JP2019178142A5 - - Google Patents
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- JP2019178142A5 JP2019178142A5 JP2019098999A JP2019098999A JP2019178142A5 JP 2019178142 A5 JP2019178142 A5 JP 2019178142A5 JP 2019098999 A JP2019098999 A JP 2019098999A JP 2019098999 A JP2019098999 A JP 2019098999A JP 2019178142 A5 JP2019178142 A5 JP 2019178142A5
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- JP
- Japan
- Prior art keywords
- cells
- glucocorticoid
- patient
- mammalian
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000001744 T-lymphocyte Anatomy 0.000 claims 26
- 150000001875 compounds Chemical class 0.000 claims 16
- 239000003862 glucocorticoid Substances 0.000 claims 16
- 238000000034 method Methods 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 11
- 108010067225 Cell Adhesion Molecules Proteins 0.000 claims 9
- 102000016289 Cell Adhesion Molecules Human genes 0.000 claims 9
- 230000002411 adverse Effects 0.000 claims 8
- 229940079593 drug Drugs 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 8
- 230000003511 endothelial effect Effects 0.000 claims 8
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 7
- 210000002889 endothelial cell Anatomy 0.000 claims 7
- 108090000184 Selectins Proteins 0.000 claims 4
- 102000003800 Selectins Human genes 0.000 claims 4
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 3
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 3
- 210000003719 b-lymphocyte Anatomy 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 229960003008 blinatumomab Drugs 0.000 claims 2
- 230000000903 blocking effect Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 230000000926 neurological effect Effects 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 108010083359 Antigen Receptors Proteins 0.000 claims 1
- 102000006306 Antigen Receptors Human genes 0.000 claims 1
- 206010003591 Ataxia Diseases 0.000 claims 1
- 102100032912 CD44 antigen Human genes 0.000 claims 1
- 206010013887 Dysarthria Diseases 0.000 claims 1
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 1
- 108010041012 Integrin alpha4 Proteins 0.000 claims 1
- 108010064593 Intercellular Adhesion Molecule-1 Proteins 0.000 claims 1
- 102000015271 Intercellular Adhesion Molecule-1 Human genes 0.000 claims 1
- 108010092694 L-Selectin Proteins 0.000 claims 1
- 102000016551 L-selectin Human genes 0.000 claims 1
- 241000288906 Primates Species 0.000 claims 1
- 208000037048 Prodromal Symptoms Diseases 0.000 claims 1
- 101710121440 Proteinase-activated receptor 1 Proteins 0.000 claims 1
- 102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 claims 1
- 206010044565 Tremor Diseases 0.000 claims 1
- 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 claims 1
- 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 claims 1
- 201000007201 aphasia Diseases 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 230000002490 cerebral effect Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- -1 etc.) Proteins 0.000 claims 1
- 108010021315 integrin beta7 Proteins 0.000 claims 1
- 108010044426 integrins Proteins 0.000 claims 1
- 102000006495 integrins Human genes 0.000 claims 1
- 210000004925 microvascular endothelial cell Anatomy 0.000 claims 1
- DYKFCLLONBREIL-KVUCHLLUSA-N minocycline Chemical compound C([C@H]1C2)C3=C(N(C)C)C=CC(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2[C@H](N(C)C)C(O)=C(C(N)=O)C1=O DYKFCLLONBREIL-KVUCHLLUSA-N 0.000 claims 1
- 229960004023 minocycline Drugs 0.000 claims 1
- 229960005027 natalizumab Drugs 0.000 claims 1
- 210000005259 peripheral blood Anatomy 0.000 claims 1
- 239000011886 peripheral blood Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 102000009076 src-Family Kinases Human genes 0.000 claims 1
- 108010087686 src-Family Kinases Proteins 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 210000003606 umbilical vein Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361762718P | 2013-02-08 | 2013-02-08 | |
