JP2019507185A5 - - Google Patents
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- Publication number
- JP2019507185A5 JP2019507185A5 JP2018559177A JP2018559177A JP2019507185A5 JP 2019507185 A5 JP2019507185 A5 JP 2019507185A5 JP 2018559177 A JP2018559177 A JP 2018559177A JP 2018559177 A JP2018559177 A JP 2018559177A JP 2019507185 A5 JP2019507185 A5 JP 2019507185A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- ring
- phenyl
- membered heterocyclic
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CCl1(=C)=CC=C(CNC(c2n[o]cc2)=CC(c(nc2N(*)*)ncc2F)=[N+])C=C1 Chemical compound CCl1(=C)=CC=C(CNC(c2n[o]cc2)=CC(c(nc2N(*)*)ncc2F)=[N+])C=C1 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662289463P | 2016-02-01 | 2016-02-01 | |
| US62/289,463 | 2016-02-01 | ||
| US201662398872P | 2016-09-23 | 2016-09-23 | |
| US62/398,872 | 2016-09-23 | ||
| PCT/US2017/015749 WO2017136309A1 (en) | 2016-02-01 | 2017-01-31 | USE OF sGC STIMULATORS FOR THE TREATMENT OF NONALCOHOLIC STEATOHEPATITIS (NASH) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019507185A JP2019507185A (ja) | 2019-03-14 |
| JP2019507185A5 true JP2019507185A5 (https=) | 2020-03-12 |
| JP7098214B2 JP7098214B2 (ja) | 2022-07-11 |
Family
ID=58018271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018559177A Active JP7098214B2 (ja) | 2016-02-01 | 2017-01-31 | 非アルコール性脂肪性肝炎（ＮＡＳＨ）の処置のためのｓＧＣ刺激物質の使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11357777B2 (https=) |
| EP (1) | EP3411026B1 (https=) |
| JP (1) | JP7098214B2 (https=) |
| KR (1) | KR20180104123A (https=) |
| CN (2) | CN108697678A (https=) |
| AU (1) | AU2017216429B2 (https=) |
| BR (1) | BR112018015718A2 (https=) |
| CA (1) | CA3012001A1 (https=) |
| IL (1) | IL260701B (https=) |
| MX (1) | MX386216B (https=) |
| WO (1) | WO2017136309A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3194386A2 (en) * | 2014-09-17 | 2017-07-26 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| WO2017107052A1 (en) | 2015-12-22 | 2017-06-29 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase stimulators |
| BR112018015718A2 (pt) | 2016-02-01 | 2019-01-08 | Ironwood Pharmaceuticals Inc | utilização de estimuladores de sgc para o tratamento de esteato-hepatite não alcoólica (nash) |
| IL271149B2 (en) * | 2017-06-14 | 2024-05-01 | Trevena Inc | Compounds for modulating s1p1 activity and methods of using the same |
| WO2019055859A1 (en) * | 2017-09-14 | 2019-03-21 | Ironwood Pharmaceuticals, Inc. | TREATMENT OF METABOLIC SYNDROME BY SGC STIMULATOR |
| KR20210031931A (ko) * | 2018-07-11 | 2021-03-23 | 사이클리온 테라퓨틱스, 인크. | 미토콘드리아 장애의 치료를 위한 sGC 자극제의 용도 |
| EP3820470B1 (en) * | 2018-07-12 | 2024-09-11 | Boehringer Ingelheim International GmbH | Alkoxy pyrazoles as soluble guanylate cyclase activators for use in treating portal hypertension |
| CN114555076B (zh) * | 2019-10-18 | 2024-02-02 | 正大天晴药业集团股份有限公司 | 用于治疗非酒精性脂肪性肝炎的药物 |
| EP4061352A4 (en) | 2019-11-19 | 2024-02-28 | Trevena, Inc. | COMPOUNDS AND METHODS FOR PRODUCING S1P1-MODULATING COMPOUNDS |
| EP4106741A1 (en) * | 2020-02-21 | 2022-12-28 | Universiteit Maastricht | Use of a soluble guanylate cyclase (sgc) stimulator or of a combination of a sgc stimulator and an sgc activator for conditions wherein the heme group of sgc is oxidized or wherein sgc is deficient in heme |
