JP2019504087A5 - - Google Patents
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- JP2019504087A5 JP2019504087A5 JP2018540115A JP2018540115A JP2019504087A5 JP 2019504087 A5 JP2019504087 A5 JP 2019504087A5 JP 2018540115 A JP2018540115 A JP 2018540115A JP 2018540115 A JP2018540115 A JP 2018540115A JP 2019504087 A5 JP2019504087 A5 JP 2019504087A5
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- Prior art keywords
- cancer
- syndrome
- disease
- autoimmune
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 18
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 8
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- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
- 208000011580 syndromic disease Diseases 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
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- 208000008839 Kidney Neoplasms Diseases 0.000 claims 4
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-dimethylformamide Substances CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 4
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 4
- 206010038389 Renal cancer Diseases 0.000 claims 4
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 4
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- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims 2
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662291453P | 2016-02-04 | 2016-02-04 | |
| US62/291,453 | 2016-02-04 | ||
| PCT/US2017/016516 WO2017136731A1 (en) | 2016-02-04 | 2017-02-03 | Rapaglutins, novel inhibitors of glut and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019504087A JP2019504087A (ja) | 2019-02-14 |
| JP2019504087A5 true JP2019504087A5 (enExample) | 2020-02-13 |
| JP7104627B2 JP7104627B2 (ja) | 2022-07-21 |
Family
ID=59500972
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018540115A Active JP7104627B2 (ja) | 2016-02-04 | 2017-02-03 | ラパグルチン（ｒａｐａｇｌｕｔｉｎｓ）、ｇｌｕｔの新規阻害剤及びその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11708391B2 (enExample) |
| EP (1) | EP3411046B1 (enExample) |
| JP (1) | JP7104627B2 (enExample) |
| CN (1) | CN108697729B (enExample) |
| AU (1) | AU2017213630B2 (enExample) |
| CA (1) | CA3013783A1 (enExample) |
| MX (1) | MX2018009408A (enExample) |
| WO (1) | WO2017136731A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX380313B (es) | 2016-02-04 | 2025-03-12 | Univ Johns Hopkins | Rapadocinas, inhibidores de transportador 1 de nucleósido equilibrador y usos de los mismos. |
| US11066416B2 (en) | 2016-02-04 | 2021-07-20 | The Johns Hopkins University | Rapafucin derivative compounds and methods of use thereof |
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| TW202126323A (zh) * | 2019-10-01 | 2021-07-16 | 約翰斯赫普金斯大學 | 雷帕弗辛（Ｒａｐａｆｕｃｉｎ）衍生化合物及其使用方法 |
| WO2021067405A1 (en) * | 2019-10-01 | 2021-04-08 | The Johns Hopkins University | Neuroprotective compounds and methods of use thereof |
| CN112294792B (zh) * | 2020-09-22 | 2021-10-22 | 厦门市中医院 | 化合物wzb117在制备治疗和/或预防肝损伤药物中的用途 |
| CN115364224B (zh) * | 2022-08-25 | 2024-02-02 | 杭州天玑济世生物科技有限公司 | Glut1抑制剂作为线粒体自噬诱导剂的用途 |
| CN120271673A (zh) * | 2024-01-08 | 2025-07-08 | 重庆医科大学 | 一种化合物、包含其的药物组合物及其用途 |
| CN120617307B (zh) * | 2025-06-16 | 2025-12-09 | 烟台大学 | 一种wzb117纳米制剂及其制备方法 |
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| MX2018009408A (es) | 2016-02-04 | 2018-11-09 | Univ Johns Hopkins | Rapaglutinas, nuevos inhibidores de transportadores de glucosa (glut) y uso de los mismos. |
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-
2017
- 2017-02-03 MX MX2018009408A patent/MX2018009408A/es unknown
- 2017-02-03 EP EP17748278.3A patent/EP3411046B1/en active Active
- 2017-02-03 JP JP2018540115A patent/JP7104627B2/ja active Active
- 2017-02-03 AU AU2017213630A patent/AU2017213630B2/en active Active
- 2017-02-03 CA CA3013783A patent/CA3013783A1/en not_active Abandoned
- 2017-02-03 WO PCT/US2017/016516 patent/WO2017136731A1/en not_active Ceased
- 2017-02-03 CN CN201780010180.3A patent/CN108697729B/zh active Active
- 2017-02-03 US US16/074,300 patent/US11708391B2/en active Active
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