JP2019502718A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019502718A5 JP2019502718A5 JP2018536439A JP2018536439A JP2019502718A5 JP 2019502718 A5 JP2019502718 A5 JP 2019502718A5 JP 2018536439 A JP2018536439 A JP 2018536439A JP 2018536439 A JP2018536439 A JP 2018536439A JP 2019502718 A5 JP2019502718 A5 JP 2019502718A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- composition
- agent
- composition according
- agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 81
- 239000003795 chemical substances by application Substances 0.000 claims 37
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 27
- 239000000284 extract Substances 0.000 claims 20
- 201000010099 disease Diseases 0.000 claims 16
- 230000015572 biosynthetic process Effects 0.000 claims 13
- 238000003786 synthesis reaction Methods 0.000 claims 13
- 208000035475 disorder Diseases 0.000 claims 11
- -1 oleosomes Substances 0.000 claims 9
- 238000002360 preparation method Methods 0.000 claims 9
- 210000000577 adipose tissue Anatomy 0.000 claims 8
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 8
- 239000003112 inhibitor Substances 0.000 claims 8
- 210000003491 skin Anatomy 0.000 claims 8
- 239000000021 stimulant Substances 0.000 claims 8
- 208000002874 Acne Vulgaris Diseases 0.000 claims 7
- 206010012289 Dementia Diseases 0.000 claims 7
- 206010000496 acne Diseases 0.000 claims 7
- 208000005264 motor neuron disease Diseases 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 206010020649 Hyperkeratosis Diseases 0.000 claims 6
- 208000026072 Motor neurone disease Diseases 0.000 claims 6
- 239000002671 adjuvant Substances 0.000 claims 6
- 230000032683 aging Effects 0.000 claims 6
- 208000011580 syndromic disease Diseases 0.000 claims 6
- 208000024827 Alzheimer disease Diseases 0.000 claims 5
- 235000013305 food Nutrition 0.000 claims 5
- 239000002502 liposome Substances 0.000 claims 5
- 230000004770 neurodegeneration Effects 0.000 claims 5
- 235000015961 tonic Nutrition 0.000 claims 5
- 230000001256 tonic effect Effects 0.000 claims 5
- GKPMARPRXONRJX-BWJWTDLKSA-N (3s)-4-[[(2s,3s)-1-[[(2s)-1-amino-5-(carbamoylamino)-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-[[(2s)-2,6-diaminohexanoyl]amino]-4-oxobutanoic acid Chemical compound NC(=O)NCCC[C@@H](C(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)CCCCN GKPMARPRXONRJX-BWJWTDLKSA-N 0.000 claims 4
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims 4
- 206010003591 Ataxia Diseases 0.000 claims 4
- MVORZMQFXBLMHM-QWRGUYRKSA-N Gly-His-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)CN)CC1=CN=CN1 MVORZMQFXBLMHM-QWRGUYRKSA-N 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 4
- 101001123331 Homo sapiens Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Proteins 0.000 claims 4
- 208000001126 Keratosis Diseases 0.000 claims 4
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 claims 4
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 claims 4
- 206010033799 Paralysis Diseases 0.000 claims 4
- 208000018737 Parkinson disease Diseases 0.000 claims 4
- 102100028960 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Human genes 0.000 claims 4
- 241000519590 Pseudoalteromonas Species 0.000 claims 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 4
- 210000001789 adipocyte Anatomy 0.000 claims 4
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims 4
- 229960002173 citrulline Drugs 0.000 claims 4
- 235000013477 citrulline Nutrition 0.000 claims 4
- 239000002537 cosmetic Substances 0.000 claims 4
- 230000003412 degenerative effect Effects 0.000 claims 4
- 230000004069 differentiation Effects 0.000 claims 4
- 238000009472 formulation Methods 0.000 claims 4
- 239000000787 lecithin Substances 0.000 claims 4
- 235000010445 lecithin Nutrition 0.000 claims 4
- 229940067606 lecithin Drugs 0.000 claims 4
- 230000002366 lipolytic effect Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 210000003205 muscle Anatomy 0.000 claims 4
- 208000015122 neurodegenerative disease Diseases 0.000 claims 4
- 239000000843 powder Substances 0.000 claims 4
- 208000008742 seborrheic dermatitis Diseases 0.000 claims 4
- 239000000243 solution Substances 0.000 claims 4
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 4
- 208000000044 Amnesia Diseases 0.000 claims 3
- 201000004624 Dermatitis Diseases 0.000 claims 3
- 208000023105 Huntington disease Diseases 0.000 claims 3
- 208000009829 Lewy Body Disease Diseases 0.000 claims 3
- 208000012902 Nervous system disease Diseases 0.000 claims 3
- 208000025966 Neurological disease Diseases 0.000 claims 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- 244000181066 Rosa eglanteria Species 0.000 claims 3
- 235000000542 Rosa eglanteria Nutrition 0.000 claims 3
- 108010073771 Soybean Proteins Proteins 0.000 claims 3
- 230000003712 anti-aging effect Effects 0.000 claims 3
- 230000001153 anti-wrinkle effect Effects 0.000 claims 3
- 230000001684 chronic effect Effects 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 230000003247 decreasing effect Effects 0.000 claims 3
- 230000007850 degeneration Effects 0.000 claims 3
- 239000000839 emulsion Substances 0.000 claims 3
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 3
- 239000000693 micelle Substances 0.000 claims 3
- 239000011707 mineral Substances 0.000 claims 3
- 206010033675 panniculitis Diseases 0.000 claims 3
- 201000002212 progressive supranuclear palsy Diseases 0.000 claims 3
- 230000035755 proliferation Effects 0.000 claims 3
- 235000018102 proteins Nutrition 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 201000010153 skin papilloma Diseases 0.000 claims 3
