CA3007910A1 - Biologically active compound conjugated to a stapled or stitched peptide - Google Patents
Biologically active compound conjugated to a stapled or stitched peptide Download PDFInfo
- Publication number
- CA3007910A1 CA3007910A1 CA3007910A CA3007910A CA3007910A1 CA 3007910 A1 CA3007910 A1 CA 3007910A1 CA 3007910 A CA3007910 A CA 3007910A CA 3007910 A CA3007910 A CA 3007910A CA 3007910 A1 CA3007910 A1 CA 3007910A1
- Authority
- CA
- Canada
- Prior art keywords
- dccpm
- pmo
- peptide
- staple
- bac
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
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- Orthopedic Medicine & Surgery (AREA)
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- Wood Science & Technology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| GB1522548.5A GB2545898B (en) | 2015-12-21 | 2015-12-21 | Improved drug delivery by conjugating oligonucleotides to stitched/stapled peptides |
| GB1522548.5 | 2015-12-21 | ||
| PCT/GB2016/054028 WO2017109494A1 (en) | 2015-12-21 | 2016-12-21 | Biologically active compound conjugated to a stapled or stitched peptide |
Publications (1)
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|---|---|
| CA3007910A1 true CA3007910A1 (en) | 2017-06-29 |
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|---|---|---|---|
| CA3007910A Pending CA3007910A1 (en) | 2015-12-21 | 2016-12-21 | Biologically active compound conjugated to a stapled or stitched peptide |
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| Country | Link |
|---|---|
| US (2) | US11541124B2 (enExample) |
| EP (1) | EP3393520A1 (enExample) |
| JP (2) | JP2019508481A (enExample) |
| KR (1) | KR20180091920A (enExample) |
| CN (1) | CN108472385A (enExample) |
| AU (1) | AU2016375869B2 (enExample) |
| BR (1) | BR112018012641A2 (enExample) |
| CA (1) | CA3007910A1 (enExample) |
| GB (1) | GB2545898B (enExample) |
| WO (1) | WO2017109494A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB2545898B (en) | 2015-12-21 | 2019-10-09 | Sutura Therapeutics Ltd | Improved drug delivery by conjugating oligonucleotides to stitched/stapled peptides |
| MA45328A (fr) | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | Compositions acide nucléique-polypeptide et utilisations de celles-ci |
| SG10202107429WA (en) | 2017-01-06 | 2021-08-30 | Avidity Biosciences Inc | Nucleic acid-polypeptide compositions and methods of inducing exon skipping |
| GB2563875B (en) * | 2017-06-28 | 2020-08-19 | Sutura Therapeutics Ltd | Improvements in drug delivery |
| GB201711809D0 (en) | 2017-07-21 | 2017-09-06 | Governors Of The Univ Of Alberta | Antisense oligonucleotide |
| CA3078504A1 (en) | 2017-10-04 | 2019-04-11 | Ohio State Innovation Foundation | Bicyclic peptidyl inhibitors |
| CN111447941B (zh) | 2017-10-27 | 2023-10-31 | 俄亥俄州国家创新基金会 | 用于细胞内递送装订肽的多肽缀合物 |
| EP3746105A4 (en) | 2018-01-29 | 2022-05-18 | Ohio State Innovation Foundation | CYCLIC PEPTIDYLIN HIBITORS OF THE CAL-PDZ-BINDING DOMAIN |
| US11952432B2 (en) | 2018-02-07 | 2024-04-09 | Dana-Farber Cancer Institute, Inc. | Cell-permeable stapled peptide modules for cellular delivery |
| US11459304B2 (en) | 2018-08-31 | 2022-10-04 | Massachusetts Institute Of Technology | Ionizable lipidoids and their uses |
| CN114026113A (zh) * | 2019-04-18 | 2022-02-08 | 丹娜法伯癌症研究院 | 通过结构稳定化肽选择性靶向泛素及泛素样e1活化酶 |
| KR102544364B1 (ko) | 2019-06-17 | 2023-06-19 | 주식회사 안단테에프엠 | Romo1 유래 항균 펩타이드 및 그 변이체 |
| KR102521182B1 (ko) * | 2020-11-06 | 2023-04-12 | 서울대학교산학협력단 | 결핵균 독소-항독소 시스템을 표적으로 하는 항균 스테이플 펩타이드 및 이의 용도 |
| WO2024069229A2 (en) | 2022-08-03 | 2024-04-04 | Sutura Therapeutics Ltd | Biologically active compounds |
| WO2025027389A1 (en) | 2023-08-03 | 2025-02-06 | Sutura Therapeutics Limited | Biologically active compounds comprising a stapled or stitched peptide |
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| ATE192465T1 (de) * | 1987-10-28 | 2000-05-15 | Florey Howard Inst | Oligonucleotid-polyamid konjugate |
| CN101790385A (zh) * | 2007-07-12 | 2010-07-28 | 普罗森那技术公司 | 用于使化合物靶向多种选定器官、组织或肿瘤细胞的分子 |
