JP2019210278A - コレステロール低減用組成物及びコレステロール低減機能性付与方法 - Google Patents
コレステロール低減用組成物及びコレステロール低減機能性付与方法 Download PDFInfo
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Abstract
Description
クロモジ(Lindera umbellata Thunb.)の幹枝の乾燥物を裁断した後、その全質量に対して10倍量の水を加え加熱し、沸騰後1時間浸漬・加熱抽出を行った。抽出後は濾過により不溶物を除き、得られた抽出液を減圧濃縮し、更に凍結乾燥により抽出溶媒を除去して、乾燥粉末状のクロモジエキスを得た。
調製例1で得られたクロモジエキスを用いて、コレステロール低減作用を検証した。
各投与群から調製した血清サンプルを、総コレステロール濃度測定キット(「LabAssayTM Cholesterol」、和光純薬工業株式会社)に供して、血中の総コレステロール濃度を求めた。
各投与群から調製した血清サンプルを、LDLコレステロール濃度測定キット(「Lタイプワコー LDL-C・M」、和光純薬工業株式会社)に供して、血中のLDLコレステロール濃度を求めた。
各投与群から調製した血清サンプルを、HDLコレステロール濃度測定キット(「HDL-コレステロール E-テストワコー」、和光純薬工業株式会社)に供して、血中のHDLコレステロール濃度を求めた。
上記(2)で求められたLDLコレステロール濃度(mg/dL)を、上記(3)で求められたHDLコレステロール濃度(mg/dL)で除し、算出した。
上記(1)で求められた総コレステロール濃度(mg/dL)から、上記(3)で求められたHDLコレステロール濃度(mg/dL)を引き、算出した。
Claims (9)
- クロモジエキスを含有するコレステロール低減用組成物。
- 血中の総コレステロール濃度を低減させるためのものである、請求項1記載のコレステロール低減用組成物。
- 血中のLDLコレステロール濃度を低減させるためのものである、請求項1記載のコレステロール低減用組成物。
- 血中のLDLコレステロール/HDLコレステロールの濃度比を低減させるためのものである、請求項1記載のコレステロール低減用組成物。
- 血中のnon−HDLコレステロール濃度を低減させるためのものである、請求項1記載のコレステロール低減用組成物。
- コレステロールによる血管壁の肥厚を予防するためのものである、請求項1記載のコレステロール低減用組成物。
- 前記クロモジエキスは、クロモジの熱水抽出物を含む、請求項1〜6のいずれか1つに記載のコレステロール低減用組成物。
- 組成物中にクロモジエキスを含有せしめる該組成物のコレステロール低減機能性付与方法。
- 前記クロモジエキスは、クロモジの熱水抽出物を含む、請求項8記載の方法。
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JP2021109858A (ja) * | 2020-01-14 | 2021-08-02 | 国立大学法人 熊本大学 | メタボリックシンドロームの予防または改善剤 |
Citations (2)
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CN106913619A (zh) * | 2017-03-14 | 2017-07-04 | 浙江中医药大学 | 一种促进胆固醇逆转运的提取物及其制备方法与应用 |
JP2018070570A (ja) * | 2016-11-04 | 2018-05-10 | 高知県公立大学法人 | クロモジ抽出物 |
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JP2018070570A (ja) * | 2016-11-04 | 2018-05-10 | 高知県公立大学法人 | クロモジ抽出物 |
CN106913619A (zh) * | 2017-03-14 | 2017-07-04 | 浙江中医药大学 | 一种促进胆固醇逆转运的提取物及其制备方法与应用 |
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JP2021109858A (ja) * | 2020-01-14 | 2021-08-02 | 国立大学法人 熊本大学 | メタボリックシンドロームの予防または改善剤 |
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