JP6975465B2 - 遺伝子改変細胞をポジティブに選択して、排除するための短ヘアピンｒｎａ（ｓｈｒｎａ７３４）およびその使用 - Google Patents

遺伝子改変細胞をポジティブに選択して、排除するための短ヘアピンｒｎａ（ｓｈｒｎａ７３４）およびその使用 Download PDF

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JP6975465B2
JP6975465B2 JP2018543719A JP2018543719A JP6975465B2 JP 6975465 B2 JP6975465 B2 JP 6975465B2 JP 2018543719 A JP2018543719 A JP 2018543719A JP 2018543719 A JP2018543719 A JP 2018543719A JP 6975465 B2 JP6975465 B2 JP 6975465B2
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cells
gene
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genetically modified
polynucleotide according
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スン アン，ドン
シミズ，サキ
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University of California
University of California San Diego UCSD
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JP2018543719A 2016-02-19 2017-02-17 遺伝子改変細胞をポジティブに選択して、排除するための短ヘアピンｒｎａ（ｓｈｒｎａ７３４）およびその使用 Active JP6975465B2 (ja)

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JP2021177252A JP7350361B2 (ja) 2016-02-19 2021-10-29 遺伝子改変細胞をポジティブに選択して、排除するための短ヘアピンｒｎａ（ｓｈｒｎａ７３４）およびその使用

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US201662297432P 2016-02-19 2016-02-19
US62/297,432 2016-02-19
PCT/US2017/018483 WO2017143266A1 (en) 2016-02-19 2017-02-17 Short hairpin rna (shrna734) and use of same to positively select and eliminate genetically modified cells

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BR112020001132A2 (pt) 2017-07-18 2020-07-21 Calimmune, Inc. interruptor modulável para seleção de células doadoras modificadas
AU2018302098A1 (en) 2017-07-18 2020-02-20 Csl Behring Gene Therapy, Inc. Compositions and methods for treating beta-hemoglobinopathies
CN113518825A (zh) * 2018-12-23 2021-10-19 美国杰特贝林生物制品有限公司 Wiskott-aldrich综合征的造血干细胞基因疗法
BR112021012318A2 (pt) * 2018-12-23 2022-01-18 Csl Behring Llc Células t doadoras com interruptor de eliminação

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WO1997043900A1 (en) 1996-05-24 1997-11-27 The President And Fellows Of Harvard College In vivo selection
AU7605796A (en) 1996-11-04 1998-05-29 Saint Jude Children's Research Hospital (in vivo) selection of primitive hematopoietic cells
US20030032003A1 (en) 2000-02-02 2003-02-13 Schiestl Robert H. In vivo selection
AU2002219828A1 (en) 2000-11-14 2002-05-27 The General Hospital Corporation Blockade of T cell migration into epithelial GVHD target tissues
US7737124B2 (en) * 2001-09-13 2010-06-15 California Institute Of Technology Method for expression of small antiviral RNA molecules with reduced cytotoxicity within a cell
EP2213738B1 (en) * 2002-11-14 2012-10-10 Dharmacon, Inc. siRNA molecules targeting Bcl-2
US20050266552A1 (en) 2003-12-05 2005-12-01 Doench John G Reagents and methods for identification of RNAi pathway genes and chemical modulators of RNAi
EP1607482A1 (de) 2004-06-16 2005-12-21 Gbf-Gesellschaft Für Biotechnologische Forschung Mbh RNAi-basierte Verfahren zur Selektion von transfizierten eukaryontischen Zellen
WO2008076370A2 (en) 2006-12-18 2008-06-26 The General Hospital Corporation P21 compositions and methods for the treatment of hiv
WO2012061075A2 (en) 2010-10-25 2012-05-10 The Regents Of The University Of California Hiv resistant and functional hematopoietic stem/progenitor cells and macrophages from induced pluripotent stem cells
GB201301125D0 (en) 2013-01-22 2013-03-06 Horizon Discovery Ltd Methods for improving the efficency of gene targeting
AU2014296059B2 (en) * 2013-08-02 2020-12-10 The Regents Of The University Of California Engineering antiviral T cell immunity through stem cells and chimeric antigen receptors
MY185961A (en) * 2015-11-04 2021-06-14 Univ Pennsylvania Methods and compositions for gene editing in hematopoietic stem cells
AU2018302098A1 (en) * 2017-07-18 2020-02-20 Csl Behring Gene Therapy, Inc. Compositions and methods for treating beta-hemoglobinopathies

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JP2022033729A (ja) 2022-03-02
US11377659B2 (en) 2022-07-05
EP3416660A1 (en) 2018-12-26
CN108495640A (zh) 2018-09-04
KR20180114008A (ko) 2018-10-17
US20230076635A1 (en) 2023-03-09
US20210310007A1 (en) 2021-10-07
AU2017221456B2 (en) 2024-04-04
JP2019509034A (ja) 2019-04-04
HK1257668A1 (zh) 2019-10-25
JP7350361B2 (ja) 2023-09-26
CN108495640B (zh) 2022-11-04
AU2017221456A1 (en) 2018-07-19
WO2017143266A1 (en) 2017-08-24
EP3416660A4 (en) 2019-11-06
CA3012332A1 (en) 2017-08-24

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