JP2019508416A5 - - Google Patents
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- Publication number
- JP2019508416A5 JP2019508416A5 JP2018542732A JP2018542732A JP2019508416A5 JP 2019508416 A5 JP2019508416 A5 JP 2019508416A5 JP 2018542732 A JP2018542732 A JP 2018542732A JP 2018542732 A JP2018542732 A JP 2018542732A JP 2019508416 A5 JP2019508416 A5 JP 2019508416A5
- Authority
- JP
- Japan
- Prior art keywords
- surgery
- pharmaceutical composition
- administered
- receptor agonist
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000001356 surgical procedure Methods 0.000 claims 22
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 229940124752 APJ receptor agonist Drugs 0.000 claims 3
- 208000028698 Cognitive impairment Diseases 0.000 claims 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 3
- 208000010877 cognitive disease Diseases 0.000 claims 3
- 210000000214 mouth Anatomy 0.000 claims 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 2
- PIWKPBJCKXDKJR-UHFFFAOYSA-N Isoflurane Chemical compound FC(F)OC(Cl)C(F)(F)F PIWKPBJCKXDKJR-UHFFFAOYSA-N 0.000 claims 2
- GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 claims 2
- 208000027418 Wounds and injury Diseases 0.000 claims 2
- 230000003444 anaesthetic effect Effects 0.000 claims 2
- 210000004204 blood vessel Anatomy 0.000 claims 2
- 210000004556 brain Anatomy 0.000 claims 2
- 230000003920 cognitive function Effects 0.000 claims 2
- 230000007547 defect Effects 0.000 claims 2
- BCQZXOMGPXTTIC-UHFFFAOYSA-N halothane Chemical compound FC(F)(F)C(Cl)Br BCQZXOMGPXTTIC-UHFFFAOYSA-N 0.000 claims 2
- 229960003132 halothane Drugs 0.000 claims 2
- 230000001771 impaired effect Effects 0.000 claims 2
- 229960002455 methoxyflurane Drugs 0.000 claims 2
- RFKMCNOHBTXSMU-UHFFFAOYSA-N methoxyflurane Chemical compound COC(F)(F)C(Cl)Cl RFKMCNOHBTXSMU-UHFFFAOYSA-N 0.000 claims 2
- 210000003205 muscle Anatomy 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 210000004197 pelvis Anatomy 0.000 claims 2
- 230000002980 postoperative effect Effects 0.000 claims 2
- 210000000664 rectum Anatomy 0.000 claims 2
- DFEYYRMXOJXZRJ-UHFFFAOYSA-N sevoflurane Chemical compound FCOC(C(F)(F)F)C(F)(F)F DFEYYRMXOJXZRJ-UHFFFAOYSA-N 0.000 claims 2
- KMPGNWMNACBPNT-UHFFFAOYSA-N 2-[difluoro-[1,1,3,3,3-pentafluoro-2-methyl-2-(trifluoromethyl)propoxy]methyl]-1,1,1,3,3,3-hexafluoro-2-methylpropane Chemical compound FC(F)(F)C(C)(C(F)(F)F)C(F)(F)OC(F)(F)C(C)(C(F)(F)F)C(F)(F)F KMPGNWMNACBPNT-UHFFFAOYSA-N 0.000 claims 1
- 108091023037 Aptamer Proteins 0.000 claims 1
- LVZWSLJZHVFIQJ-UHFFFAOYSA-N Cyclopropane Chemical compound C1CC1 LVZWSLJZHVFIQJ-UHFFFAOYSA-N 0.000 claims 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- 239000005977 Ethylene Substances 0.000 claims 1
- 208000026301 Postoperative Cognitive Complications Diseases 0.000 claims 1
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical group ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 claims 1
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 claims 1
- 206010052428 Wound Diseases 0.000 claims 1
- 230000003187 abdominal effect Effects 0.000 claims 1
- 238000012084 abdominal surgery Methods 0.000 claims 1
- 150000001350 alkyl halides Chemical class 0.000 claims 1
- 238000002266 amputation Methods 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 229960003537 desflurane Drugs 0.000 claims 1
- DPYMFVXJLLWWEU-UHFFFAOYSA-N desflurane Chemical compound FC(F)OC(F)C(F)(F)F DPYMFVXJLLWWEU-UHFFFAOYSA-N 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229960000305 enflurane Drugs 0.000 claims 1
- JPGQOUSTVILISH-UHFFFAOYSA-N enflurane Chemical compound FC(F)OC(F)(F)C(F)Cl JPGQOUSTVILISH-UHFFFAOYSA-N 0.000 claims 1
- 150000002170 ethers Chemical class 0.000 claims 1
- 210000003414 extremity Anatomy 0.000 claims 1
- 230000001815 facial effect Effects 0.000 claims 1