- 229940001941 soy protein Drugs 0.000 claims 3
- 210000004003 subcutaneous fat Anatomy 0.000 claims 3
- 238000013268 sustained release Methods 0.000 claims 3
- 239000012730 sustained-release form Substances 0.000 claims 3
- ZHUJMSMQIPIPTF-JMBSJVKXSA-N (2s)-2-[[(2s)-2-[[2-[[(2r)-2-[[(2s)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 ZHUJMSMQIPIPTF-JMBSJVKXSA-N 0.000 claims 2
- PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical compound C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 claims 2
- 208000031091 Amnestic disease Diseases 0.000 claims 2
- 206010006895 Cachexia Diseases 0.000 claims 2
- 206010011878 Deafness Diseases 0.000 claims 2
- 208000001708 Dupuytren contracture Diseases 0.000 claims 2
- 102000016942 Elastin Human genes 0.000 claims 2
- 108010014258 Elastin Proteins 0.000 claims 2
- OHCQJHSOBUTRHG-KGGHGJDLSA-N FORSKOLIN Chemical compound O=C([C@@]12O)C[C@](C)(C=C)O[C@]1(C)[C@@H](OC(=O)C)[C@@H](O)[C@@H]1[C@]2(C)[C@@H](O)CCC1(C)C OHCQJHSOBUTRHG-KGGHGJDLSA-N 0.000 claims 2
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 2
- 108010004889 Heat-Shock Proteins Proteins 0.000 claims 2
- 102000002812 Heat-Shock Proteins Human genes 0.000 claims 2
- 240000008669 Hedera helix Species 0.000 claims 2
- 208000032087 Hereditary Leber Optic Atrophy Diseases 0.000 claims 2
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims 2
- 201000000639 Leber hereditary optic neuropathy Diseases 0.000 claims 2
- 208000006136 Leigh Disease Diseases 0.000 claims 2
- 208000017507 Leigh syndrome Diseases 0.000 claims 2
- 201000002832 Lewy body dementia Diseases 0.000 claims 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 claims 2
- 208000001089 Multiple system atrophy Diseases 0.000 claims 2
- 206010051246 Photodermatosis Diseases 0.000 claims 2
- 208000000609 Pick Disease of the Brain Diseases 0.000 claims 2
- 108010039491 Ricin Proteins 0.000 claims 2
- GMBQZIIUCVWOCD-WWASVFFGSA-N Sarsapogenine Chemical compound O([C@@H]1[C@@H]([C@]2(CC[C@@H]3[C@@]4(C)CC[C@H](O)C[C@H]4CC[C@H]3[C@@H]2C1)C)[C@@H]1C)[C@]11CC[C@H](C)CO1 GMBQZIIUCVWOCD-WWASVFFGSA-N 0.000 claims 2
- 206010039710 Scleroderma Diseases 0.000 claims 2
- 206010039792 Seborrhoea Diseases 0.000 claims 2
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 claims 2
- 208000037065 Subacute sclerosing leukoencephalitis Diseases 0.000 claims 2
- 206010042297 Subacute sclerosing panencephalitis Diseases 0.000 claims 2
- 241000209140 Triticum Species 0.000 claims 2
- 235000021307 Triticum Nutrition 0.000 claims 2
- 201000004810 Vascular dementia Diseases 0.000 claims 2
- 208000000260 Warts Diseases 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 239000000853 adhesive Substances 0.000 claims 2
- 230000001070 adhesive effect Effects 0.000 claims 2
- 230000006986 amnesia Effects 0.000 claims 2
- 229960001948 caffeine Drugs 0.000 claims 2
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 229960004203 carnitine Drugs 0.000 claims 2
- 239000006071 cream Substances 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 238000012377 drug delivery Methods 0.000 claims 2
- 239000000975 dye Substances 0.000 claims 2
- 208000010118 dystonia Diseases 0.000 claims 2
- 229920002549 elastin Polymers 0.000 claims 2
- 229940011399 escin Drugs 0.000 claims 2
- 229930186222 escin Natural products 0.000 claims 2
- 239000000835 fiber Substances 0.000 claims 2
- 210000002950 fibroblast Anatomy 0.000 claims 2
- 239000000499 gel Substances 0.000 claims 2
- 235000011187 glycerol Nutrition 0.000 claims 2
- 239000008187 granular material Substances 0.000 claims 2
- 208000016354 hearing loss disease Diseases 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 2
- 210000002510 keratinocyte Anatomy 0.000 claims 2
- 230000037356 lipid metabolism Effects 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 239000006210 lotion Substances 0.000 claims 2
- 206010025135 lupus erythematosus Diseases 0.000 claims 2
- 208000030159 metabolic disease Diseases 0.000 claims 2
- 239000004530 micro-emulsion Substances 0.000 claims 2
- 235000013336 milk Nutrition 0.000 claims 2
- 239000008267 milk Substances 0.000 claims 2
- 210000004080 milk Anatomy 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 239000002088 nanocapsule Substances 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000008845 photoaging Effects 0.000 claims 2
- 239000000419 plant extract Substances 0.000 claims 2
- 230000008569 process Effects 0.000 claims 2
- 208000001076 sarcopenia Diseases 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 239000000377 silicon dioxide Substances 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 239000006188 syrup Substances 0.000 claims 2
- 235000020357 syrup Nutrition 0.000 claims 2
- 239000003826 tablet Substances 0.000 claims 2
- 230000000699 topical effect Effects 0.000 claims 2
- 229920001285 xanthan gum Polymers 0.000 claims 2
- 239000000230 xanthan gum Substances 0.000 claims 2
- 235000010493 xanthan gum Nutrition 0.000 claims 2
- 229940082509 xanthan gum Drugs 0.000 claims 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- ROTFCACGLKOUGI-JYJNAYRXSA-N (2s)-2-[[(2s)-2-[[(2s)-2-(3-acetamidopropanoylamino)-3-(1h-imidazol-5-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1h-imidazol-5-yl)propanoic acid Chemical compound C([C@H](NC(=O)CCNC(=O)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1NC=NC=1)C(O)=O)C1=CN=CN1 ROTFCACGLKOUGI-JYJNAYRXSA-N 0.000 claims 1
