JP2019500324A5 - - Google Patents
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- JP2019500324A5 JP2019500324A5 JP2018522968A JP2018522968A JP2019500324A5 JP 2019500324 A5 JP2019500324 A5 JP 2019500324A5 JP 2018522968 A JP2018522968 A JP 2018522968A JP 2018522968 A JP2018522968 A JP 2018522968A JP 2019500324 A5 JP2019500324 A5 JP 2019500324A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- disulfide
- deoxynucleoside triphosphate
- labeled
- deoxynucleoside
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562251884P | 2015-11-06 | 2015-11-06 | |
| US62/251,884 | 2015-11-06 | ||
| US201662327555P | 2016-04-26 | 2016-04-26 | |
| US62/327,555 | 2016-04-26 | ||
| PCT/US2016/060435 WO2017079498A2 (en) | 2015-11-06 | 2016-11-04 | Nucleotide analogues |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020168502A Division JP7119041B2 (ja) | 2015-11-06 | 2020-10-05 | Ｄｎａ配列において標識されたヌクレオチドを検出する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019500324A JP2019500324A (ja) | 2019-01-10 |
| JP2019500324A5 true JP2019500324A5 (https=) | 2019-08-08 |
| JP6775014B2 JP6775014B2 (ja) | 2020-10-28 |
Family
ID=58663032
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018522968A Expired - Fee Related JP6775014B2 (ja) | 2015-11-06 | 2016-11-04 | ヌクレオチド類似体 |
| JP2020168502A Expired - Fee Related JP7119041B2 (ja) | 2015-11-06 | 2020-10-05 | Ｄｎａ配列において標識されたヌクレオチドを検出する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020168502A Expired - Fee Related JP7119041B2 (ja) | 2015-11-06 | 2020-10-05 | Ｄｎａ配列において標識されたヌクレオチドを検出する方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (7) | US10273539B2 (https=) |
| EP (1) | EP3370731A4 (https=) |
| JP (2) | JP6775014B2 (https=) |
| KR (2) | KR102454782B1 (https=) |
| CN (1) | CN109476694B (https=) |
| AU (1) | AU2016349457B2 (https=) |
| CA (2) | CA3004060C (https=) |
| TW (3) | TWI698530B (https=) |
| WO (1) | WO2017079498A2 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3356381A4 (en) | 2015-09-28 | 2019-06-12 | The Trustees of Columbia University in the City of New York | DESIGN AND SYNTHESIS OF NUCLEOTIDES BASED ON NOVEL DISULFIDE COMPOUNDS AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS |
| TWI698530B (zh) * | 2015-11-06 | 2020-07-11 | 美商齊亞雋科學公司 | 核苷酸類似物 |
| US11266673B2 (en) | 2016-05-23 | 2022-03-08 | The Trustees Of Columbia University In The City Of New York | Nucleotide derivatives and methods of use thereof |
| WO2018129644A1 (zh) * | 2017-01-10 | 2018-07-19 | 深圳华大智造科技有限公司 | 一种提高核酸聚合测序质量的方法、反应体系和试剂盒 |
| US20200002689A1 (en) | 2017-02-13 | 2020-01-02 | Qiagen Sciences, Llc | Polymerase enzyme from 9°n |
| US11591647B2 (en) | 2017-03-06 | 2023-02-28 | Singular Genomics Systems, Inc. | Nucleic acid sequencing-by-synthesis (SBS) methods that combine SBS cycle steps |
| CN119639879A (zh) * | 2017-03-28 | 2025-03-18 | 哥伦比亚大学董事会 | 用于连接荧光标记与用于dna合成测序的碱基的具有不同可裂解连接子的3'-o-改性的核苷酸类似物 |
| EP3733683A4 (en) | 2017-11-30 | 2022-04-06 | GeneMind Biosciences Company Limited | NUCLEOSIDE ANALOGUES, METHOD OF MANUFACTURE AND USE |
| US12215124B2 (en) | 2018-02-21 | 2025-02-04 | Singular Genomics Systems, Inc. | Fluorinated nucleotides and uses thereof |
| US12188086B2 (en) | 2018-03-15 | 2025-01-07 | The Trustees Of Columbia University In The City Of New York | Nucleotide analogues and use thereof for nucleic acid sequencing and analysis preliminary class |
