JP2019508481A5 - - Google Patents
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- Publication number
- JP2019508481A5 JP2019508481A5 JP2018550872A JP2018550872A JP2019508481A5 JP 2019508481 A5 JP2019508481 A5 JP 2019508481A5 JP 2018550872 A JP2018550872 A JP 2018550872A JP 2018550872 A JP2018550872 A JP 2018550872A JP 2019508481 A5 JP2019508481 A5 JP 2019508481A5
- Authority
- JP
- Japan
- Prior art keywords
- stap
- pmo
- stip
- compound according
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023014917A JP2023055874A (ja) | 2015-12-21 | 2023-02-02 | ステープルまたはステッチペプチドに複合された生物活性化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1522548.5A GB2545898B (en) | 2015-12-21 | 2015-12-21 | Improved drug delivery by conjugating oligonucleotides to stitched/stapled peptides |
| GB1522548.5 | 2015-12-21 | ||
| PCT/GB2016/054028 WO2017109494A1 (en) | 2015-12-21 | 2016-12-21 | Biologically active compound conjugated to a stapled or stitched peptide |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023014917A Division JP2023055874A (ja) | 2015-12-21 | 2023-02-02 | ステープルまたはステッチペプチドに複合された生物活性化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019508481A JP2019508481A (ja) | 2019-03-28 |
| JP2019508481A5 true JP2019508481A5 (enExample) | 2022-06-16 |
Family
ID=55311362
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018550872A Pending JP2019508481A (ja) | 2015-12-21 | 2016-12-21 | ステープルまたはステッチペプチドに複合された生物活性化合物 |
| JP2023014917A Pending JP2023055874A (ja) | 2015-12-21 | 2023-02-02 | ステープルまたはステッチペプチドに複合された生物活性化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023014917A Pending JP2023055874A (ja) | 2015-12-21 | 2023-02-02 | ステープルまたはステッチペプチドに複合された生物活性化合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11541124B2 (enExample) |
| EP (1) | EP3393520A1 (enExample) |
| JP (2) | JP2019508481A (enExample) |
| KR (1) | KR20180091920A (enExample) |
| CN (1) | CN108472385A (enExample) |
| AU (1) | AU2016375869B2 (enExample) |
| BR (1) | BR112018012641A2 (enExample) |
| CA (1) | CA3007910A1 (enExample) |
| GB (1) | GB2545898B (enExample) |
| WO (1) | WO2017109494A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2545898B (en) | 2015-12-21 | 2019-10-09 | Sutura Therapeutics Ltd | Improved drug delivery by conjugating oligonucleotides to stitched/stapled peptides |
| KR102775461B1 (ko) | 2016-04-01 | 2025-02-28 | 어비디티 바이오사이언시스 인크. | 핵산-폴리펩타이드 조성물 및 이의 용도 |
| KR20240172236A (ko) | 2017-01-06 | 2024-12-09 | 어비디티 바이오사이언시스 인크. | 핵산-폴리펩티드 조성물 및 엑손 스키핑을 유도하는 방법 |
| GB2563875B (en) * | 2017-06-28 | 2020-08-19 | Sutura Therapeutics Ltd | Improvements in drug delivery |
| GB201711809D0 (en) | 2017-07-21 | 2017-09-06 | Governors Of The Univ Of Alberta | Antisense oligonucleotide |
| US11339192B2 (en) | 2017-10-04 | 2022-05-24 | Ohio State Innovation Foundation | Bicyclic peptidyl inhibitors |
| CN111447941B (zh) | 2017-10-27 | 2023-10-31 | 俄亥俄州国家创新基金会 | 用于细胞内递送装订肽的多肽缀合物 |
| EP3746105A4 (en) | 2018-01-29 | 2022-05-18 | Ohio State Innovation Foundation | CYCLIC PEPTIDYLIN HIBITORS OF THE CAL-PDZ-BINDING DOMAIN |
| EP3749678A1 (en) | 2018-02-07 | 2020-12-16 | Dana Farber Cancer Institute, Inc. | Cell-permeable stapled peptide modules for cellular delivery |
| US11459304B2 (en) | 2018-08-31 | 2022-10-04 | Massachusetts Institute Of Technology | Ionizable lipidoids and their uses |
| JP7727551B2 (ja) * | 2019-04-18 | 2025-08-21 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | 構造的に安定化されたペプチドによるユビキチンおよびユビキチン様ｅ１活性化酵素の選択的標的化 |
| KR102544364B1 (ko) * | 2019-06-17 | 2023-06-19 | 주식회사 안단테에프엠 | Romo1 유래 항균 펩타이드 및 그 변이체 |
| KR102521182B1 (ko) * | 2020-11-06 | 2023-04-12 | 서울대학교산학협력단 | 결핵균 독소-항독소 시스템을 표적으로 하는 항균 스테이플 펩타이드 및 이의 용도 |