- OFGVZFQUFJYSGS-CPDXTSBQSA-N (2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-6-amino-2-[[(2s,3s)-2-[[(2s)-2-amino-3-hydroxypropanoyl]amino]-3-methylpentanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-3-methylbutanoic acid Chemical compound OC[C@H](N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(O)=O OFGVZFQUFJYSGS-CPDXTSBQSA-N 0.000 claims 1
- GIVDXZIVXCCQLT-AYZYUMGXSA-N (4S)-4-acetamido-7-(diaminomethylideneamino)-3-oxo-2-(N-(2,3,4-triphenylphenyl)anilino)heptanoic acid Chemical compound C(C)(=O)N[C@@H](CCCNC(N)=N)C(=O)C(N(C1=C(C(=C(C=C1)C1=CC=CC=C1)C1=CC=CC=C1)C1=CC=CC=C1)C1=CC=CC=C1)C(=O)O GIVDXZIVXCCQLT-AYZYUMGXSA-N 0.000 claims 1
- QGGBBQJHVCVVKM-XOBYPWAZSA-N (4s)-4-acetamido-5-[[(2s)-1-[[(2s)-1-[[(2s)-5-amino-1-[[(2s)-1-[[(2s)-1-[[(2s)-1-[[(2s)-1-amino-3-carboxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amin Chemical compound OC(=O)CC[C@H](NC(C)=O)C(=C)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(N)=O QGGBBQJHVCVVKM-XOBYPWAZSA-N 0.000 claims 1
- AJLNZWYOJAWBCR-OOPVGHQCSA-N (4s)-4-acetamido-5-[[(2s)-1-[[(2s)-1-[[(2s)-5-amino-1-[[(2s)-1-[[(2s)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-car Chemical compound OC(=O)CC[C@H](NC(C)=O)C(=C)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(N)=O AJLNZWYOJAWBCR-OOPVGHQCSA-N 0.000 claims 1
- RUZIUYOSRDWYQF-HNNXBMFYSA-N (S)-glaucine Chemical compound CN1CCC2=CC(OC)=C(OC)C3=C2[C@@H]1CC1=C3C=C(OC)C(OC)=C1 RUZIUYOSRDWYQF-HNNXBMFYSA-N 0.000 claims 1
- JPHRNERQGZBBPQ-UHFFFAOYSA-N 1-(7-methoxy-2,2-dimethyl-3,4-dihydrochromen-6-yl)hexadecan-1-one Chemical compound C1CC(C)(C)OC2=C1C=C(C(=O)CCCCCCCCCCCCCCC)C(OC)=C2 JPHRNERQGZBBPQ-UHFFFAOYSA-N 0.000 claims 1
- KFLKTDAONDZLAN-UHFFFAOYSA-N 2-(n-phenylanilino)acetic acid Chemical compound C=1C=CC=CC=1N(CC(=O)O)C1=CC=CC=C1 KFLKTDAONDZLAN-UHFFFAOYSA-N 0.000 claims 1
- 102000008490 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine Human genes 0.000 claims 1
- 108010020504 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine Proteins 0.000 claims 1
- 239000002677 5-alpha reductase inhibitor Substances 0.000 claims 1
- WOTJLFCDHRGDBB-UHFFFAOYSA-N 5-chloro-2h-pyrazolo[3,4-b]pyridin-3-amine Chemical compound N1=CC(Cl)=CC2=C(N)NN=C21 WOTJLFCDHRGDBB-UHFFFAOYSA-N 0.000 claims 1
- JXPHIHWXMBYJAU-UHFFFAOYSA-N 7-methoxy-2,2-dimethyl-3,4-dihydrochromen-6-ol Chemical compound O1C(C)(C)CCC2=C1C=C(OC)C(O)=C2 JXPHIHWXMBYJAU-UHFFFAOYSA-N 0.000 claims 1
- 235000007173 Abies balsamea Nutrition 0.000 claims 1
- 229940100578 Acetylcholinesterase inhibitor Drugs 0.000 claims 1
- 206010000503 Acne cystic Diseases 0.000 claims 1
- PLXMOAALOJOTIY-FPTXNFDTSA-N Aesculin Natural products OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1Oc2cc3C=CC(=O)Oc3cc2O PLXMOAALOJOTIY-FPTXNFDTSA-N 0.000 claims 1
- 208000017194 Affective disease Diseases 0.000 claims 1
- 206010001541 Akinesia Diseases 0.000 claims 1
- 241000605447 Anemarrhena Species 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 102000010637 Aquaporins Human genes 0.000 claims 1
- 108010063290 Aquaporins Proteins 0.000 claims 1
- 206010003840 Autonomic nervous system imbalance Diseases 0.000 claims 1
- 239000004857 Balsam Substances 0.000 claims 1
- 235000017166 Bambusa arundinacea Nutrition 0.000 claims 1
- 235000017491 Bambusa tulda Nutrition 0.000 claims 1
- 102100022548 Beta-hexosaminidase subunit alpha Human genes 0.000 claims 1
- 241000195940 Bryophyta Species 0.000 claims 1
- 206010068597 Bulbospinal muscular atrophy congenital Diseases 0.000 claims 1
- SNCIAAAFBLUWEE-NMTVEPIMSA-N CSCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(C)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(O)=O Chemical compound CSCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(C)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(O)=O SNCIAAAFBLUWEE-NMTVEPIMSA-N 0.000 claims 1
- 208000035484 Cellulite Diseases 0.000 claims 1
- 244000146462 Centella asiatica Species 0.000 claims 1
- 235000004032 Centella asiatica Nutrition 0.000 claims 1
- 206010008025 Cerebellar ataxia Diseases 0.000 claims 1
- 206010008111 Cerebral haemorrhage Diseases 0.000 claims 1
- 101710163595 Chaperone protein DnaK Proteins 0.000 claims 1
- 108010009685 Cholinergic Receptors Proteins 0.000 claims 1
- 241000206576 Chondrus Species 0.000 claims 1
- WNBCMONIPIJTSB-BGNCJLHMSA-N Cichoriin Natural products O([C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1)c1c(O)cc2c(OC(=O)C=C2)c1 WNBCMONIPIJTSB-BGNCJLHMSA-N 0.000 claims 1
- 208000033647 Classic progressive supranuclear palsy syndrome Diseases 0.000 claims 1
- 240000007154 Coffea arabica Species 0.000 claims 1
- 235000007460 Coffea arabica Nutrition 0.000 claims 1
- 235000005320 Coleus barbatus Nutrition 0.000 claims 1
- 208000020406 Creutzfeldt Jacob disease Diseases 0.000 claims 1
- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 claims 1
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 claims 1
- 229920000858 Cyclodextrin Polymers 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 230000033616 DNA repair Effects 0.000 claims 1
- 208000001840 Dandruff Diseases 0.000 claims 1
- 208000002506 Darier Disease Diseases 0.000 claims 1
- 102000004237 Decorin Human genes 0.000 claims 1
- 108090000738 Decorin Proteins 0.000 claims 1
- 102000000541 Defensins Human genes 0.000 claims 1
- 108010002069 Defensins Proteins 0.000 claims 1
- 206010067889 Dementia with Lewy bodies Diseases 0.000 claims 1
- 208000016192 Demyelinating disease Diseases 0.000 claims 1
- SUZLHDUTVMZSEV-UHFFFAOYSA-N Deoxycoleonol Natural products C12C(=O)CC(C)(C=C)OC2(C)C(OC(=O)C)C(O)C2C1(C)C(O)CCC2(C)C SUZLHDUTVMZSEV-UHFFFAOYSA-N 0.000 claims 1
- 206010048768 Dermatosis Diseases 0.000 claims 1
