JP2019509014A5 - - Google Patents
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- JP2019509014A5 JP2019509014A5 JP2018526708A JP2018526708A JP2019509014A5 JP 2019509014 A5 JP2019509014 A5 JP 2019509014A5 JP 2018526708 A JP2018526708 A JP 2018526708A JP 2018526708 A JP2018526708 A JP 2018526708A JP 2019509014 A5 JP2019509014 A5 JP 2019509014A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- polypeptide
- binding
- human
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 101001012447 Homo sapiens Ectonucleoside triphosphate diphosphohydrolase 1 Proteins 0.000 claims 21
- 102100029722 Ectonucleoside triphosphate diphosphohydrolase 1 Human genes 0.000 claims 20
- 108090000765 processed proteins & peptides Proteins 0.000 claims 11
- 229920001184 polypeptide Polymers 0.000 claims 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 8
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical group COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 7
- 230000000694 effects Effects 0.000 claims 6
- 108091006112 ATPases Proteins 0.000 claims 5
- 102000057290 Adenosine Triphosphatases Human genes 0.000 claims 5
- 150000001413 amino acids Chemical group 0.000 claims 5
- 238000006467 substitution reaction Methods 0.000 claims 5
- 230000001965 increasing effect Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 108010080422 CD39 antigen Proteins 0.000 claims 2
- 239000004214 Fast Green FCF Substances 0.000 claims 2
- 101000913074 Homo sapiens High affinity immunoglobulin gamma Fc receptor I Proteins 0.000 claims 2
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 2
- 239000004473 Threonine Substances 0.000 claims 2
- 235000004279 alanine Nutrition 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 230000003828 downregulation Effects 0.000 claims 2
- 230000002255 enzymatic effect Effects 0.000 claims 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 230000003834 intracellular effect Effects 0.000 claims 2
- GSEKYIWUAPZIEF-UHFFFAOYSA-N ismine hydrochloride Natural products CNC1=CC=CC=C1C(C(=C1)CO)=CC2=C1OCO2 GSEKYIWUAPZIEF-UHFFFAOYSA-N 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 238000006386 neutralization reaction Methods 0.000 claims 2
- 230000003472 neutralizing effect Effects 0.000 claims 2
- 238000012360 testing method Methods 0.000 claims 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- 101150046224 ABAT gene Proteins 0.000 claims 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 1
- 101100501552 Homo sapiens ENTPD1 gene Proteins 0.000 claims 1
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 1
- 108010073807 IgG Receptors Proteins 0.000 claims 1
- 102000009490 IgG Receptors Human genes 0.000 claims 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 1
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 229940024606 amino acid Drugs 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 229960001230 asparagine Drugs 0.000 claims 1
- 235000009582 asparagine Nutrition 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 1
- 102000053350 human FCGR3B Human genes 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 125000001165 hydrophobic group Chemical group 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- WWJZWCUNLNYYAU-UHFFFAOYSA-N temephos Chemical group C1=CC(OP(=S)(OC)OC)=CC=C1SC1=CC=C(OP(=S)(OC)OC)C=C1 WWJZWCUNLNYYAU-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562258701P | 2015-11-23 | 2015-11-23 | |
| US62/258,701 | 2015-11-23 | ||
| US201562263760P | 2015-12-07 | 2015-12-07 | |
| US62/263,760 | 2015-12-07 | ||
| US201562267343P | 2015-12-15 | 2015-12-15 | |
| US62/267,343 | 2015-12-15 | ||
| US201662320738P | 2016-04-11 | 2016-04-11 | |
| US62/320,738 | 2016-04-11 | ||
| US201662404779P | 2016-10-06 | 2016-10-06 | |
| US62/404,779 | 2016-10-06 | ||
| PCT/EP2016/078395 WO2017089334A1 (en) | 2015-11-23 | 2016-11-22 | Cd39 vascular isoform targeting agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019509014A JP2019509014A (ja) | 2019-04-04 |
| JP2019509014A5 true JP2019509014A5 (enExample) | 2019-12-12 |
Family
ID=57391960
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018526708A Pending JP2019509014A (ja) | 2015-11-23 | 2016-11-22 | Ｃｄ３９血管アイソフォームターゲティング剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20190153113A1 (enExample) |
| EP (1) | EP3380519A1 (enExample) |
| JP (1) | JP2019509014A (enExample) |