| WO2020056044A1 (en) | 2018-09-11 | 2020-03-19 | Singular Genomics Systems, Inc. | Modified archaeal family b polymerases |
| EP3856753A4 (en) * | 2018-09-28 | 2022-11-16 | Centrillion Technology Holdings Corporation | DISULFIDE CROSSLINKED REVERSIBLE TERMINATORS |
| US10738072B1 (en) | 2018-10-25 | 2020-08-11 | Singular Genomics Systems, Inc. | Nucleotide analogues |
| CN112888699B (zh) * | 2018-11-20 | 2024-05-17 | 深圳华大生命科学研究院 | 测序用核苷酸的制备方法 |
| WO2020118255A1 (en) * | 2018-12-07 | 2020-06-11 | Element Biosciences, Inc. | Flow cell device and use thereof |
| US11293061B2 (en) | 2018-12-26 | 2022-04-05 | Illumina Cambridge Limited | Sequencing methods using nucleotides with 3′ AOM blocking group |
| CN113453692A (zh) | 2019-01-08 | 2021-09-28 | 奇异基因组学系统公司 | 核苷酸可裂解接头和其用途 |
| US11512295B2 (en) | 2019-09-12 | 2022-11-29 | Singular Genomics Systems, Inc. | Modified thermoccocus polymerases |
| WO2021067970A1 (en) * | 2019-10-04 | 2021-04-08 | Centrillion Technologies, Inc. | Reversible terminators for dna sequencing and methods of using the same |
| US11034942B1 (en) | 2020-02-27 | 2021-06-15 | Singular Genomics Systems, Inc. | Modified pyrococcus polymerases and uses thereof |
| EP4117682B1 (en) | 2020-04-24 | 2025-06-04 | Singular Genomics Systems, Inc. | Modified nucleotides and uses thereof |
| US20230160001A1 (en) * | 2020-05-08 | 2023-05-25 | Singular Genomics Systems, Inc. | Nucleotide cleavable linkers with rigid spacers and uses thereof |
| IL316161A (en) | 2020-06-22 | 2024-12-01 | Illumina Cambridge Ltd | Nucleotides and nucleosides with a 3' masking group |
| EP4200444A4 (en) | 2020-10-30 | 2024-09-25 | Singular Genomics Systems, Inc. | METHODS AND COMPOSITIONS FOR REDUCING NUCLEOTIDE IMPURITIES CONTENT |
| EP4036098B1 (en) | 2021-02-02 | 2026-01-28 | Miltenyi Biotec B.V. & Co. KG | Synthesis of reversible nucleotide terminators by in-situ thio-alkyl group transfer for use in dna sequencing by synthesis |
| US20240209439A1 (en) * | 2021-04-01 | 2024-06-27 | Bgi Shenzhen | Nucleotide analogue for sequencing |
| EP4089098A1 (en) | 2021-05-10 | 2022-11-16 | Miltenyi Biotec B.V. & Co. KG | Fret dye labeled reversible nucleotide terminators and their use in sequencing of dna |
| CN113341058A (zh) * | 2021-06-09 | 2021-09-03 | 南京溯远基因科技有限公司 | 一种三色高通量测序试剂及测序方法 |
| EP4444320A4 (en) * | 2021-12-10 | 2025-12-10 | Singular Genomics Systems Inc | Cleftable disulfide binders and their uses |
| US20230242571A1 (en) * | 2022-02-02 | 2023-08-03 | Singular Genomics Systems, Inc. | Silicon containing modified nucleotide analogs |
| WO2023152269A1 (en) | 2022-02-11 | 2023-08-17 | Miltenyi Biotec B.V. & Co. KG | Use of 3'-oxymethylene alkyl disulfide protected nucleotides for enzymatic dna and rna synthesis |
| CN119546619A (zh) * | 2022-03-22 | 2025-02-28 | 得克斯奥梅有限公司 | 测序l-多核苷酸的方法 |
| EP4499878A2 (en) * | 2022-03-28 | 2025-02-05 | Baylor College of Medicine | Taxonomic signatures and methods of determining the same |
| CN115417907A (zh) * | 2022-08-15 | 2022-12-02 | 上海交通大学医学院 | 一种连接体及其制备方法 |
| EP4342998A1 (en) | 2022-09-23 | 2024-03-27 | Miltenyi Biotec B.V. & Co. KG | Labeled probes with differentially cleavable linkers and their use in de-coding dna and rna molecules |