- 208000012184 Diffuse Brain injury Diseases 0.000 claims 1
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims 1
- 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 claims 1
- 208000014094 Dystonic disease Diseases 0.000 claims 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 1
- 229940122858 Elastase inhibitor Drugs 0.000 claims 1
- 206010016228 Fasciitis Diseases 0.000 claims 1
- 208000003241 Fat Embolism Diseases 0.000 claims 1
- 102000016359 Fibronectins Human genes 0.000 claims 1
- 108010067306 Fibronectins Proteins 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 208000003736 Gerstmann-Straussler-Scheinker Disease Diseases 0.000 claims 1
- 206010072075 Gerstmann-Straussler-Scheinker syndrome Diseases 0.000 claims 1
- DABPOQZSGVNAAS-UHFFFAOYSA-N Glaucocalactone Natural products O=CC12C3C(C4)OC(=O)C2C(C)(C)CCC1OC(=O)C13CC4C(=C)C1OC(=O)C DABPOQZSGVNAAS-UHFFFAOYSA-N 0.000 claims 1
- 206010019196 Head injury Diseases 0.000 claims 1
- 101710178376 Heat shock 70 kDa protein Proteins 0.000 claims 1
- 101710152018 Heat shock cognate 70 kDa protein Proteins 0.000 claims 1
- 208000002972 Hepatolenticular Degeneration Diseases 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 108090000604 Hydrolases Proteins 0.000 claims 1
- 102000004157 Hydrolases Human genes 0.000 claims 1
- 244000018716 Impatiens biflora Species 0.000 claims 1
- 208000027747 Kennedy disease Diseases 0.000 claims 1
- 206010023369 Keratosis follicular Diseases 0.000 claims 1
- 208000006264 Korsakoff syndrome Diseases 0.000 claims 1
- 206010024229 Leprosy Diseases 0.000 claims 1
- 208000034800 Leukoencephalopathies Diseases 0.000 claims 1
- 239000004367 Lipase Substances 0.000 claims 1
- 102000004882 Lipase Human genes 0.000 claims 1
- 108090001060 Lipase Proteins 0.000 claims 1
- 206010049287 Lipodystrophy acquired Diseases 0.000 claims 1
- WGCKDDHUFPQSMZ-ZPFDUUQYSA-N Lys-Asp-Ile Chemical compound CC[C@H](C)[C@@H](C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)CCCCN WGCKDDHUFPQSMZ-ZPFDUUQYSA-N 0.000 claims 1
- 208000002569 Machado-Joseph Disease Diseases 0.000 claims 1
- 229920002774 Maltodextrin Polymers 0.000 claims 1
- 239000005913 Maltodextrin Substances 0.000 claims 1
- 206010026749 Mania Diseases 0.000 claims 1
- 206010027145 Melanocytic naevus Diseases 0.000 claims 1
- 208000026139 Memory disease Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 208000035155 Mitochondrial DNA-associated Leigh syndrome Diseases 0.000 claims 1
- 239000004909 Moisturizer Substances 0.000 claims 1
- 108010006519 Molecular Chaperones Proteins 0.000 claims 1
- 241000108056 Monas Species 0.000 claims 1
- 208000019022 Mood disease Diseases 0.000 claims 1
- 208000016285 Movement disease Diseases 0.000 claims 1
- 208000002537 Neuronal Ceroid-Lipofuscinoses Diseases 0.000 claims 1
- 208000007256 Nevus Diseases 0.000 claims 1
- 102000008299 Nitric Oxide Synthase Human genes 0.000 claims 1
- 108010021487 Nitric Oxide Synthase Proteins 0.000 claims 1
- 241000238413 Octopus Species 0.000 claims 1
- 240000007817 Olea europaea Species 0.000 claims 1
- 102000000536 PPAR gamma Human genes 0.000 claims 1
- 108010016731 PPAR gamma Proteins 0.000 claims 1
- 206010033892 Paraplegia Diseases 0.000 claims 1
- 206010049752 Peau d'orange Diseases 0.000 claims 1
- 206010034277 Pemphigoid Diseases 0.000 claims 1
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 claims 1
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 claims 1
- 244000082204 Phyllostachys viridis Species 0.000 claims 1
- 235000015334 Phyllostachys viridis Nutrition 0.000 claims 1
- 208000024571 Pick disease Diseases 0.000 claims 1
- 208000012641 Pigmentation disease Diseases 0.000 claims 1
- 241000131459 Plectranthus barbatus Species 0.000 claims 1
- 208000032319 Primary lateral sclerosis Diseases 0.000 claims 1
- 208000024777 Prion disease Diseases 0.000 claims 1
- 102000004079 Prolyl Hydroxylases Human genes 0.000 claims 1
- 108010043005 Prolyl Hydroxylases Proteins 0.000 claims 1
- 229940123575 Protein synthesis stimulant Drugs 0.000 claims 1
- 208000033526 Proximal spinal muscular atrophy type 3 Diseases 0.000 claims 1
- 208000007014 Retinitis pigmentosa Diseases 0.000 claims 1
- 241000220317 Rosa Species 0.000 claims 1
- 240000008530 Rosa canina Species 0.000 claims 1
- 235000000539 Rosa canina Nutrition 0.000 claims 1
- 244000050054 Rosa moschata Species 0.000 claims 1
- 235000000657 Rosa moschata Nutrition 0.000 claims 1
- 241000605385 Ruscus Species 0.000 claims 1
- 208000021811 Sandhoff disease Diseases 0.000 claims 1
- 206010039796 Seborrhoeic keratosis Diseases 0.000 claims 1
- 206010039966 Senile dementia Diseases 0.000 claims 1
- 229940122055 Serine protease inhibitor Drugs 0.000 claims 1
- 101710102218 Serine protease inhibitor Proteins 0.000 claims 1
- 102000011990 Sirtuin Human genes 0.000 claims 1
- 108050002485 Sirtuin Proteins 0.000 claims 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 1
- 206010041290 Soft tissue inflammation Diseases 0.000 claims 1
- 208000005392 Spasm Diseases 0.000 claims 1
- 208000003954 Spinal Muscular Atrophies of Childhood Diseases 0.000 claims 1
- 208000036834 Spinocerebellar ataxia type 3 Diseases 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- 229910000831 Steel Inorganic materials 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000005716 Subacute Combined Degeneration Diseases 0.000 claims 1
- 208000032859 Synucleinopathies Diseases 0.000 claims 1
- 208000022292 Tay-Sachs disease Diseases 0.000 claims 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims 1
