JP2019503995A - 皮膚用のセルロース含有物品 - Google Patents
皮膚用のセルロース含有物品 Download PDFInfo
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Abstract
【選択図】図2
Description
a.本発明によるBNC含有物品を該皮膚の領域に適用し、
b.該皮膚上の該物品を所定の時間そのままにし、
c.該物品を該皮膚から取り除く
を含む。
a)BNCを連続半静的(semi-static)工程で提供し;b)本発明の物品を提供し;そしてc)場合によっては該物品を殺菌する。
−a’)培地を含む反応容器を提供し;
−a”)該培地にBNC生成バクテリア株を接種し;そして/又は
−a''')該反応容器中でBNCをバクテリア合成する。
WAC=質量(湿潤)/質量(乾燥)*100%
半静的連続法を使用して製造した本発明によるセルロース含有物品を、その材料特性に関して、静的且つ非連続培養を使用して製造したセルロース含有物品(比較例)と比較した。
本発明の物品の分子構造を、ゲル透過クロマトグラフィー(GPC)を使用して決定した。この目的で、株ATCC11142のセルロースを使用した。比較例を、静的セルロース製造工程を使用して製造した。本発明の物品を、連続半静的セルロース製造行程を使用して製造した。
本発明の物品の近似構造を、NMRを使用して決定した。
このために、株ATCC11142のセルロース及び株DSM14666のセルロースを使用した。比較例を、静的セルロース製造工程を使用して湿ったフリースとして製造した。本発明の物品は、連続半静的セルロース製造工程を使用して湿ったフリースとして製造した。
上部分子構造を、先に炭素で、そして引き続き金でのスパッタリングで標識化した後、REMを使用し、2,000の倍率で決定した。電子顕微鏡Leica S440i,タングステンカソード使用、最大30kV,シンチレーション−SE−検出器、4−象限場(quadrantfield)半導体RE−検出器を使用。株ATCC11142及び株DSM14666のセルロースのそれぞれのBNCフリースを凍結乾燥し、引き続きREMに付した。使用した株には依存せずに、本発明のサンプル(連続半静的セルロース製造工程)の上部分子構造は比較例のサンプル(静的セルロース製造工程)の上部分子構造と区別できないことが見出された。
セルロース含有物品の表面構造は、特に傷包帯又は化粧品として使用した場合、重要である。表面構造をレーザー走査顕微鏡(LSM)を使用して分析した。この目的で、株ATCC11142及び株DSM14666のそれぞれのBNCフリースを、それぞれ静的工程及び半静的連続工程で製造した。
BNCは本来、ヒドロゲルを形成し、その結果、その特性が水又は他の有機溶液と液体親和性となる。これにより、BNC物品の吸水能及び保水容量は重要な特徴である。
WRC=(湿潤質量−乾燥質量)/湿潤質量×100%
Claims (15)
- 皮膚の領域を処置するためのBNC含有物品であって、該物品は
−BNCを少なくとも1重量%そして最大15重量%の量で含み、
−流体を少なくとも85重量%そして最大99重量%の量で含み、
−少なくとも0.5mmそして最大8mmの平均厚さを有し、
上記BNCは微生物起源である、BNC含有物品。 - 最大6mm、好ましくは最大5mmの平均厚さを有する、請求項1記載のセルロース含有物品。
- 少なくとも1種の活性剤を含み、該活性剤は、好ましくは薬学的、化粧品学的、天然の又は美容学的活性剤を含む群から選ばれる、先行請求項のいずれか1項記載のセルロース含有物品。
- 上記物品、特に該物品のBNC、の重量平均分子量Mwが、最大1,500,000g/mol,好ましくは最大1,200,000g/mol,最大1,000,000g/mol,最大900,000g/mol,最大850,000g/mol,最大800,000g/mol,最も好ましくは最大780,000g/molである、先行請求項のいずれか1項記載のセルロース含有物品。
- 上記物品、特に該物品のBNCが、カルボニル基を8.5μmol/g未満、好ましくは8.0μmol/g未満、7.5μmol/g未満、7.0μmol/g未満、6.0μmol/g未満、更に好ましくは5.75μmol/g未満の量で含む、先行請求項のいずれか1項記載のセルロース含有物品。
- 上記物品の多分散性インデックス(Mw/Mn)が3.5未満、好ましくは3.0未満、更に好ましくは2.75未満、そして/又は2.5を越える、先行請求項のいずれか1項記載のセルロース含有物品。
- 上記物品が、252Mpaを越える、好ましくは275MPaを越える、更に好ましくは300Mpaを越える、そして最も好ましくは310MPaを越える引張強度を有する、先行請求項のいずれか1項記載のセルロース含有物品。
- 下記を含む、対象者の皮膚領域の処置方法:
a.セルロース含有物品を該皮膚領域に塗布し、
b.該物品を該皮膚上に所定の時間そのままにし、
c.該物品を該皮膚から除去する、
ここで、該物品は、
−BNCを少なくとも1重量%そして最大15重量%の量で含み、
−流体を少なくとも85重量%そして最大99重量%の量で含み、
−少なくとも0.5mmそして最大8mmの平均厚さを有し、そして
上記BNCは微生物起源である。 - ステップa.が、上記物品を皮膚に付着により、好ましくはいかなる固定手段も用いずに付着することを含む、請求項8記載の方法。
- 上記処置が、皮膚状態又は障害又は疾患、好ましくは皮膚炎、特に顔の皮膚炎、口周囲、眼窩、眼の周囲及び鼻周囲の皮膚炎;乾燥肌;アトピー性皮膚炎;日焼け;乾癬;ニキビ;酒さ及び/又は光力学的療法を施された皮膚を含む群から選ばれる皮膚状態又は障害又は疾患の処置である、請求項8〜9のいずれか1項記載の方法。
- 上記方法が更に、活性剤、好ましくは薬学的活性剤、を用いた物品の予備処理のステップを含み、ここで好ましくは該活性剤が皮膚の症状又は障害又は疾患の治療に有効である、請求項8〜10のいずれか1項記載の方法。
- ステップa.〜c.及び場合によっては上記物品の予備処理のステップが、少なくとも1日、少なくとも2日、少なくとも3日、又は少なくとも4日の処置区間中の24時間以内に1回行われる、請求項8〜11のいずれか1項記載の方法。