- 238000011540 hip replacement Methods 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 229960002725 isoflurane Drugs 0.000 claims 1
- VNKYTQGIUYNRMY-UHFFFAOYSA-N methoxypropane Chemical compound CCCOC VNKYTQGIUYNRMY-UHFFFAOYSA-N 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 239000001272 nitrous oxide Substances 0.000 claims 1
- 230000000399 orthopedic effect Effects 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 210000001428 peripheral nervous system Anatomy 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 229940044601 receptor agonist Drugs 0.000 claims 1
- 239000000018 receptor agonist Substances 0.000 claims 1
- 229960002078 sevoflurane Drugs 0.000 claims 1
- 238000007493 shaping process Methods 0.000 claims 1
- UBOXGVDOUJQMTN-UHFFFAOYSA-N trichloroethylene Natural products ClCC(Cl)Cl UBOXGVDOUJQMTN-UHFFFAOYSA-N 0.000 claims 1
- 230000002485 urinary effect Effects 0.000 claims 1
- 210000002229 urogenital system Anatomy 0.000 claims 1
- 210000001835 viscera Anatomy 0.000 claims 1
- 229910052724 xenon Inorganic materials 0.000 claims 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16305170 | 2016-02-15 | ||
| EP16305170.9 | 2016-02-15 | ||
| PCT/EP2017/053308 WO2017140684A2 (en) | 2016-02-15 | 2017-02-14 | Methods and pharmaceutical compositions for the treatment of post-operative cognitive dysfunction |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019508416A JP2019508416A (ja) | 2019-03-28 |
| JP2019508416A5 true JP2019508416A5 (enExample) | 2020-01-23 |
| JP7063813B2 JP7063813B2 (ja) | 2022-05-09 |
Family
ID=55359484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018542732A Active JP7063813B2 (ja) | 2016-02-15 | 2017-02-14 | 術後認知機能障害の処置のための方法及び医薬組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US11484577B2 (enExample) |
| EP (1) | EP3416688B1 (enExample) |
| JP (1) | JP7063813B2 (enExample) |
| ES (1) | ES2930077T3 (enExample) |
| WO (1) | WO2017140684A2 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3931178B1 (en) * | 2019-03-01 | 2025-06-25 | Abrexa Pharmaceuticals, Inc. | Compounds for prevention and treatment of post-operative cognitive dysfunction |
| CA3177262A1 (en) * | 2020-04-28 | 2021-11-04 | Jesus E. Villafranca | Compounds for prevention and treatment of post-intensive care cognitive dysfunction and cognitive dysfunction resulting from respiratory distress |
| WO2023211684A2 (en) * | 2022-04-29 | 2023-11-02 | Noetix Pharma Llc | Prevention and treatment of post-operative cognitive dysfunction (pocd) |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3932667A (en) | 1971-08-02 | 1976-01-13 | Airco, Inc. | Ether compound as an inhalation anesthetic |
| US3954893A (en) | 1971-08-09 | 1976-05-04 | W. R. Grace & Co. | New halogenated cyclobutanes |
| US3987203A (en) | 1973-03-16 | 1976-10-19 | Airco, Inc. | Anesthetizing composition and method |
| DE2340560C2 (de) | 1973-08-10 | 1982-12-16 | Hoechst Ag, 6000 Frankfurt | 1.2.2.2-Tetrafluoräthyl-äther, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltendes Inhalations-Anästhetikum |
| DE2340561C2 (de) | 1973-08-10 | 1982-12-16 | Hoechst Ag, 6000 Frankfurt | 2.2.2-Trifluor-1-chloräthyl-äther und Verfahren zu ihrer Herstellung sowie Inhalations-Anästhetikum, das einen dieser Stoffe enthält |
| US3987100A (en) | 1974-04-11 | 1976-10-19 | E. I. Du Pont De Nemours And Company | Cyclohexane oxidation in the presence of binary catalysts |
| US3949005A (en) | 1974-05-09 | 1976-04-06 | Airco, Inc. | Hexafluoro-t-butyl-difluoromethyl ether as an inhalation anesthetic |
| US3931344A (en) | 1974-08-22 | 1976-01-06 | W. R. Grace & Co. | Bromofluorocyclopropanes |
| US3932529A (en) | 1974-12-26 | 1976-01-13 | W. R. Grace & Co. | Halocyclopropyl halomethyl ethers |
| US3995062A (en) | 1974-12-26 | 1976-11-30 | W. R. Grace & Co. | Halocyclopropyl halomethyl ethers |
| US3932669A (en) | 1975-01-10 | 1976-01-13 | W. R. Grace & Co. | 1-Chloro-2,2-dimethyl-1,4,4-trifluorocyclobutane as an anesthetics |