- RTMWIZOXNKJHRE-UHFFFAOYSA-N Tigogenin Natural products CC1COC2CC(C)(OC12)C3CCC4C5CCC6CC(O)CCC6(C)C5CCC34C RTMWIZOXNKJHRE-UHFFFAOYSA-N 0.000 claims 1
- 208000000323 Tourette Syndrome Diseases 0.000 claims 1
- 208000016620 Tourette disease Diseases 0.000 claims 1
- 206010046298 Upper motor neurone lesion Diseases 0.000 claims 1
- 206010063661 Vascular encephalopathy Diseases 0.000 claims 1
- GVBNSPFBYXGREE-CXWAGAITSA-N Visnadin Chemical compound C1=CC(=O)OC2=C1C=CC1=C2[C@@H](OC(C)=O)[C@@H](OC(=O)[C@H](C)CC)C(C)(C)O1 GVBNSPFBYXGREE-CXWAGAITSA-N 0.000 claims 1
- GVBNSPFBYXGREE-UHFFFAOYSA-N Visnadine Natural products C1=CC(=O)OC2=C1C=CC1=C2C(OC(C)=O)C(OC(=O)C(C)CC)C(C)(C)O1 GVBNSPFBYXGREE-UHFFFAOYSA-N 0.000 claims 1
- 206010047642 Vitiligo Diseases 0.000 claims 1
- 201000008485 Wernicke-Korsakoff syndrome Diseases 0.000 claims 1
- 208000018839 Wilson disease Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 208000006269 X-Linked Bulbo-Spinal Atrophy Diseases 0.000 claims 1
- 206010048222 Xerosis Diseases 0.000 claims 1
- 101000998548 Yersinia ruckeri Alkaline proteinase inhibitor Proteins 0.000 claims 1
- 229940095094 acetyl hexapeptide-8 Drugs 0.000 claims 1
- 229940078033 acetyl octapeptide-3 Drugs 0.000 claims 1
- 108010006338 acetyl-glutamyl-glutamyl-methionyl-glutaminyl-arginyl-argininamide Proteins 0.000 claims 1
- 102000034337 acetylcholine receptors Human genes 0.000 claims 1
- 208000009621 actinic keratosis Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 230000002776 aggregation Effects 0.000 claims 1
- 238000004220 aggregation Methods 0.000 claims 1
- 238000003915 air pollution Methods 0.000 claims 1
- 208000004631 alopecia areata Diseases 0.000 claims 1
- 229940061720 alpha hydroxy acid Drugs 0.000 claims 1
- 150000001280 alpha hydroxy acids Chemical class 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 201000008257 amyotrophic lateral sclerosis type 1 Diseases 0.000 claims 1
- 229930191283 anemarrhena Natural products 0.000 claims 1
- 229940035674 anesthetics Drugs 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 claims 1
- 230000001078 anti-cholinergic effect Effects 0.000 claims 1
- 230000000843 anti-fungal effect Effects 0.000 claims 1
- 230000001387 anti-histamine Effects 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 230000002141 anti-parasite Effects 0.000 claims 1
- 230000001166 anti-perspirative effect Effects 0.000 claims 1
- 230000000840 anti-viral effect Effects 0.000 claims 1
- 239000003472 antidiabetic agent Substances 0.000 claims 1
- 229940125708 antidiabetic agent Drugs 0.000 claims 1
- 239000003429 antifungal agent Substances 0.000 claims 1
- 229940121375 antifungal agent Drugs 0.000 claims 1
- 239000000739 antihistaminic agent Substances 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 239000003096 antiparasitic agent Substances 0.000 claims 1
- 239000003213 antiperspirant Substances 0.000 claims 1
- 239000003908 antipruritic agent Substances 0.000 claims 1
- 239000002249 anxiolytic agent Substances 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 239000000022 bacteriostatic agent Substances 0.000 claims 1
- 239000011425 bamboo Substances 0.000 claims 1
- 239000000440 bentonite Substances 0.000 claims 1
- 229910000278 bentonite Inorganic materials 0.000 claims 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims 1
- 150000001277 beta hydroxy acids Chemical class 0.000 claims 1
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 229920001222 biopolymer Polymers 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 claims 1
- 208000000594 bullous pemphigoid Diseases 0.000 claims 1
- 210000001217 buttock Anatomy 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 239000000679 carrageenan Substances 0.000 claims 1
- 235000010418 carrageenan Nutrition 0.000 claims 1
- 229920001525 carrageenan Polymers 0.000 claims 1
- 229940113118 carrageenan Drugs 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000019522 cellular metabolic process Effects 0.000 claims 1
- 229940106189 ceramide Drugs 0.000 claims 1
- 150000001783 ceramides Chemical class 0.000 claims 1
- 206010008118 cerebral infarction Diseases 0.000 claims 1
- 208000026106 cerebrovascular disease Diseases 0.000 claims 1
- 230000008859 change Effects 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- 229940112822 chewing gum Drugs 0.000 claims 1
- 235000015218 chewing gum Nutrition 0.000 claims 1
- 239000000544 cholinesterase inhibitor Substances 0.000 claims 1
- 230000003081 coactivator Effects 0.000 claims 1
- 239000000701 coagulant Substances 0.000 claims 1
- 239000005515 coenzyme Substances 0.000 claims 1
- OHCQJHSOBUTRHG-UHFFFAOYSA-N colforsin Natural products OC12C(=O)CC(C)(C=C)OC1(C)C(OC(=O)C)C(O)C1C2(C)C(O)CCC1(C)C OHCQJHSOBUTRHG-UHFFFAOYSA-N 0.000 claims 1
- 230000011382 collagen catabolic process Effects 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 235000008504 concentrate Nutrition 0.000 claims 1
- 239000012141 concentrate Substances 0.000 claims 1
- 230000001054 cortical effect Effects 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 229940097362 cyclodextrins Drugs 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 208000024515 deafness dystonia syndrome Diseases 0.000 claims 1
- 201000008696 deafness-dystonia-optic neuronopathy syndrome Diseases 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 230000018044 dehydration Effects 0.000 claims 1
- 238000006297 dehydration reaction Methods 0.000 claims 1
- 230000001934 delay Effects 0.000 claims 1
- 239000003405 delayed action preparation Substances 0.000 claims 1