| CA2704049A1 (en) * | 2007-10-26 | 2009-04-30 | Academisch Ziekenhuis Leiden | Means and methods for counteracting muscle disorders |
| US20110250685A1 (en) * | 2008-06-03 | 2011-10-13 | Nash Huw M | Compositions and methods for enhancing cellular transport of biomolecules |
| WO2010048586A1 (en) | 2008-10-24 | 2010-04-29 | Avi Biopharma, Inc. | Multiple exon skipping compositions for dmd |
| EP2421971B1 (en) * | 2009-04-24 | 2016-07-06 | BioMarin Technologies B.V. | Oligonucleotide comprising an inosine for treating dmd |
| US9163330B2 (en) * | 2009-07-13 | 2015-10-20 | President And Fellows Of Harvard College | Bifunctional stapled polypeptides and uses thereof |
| WO2011111874A1 (ja) | 2010-03-11 | 2011-09-15 | 独立行政法人理化学研究所 | 細胞膜透過性ダンベル型rnaおよびその製造方法 |
| EP2560687B1 (en) * | 2010-04-19 | 2017-05-24 | Nlife Therapeutics S.L. | Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types |
| CA2834128A1 (en) | 2011-05-05 | 2012-11-08 | Sarepta Therapeutics, Inc. | Peptide oligonucleotide conjugates |
| EP2751128B1 (en) * | 2011-08-30 | 2021-03-03 | United Kingdom Research and Innovation | Cell-penetrating peptides having a central hydrophobic domain |
| CN103121959B (zh) * | 2011-11-21 | 2016-09-21 | 昆山市工业技术研究院小核酸生物技术研究所有限责任公司 | 化合物和核酸复合分子与核酸复合物及其制备方法和应用 |
| WO2013150338A1 (en) * | 2012-04-04 | 2013-10-10 | Centre National De La Recherche Scientifique | Stapled cell penetrating peptides for intracellular delivery of molecules |
| WO2014053879A1 (en) * | 2012-10-04 | 2014-04-10 | Centre National De La Recherche Scientifique | Cell penetrating peptides for intracellular delivery of molecules |
| AU2013336582A1 (en) * | 2012-10-26 | 2015-06-11 | Nlife Therapeutics, S.L. | Compositions and methods for selective delivery of oligonucleotide molecules to cell types |
| CN103626850B (zh) * | 2013-04-03 | 2015-08-26 | 安徽省新星药物开发有限责任公司 | 具有细胞穿透功能的多肽及其在药物递送中的用途 |
| EP4306538A3 (en) | 2015-05-19 | 2024-05-01 | Sarepta Therapeutics, Inc. | Peptide oligonucleotide conjugates |
| MX384213B (es) | 2015-07-15 | 2025-03-14 | Protagonist Therapeutics Inc | Inhibidores peptidicos del receptor de interleucina 23 y su uso para tratar enfermedades inflamatorias. |
| GB2545898B (en) | 2015-12-21 | 2019-10-09 | Sutura Therapeutics Ltd | Improved drug delivery by conjugating oligonucleotides to stitched/stapled peptides |
| GB2563875B (en) | 2017-06-28 | 2020-08-19 | Sutura Therapeutics Ltd | Improvements in drug delivery |
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2015
- 2015-12-21 GB GB1522548.5A patent/GB2545898B/en not_active Expired - Fee Related
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2016
- 2016-12-21 EP EP16822244.6A patent/EP3393520A1/en not_active Withdrawn
- 2016-12-21 BR BR112018012641A patent/BR112018012641A2/pt active Search and Examination
- 2016-12-21 AU AU2016375869A patent/AU2016375869B2/en not_active Ceased
- 2016-12-21 US US16/061,548 patent/US11541124B2/en active Active
- 2016-12-21 WO PCT/GB2016/054028 patent/WO2017109494A1/en not_active Ceased
- 2016-12-21 KR KR1020187020172A patent/KR20180091920A/ko active Pending
- 2016-12-21 JP JP2018550872A patent/JP2019508481A/ja active Pending
- 2016-12-21 CN CN201680073127.3A patent/CN108472385A/zh active Pending
- 2016-12-21 CA CA3007910A patent/CA3007910A1/en active Pending
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2022
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2023
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Also Published As
| Publication number | Publication date |
|---|---|
| EP3393520A1 (en) | 2018-10-31 |
| CN108472385A (zh) | 2018-08-31 |
| US11541124B2 (en) | 2023-01-03 |
| KR20180091920A (ko) | 2018-08-16 |
| US20230158166A1 (en) | 2023-05-25 |
| BR112018012641A2 (pt) | 2018-12-04 |
| WO2017109494A1 (en) | 2017-06-29 |
| GB201522548D0 (en) | 2016-02-03 |
| US11944688B2 (en) | 2024-04-02 |
| US20200353092A1 (en) | 2020-11-12 |
| JP2019508481A (ja) | 2019-03-28 |
| GB2545898B (en) | 2019-10-09 |
| AU2016375869A1 (en) | 2018-08-09 |
| GB2545898A (en) | 2017-07-05 |
| JP2023055874A (ja) | 2023-04-18 |
| AU2016375869B2 (en) | 2023-07-13 |
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