| US4220644A (en) | 1976-05-03 | 1980-09-02 | Smithkline Corporation | 7-Acylamino-3-(substituted tetrazolyl thiomethyl) cephalosporins |
| US4281020A (en) | 1979-03-01 | 1981-07-28 | The Dow Chemical Company | Deuterated analogues of methoxyflurane useful as an anesthetic |
| US4346246A (en) | 1979-03-12 | 1982-08-24 | Airco, Inc. | Process for adjusting the halogen content of halogenated aliphatic ethers |
| US4262144A (en) | 1979-10-25 | 1981-04-14 | The Dow Chemical Company | Deuterated isoflurane |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| US5391579A (en) | 1993-01-28 | 1995-02-21 | University Of Iowa Research Foundation | Deuterated sevoflurane as an inhalational anesthetic |
| EP0690452A3 (en) | 1994-06-28 | 1999-01-07 | Advanced Micro Devices, Inc. | Electrically erasable memory and method of erasure |
| EP1040189B1 (en) | 1997-12-24 | 2008-01-09 | Takeda Pharmaceutical Company Limited | Polypeptides, their production and use |
| AU2001242749A1 (en) | 2000-03-23 | 2001-10-03 | Takeda Chemical Industries Ltd. | Peptide derivative |
| US7947280B2 (en) | 2003-05-22 | 2011-05-24 | The Board Of Trustees Of The Leland Stanford Junior University | Apelin and uses thereof |
| US20050112701A1 (en) | 2003-09-11 | 2005-05-26 | Aventis Pharma Deutschland Gmbh | Test system for the identification of APJ receptor ligands |
| US8673848B2 (en) | 2012-01-27 | 2014-03-18 | Novartis Ag | Synthetic apelin mimetics for the treatment of heart failure |
| US9308232B2 (en) * | 2006-06-05 | 2016-04-12 | Keyview Labs, Inc. | Compositions and methods for enhancing brain function |
| EP1903052A3 (en) | 2006-07-28 | 2008-04-02 | Faust Pharmaceuticals SA | APJ receptor ligands and uses thereof |
| US20100113570A1 (en) * | 2008-04-23 | 2010-05-06 | The General Hospital Corporation | Prevention and treatment of post-operative cognitive dysfunction |
| US8946382B2 (en) | 2009-02-27 | 2015-02-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Apelin peptides and methods of use |
| US20120316247A1 (en) * | 2009-10-20 | 2012-12-13 | The General Hospital Corporation | Prevention and treatment of post-operative cognitive dysfunction (pocd) |
| EP2547363B1 (en) * | 2010-02-17 | 2020-06-03 | The Kennedy Trust For Rheumatology Research | Methods of prevention or treatment of triggered inflammatory reactions using tumor necrosis factor alpha antagonist |
| DK2643782T3 (da) * | 2010-11-24 | 2020-11-09 | Digital Artefacts Llc | Systemer og fremgangsmåder til bedømmelse af kognitiv funktion |
| UY35144A (es) * | 2012-11-20 | 2014-06-30 | Novartis Ag | Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca |
| US20160067347A1 (en) | 2012-12-20 | 2016-03-10 | Amgen Inc. | Apj receptor agonists and uses thereof |
| AU2014284496A1 (en) * | 2013-07-03 | 2016-01-21 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Method for treating cognitive dysfunction |
| GB201311948D0 (en) | 2013-07-03 | 2013-08-14 | British American Tobacco Co | Curling Machine |
| SG11201600211XA (en) | 2013-07-25 | 2016-02-26 | Novartis Ag | Cyclic polypeptides for the treatment of heart failure |
| TW201518323A (zh) | 2013-07-25 | 2015-05-16 | Novartis Ag | 合成ａｐｅｌｉｎ多肽之生物結合物 |
| WO2015013165A1 (en) * | 2013-07-25 | 2015-01-29 | Novartis Ag | Cyclic apelin derivatives for the treatment of heart failure |
-
2017
- 2017-02-14 WO PCT/EP2017/053308 patent/WO2017140684A2/en not_active Ceased
- 2017-02-14 US US16/077,949 patent/US11484577B2/en active Active
- 2017-02-14 ES ES17704039T patent/ES2930077T3/es active Active
- 2017-02-14 JP JP2018542732A patent/JP7063813B2/ja active Active
- 2017-02-14 EP EP17704039.1A patent/EP3416688B1/en active Active
-
2022
- 2022-09-27 US US17/935,667 patent/US11896649B2/en active Active
-
2023
- 2023-12-27 US US18/396,828 patent/US20240226238A1/en not_active Abandoned
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