- 239000007854 depigmenting agent Substances 0.000 claims 1
- 238000000151 deposition Methods 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 229940117973 dimethylmethoxy chromanol Drugs 0.000 claims 1
- 229940017184 dimethylmethoxy chromanyl palmitate Drugs 0.000 claims 1
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 239000008298 dragée Substances 0.000 claims 1
- 239000002961 echo contrast media Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000003602 elastase inhibitor Substances 0.000 claims 1
- 238000001962 electrophoresis Methods 0.000 claims 1
- 238000004520 electroporation Methods 0.000 claims 1
- 239000003974 emollient agent Substances 0.000 claims 1
- 239000003995 emulsifying agent Substances 0.000 claims 1
- 206010014599 encephalitis Diseases 0.000 claims 1
- 230000002124 endocrine Effects 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 230000001037 epileptic effect Effects 0.000 claims 1
- 229940093496 esculin Drugs 0.000 claims 1
- XHCADAYNFIFUHF-TVKJYDDYSA-N esculin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C(=C1)O)=CC2=C1OC(=O)C=C2 XHCADAYNFIFUHF-TVKJYDDYSA-N 0.000 claims 1
- AWRMZKLXZLNBBK-UHFFFAOYSA-N esculin Natural products OC1OC(COc2cc3C=CC(=O)Oc3cc2O)C(O)C(O)C1O AWRMZKLXZLNBBK-UHFFFAOYSA-N 0.000 claims 1
- 210000000744 eyelid Anatomy 0.000 claims 1
- 230000001815 facial effect Effects 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 238000000855 fermentation Methods 0.000 claims 1
- 230000004151 fermentation Effects 0.000 claims 1
- 239000010408 film Substances 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 239000003205 fragrance Substances 0.000 claims 1
- 210000001652 frontal lobe Anatomy 0.000 claims 1
- 235000013376 functional food Nutrition 0.000 claims 1
- 230000000855 fungicidal effect Effects 0.000 claims 1
- 239000000417 fungicide Substances 0.000 claims 1
- 230000001408 fungistatic effect Effects 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000007903 gelatin capsule Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 239000003193 general anesthetic agent Substances 0.000 claims 1
- 229940113086 glaucine Drugs 0.000 claims 1
- 229930004041 glaucine Natural products 0.000 claims 1
- 230000004110 gluconeogenesis Effects 0.000 claims 1
- 229930182478 glucoside Natural products 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 229960005150 glycerol Drugs 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 210000003780 hair follicle Anatomy 0.000 claims 1
- 230000003779 hair growth Effects 0.000 claims 1
- 239000007902 hard capsule Substances 0.000 claims 1
- 230000035876 healing Effects 0.000 claims 1
- 239000013003 healing agent Substances 0.000 claims 1
- 230000010370 hearing loss Effects 0.000 claims 1
- 231100000888 hearing loss Toxicity 0.000 claims 1
- 239000003906 humectant Substances 0.000 claims 1
- 210000004276 hyalin Anatomy 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 239000000017 hydrogel Substances 0.000 claims 1
- 208000013403 hyperactivity Diseases 0.000 claims 1
- 206010021198 ichthyosis Diseases 0.000 claims 1
- 239000000411 inducer Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 206010022437 insomnia Diseases 0.000 claims 1
- 235000015110 jellies Nutrition 0.000 claims 1
- 239000008274 jelly Substances 0.000 claims 1
- 201000004815 juvenile spinal muscular atrophy Diseases 0.000 claims 1
- 230000003780 keratinization Effects 0.000 claims 1
- 239000003410 keratolytic agent Substances 0.000 claims 1
- 201000004607 keratosis follicularis Diseases 0.000 claims 1
- 206010023497 kuru Diseases 0.000 claims 1
- 201000010901 lateral sclerosis Diseases 0.000 claims 1
- 230000028252 learning or memory Effects 0.000 claims 1
- 208000002741 leukoplakia Diseases 0.000 claims 1
- 201000011486 lichen planus Diseases 0.000 claims 1
- 235000019421 lipase Nutrition 0.000 claims 1
- 229940040461 lipase Drugs 0.000 claims 1
- 208000006132 lipodystrophy Diseases 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 229940035034 maltodextrin Drugs 0.000 claims 1
- 238000007726 management method Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 208000003531 maternally-inherited Leigh syndrome Diseases 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 235000013372 meat Nutrition 0.000 claims 1
- 210000002752 melanocyte Anatomy 0.000 claims 1
- 230000006984 memory degeneration Effects 0.000 claims 1
- 206010027175 memory impairment Diseases 0.000 claims 1
- 208000023060 memory loss Diseases 0.000 claims 1
- 230000002503 metabolic effect Effects 0.000 claims 1
- 239000003475 metalloproteinase inhibitor Substances 0.000 claims 1
- 239000003094 microcapsule Substances 0.000 claims 1
- 230000004089 microcirculation Effects 0.000 claims 1
- 238000000520 microinjection Methods 0.000 claims 1
- 239000011859 microparticle Substances 0.000 claims 1
- 239000004005 microsphere Substances 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 230000001333 moisturizer Effects 0.000 claims 1
- 150000002772 monosaccharides Chemical group 0.000 claims 1
- 230000036651 mood Effects 0.000 claims 1
- 235000011929 mousse Nutrition 0.000 claims 1
- 210000004877 mucosa Anatomy 0.000 claims 1
- 230000004118 muscle contraction Effects 0.000 claims 1
- 230000003387 muscular Effects 0.000 claims 1
- 201000000585 muscular atrophy Diseases 0.000 claims 1
- 206010028417 myasthenia gravis Diseases 0.000 claims 1
- 239000007908 nanoemulsion Substances 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 239000002077 nanosphere Substances 0.000 claims 1