| AU (1) | AU2016359790A1 (enExample) |
| CA (1) | CA3005986A1 (enExample) |
| WO (1) | WO2017089334A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2848323T3 (es) | 2008-01-31 | 2021-08-06 | Inst Nat Sante Rech Med | Anticuerpos contra CD39 humano y uso de los mismos para inhibir la actividad de las células T reguladoras |
| TW201803905A (zh) | 2016-06-20 | 2018-02-01 | 克馬伯有限公司 | 用於免疫腫瘤學之多重專一性抗體 |
| EP3596124A1 (en) | 2017-03-16 | 2020-01-22 | Innate Pharma | Compositions and methods for treating cancer |
| EP3622092A4 (en) * | 2017-05-11 | 2021-06-23 | The Broad Institute, Inc. | METHODS AND COMPOSITIONS OF USE OF CD8 + TUMOR-INFILTRATING LYMPHOCYTE SUBTYPES AND GENE SIGNATURES THEREOF |
| BR112020002012A8 (pt) * | 2017-07-31 | 2022-06-28 | Tizona Therapeutics | Anticorpos anti-cd39, composições que compreendem anticorpos anti-cd39 e métodos de utilização de anticorpos anti-cd39 |
| CN111542539B (zh) * | 2017-10-06 | 2023-10-20 | 先天制药公司 | 通过cd39/cd73轴恢复t细胞活性 |
| KR102781619B1 (ko) * | 2017-11-15 | 2025-03-14 | 이나뜨 파르마 에스.에이. | 암의 치료를 위한 인간 CD39 단백질의 ATPase 활성을 결합 및 저해하는 항체 |
| JP7800852B2 (ja) * | 2018-01-10 | 2026-01-16 | バイオインヴェント インターナショナル アーベー | 抗体の新規組み合わせおよびその使用 |
| EP3788079A4 (en) | 2018-05-03 | 2022-12-21 | Shanghai Epimab Biotherapeutics Co., Ltd. | High affinity antibodies to pd-1 and lag-3 and bispecific binding proteins made therefrom |
| UY38247A (es) | 2018-05-30 | 2019-12-31 | Novartis Ag | Anticuerpos frente a entpd2, terapias de combinación y métodos de uso de los anticuerpos y las terapias de combinación |
| WO2019241707A1 (en) * | 2018-06-14 | 2019-12-19 | Beth Israel Deaconess Medical Center, Inc. | Compositions and methods for preventing or reversing t-cell exhaustion through ectonucleotidase inhibition antibody-mediated target cytosis |
| CN112334486B (zh) * | 2018-06-18 | 2025-02-18 | 先天制药公司 | 用于治疗癌症的组合物和方法 |
| BR112021012685A2 (pt) | 2019-01-11 | 2021-12-28 | Omeros Corp | Métodos para tratar câncer, para aumentar o nível de citocinas th1 nas células mononucleares de sangue periférico humanas, para realçar uma resposta imune antitumoral e para estimular e/ou amplificar uma resposta imune em um sujeito mamífero sofrendo de ou em risco de desenvolver câncer ou metástase de câncer, e, composição farmacêutica |
| CN113795267A (zh) | 2019-03-12 | 2021-12-14 | 艾库斯生物科学有限公司 | 致癌基因驱动的癌症的治疗 |
| WO2020205527A1 (en) | 2019-03-29 | 2020-10-08 | Arcus Biosciences, Inc. | Treatment of cancer utilizing an identified adenosine fingerprint |
| KR20220061977A (ko) | 2019-08-12 | 2022-05-13 | 퓨리노미아 바이오테크, 아이엔씨. | Cd39 발현 세포의 adcc 표적화를 통해 t 세포 매개 면역 반응을 촉진 및 강화하기 위한 방법 및 조성물 |
| KR20220050971A (ko) * | 2019-08-27 | 2022-04-25 | 엘피사이언스 (쑤저우) 바이오파마, 엘티디. | 신규 항-cd39 항체 |
| JP2022548484A (ja) | 2019-09-16 | 2022-11-21 | サーフィス オンコロジー インコーポレイテッド | 抗ｃｄ３９抗体の組成物及び方法 |
| CN110407941B (zh) * | 2019-09-25 | 2020-01-14 | 上海岸迈生物科技有限公司 | Cd39的高亲和力抗体及其用途 |
| TW202118791A (zh) * | 2019-11-05 | 2021-05-16 | 大陸商北京加科思新藥研發有限公司 | 對cd39具有特異性的結合分子及其用途 |
| US20230036592A1 (en) * | 2021-06-03 | 2023-02-02 | Surface Oncology, Inc. | Methods of treating cancer with an anti-cd39 antibody and pembrolizumab |
| CN119173535A (zh) | 2022-03-03 | 2024-12-20 | 艾库斯生物科学有限公司 | 抗cd39抗体及其用途 |
| KR20250006965A (ko) | 2022-04-29 | 2025-01-13 | 퓨리노미아 바이오테크, 아이엔씨. | 호산구에 의해 유발되는 질환 및 장애의 치료를 위한 방법 및 조성물 |
| WO2024115935A1 (en) * | 2022-11-29 | 2024-06-06 | Inserm | Methods for the treatment of b-cell lymphoma using cd39 inhibitors |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2848323T3 (es) * | 2008-01-31 | 2021-08-06 | Inst Nat Sante Rech Med | Anticuerpos contra CD39 humano y uso de los mismos para inhibir la actividad de las células T reguladoras |
| WO2012085132A1 (en) * | 2010-12-22 | 2012-06-28 | Orega Biotech | Antibodies against human cd39 and use thereof |
| RU2616881C2 (ru) * | 2011-06-06 | 2017-04-18 | Ново Нордиск А/С | Терапевтические антитела |
-
2016
- 2016-11-22 CA CA3005986A patent/CA3005986A1/en active Pending
- 2016-11-22 WO PCT/EP2016/078395 patent/WO2017089334A1/en not_active Ceased
- 2016-11-22 AU AU2016359790A patent/AU2016359790A1/en not_active Abandoned
- 2016-11-22 EP EP16800926.4A patent/EP3380519A1/en not_active Withdrawn
- 2016-11-22 US US15/778,202 patent/US20190153113A1/en not_active Abandoned
- 2016-11-22 JP JP2018526708A patent/JP2019509014A/ja active Pending
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