JP2019508481A5 - - Google Patents
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- Publication number
- JP2019508481A5 JP2019508481A5 JP2018550872A JP2018550872A JP2019508481A5 JP 2019508481 A5 JP2019508481 A5 JP 2019508481A5 JP 2018550872 A JP2018550872 A JP 2018550872A JP 2018550872 A JP2018550872 A JP 2018550872A JP 2019508481 A5 JP2019508481 A5 JP 2019508481A5
- Authority
- JP
- Japan
- Prior art keywords
- stap
- pmo
- stip
- compound according
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023014917A JP2023055874A (ja) | 2015-12-21 | 2023-02-02 | ステープルまたはステッチペプチドに複合された生物活性化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1522548.5A GB2545898B (en) | 2015-12-21 | 2015-12-21 | Improved drug delivery by conjugating oligonucleotides to stitched/stapled peptides |
| GB1522548.5 | 2015-12-21 | ||
| PCT/GB2016/054028 WO2017109494A1 (en) | 2015-12-21 | 2016-12-21 | Biologically active compound conjugated to a stapled or stitched peptide |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023014917A Division JP2023055874A (ja) | 2015-12-21 | 2023-02-02 | ステープルまたはステッチペプチドに複合された生物活性化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019508481A JP2019508481A (ja) | 2019-03-28 |
| JP2019508481A5 true JP2019508481A5 (enExample) | 2022-06-16 |
Family
ID=55311362
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018550872A Pending JP2019508481A (ja) | 2015-12-21 | 2016-12-21 | ステープルまたはステッチペプチドに複合された生物活性化合物 |
| JP2023014917A Pending JP2023055874A (ja) | 2015-12-21 | 2023-02-02 | ステープルまたはステッチペプチドに複合された生物活性化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023014917A Pending JP2023055874A (ja) | 2015-12-21 | 2023-02-02 | ステープルまたはステッチペプチドに複合された生物活性化合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11541124B2 (enExample) |
| EP (1) | EP3393520A1 (enExample) |
| JP (2) | JP2019508481A (enExample) |
| KR (1) | KR20180091920A (enExample) |
| CN (1) | CN108472385A (enExample) |
| AU (1) | AU2016375869B2 (enExample) |
| BR (1) | BR112018012641A2 (enExample) |
| CA (1) | CA3007910A1 (enExample) |
| GB (1) | GB2545898B (enExample) |
| WO (1) | WO2017109494A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2545898B (en) | 2015-12-21 | 2019-10-09 | Sutura Therapeutics Ltd | Improved drug delivery by conjugating oligonucleotides to stitched/stapled peptides |
| JP2019513371A (ja) | 2016-04-01 | 2019-05-30 | アビディティー バイオサイエンシーズ エルエルシー | 核酸ポリペプチド組成物とその使用 |
| MX2019008199A (es) | 2017-01-06 | 2019-11-25 | Avidity Biosciences Llc | Composiciones de acido nucleico polipeptido y metodos de induccion de la omision de exon. |
| GB2563875B (en) * | 2017-06-28 | 2020-08-19 | Sutura Therapeutics Ltd | Improvements in drug delivery |
| GB201711809D0 (en) | 2017-07-21 | 2017-09-06 | Governors Of The Univ Of Alberta | Antisense oligonucleotide |
| CA3078504A1 (en) | 2017-10-04 | 2019-04-11 | Ohio State Innovation Foundation | Bicyclic peptidyl inhibitors |
| CN117567639A (zh) | 2017-10-27 | 2024-02-20 | 俄亥俄州国家创新基金会 | 用于细胞内递送装订肽的多肽缀合物 |
| WO2019148195A2 (en) | 2018-01-29 | 2019-08-01 | Ohio State Innovation Foundation | Cyclic peptidyl inhibitors of cal-pdz binding domain |
| US11952432B2 (en) | 2018-02-07 | 2024-04-09 | Dana-Farber Cancer Institute, Inc. | Cell-permeable stapled peptide modules for cellular delivery |
| WO2020047399A1 (en) * | 2018-08-31 | 2020-03-05 | Massachusetts Institute Of Technology | Ionizable lipidoids and their uses |
| AU2020258482B2 (en) * | 2019-04-18 | 2026-02-12 | Dana-Farber Cancer Institute, Inc. | Selective targeting of ubiquitin- and ubiquitin-like E1-activating enzymes by structurally-stabilized peptides |
| KR102544364B1 (ko) * | 2019-06-17 | 2023-06-19 | 주식회사 안단테에프엠 | Romo1 유래 항균 펩타이드 및 그 변이체 |
| KR102521182B1 (ko) * | 2020-11-06 | 2023-04-12 | 서울대학교산학협력단 | 결핵균 독소-항독소 시스템을 표적으로 하는 항균 스테이플 펩타이드 및 이의 용도 |
| WO2024069229A2 (en) | 2022-08-03 | 2024-04-04 | Sutura Therapeutics Ltd | Biologically active compounds |