- 230000002956 necrotizing effect Effects 0.000 claims 1
- 208000029522 neoplastic syndrome Diseases 0.000 claims 1
- 210000004126 nerve fiber Anatomy 0.000 claims 1
- 210000000653 nervous system Anatomy 0.000 claims 1
- 230000001537 neural effect Effects 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 239000002353 niosome Substances 0.000 claims 1
- 239000004745 nonwoven fabric Substances 0.000 claims 1
- 208000030459 obsessive-compulsive personality disease Diseases 0.000 claims 1
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 claims 1
- 239000003921 oil Substances 0.000 claims 1
- 235000019198 oils Nutrition 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 210000001328 optic nerve Anatomy 0.000 claims 1
- 229920000620 organic polymer Polymers 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 230000003204 osmotic effect Effects 0.000 claims 1
- 208000021090 palsy Diseases 0.000 claims 1
- 208000019906 panic disease Diseases 0.000 claims 1
- 208000003154 papilloma Diseases 0.000 claims 1
- 208000029211 papillomatosis Diseases 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 230000035699 permeability Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 150000003904 phospholipids Chemical class 0.000 claims 1
- 230000003711 photoprotective effect Effects 0.000 claims 1
- 239000000049 pigment Substances 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 208000001282 primary progressive aphasia Diseases 0.000 claims 1
- 208000032207 progressive 1 supranuclear palsy Diseases 0.000 claims 1
- 206010036807 progressive multifocal leukoencephalopathy Diseases 0.000 claims 1
- 239000003380 propellant Substances 0.000 claims 1
- 239000002516 radical scavenger Substances 0.000 claims 1
- 210000001732 sebaceous gland Anatomy 0.000 claims 1
- 201000003779 seborrheic infantile dermatitis Diseases 0.000 claims 1
- 201000003385 seborrheic keratosis Diseases 0.000 claims 1
- 210000002374 sebum Anatomy 0.000 claims 1
- 229940125723 sedative agent Drugs 0.000 claims 1
- 239000000932 sedative agent Substances 0.000 claims 1
- 230000037307 sensitive skin Effects 0.000 claims 1
- 239000003001 serine protease inhibitor Substances 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 239000002453 shampoo Substances 0.000 claims 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 206010040882 skin lesion Diseases 0.000 claims 1
- 231100000444 skin lesion Toxicity 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
- 239000000344 soap Substances 0.000 claims 1
- 239000007901 soft capsule Substances 0.000 claims 1
- 239000002047 solid lipid nanoparticle Substances 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 210000000278 spinal cord Anatomy 0.000 claims 1
- 208000020431 spinal cord injury Diseases 0.000 claims 1
- 208000002320 spinal muscular atrophy Diseases 0.000 claims 1
- 208000019929 sporadic amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 239000010959 steel Substances 0.000 claims 1
- 210000000434 stratum corneum Anatomy 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 208000011117 substance-related disease Diseases 0.000 claims 1
- 210000003523 substantia nigra Anatomy 0.000 claims 1
- 230000000475 sunscreen effect Effects 0.000 claims 1
- 239000000516 sunscreening agent Substances 0.000 claims 1
- 239000000454 talc Substances 0.000 claims 1
- 229910052623 talc Inorganic materials 0.000 claims 1
- 239000004753 textile Substances 0.000 claims 1
- 239000002562 thickening agent Substances 0.000 claims 1
- 239000012929 tonicity agent Substances 0.000 claims 1
- 229960000716 tonics Drugs 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
- 208000018726 traumatic encephalopathy Diseases 0.000 claims 1
- 208000032527 type III spinal muscular atrophy Diseases 0.000 claims 1
- 238000002604 ultrasonography Methods 0.000 claims 1
- 210000000689 upper leg Anatomy 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 239000000341 volatile oil Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022128627A JP7467543B2 (ja) | 2016-01-13 | 2022-08-12 | ＰＧＣ－１αの発現を増加させる組成物 |
| JP2024059854A JP2024081767A (ja) | 2016-01-13 | 2024-04-03 | ＰＧＣ－１αの発現を増加させる組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20160004383 | 2016-01-13 | ||
| KR10-2016-0004383 | 2016-01-13 | ||
| PCT/KR2017/000505 WO2017123066A1 (ko) | 2016-01-13 | 2017-01-13 | Pgc-1알파의 발현을 증가시키는 조성물 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022128627A Division JP7467543B2 (ja) | 2016-01-13 | 2022-08-12 | ＰＧＣ－１αの発現を増加させる組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019502718A JP2019502718A (ja) | 2019-01-31 |
| JP2019502718A5 true JP2019502718A5 (enExample) | 2020-02-20 |
| JP7125348B2 JP7125348B2 (ja) | 2022-08-24 |
Family
ID=59311711
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018536439A Active JP7125348B2 (ja) | 2016-01-13 | 2017-01-13 | ＰＧＣ－１αの発現を増加させる組成物 |
| JP2022128627A Active JP7467543B2 (ja) | 2016-01-13 | 2022-08-12 | ＰＧＣ－１αの発現を増加させる組成物 |
| JP2024059854A Pending JP2024081767A (ja) | 2016-01-13 | 2024-04-03 | ＰＧＣ－１αの発現を増加させる組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022128627A Active JP7467543B2 (ja) | 2016-01-13 | 2022-08-12 | ＰＧＣ－１αの発現を増加させる組成物 |
| JP2024059854A Pending JP2024081767A (ja) | 2016-01-13 | 2024-04-03 | ＰＧＣ－１αの発現を増加させる組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20190030053A1 (enExample) |
| EP (2) | EP3403655B1 (enExample) |
| JP (3) | JP7125348B2 (enExample) |
| KR (3) | KR20180099885A (enExample) |
| CN (3) | CN120643579A (enExample) |
| CA (2) | CA3010338C (enExample) |
| ES (1) | ES2946945T3 (enExample) |
| HK (1) | HK1257689A1 (enExample) |