| CN115960152A (zh) * | 2022-10-11 | 2023-04-14 | 河南师范大学 | 一种炔丙醚基取代tpt3型非天然碱基三磷酸及其合成方法和应用 |
| CN115785170A (zh) * | 2022-12-02 | 2023-03-14 | 重庆铭毅智造科技有限公司 | 一种可逆终止子核苷酸3’-oh保护基团的引入方法 |
| WO2025072834A2 (en) * | 2023-09-27 | 2025-04-03 | Dxome Co., Ltd. | Method of sequencing and synthesizing l-polynucleotide |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO873956L (no) | 1986-09-25 | 1988-03-28 | Bp Chem Int Ltd | Rensemidler inneholdende peroksyder for fremstilling av flyktige sulfider. |
| US5756334A (en) | 1990-04-26 | 1998-05-26 | New England Biolabs, Inc. | Thermostable DNA polymerase from 9°N-7 and methods for producing the same |
| US5633360A (en) * | 1992-04-14 | 1997-05-27 | Gilead Sciences, Inc. | Oligonucleotide analogs capable of passive cell membrane permeation |
| US5990300A (en) | 1994-09-02 | 1999-11-23 | Andrew C. Hiatt | Enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides |
| US6046039A (en) | 1998-08-19 | 2000-04-04 | Battelle Memorial Institute | Methods for producing partially digested restriction DNA fragments and for producing a partially modified PCR product |
| US6465628B1 (en) | 1999-02-04 | 2002-10-15 | Isis Pharmaceuticals, Inc. | Process for the synthesis of oligomeric compounds |
| AU2002301870A1 (en) * | 1999-03-12 | 2003-03-13 | President And Fellows Of Harvard College | Nuclotide Compounds Having a Cleavable Linker |
| WO2001023610A2 (en) | 1999-09-29 | 2001-04-05 | Solexa Ltd. | Polynucleotide sequencing |
| US6309836B1 (en) | 1999-10-05 | 2001-10-30 | Marek Kwiatkowski | Compounds for protecting hydroxyls and methods for their use |
| US6498189B1 (en) | 1999-11-10 | 2002-12-24 | University Of New Mexico | Method for induction of L-selectin shedding |
| JP2004510433A (ja) | 2000-10-06 | 2004-04-08 | ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク | Ｄｎａおよびｒｎａを解読するための大量並行方法 |
| GB0129012D0 (en) * | 2001-12-04 | 2002-01-23 | Solexa Ltd | Labelled nucleotides |
| US7057026B2 (en) | 2001-12-04 | 2006-06-06 | Solexa Limited | Labelled nucleotides |
| US7414116B2 (en) | 2002-08-23 | 2008-08-19 | Illumina Cambridge Limited | Labelled nucleotides |
| WO2004087865A2 (en) * | 2003-03-31 | 2004-10-14 | The Regents Of The University Of California | The preparation and application of ligand-biopolymer conjugates |
| GB0321306D0 (en) | 2003-09-11 | 2003-10-15 | Solexa Ltd | Modified polymerases for improved incorporation of nucleotide analogues |
| US20070117104A1 (en) | 2005-11-22 | 2007-05-24 | Buzby Philip R | Nucleotide analogs |
| WO2007053719A2 (en) | 2005-10-31 | 2007-05-10 | The Trustees Of Columbia University In The City Of New York | Chemically cleavable 3'-o-allyl-dntp-allyl-fluorophore fluorescent nucleotide analogues and related methods |
| US8399188B2 (en) | 2006-09-28 | 2013-03-19 | Illumina, Inc. | Compositions and methods for nucleotide sequencing |
| WO2008069973A2 (en) | 2006-12-01 | 2008-06-12 | The Trustees Of Columbia University In The City Of New York | Four-color dna sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators |
| US8481259B2 (en) * | 2007-02-05 | 2013-07-09 | Intelligent Bio-Systems, Inc. | Methods and devices for sequencing nucleic acids in smaller batches |
