saint Jude Children's Research Hospital (in vivo) selection of primitive hematopoietic cells
US20030032003A1 (en) 2000-02-02 2003-02-13 Schiestl Robert H. In vivo selection
WO2002040049A2 (en) 2000-11-14 2002-05-23 The General Hospital Corporation Blockade of t cell migration into epithelial gvhd target tissues
US7737124B2 (en) * 2001-09-13 2010-06-15 California Institute Of Technology Method for expression of small antiviral RNA molecules with reduced cytotoxicity within a cell
EP2305813A3 (en) * 2002-11-14 2012-03-28 Dharmacon, Inc. Fuctional and hyperfunctional sirna
WO2005056761A2 (en) * 2003-12-05 2005-06-23 Massachusetts Institute Of Technology REAGENTS AND METHODS FOR IDENTIFICATION OF RNAi PATHWAY GENES AND CHEMICAL MODULATORS OF RNAi
EP1607482A1 (de) 2004-06-16 2005-12-21 Gbf-Gesellschaft Für Biotechnologische Forschung Mbh RNAi-basierte Verfahren zur Selektion von transfizierten eukaryontischen Zellen
WO2008076370A2 (en) * 2006-12-18 2008-06-26 The General Hospital Corporation P21 compositions and methods for the treatment of hiv
WO2012061075A2 (en) * 2010-10-25 2012-05-10 The Regents Of The University Of California Hiv resistant and functional hematopoietic stem/progenitor cells and macrophages from induced pluripotent stem cells
GB201301125D0 (en) * 2013-01-22 2013-03-06 Horizon Discovery Ltd Methods for improving the efficency of gene targeting
EP3027755B1 (en) * 2013-08-02 2019-10-09 The Regents of The University of California Engineering antiviral t cell immunity through stem cells and chimeric antigen receptors
EP3370741B1 (en) * 2015-11-04 2025-10-08 The Trustees of the University of Pennsylvania Methods and compositions for gene editing in hematopoietic stem cells
CA3070242A1 (en) * 2017-07-18 2019-01-24 Calimmune, Inc. Compositions and methods for treating beta-hemoglobinopathies

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