- 上記方法が皮膚領域に光力学的療法を適用するステップを含む、請求項8〜12のいずれか1項記載の方法。
- 請求項1〜8のいずれか1項記載のセルロース含有物品の製造方法であって、該方法が少なくとも下記のステップ:
a.半静的連続工程でBNCを提供し、
b.本発明の物品を提供し、
c.場合によっては該物品を殺菌する
を含む、セルロース含有物品の製造方法。 - 請求項14の方法で提供されたBNC含有物品。
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JP2021169834A JP7382373B2 (ja) | 2015-11-25 | 2021-10-15 | 皮膚用のセルロース含有物品 |
JP2023132391A JP2023159252A (ja) | 2015-11-25 | 2023-08-15 | 皮膚用のセルロース含有物品 |
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EP15196348 | 2015-11-25 | ||
EP15196348.5 | 2015-11-25 | ||
PCT/EP2016/072972 WO2017089005A1 (en) | 2015-11-25 | 2016-09-27 | Biotechnologically-produced cellulose-containing article for dermatological use |
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JP2021169834A Active JP7382373B2 (ja) | 2015-11-25 | 2021-10-15 | 皮膚用のセルロース含有物品 |
JP2023132391A Pending JP2023159252A (ja) | 2015-11-25 | 2023-08-15 | 皮膚用のセルロース含有物品 |
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US (2) | US10736823B2 (ja) |
EP (2) | EP3380072B1 (ja) |
JP (3) | JP6963549B2 (ja) |
KR (1) | KR20180085005A (ja) |
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EP3312608B1 (en) | 2016-10-24 | 2019-10-02 | Akribes Biomedical GmbH | Methods for identifying a non-healing skin wound and for monitoring the healing of a skin wound |
USD910239S1 (en) * | 2018-10-30 | 2021-02-09 | Byung Suk Yoo | Eyelash extension holder |
WO2020262727A1 (ko) * | 2019-06-26 | 2020-12-30 | 네이처코스텍 주식회사 | 변성 셀룰로오스를 포함하는 피부필러용 조성물 |
EP3997207A1 (en) * | 2019-07-12 | 2022-05-18 | Evonik Operations GmbH | Method for loading of microorganisms on multiphase biomaterials |
CN112220923B (zh) * | 2020-08-14 | 2021-09-10 | 江南大学 | 一种基于细菌纤维素的光敏抗菌复合材料的制备方法 |
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EP3380072B1 (en) | 2021-07-21 |
JP6963549B2 (ja) | 2021-11-10 |
JP2022025089A (ja) | 2022-02-09 |
EP3900699A1 (en) | 2021-10-27 |
JP7382373B2 (ja) | 2023-11-16 |
FI3900699T3 (fi) | 2023-09-25 |
PL3380072T3 (pl) | 2021-12-13 |
JP2023159252A (ja) | 2023-10-31 |
KR20180085005A (ko) | 2018-07-25 |
CA3005979A1 (en) | 2017-06-01 |
MX2018006409A (es) | 2018-09-27 |
CA3005979C (en) | 2024-04-23 |
CN108697618B (zh) | 2021-10-15 |
ES2955825T3 (es) | 2023-12-07 |
EA201891228A1 (ru) | 2018-11-30 |
US11529433B2 (en) | 2022-12-20 |
US20180303726A1 (en) | 2018-10-25 |
CN113855589A (zh) | 2021-12-31 |
WO2017089005A1 (en) | 2017-06-01 |
CN108697618A (zh) | 2018-10-23 |
PL3900699T3 (pl) | 2023-11-20 |
CN113855589B (zh) | 2024-01-23 |
EP3380072A1 (en) | 2018-10-03 |
US20200364264A1 (en) | 2020-11-19 |
EP3900699B1 (en) | 2023-08-02 |
EA035677B1 (ru) | 2020-07-24 |
ES2883223T3 (es) | 2021-12-07 |
US10736823B2 (en) | 2020-08-11 |
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