| MX (2) | MX389553B (enExample) |
| MY (1) | MY197561A (enExample) |
| SG (1) | SG11201805791RA (enExample) |
| WO (1) | WO2017123066A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3498282A1 (en) * | 2017-12-12 | 2019-06-19 | Rheinische Friedrich-Wilhelms-Universität Bonn | 6'-sialyllactose for use in the treatment of hearing loss |
| US11234992B2 (en) * | 2018-02-28 | 2022-02-01 | The Regents Of The University Of California | Methods and therapies for treating atherosclerosis and/or hyperlipidemia using oligosaccharides |
| AU2020230410A1 (en) * | 2019-03-05 | 2021-09-02 | Société des Produits Nestlé S.A. | A nutritional composition for use to enhance executive function |
| MX2021010289A (es) * | 2019-03-05 | 2022-02-10 | Glycom As | Oligosacaridos de leche humana para uso en el mejoramiento de la funcion ejecutiva. |
| JP2021038147A (ja) * | 2019-08-30 | 2021-03-11 | 国立大学法人 鹿児島大学 | ミトコンドリア生合成促進剤 |
| KR102186761B1 (ko) * | 2020-06-03 | 2020-12-04 | 옙바이오 주식회사 | 2-(4-(1-하이드록시프로판-2-일)페닐)이소인돌린-1-온 화합물을 포함하는 파킨슨병 예방 또는 치료용 약학적 조성물 |
| GB202114190D0 (en) * | 2021-10-04 | 2021-11-17 | Mjn Us Holdings Llc | Compositions for preventing and/or treating demyelination |
| CN121100111A (zh) * | 2023-06-02 | 2025-12-09 | 兹杜斯生命科学有限公司 | 用于肌萎缩侧索硬化(als)的治疗 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5164374A (en) * | 1990-12-17 | 1992-11-17 | Monsanto Company | Use of oligosaccharides for treatment of arthritis |
| JPH07258093A (ja) * | 1994-03-23 | 1995-10-09 | Morinaga Milk Ind Co Ltd | 神経成長因子様剤 |
| KR101116864B1 (ko) * | 2008-08-01 | 2012-02-29 | 주식회사 베네비오 | 고지혈증, 지방간 또는 비만의 예방 또는 치료용 조성물 |
| KR101112051B1 (ko) * | 2009-04-09 | 2012-02-14 | 주식회사 베네비오 | 비후성 반흔 또는 켈로이드 예방 또는 치료용 조성물 |
| KR20110092602A (ko) * | 2010-02-09 | 2011-08-18 | 주식회사 베네비오 | 플라스미노겐 활성 억제인자-1의 억제제 |
| SG10202110501RA (en) * | 2010-12-31 | 2021-11-29 | Abbott Lab | Methods For Decreasing The Incidence Of Necrotizing Enterocolitis In Infants, Toddlers, Or Children Using Human Milk Oligosaccharides |
| DE112013004483T5 (de) * | 2012-09-14 | 2015-06-03 | Robert Bosch Gmbh | Überprüfung einer Vorrichtung unter Verwenden eines Versperrens einer akustischen Öffnung |
| TW201438719A (zh) * | 2012-12-18 | 2014-10-16 | Abbott Lab | 改善壓力症狀之母乳寡糖 |
| WO2014100191A1 (en) * | 2012-12-18 | 2014-06-26 | Abbott Laboratories | Nutritional compositions comprising neuroprotective dietary oligosaccharides |
| DE102013208103A1 (de) | 2013-05-03 | 2014-11-06 | Siemens Aktiengesellschaft | Röntgenquelle und bildgebendes System |
| WO2016145628A1 (en) * | 2015-03-18 | 2016-09-22 | Nestec S.A. | Composition comprising siallyllactose for use in enhancing learning skills and memory function |
-
2017
- 2017-01-13 MY MYPI2018702452A patent/MY197561A/en unknown
- 2017-01-13 US US16/069,972 patent/US20190030053A1/en active Pending
- 2017-01-13 CN CN202511095571.2A patent/CN120643579A/zh active Pending
- 2017-01-13 CA CA3010338A patent/CA3010338C/en active Active
- 2017-01-13 CN CN201780006641.XA patent/CN108472305A/zh active Pending
- 2017-01-13 EP EP17738695.0A patent/EP3403655B1/en active Active
- 2017-01-13 CA CA3203927A patent/CA3203927A1/en active Pending
- 2017-01-13 JP JP2018536439A patent/JP7125348B2/ja active Active
- 2017-01-13 EP EP21154787.2A patent/EP3845233A1/en active Pending
- 2017-01-13 KR KR1020187023369A patent/KR20180099885A/ko not_active Ceased
- 2017-01-13 KR KR1020217017487A patent/KR20210079376A/ko not_active Ceased
- 2017-01-13 HK HK19100055.1A patent/HK1257689A1/zh unknown
- 2017-01-13 KR KR1020237023071A patent/KR102771814B1/ko active Active
- 2017-01-13 WO PCT/KR2017/000505 patent/WO2017123066A1/ko not_active Ceased
- 2017-01-13 MX MX2018008671A patent/MX389553B/es unknown
- 2017-01-13 SG SG11201805791RA patent/SG11201805791RA/en unknown
- 2017-01-13 ES ES17738695T patent/ES2946945T3/es active Active
- 2017-01-13 CN CN202511095689.5A patent/CN120661527A/zh active Pending
-
2018
- 2018-07-13 MX MX2022000945A patent/MX2022000945A/es unknown
-
2022
- 2022-08-12 JP JP2022128627A patent/JP7467543B2/ja active Active
-
2024
- 2024-04-03 JP JP2024059854A patent/JP2024081767A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019502718A5 (enExample) | ||
| CA2604962C (en) | Personal care compositions comprising a dipeptide | |
| TWI407976B (zh) | 色素調節化合物 | |
| JP2016519105A5 (enExample) | ||
| RU2012118581A (ru) | Пептиды, используемые в лечении и/или наблюдении за кожей, слизистыми оболочками и/или волосами, и их применение в косметических или фармацевтических композициях | |
| JP2016502550A5 (enExample) | ||
| JP2015514721A5 (enExample) | ||
| JP2015514722A5 (enExample) | ||
| JP2019502677A5 (enExample) | ||
| JP2015514124A5 (enExample) | ||
| KR101510092B1 (ko) | 복분자 씨 추출물을 유효성분으로 함유하는 미백 및 피부노화의 예방 및 치료용 조성물 | |
| CA3010338C (en) | Composition for increasing expression of pgc-1a | |
| JP2015514125A5 (enExample) | ||
| KR100828193B1 (ko) | 연 추출물을 함유하는 미백, 노화방지 및 주름개선용조성물 | |
| WO2004103334A1 (en) | Slimming cosmetic composition comprising cafestol or kahweol | |
| US20110059892A1 (en) | Cosmetic preparations containing PTH fragments | |
| EP1273285A2 (de) | Verwendung von 5'-Desoxy-5'-methylthioadenosin in hautkosmetischen Mitteln | |
| JP3900388B2 (ja) | 美白剤および美白化粧料 | |
| KR20210060801A (ko) | 식물 복합 발효물을 유효성분으로 포함하는 항노화 화장료 조성물 | |
| JP5113756B2 (ja) | 新規カルボン酸誘導体 | |
| KR20210051673A (ko) | 황기 발효물을 유효성분으로 포함하는 항노화 화장료 조성물 | |
| WO2025114961A1 (en) | Methods to counteract skin aging | |
| JP3526806B2 (ja) | 化粧料 | |
| CN118234480A (zh) | 局部组合物和其用途 | |
| JP2022044101A (ja) | ニキビ改善用組成物 |