| US61/762,718 | 2013-02-08 | ||
| US201361811526P | 2013-04-12 | 2013-04-12 | |
| US61/811,526 | 2013-04-12 | ||
| JP2015556506A JP6567425B2 (ja) | 2013-02-08 | 2014-02-07 | Ｃｄ３特異的結合ドメインによって引き起こされる潜在的有害事象を緩和するための抗白血球接着 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015556506A Division JP6567425B2 (ja) | 2013-02-08 | 2014-02-07 | Ｃｄ３特異的結合ドメインによって引き起こされる潜在的有害事象を緩和するための抗白血球接着 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019178142A JP2019178142A (ja) | 2019-10-17 |
| JP2019178142A5 true JP2019178142A5 (OSRAM) | 2019-12-19 |
| JP6933684B2 JP6933684B2 (ja) | 2021-09-08 |
Family
ID=50231117
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015556506A Active JP6567425B2 (ja) | 2013-02-08 | 2014-02-07 | Ｃｄ３特異的結合ドメインによって引き起こされる潜在的有害事象を緩和するための抗白血球接着 |
| JP2019098999A Active JP6933684B2 (ja) | 2013-02-08 | 2019-05-28 | Ｃｄ３特異的結合ドメインによって引き起こされる潜在的有害事象を緩和するための抗白血球接着 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015556506A Active JP6567425B2 (ja) | 2013-02-08 | 2014-02-07 | Ｃｄ３特異的結合ドメインによって引き起こされる潜在的有害事象を緩和するための抗白血球接着 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9688760B2 (OSRAM) |
| EP (2) | EP2953630B1 (OSRAM) |
| JP (2) | JP6567425B2 (OSRAM) |
| AR (1) | AR094740A1 (OSRAM) |
| AU (2) | AU2014214020B2 (OSRAM) |
| CA (1) | CA2898032C (OSRAM) |
| ES (1) | ES2811764T3 (OSRAM) |
| JO (1) | JO3529B1 (OSRAM) |
| MX (2) | MX368842B (OSRAM) |
| TW (2) | TW201929865A (OSRAM) |
| UY (1) | UY35313A (OSRAM) |
| WO (1) | WO2014122251A2 (OSRAM) |
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| US20130058936A1 (en) | 2011-08-23 | 2013-03-07 | Peter Bruenker | Bispecific antibodies specific for t-cell activating antigens and a tumor antigen and methods of use |
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| EP2934532B1 (en) | 2012-12-20 | 2019-10-23 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| JO3529B1 (ar) * | 2013-02-08 | 2020-07-05 | Amgen Res Munich Gmbh | مضاد التصاق خلايا الدم البيض من أجل التخفيف من الاثار السلبية الممكنة الناتجة عن مجالات ارتباط cd3- المحدد |
| US9486475B2 (en) * | 2013-02-08 | 2016-11-08 | Amgen Research (Munich) Gmbh | PPS for the prevention of potential adverse effects caused by CD3 specific binding domains |
| CN105143270B (zh) | 2013-02-26 | 2019-11-12 | 罗切格利卡特公司 | 双特异性t细胞活化抗原结合分子 |
| PT2961771T (pt) | 2013-02-26 | 2020-02-28 | Roche Glycart Ag | Moléculas de ligação ao antigénio biespecíficas para ativação das células t, específicas para cd3 e cea |
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| EP3755349A4 (en) | 2018-02-21 | 2021-11-17 | Board of Regents, The University of Texas System | PROCESS FOR ACTIVATION AND EXPANSION OF NATURAL KILLER CELLS AND THEIR USES |
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-
2014
- 2014-02-06 JO JOP/2014/0028A patent/JO3529B1/ar active
- 2014-02-07 EP EP14707953.7A patent/EP2953630B1/en active Active
- 2014-02-07 MX MX2015009922A patent/MX368842B/es active IP Right Grant
- 2014-02-07 ES ES14707953T patent/ES2811764T3/es active Active
- 2014-02-07 AU AU2014214020A patent/AU2014214020B2/en active Active
- 2014-02-07 EP EP20182831.6A patent/EP3760210A1/en not_active Withdrawn
- 2014-02-07 WO PCT/EP2014/052406 patent/WO2014122251A2/en not_active Ceased
- 2014-02-07 JP JP2015556506A patent/JP6567425B2/ja active Active
- 2014-02-07 UY UY0001035313A patent/UY35313A/es unknown
- 2014-02-07 TW TW107140068A patent/TW201929865A/zh unknown
- 2014-02-07 CA CA2898032A patent/CA2898032C/en active Active
- 2014-02-07 TW TW103104162A patent/TWI704920B/zh active
- 2014-02-07 MX MX2019012421A patent/MX2019012421A/es unknown
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2017
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2019
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