| DK2725107T3 (da) * | 2007-10-19 | 2019-01-02 | Univ Columbia | DNA-sekventering med ikke-fluorescerende nukleotidreversible terminatorer og ddNTP'er modificeret med spaltbart mærke og nukleinsyre omfattende inosin med reversible terminatorer |
| US8017338B2 (en) | 2007-11-20 | 2011-09-13 | Life Technologies Corporation | Reversible di-nucleotide terminator sequencing |
| US8101353B2 (en) | 2007-12-18 | 2012-01-24 | Advanced Analytical Technologies, Inc. | System and method for nucleotide sequence profiling for sample identification |
| US8883999B2 (en) | 2008-03-19 | 2014-11-11 | Intelligent Bio Systems, Inc. | Methods and solutions for inhibiting undesired cleaving of labels |
| US9017973B2 (en) | 2008-03-19 | 2015-04-28 | Intelligent Biosystems, Inc. | Methods and compositions for incorporating nucleotides |
| US20100330569A1 (en) | 2009-04-23 | 2010-12-30 | Intelligent Bio-Systems, Inc. | Hydroxymethyl Linkers For Labeling Nucleotides |
| MX342195B (es) * | 2011-09-13 | 2016-09-20 | Lasergen Inc | Nucleótidos de terminación de rápida fotodescomposición 5-metoxi, 3' -oh no bloqueados y métodos para secuenciación de ácido nucleico. |
| CN103484106B (zh) * | 2013-09-05 | 2015-08-19 | 上海交通大学 | 四色荧光标记可逆终端及其在dna测序中的用途 |
| AU2014346658A1 (en) * | 2013-11-06 | 2016-06-02 | Solstice Biologics, Ltd. | Polynucleotide constructs having disulfide groups |
| EP2876166B1 (en) * | 2013-11-20 | 2016-12-14 | Roche Diagnostics GmbH | New compound for sequencing by synthesis |
| EP3356381A4 (en) * | 2015-09-28 | 2019-06-12 | The Trustees of Columbia University in the City of New York | DESIGN AND SYNTHESIS OF NUCLEOTIDES BASED ON NOVEL DISULFIDE COMPOUNDS AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS |
| TWI698530B (zh) * | 2015-11-06 | 2020-07-11 | 美商齊亞雋科學公司 | 核苷酸類似物 |
-
2016
- 2016-11-04 TW TW108112168A patent/TWI698530B/zh not_active IP Right Cessation
- 2016-11-04 KR KR1020217027925A patent/KR102454782B1/ko active Active
- 2016-11-04 CN CN201680074649.5A patent/CN109476694B/zh active Active
- 2016-11-04 EP EP16863015.0A patent/EP3370731A4/en not_active Withdrawn
- 2016-11-04 WO PCT/US2016/060435 patent/WO2017079498A2/en not_active Ceased
- 2016-11-04 CA CA3004060A patent/CA3004060C/en active Active
- 2016-11-04 TW TW107128049A patent/TWI664160B/zh active
- 2016-11-04 CA CA3158679A patent/CA3158679A1/en active Pending
- 2016-11-04 US US15/343,279 patent/US10273539B2/en active Active
- 2016-11-04 US US15/343,267 patent/US10301346B2/en active Active
- 2016-11-04 JP JP2018522968A patent/JP6775014B2/ja not_active Expired - Fee Related
- 2016-11-04 AU AU2016349457A patent/AU2016349457B2/en active Active
- 2016-11-04 KR KR1020187015618A patent/KR102298737B1/ko not_active Expired - Fee Related
- 2016-11-04 US US15/343,341 patent/US10336785B2/en active Active
- 2016-11-04 TW TW105135999A patent/TWI639614B/zh not_active IP Right Cessation
-
2018
- 2018-03-22 US US15/928,562 patent/US11548909B2/en active Active
- 2018-03-22 US US15/928,533 patent/US11046726B2/en active Active
-
2019
- 2019-05-28 US US16/423,466 patent/US11117921B2/en not_active Expired - Fee Related
-
2020
- 2020-10-05 JP JP2020168502A patent/JP7119041B2/ja not_active Expired - Fee Related
-
2021
- 2021-06-28 US US17/360,427 patent/US20220162251A1/en not_active Abandoned
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