| WO2025027389A1 (en) | 2023-08-03 | 2025-02-06 | Sutura Therapeutics Limited | Biologically active compounds comprising a stapled or stitched peptide |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989003849A1 (en) * | 1987-10-28 | 1989-05-05 | Howard Florey Institute Of Experimental Physiology | Oligonucleotide-polyamide conjugates |
| CA2693742A1 (en) | 2007-07-12 | 2009-01-15 | Prosensa Technologies B.V. | Molecules for targeting compounds to various selected organs, tissues or tumor cells |
| ES2639852T3 (es) * | 2007-10-26 | 2017-10-30 | Academisch Ziekenhuis Leiden | Medios y métodos para contrarrestar los trastornos musculares |
| WO2009149214A2 (en) | 2008-06-03 | 2009-12-10 | Aileron Therapeutics, Inc. | Compositions and methods for enhancing cellular transport of biomolecules |
| BR122020021379B1 (pt) | 2008-10-24 | 2021-05-11 | Sarepta Therapeutics, Inc. | oligômero morfolino fosforodiamidato, composição que compreende o mesmo e uso do dito oligômero para tratar distrofia muscular |
| EP2421971B1 (en) * | 2009-04-24 | 2016-07-06 | BioMarin Technologies B.V. | Oligonucleotide comprising an inosine for treating dmd |
| AU2010273220B2 (en) | 2009-07-13 | 2015-10-15 | President And Fellows Of Harvard College | Bifunctional stapled polypeptides and uses thereof |
| WO2011111874A1 (ja) | 2010-03-11 | 2011-09-15 | 独立行政法人理化学研究所 | 細胞膜透過性ダンベル型rnaおよびその製造方法 |
| CA2796722C (en) * | 2010-04-19 | 2021-06-01 | Nlife Therapeutics, S.L. | Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types |
| CA3092114A1 (en) | 2011-05-05 | 2012-11-08 | Sarepta Therapeutics, Inc. | Peptide oligonucleotide conjugates |
| CN103998458B (zh) | 2011-08-30 | 2018-10-09 | 医学研究理事会 | 具有中央疏水域的细胞穿透肽 |
| CN103121959B (zh) | 2011-11-21 | 2016-09-21 | 昆山市工业技术研究院小核酸生物技术研究所有限责任公司 | 化合物和核酸复合分子与核酸复合物及其制备方法和应用 |
| WO2013150338A1 (en) * | 2012-04-04 | 2013-10-10 | Centre National De La Recherche Scientifique | Stapled cell penetrating peptides for intracellular delivery of molecules |
| WO2014053879A1 (en) * | 2012-10-04 | 2014-04-10 | Centre National De La Recherche Scientifique | Cell penetrating peptides for intracellular delivery of molecules |
| AU2013336582A1 (en) * | 2012-10-26 | 2015-06-11 | Nlife Therapeutics, S.L. | Compositions and methods for selective delivery of oligonucleotide molecules to cell types |
| CN103626850B (zh) | 2013-04-03 | 2015-08-26 | 安徽省新星药物开发有限责任公司 | 具有细胞穿透功能的多肽及其在药物递送中的用途 |
| AU2016264471B2 (en) | 2015-05-19 | 2022-01-27 | Sarepta Therapeutics, Inc. | Peptide oligonucleotide conjugates |
| MX384213B (es) | 2015-07-15 | 2025-03-14 | Protagonist Therapeutics Inc | Inhibidores peptidicos del receptor de interleucina 23 y su uso para tratar enfermedades inflamatorias. |
| GB2545898B (en) | 2015-12-21 | 2019-10-09 | Sutura Therapeutics Ltd | Improved drug delivery by conjugating oligonucleotides to stitched/stapled peptides |
| GB2563875B (en) | 2017-06-28 | 2020-08-19 | Sutura Therapeutics Ltd | Improvements in drug delivery |
-
2015
- 2015-12-21 GB GB1522548.5A patent/GB2545898B/en not_active Expired - Fee Related
-
2016
- 2016-12-21 WO PCT/GB2016/054028 patent/WO2017109494A1/en not_active Ceased
- 2016-12-21 AU AU2016375869A patent/AU2016375869B2/en not_active Ceased
- 2016-12-21 CN CN201680073127.3A patent/CN108472385A/zh active Pending
- 2016-12-21 JP JP2018550872A patent/JP2019508481A/ja active Pending
- 2016-12-21 KR KR1020187020172A patent/KR20180091920A/ko active Pending
- 2016-12-21 EP EP16822244.6A patent/EP3393520A1/en not_active Withdrawn
- 2016-12-21 CA CA3007910A patent/CA3007910A1/en active Pending
- 2016-12-21 US US16/061,548 patent/US11541124B2/en active Active
- 2016-12-21 BR BR112018012641A patent/BR112018012641A2/pt active Search and Examination
-
2022
- 2022-12-27 US US18/088,933 patent/US11944688B2/en active Active
-
2023
- 2023-02-02 JP JP2023014917A patent/JP2023055874A/ja active Pending
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