JP2019508481A5 - - Google Patents
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- Publication number
- JP2019508481A5 JP2019508481A5 JP2018550872A JP2018550872A JP2019508481A5 JP 2019508481 A5 JP2019508481 A5 JP 2019508481A5 JP 2018550872 A JP2018550872 A JP 2018550872A JP 2018550872 A JP2018550872 A JP 2018550872A JP 2019508481 A5 JP2019508481 A5 JP 2019508481A5
- Authority
- JP
- Japan
- Prior art keywords
- stap
- pmo
- stip
- compound according
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023014917A JP2023055874A (ja) | 2015-12-21 | 2023-02-02 | ステープルまたはステッチペプチドに複合された生物活性化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1522548.5A GB2545898B (en) | 2015-12-21 | 2015-12-21 | Improved drug delivery by conjugating oligonucleotides to stitched/stapled peptides |
| GB1522548.5 | 2015-12-21 | ||
| PCT/GB2016/054028 WO2017109494A1 (en) | 2015-12-21 | 2016-12-21 | Biologically active compound conjugated to a stapled or stitched peptide |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023014917A Division JP2023055874A (ja) | 2015-12-21 | 2023-02-02 | ステープルまたはステッチペプチドに複合された生物活性化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019508481A JP2019508481A (ja) | 2019-03-28 |
| JP2019508481A5 true JP2019508481A5 (enExample) | 2022-06-16 |
Family
ID=55311362
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018550872A Pending JP2019508481A (ja) | 2015-12-21 | 2016-12-21 | ステープルまたはステッチペプチドに複合された生物活性化合物 |
| JP2023014917A Pending JP2023055874A (ja) | 2015-12-21 | 2023-02-02 | ステープルまたはステッチペプチドに複合された生物活性化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023014917A Pending JP2023055874A (ja) | 2015-12-21 | 2023-02-02 | ステープルまたはステッチペプチドに複合された生物活性化合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11541124B2 (enExample) |
| EP (1) | EP3393520A1 (enExample) |
| JP (2) | JP2019508481A (enExample) |
| KR (1) | KR20180091920A (enExample) |
| CN (1) | CN108472385A (enExample) |
| AU (1) | AU2016375869B2 (enExample) |
| BR (1) | BR112018012641A2 (enExample) |
| CA (1) | CA3007910A1 (enExample) |
| GB (1) | GB2545898B (enExample) |
| WO (1) | WO2017109494A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2545898B (en) | 2015-12-21 | 2019-10-09 | Sutura Therapeutics Ltd | Improved drug delivery by conjugating oligonucleotides to stitched/stapled peptides |
| KR102775461B1 (ko) | 2016-04-01 | 2025-02-28 | 어비디티 바이오사이언시스 인크. | 핵산-폴리펩타이드 조성물 및 이의 용도 |
| CN110381980A (zh) | 2017-01-06 | 2019-10-25 | 艾维迪提生物科学有限责任公司 | 核酸-多肽组合物以及诱导外显子跳读的方法 |
| GB2563875B (en) * | 2017-06-28 | 2020-08-19 | Sutura Therapeutics Ltd | Improvements in drug delivery |
| GB201711809D0 (en) | 2017-07-21 | 2017-09-06 | Governors Of The Univ Of Alberta | Antisense oligonucleotide |
| WO2019070962A1 (en) | 2017-10-04 | 2019-04-11 | Ohio State Innovation Foundation | BICYCLIC PEPTIDE INHIBITORS |
| CN111447941B (zh) | 2017-10-27 | 2023-10-31 | 俄亥俄州国家创新基金会 | 用于细胞内递送装订肽的多肽缀合物 |
| US11793884B2 (en) | 2018-01-29 | 2023-10-24 | Ohio State Innovation Foundation | Cyclic peptidyl inhibitors of CAL-PDZ binding domain |
| WO2019157131A1 (en) * | 2018-02-07 | 2019-08-15 | Dana-Farber Cancer Institute, Inc. | Cell-permeable stapled peptide modules for cellular delivery |
| EP3844154A1 (en) | 2018-08-31 | 2021-07-07 | Massachusetts Institute of Technology | Ionizable lipidoids and their uses |
| EP3962933A1 (en) * | 2019-04-18 | 2022-03-09 | Dana-Farber Cancer Institute, Inc. | Selective targeting of ubiquitin- and ubiquitin-like e1-activating enzymes by structurally-stabilized peptides |
| KR102544364B1 (ko) | 2019-06-17 | 2023-06-19 | 주식회사 안단테에프엠 | Romo1 유래 항균 펩타이드 및 그 변이체 |
| KR102521182B1 (ko) * | 2020-11-06 | 2023-04-12 | 서울대학교산학협력단 | 결핵균 독소-항독소 시스템을 표적으로 하는 항균 스테이플 펩타이드 및 이의 용도 |
| WO2024069229A2 (en) | 2022-08-03 | 2024-04-04 | Sutura Therapeutics Ltd | Biologically active compounds |