| CN118525022A (zh) * | 2022-01-27 | 2024-08-20 | 西藏海思科制药有限公司 | 一种氮杂并环衍生物及其在医药上的应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10109861A1 (de) | 2001-03-01 | 2002-09-05 | Bayer Ag | Neuartige seitenkettenhalogenierte Aminodicarbonsäurederivate |
| US20100144864A1 (en) * | 2007-04-05 | 2010-06-10 | Ironwood Pharmaceuticals, Inc. | Soluble guanylate cyclase (sgc) modulators for treatment of lipid related disorders |
| CN102056907B (zh) | 2008-04-04 | 2014-12-31 | 武田药品工业株式会社 | 杂环衍生物及其用途 |
| US9260424B2 (en) | 2009-10-26 | 2016-02-16 | Auspex Pharmaceuticals, Inc. | 4,6-diaminopyrimidine stimulators of soluble guanylate cyclase |
| SI2576548T1 (sl) | 2010-05-26 | 2015-11-30 | Adverio Pharma Gmbh | Uporaba sGC stimulatorjev, sGC aktivatorjev, samih in v kombinacijah s PDE5 inhibitorji za zdravljenje sistemske skleroze |
| DE102010021637A1 (de) * | 2010-05-26 | 2011-12-01 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung |
| JP5715713B2 (ja) | 2011-03-10 | 2015-05-13 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 可溶性グアニル酸シクラーゼ活性化因子 |
| CN102164320B (zh) | 2011-04-11 | 2016-06-22 | 北京数字太和科技有限责任公司 | 一种改进的基于条件接收技术的终端 |
| SI2970243T1 (sl) * | 2013-03-15 | 2020-04-30 | Cyclerion Therapeutics, Inc. | SGC stimulatorji |
| WO2015106268A1 (en) * | 2014-01-13 | 2015-07-16 | Ironwood Pharmaceuticals, Inc. | USE OF sGC STIMULATORS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS |
| WO2015123090A1 (en) * | 2014-02-11 | 2015-08-20 | Merck Sharp & Dohme Corp. | Factor xia inhibitors |
| EP3172202B1 (en) * | 2014-07-22 | 2020-01-29 | Boehringer Ingelheim International GmbH | Heterocyclic carboxylic acids as activators of soluble guanylate cyclase |
| CA3006746C (en) | 2015-11-30 | 2024-01-30 | Ironwood Pharmaceuticals, Inc. | Solid dispersions comprising a sgc stimulator |
| BR112018015718A2 (pt) | 2016-02-01 | 2019-01-08 | Ironwood Pharmaceuticals Inc | utilização de estimuladores de sgc para o tratamento de esteato-hepatite não alcoólica (nash) |
| US10925876B2 (en) | 2016-05-18 | 2021-02-23 | Merck Sharp & Dohme Corp. | Methods for using triazolo-pyrazinyl soluble guanylate cyclase activators in fibrotic disorders |
-
2017
- 2017-01-31 BR BR112018015718A patent/BR112018015718A2/pt not_active Application Discontinuation
- 2017-01-31 JP JP2018559177A patent/JP7098214B2/ja active Active
- 2017-01-31 US US16/074,357 patent/US11357777B2/en active Active
- 2017-01-31 CN CN201780013129.8A patent/CN108697678A/zh active Pending
- 2017-01-31 WO PCT/US2017/015749 patent/WO2017136309A1/en not_active Ceased
- 2017-01-31 EP EP17704916.0A patent/EP3411026B1/en active Active
- 2017-01-31 MX MX2018009173A patent/MX386216B/es unknown
- 2017-01-31 CA CA3012001A patent/CA3012001A1/en active Pending
- 2017-01-31 AU AU2017216429A patent/AU2017216429B2/en not_active Ceased
- 2017-01-31 KR KR1020187024680A patent/KR20180104123A/ko not_active Ceased
- 2017-01-31 CN CN202310699763.9A patent/CN116726178A/zh active Pending
- 2017-01-31 IL IL260701A patent/IL260701B/en unknown
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