JP2019506382A5 - - Google Patents
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- Publication number
- JP2019506382A5 JP2019506382A5 JP2018536167A JP2018536167A JP2019506382A5 JP 2019506382 A5 JP2019506382 A5 JP 2019506382A5 JP 2018536167 A JP2018536167 A JP 2018536167A JP 2018536167 A JP2018536167 A JP 2018536167A JP 2019506382 A5 JP2019506382 A5 JP 2019506382A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- tautomer
- stereoisomer
- enantiomer
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 9
- 239000012453 solvate Substances 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- -1 NH 2 Inorganic materials 0.000 claims 5
- 229910004013 NO 2 Inorganic materials 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000000328 arabinofuranosyl group Chemical group C1([C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 125000005640 glucopyranosyl group Chemical group 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000000548 ribosyl group Chemical group C1([C@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 208000005440 Basal Cell Neoplasms Diseases 0.000 claims 1
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 1
- 206010004593 Bile duct cancer Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 208000022072 Gallbladder Neoplasms Diseases 0.000 claims 1
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 1
- 208000031852 Gastrointestinal stromal cancer Diseases 0.000 claims 1
- 208000032320 Germ cell tumor of testis Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 208000007766 Kaposi sarcoma Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 claims 1
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000009565 Pharyngeal Neoplasms Diseases 0.000 claims 1
- 206010034811 Pharyngeal cancer Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000001455 Zika Virus Infection Diseases 0.000 claims 1
- 208000035332 Zika virus disease Diseases 0.000 claims 1
- 208000020329 Zika virus infectious disease Diseases 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 208000026900 bile duct neoplasm Diseases 0.000 claims 1
- 201000008274 breast adenocarcinoma Diseases 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 1
- 208000024207 chronic leukemia Diseases 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 201000010175 gallbladder cancer Diseases 0.000 claims 1
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims 1
- 208000006359 hepatoblastoma Diseases 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000006512 mast cell neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 208000017058 pharyngeal squamous cell carcinoma Diseases 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 208000002918 testicular germ cell tumor Diseases 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 206010044412 transitional cell carcinoma Diseases 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 208000023747 urothelial carcinoma Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662277653P | 2016-01-12 | 2016-01-12 | |
| US62/277,653 | 2016-01-12 | ||
| PCT/US2017/013253 WO2017123809A1 (en) | 2016-01-12 | 2017-01-12 | Compounds for inhibiting cancer and virus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019506382A JP2019506382A (ja) | 2019-03-07 |
| JP2019506382A5 true JP2019506382A5 (enrdf_load_stackoverflow) | 2020-03-05 |
Family
ID=59311465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018536167A Pending JP2019506382A (ja) | 2016-01-12 | 2017-01-12 | 癌及びウイルスを阻害するための化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10745433B2 (enrdf_load_stackoverflow) |
| EP (1) | EP3402800A4 (enrdf_load_stackoverflow) |
| JP (1) | JP2019506382A (enrdf_load_stackoverflow) |
| CN (1) | CN108884123A (enrdf_load_stackoverflow) |
| CA (1) | CA3011289A1 (enrdf_load_stackoverflow) |
| TW (1) | TWI638825B (enrdf_load_stackoverflow) |
| WO (1) | WO2017123809A1 (enrdf_load_stackoverflow) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11491123B2 (en) * | 2016-06-23 | 2022-11-08 | Health Research, Inc. | Pharmaceutical compositions with antiflaviviral activity |
| US11384114B2 (en) | 2016-12-09 | 2022-07-12 | Warsaw Orthopedic, Inc. | Polymorphic forms of an oxysterol and methods of making them |
| CN111518147A (zh) * | 2020-04-29 | 2020-08-11 | 华东理工大学 | 苯甲酰苯胺类化合物及在制备铜绿假单胞菌抑制剂的增敏剂中的应用 |
| US11767303B2 (en) | 2020-07-24 | 2023-09-26 | Health Research, Inc. | Compounds and methods for inhibiting viral replication and methods of treating and preventing flaviviral infections |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE150471C (enrdf_load_stackoverflow) * | ||||
| DD150471A1 (de) * | 1979-07-02 | 1981-09-02 | Konrad Schwabe | Verfahren zur herstellung von 5-bromsalizyl-4'-chloranilid-0-glykosiden |
| US6555519B2 (en) | 2000-03-30 | 2003-04-29 | Bristol-Myers Squibb Company | O-glucosylated benzamide SGLT2 inhibitors and method |
| CA2488363C (en) * | 2002-06-06 | 2011-01-04 | Institute Of Medicinal Molecular Design, Inc. | O-substituted hydroxyaryl derivatives |
| AU2003249244A1 (en) * | 2002-07-15 | 2004-02-02 | Combinatorx, Incorporated | Methods for the treatment of neoplasms |
| TW200529812A (en) * | 2003-12-26 | 2005-09-16 | Chugai Pharmaceutical Co Ltd | Benzamide derivatives |
| WO2008033466A2 (en) * | 2006-09-14 | 2008-03-20 | Combinatorx (Singapore) Pre. Ltd. | Compositions and methods for treatment of viral diseases |
| US8211882B2 (en) | 2008-03-08 | 2012-07-03 | Richard Delarey Wood | Glutamate receptor modulators and therapeutic agents |
| EP2699319B1 (en) | 2011-04-18 | 2017-08-09 | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft | Niclosamide for the treatment of cancer metastasis |
| WO2014023329A1 (en) | 2012-08-06 | 2014-02-13 | Life And Brain Gmbh | Niclosamide and its derivatives for use in the treatment of solid tumors |
| WO2014113467A1 (en) * | 2013-01-15 | 2014-07-24 | Board Of Regents, The University Of Texas System | Stat3 inhibitor |
| CN103130696B (zh) * | 2013-03-21 | 2014-06-11 | 山东大学 | 邻氨基苯甲酰胺类化合物及其制备方法与应用 |
| CN104771386A (zh) | 2014-01-10 | 2015-07-15 | 中国科学院广州生物医药与健康研究院 | 苯甲酰胺类化合物及其应用 |
-
2017
- 2017-01-12 CA CA3011289A patent/CA3011289A1/en not_active Abandoned
- 2017-01-12 EP EP17738972.3A patent/EP3402800A4/en not_active Withdrawn
- 2017-01-12 JP JP2018536167A patent/JP2019506382A/ja active Pending
- 2017-01-12 WO PCT/US2017/013253 patent/WO2017123809A1/en active Application Filing
- 2017-01-12 US US16/069,100 patent/US10745433B2/en active Active
- 2017-01-12 TW TW106101068A patent/TWI638825B/zh not_active IP Right Cessation
- 2017-01-12 CN CN201780006499.9A patent/CN108884123A/zh active Pending