JP2019508416A5 - - Google Patents

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JP2019508416A5
JP2019508416A5 JP2018542732A JP2018542732A JP2019508416A5 JP 2019508416 A5 JP2019508416 A5 JP 2019508416A5 JP 2018542732 A JP2018542732 A JP 2018542732A JP 2018542732 A JP2018542732 A JP 2018542732A JP 2019508416 A5 JP2019508416 A5 JP 2019508416A5
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Japan
Prior art keywords
surgery
pharmaceutical composition
administered
receptor agonist
subject
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JP2018542732A
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JP2019508416A (ja
JP7063813B2 (ja
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Priority claimed from PCT/EP2017/053308 external-priority patent/WO2017140684A2/en
Publication of JP2019508416A publication Critical patent/JP2019508416A/ja
Publication of JP2019508416A5 publication Critical patent/JP2019508416A5/ja
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Claims (8)

  1. ＡＰＪレセプターアゴニストを含む、術後認知機能障害を処置するための医薬組成物。
  2. 術後認知機能障害のリスクにあると判定されている対象に投与される、請求項１記載の医薬組成物。
  3. 認知機能に障害があると診断されている又は認知機能に障害を有することが示されている対象に投与される、請求項１記載の医薬組成物。
  4. ＡＰＪレセプターアゴニストが、手術に際して（すなわち、手術の前、術中及び／又は後）並びに退院後に、投与される、請求項１記載の医薬組成物。
  5. 術後認知機能障害が、腹部手術（例えば、腹部の内臓の手術）、ベンチサージェリー（例えば、その後に臓器が再移植されうる、身体から取り出された臓器に行われる手術）、心臓（例えば、心臓の手術）、脳（例えば、脳の手術）、動形成切断（例えば、義肢を動作させるのに筋肉を使用することを可能にするために、切断された四肢の断端に隣接する筋肉を通してトンネルを形成するための手術）、美容（例えば、傷の成形修復、矯正又は除去により対象の外観を改善するための手術）、歯牙顔面（例えば、顔の欠陥及び口の構造に関連する手術）、神経（例えば、末梢又は中枢神経系に関連する手術）、口腔（例えば、口、顎及び関連する構造の欠陥に関連する手術）、整形外科（例えば、骨及び骨構造（例えば人工股関節置換）を取り扱う手術）、骨盤（例えば、骨盤（主に産婦人科）に関連する手術）、形成（例えば、傷害、疾患、又は成長及び発達により欠損、損傷又は奇形している身体構造の形及び外観の修復、再建、修正又は改善に関連する手術）、又は直腸（例えば、直腸の手術）、泌尿器（例えば、尿生殖器系（主に男性における）に関連する手術）、血管（例えば、血管の手術）、又は耳鼻咽喉科に関連する手術（例えば、耳、鼻、喉又は関連する構造の手術）を含む手術後に経験する認知機能障害である、請求項１記載の医薬組成物。
  6. ＡＰＪレセプターアゴニストが、麻酔剤と同時又は順次に対象に投与される、請求項１記載の医薬組成物。
  7. 麻酔剤が、ジエチルエーテル、メトキシプロパン、ビニルエーテル、ハロゲン化エーテル、例えば、デスフルラン、エンフルラン、ハロタン、イソフルラン、メトキシフルラン；ハロアルカン、例えば、クロロホルム、ハロタン、トリクロロエチレン、シクロプロパン、エチレン、亜酸化窒素、セボフルラン、キセノン、重水素化イソフルラン、ヘキサフルオロ−ｔ−ブチル−ジフルオロメチルエーテル、及びメトキシフルランの重水素化アナログ、重水素化セボフルランからなる群より選択される、請求項６記載の医薬組成物。
  8. ＡＰＪレセプターアゴニストが、有機小分子、アプタマー、抗体及びポリペプチドからなる群より選択される、請求項１記載の医薬組成物。
JP2018542732A 2016-02-15 2017-02-14 術後認知機能障害の処置のための方法及び医薬組成物 Active JP7063813B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16305170.9 2016-02-15
EP16305170 2016-02-15
PCT/EP2017/053308 WO2017140684A2 (en) 2016-02-15 2017-02-14 Methods and pharmaceutical compositions for the treatment of post-operative cognitive dysfunction

Publications (3)

Publication Number Publication Date
JP2019508416A JP2019508416A (ja) 2019-03-28
JP2019508416A5 true JP2019508416A5 (ja) 2020-01-23
JP7063813B2 JP7063813B2 (ja) 2022-05-09

Family

ID=55359484

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018542732A Active JP7063813B2 (ja) 2016-02-15 2017-02-14 術後認知機能障害の処置のための方法及び医薬組成物

Country Status (5)

Country Link
US (2) US11484577B2 (ja)
EP (1) EP3416688B1 (ja)
JP (1) JP7063813B2 (ja)
ES (1) ES2930077T3 (ja)
WO (1) WO2017140684A2 (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
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CN114174255A (zh) * 2019-03-01 2022-03-11 阿布雷克斯制药股份有限公司 用于预防和治疗手术后认知功能障碍的化合物
EP4143218A4 (en) * 2020-04-28 2024-05-29 Abrexa Pharmaceuticals Inc COMPOUNDS FOR THE PREVENTION AND TREATMENT OF POST-INTENSIVE CARE COGNITIVE DYSFUNCTION AND COGNITIVE DYSFUNCTION RESULTING FROM RESPIRATORY DISTRESS
WO2023211684A2 (en) * 2022-04-29 2023-11-02 Noetix Pharma Llc Prevention and treatment of post-operative cognitive dysfunction (pocd)

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