| WO2024069229A2 (en) | 2022-08-03 | 2024-04-04 | Sutura Therapeutics Ltd | Biologically active compounds |
| WO2025027389A1 (en) | 2023-08-03 | 2025-02-06 | Sutura Therapeutics Limited | Biologically active compounds comprising a stapled or stitched peptide |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3856406T2 (de) * | 1987-10-28 | 2000-10-19 | Howard Florey Institute Of Experimental Physiology And Medicine, Parkville | Oligonucleotid-polyamid konjugate |
| JP2010533170A (ja) | 2007-07-12 | 2010-10-21 | プロセンサ テクノロジーズ ビー．ブイ． | 化合物を種々の選択された臓器、組織又は腫瘍細胞に標的化するための分子 |
| NZ584793A (en) * | 2007-10-26 | 2012-05-25 | Academisch Ziekenhuis Leiden | Means and methods for counteracting muscle disorders |
| WO2009149214A2 (en) | 2008-06-03 | 2009-12-10 | Aileron Therapeutics, Inc. | Compositions and methods for enhancing cellular transport of biomolecules |
| EP3133160B1 (en) | 2008-10-24 | 2018-12-12 | Sarepta Therapeutics, Inc. | Exon skipping compositions for dmd |
| CN102459595A (zh) * | 2009-04-24 | 2012-05-16 | 普罗森那技术公司 | 用于治疗dmd的包含肌苷的寡核苷酸 |
| WO2011008260A2 (en) | 2009-07-13 | 2011-01-20 | President And Fellows Of Harvard College | Bifunctional stapled polypeptides and uses thereof |
| WO2011111874A1 (ja) | 2010-03-11 | 2011-09-15 | 独立行政法人理化学研究所 | 細胞膜透過性ダンベル型rnaおよびその製造方法 |
| KR20130103662A (ko) * | 2010-04-19 | 2013-09-24 | 엔라이프 떼라퓨틱스, 에스.엘. | 올리고뉴클레오티드 분자들의 특정 뉴런 유형들로의 선택적인 전달을 위한 조성물들 및 방법 |
| AU2011367230B2 (en) | 2011-05-05 | 2017-08-10 | Sarepta Therapeutics, Inc. | Peptide oligonucleotide conjugates |
| WO2013030569A2 (en) | 2011-08-30 | 2013-03-07 | Michael John Gait | Peptides |
| CN103121959B (zh) | 2011-11-21 | 2016-09-21 | 昆山市工业技术研究院小核酸生物技术研究所有限责任公司 | 化合物和核酸复合分子与核酸复合物及其制备方法和应用 |
| WO2013150338A1 (en) * | 2012-04-04 | 2013-10-10 | Centre National De La Recherche Scientifique | Stapled cell penetrating peptides for intracellular delivery of molecules |
| WO2014053879A1 (en) * | 2012-10-04 | 2014-04-10 | Centre National De La Recherche Scientifique | Cell penetrating peptides for intracellular delivery of molecules |
| MX2015005328A (es) * | 2012-10-26 | 2015-09-25 | Nlife Therapeutics S L | Composiciones y metodos para la administracion selectiva de moleculas de oligonucleotidos a tipos de celulas. |
| CN103626850B (zh) | 2013-04-03 | 2015-08-26 | 安徽省新星药物开发有限责任公司 | 具有细胞穿透功能的多肽及其在药物递送中的用途 |
| KR102644053B1 (ko) | 2015-05-19 | 2024-03-06 | 사렙타 쎄러퓨틱스 인코퍼레이티드 | 펩티드 올리고뉴클레오티드 콘주게이트 |
| HK1257747A1 (zh) | 2015-07-15 | 2019-10-25 | Protagonist Therapeutics Inc. | 白细胞介素-23受体的肽抑制剂以及其治疗炎症性疾病的用途 |
| GB2545898B (en) | 2015-12-21 | 2019-10-09 | Sutura Therapeutics Ltd | Improved drug delivery by conjugating oligonucleotides to stitched/stapled peptides |
| GB2563875B (en) | 2017-06-28 | 2020-08-19 | Sutura Therapeutics Ltd | Improvements in drug delivery |
-
2015
- 2015-12-21 GB GB1522548.5A patent/GB2545898B/en not_active Expired - Fee Related
-
2016
- 2016-12-21 WO PCT/GB2016/054028 patent/WO2017109494A1/en not_active Ceased
- 2016-12-21 BR BR112018012641A patent/BR112018012641A2/pt active Search and Examination
- 2016-12-21 EP EP16822244.6A patent/EP3393520A1/en not_active Withdrawn
- 2016-12-21 KR KR1020187020172A patent/KR20180091920A/ko active Pending
- 2016-12-21 JP JP2018550872A patent/JP2019508481A/ja active Pending
- 2016-12-21 AU AU2016375869A patent/AU2016375869B2/en not_active Ceased
- 2016-12-21 CA CA3007910A patent/CA3007910A1/en active Pending
- 2016-12-21 CN CN201680073127.3A patent/CN108472385A/zh active Pending
- 2016-12-21 US US16/061,548 patent/US11541124B2/en active Active
-
2022
- 2022-12-27 US US18/088,933 patent/US11944688B2/en active Active
-
2023
- 2023-02-02 JP JP2023014917A patent/JP2023055874A/ja active Pending
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