| WO2025027389A1 (en) | 2023-08-03 | 2025-02-06 | Sutura Therapeutics Limited | Biologically active compounds comprising a stapled or stitched peptide |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0972779A3 (en) * | 1987-10-28 | 2004-10-20 | Howard Florey Institute Of Experimental Physiology And Medicine | Oligonucleotide-polyamide conjugates |
| CA2693742A1 (en) | 2007-07-12 | 2009-01-15 | Prosensa Technologies B.V. | Molecules for targeting compounds to various selected organs, tissues or tumor cells |
| EP2203173B1 (en) * | 2007-10-26 | 2015-12-23 | Academisch Ziekenhuis Leiden | Means and methods for counteracting muscle disorders |
| WO2009149214A2 (en) | 2008-06-03 | 2009-12-10 | Aileron Therapeutics, Inc. | Compositions and methods for enhancing cellular transport of biomolecules |
| CN105779453A (zh) | 2008-10-24 | 2016-07-20 | 萨雷普塔治疗公司 | 用于dmd的多外显子跳跃组合物 |
| EP2421971B1 (en) * | 2009-04-24 | 2016-07-06 | BioMarin Technologies B.V. | Oligonucleotide comprising an inosine for treating dmd |
| BR112012000867A2 (pt) * | 2009-07-13 | 2019-09-24 | Harvard College | "polipeptídeos bifuncional costurado e uso do mesmo" |
| WO2011111874A1 (ja) | 2010-03-11 | 2011-09-15 | 独立行政法人理化学研究所 | 細胞膜透過性ダンベル型rnaおよびその製造方法 |
| LT2560687T (lt) * | 2010-04-19 | 2017-09-25 | Nlife Therapeutics S.L. | Kompozicijos ir būdai, skirti selektyviam oligonukleotido molekulių pristatymui specifiniams neuronų tipams |
| IL273838B (en) | 2011-05-05 | 2022-09-01 | Sarepta Therapeutics Inc | Peptide and oligonucleotide conjugates, preparations containing them and their uses |
| AU2012300633B2 (en) | 2011-08-30 | 2017-04-27 | United Kingdom Research And Innovation | Cell- penetrating peptides having a central hydrophobic domain |
| CN103121959B (zh) | 2011-11-21 | 2016-09-21 | 昆山市工业技术研究院小核酸生物技术研究所有限责任公司 | 化合物和核酸复合分子与核酸复合物及其制备方法和应用 |
| WO2013150338A1 (en) * | 2012-04-04 | 2013-10-10 | Centre National De La Recherche Scientifique | Stapled cell penetrating peptides for intracellular delivery of molecules |
| WO2014053879A1 (en) * | 2012-10-04 | 2014-04-10 | Centre National De La Recherche Scientifique | Cell penetrating peptides for intracellular delivery of molecules |
| EP2911697A1 (en) * | 2012-10-26 | 2015-09-02 | Nlife Therapeutics S.L. | Compositions and methods for selective delivery of oligonucleotide molecules to cell types |
| CN103626850B (zh) | 2013-04-03 | 2015-08-26 | 安徽省新星药物开发有限责任公司 | 具有细胞穿透功能的多肽及其在药物递送中的用途 |
| CN114681621B (zh) | 2015-05-19 | 2024-08-06 | 萨勒普塔医疗公司 | 肽寡核苷酸缀合物 |
| UA123772C2 (uk) | 2015-07-15 | 2021-06-02 | Протагоніст Терепьютікс, Інк. | Пептидний інгібітор рецептора інтерлейкіну-23 та спосіб лікування запального захворювання кишечнику (ibd) |
| GB2545898B (en) | 2015-12-21 | 2019-10-09 | Sutura Therapeutics Ltd | Improved drug delivery by conjugating oligonucleotides to stitched/stapled peptides |
| GB2563875B (en) | 2017-06-28 | 2020-08-19 | Sutura Therapeutics Ltd | Improvements in drug delivery |
-
2015
- 2015-12-21 GB GB1522548.5A patent/GB2545898B/en not_active Expired - Fee Related
-
2016
- 2016-12-21 US US16/061,548 patent/US11541124B2/en active Active
- 2016-12-21 CA CA3007910A patent/CA3007910A1/en active Pending
- 2016-12-21 BR BR112018012641A patent/BR112018012641A2/pt active Search and Examination
- 2016-12-21 CN CN201680073127.3A patent/CN108472385A/zh active Pending
- 2016-12-21 WO PCT/GB2016/054028 patent/WO2017109494A1/en not_active Ceased
- 2016-12-21 JP JP2018550872A patent/JP2019508481A/ja active Pending
- 2016-12-21 KR KR1020187020172A patent/KR20180091920A/ko active Pending
- 2016-12-21 AU AU2016375869A patent/AU2016375869B2/en not_active Ceased
- 2016-12-21 EP EP16822244.6A patent/EP3393520A1/en not_active Withdrawn
-
2022
- 2022-12-27 US US18/088,933 patent/US11944688B2/en active Active
-
2023
- 2023-02-02 JP JP2023014917A patent/JP2023055874A/ja active Pending
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