JP2019119681A - 外用組成物 - Google Patents
外用組成物 Download PDFInfo
- Publication number
- JP2019119681A JP2019119681A JP2017253290A JP2017253290A JP2019119681A JP 2019119681 A JP2019119681 A JP 2019119681A JP 2017253290 A JP2017253290 A JP 2017253290A JP 2017253290 A JP2017253290 A JP 2017253290A JP 2019119681 A JP2019119681 A JP 2019119681A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- loxoprofen
- present
- nicotinic acid
- external use
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- BAZQYVYVKYOAGO-UHFFFAOYSA-M loxoprofen sodium hydrate Chemical compound O.O.[Na+].C1=CC(C(C([O-])=O)C)=CC=C1CC1C(=O)CCC1 BAZQYVYVKYOAGO-UHFFFAOYSA-M 0.000 claims abstract 4
- -1 Nicotinic acid ester Chemical class 0.000 claims description 39
- PVNIIMVLHYAWGP-UHFFFAOYSA-N nicotinic acid Natural products OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 32
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- QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 description 1
- 239000002446 δ-tocopherol Substances 0.000 description 1
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Abstract
Description
(I-1)
ロキソプロフェン及び/又はその薬学的に許容される塩、
トコフェロール類、
ニコチン酸エステル誘導体、
炭素数1〜4のアルコール、並びに
水
を含有する、外用組成物。
(I-2)
前記ロキソプロフェンの薬学的に許容される塩が、ロキソプロフェンナトリウム水和物である、(I-1)に記載の外用組成物。
(I-3)
前記トコフェロール類が、酢酸トコフェロールである、(I-1)又は(I-2)に記載の外用組成物。
(I-4)
前記ニコチン酸エステル誘導体が、ニコチン酸ベンジルエステルである、(I-1)〜(I-3)のいずれか一項に記載の外用組成物。
(I-5)
鎮痛用途で用いられる、(I-1)〜(I-4)のいずれか一項に記載の外用組成物。
(I-6)
液剤である、(I-1)〜(I-5)のいずれか一項に記載の外用組成物。
(II-1)
トコフェロール類、ニコチン酸エステル誘導体、炭素数1〜4のアルコール及び水を含有する組成物における白濁を抑制する方法であって、
ロキソプロフェン及び/又はその薬学的に許容される塩を該組成物に含ませる工程を含む方法。
(II-2)
前記ロキソプロフェンの薬学的に許容される塩が、ロキソプロフェンナトリウム水和物である、(II-1)に記載の方法。
(II-3)
前記トコフェロール類が、酢酸トコフェロールである、(II-1)又は(II-2)に記載の方法。
(II-4)
前記ニコチン酸エステル誘導体が、ニコチン酸ベンジルエステルである、(II-1)〜(II-3)のいずれか一項に記載の方法。
(II-5)
前記組成物が、液剤である、(II-1)〜(II-4)のいずれか一項に記載の方法。
本発明の外用組成物は、
ロキソプロフェン及び/又はその薬学的に許容される塩、
トコフェロール類、
ニコチン酸エステル誘導体、
炭素数1〜4のアルコール、並びに
水
を含有する。
本発明の外用組成物は、ロキソプロフェン及び/又はその薬学的に許容される塩(本明細書において、これらを「ロキソプロフェン類」と総称することがある)を含有する。
本発明の外用組成物は、血行促進成分としてトコフェロール類を含有する。
本発明の外用組成物は、血行促進成分としてニコチン酸エステル誘導体を含有する。
低級アルコールは、特に限定されず、上記の成分に対して有効な基剤として機能するものであれば幅広く使用できる。
本発明の外用組成物には、本発明の効果を妨げない限り、上記成分の他に、別の血行促進成分を配合することもできる。
別の血行促進成分としては、例えば、カプサイシノイド等が挙げられる。
本発明の外用組成物は、その形態を特に制限するものではないが、好ましくは液剤(ローション剤、スプレー剤、エアゾール剤、及び乳液剤を含む)である。
本発明の方法は、トコフェロール類、ニコチン酸エステル誘導体、炭素数1〜4のアルコール及び水を含有する組成物における白濁を抑制する方法であって、
ロキソプロフェン及び/又はその薬学的に許容される塩を該組成物に含ませる工程
を含む方法である。
Claims (6)
- ロキソプロフェン及び/又はその薬学的に許容される塩、
トコフェロール類、
ニコチン酸エステル誘導体、
炭素数1〜4のアルコール、並びに
水
を含有する、外用組成物。 - 前記ロキソプロフェンの薬学的に許容される塩が、ロキソプロフェンナトリウム水和物である、請求項1に記載の外用組成物。
- 前記トコフェロール類が、酢酸トコフェロールである、請求項1又は2に記載の外用組成物。
- 前記ニコチン酸エステル誘導体が、ニコチン酸ベンジルエステルである、請求項1〜3のいずれか一項に記載の外用組成物。
- 鎮痛用途で用いられる、請求項1〜4のいずれか一項に記載の外用組成物。
- 液剤である、請求項1〜5のいずれか一項に記載の外用組成物。
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Citations (3)
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JP2016193850A (ja) * | 2015-03-31 | 2016-11-17 | 小林製薬株式会社 | 外用医薬組成物 |
WO2017111167A1 (ja) * | 2015-12-25 | 2017-06-29 | 興和株式会社 | ロキソプロフェンを含有する医薬製剤 |
JP2018188429A (ja) * | 2017-04-28 | 2018-11-29 | 第一三共ヘルスケア株式会社 | ロキソプロフェン配合皮膚用外用剤 |
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JP5590846B2 (ja) * | 2009-09-30 | 2014-09-17 | 小林製薬株式会社 | 外用医薬組成物 |
WO2014163030A1 (ja) * | 2013-04-01 | 2014-10-09 | 第一三共株式会社 | 馬の炎症治療のための製剤 |
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JP2016193850A (ja) * | 2015-03-31 | 2016-11-17 | 小林製薬株式会社 | 外用医薬組成物 |
WO2017111167A1 (ja) * | 2015-12-25 | 2017-06-29 | 興和株式会社 | ロキソプロフェンを含有する医薬製剤 |
JP2018188429A (ja) * | 2017-04-28 | 2018-11-29 | 第一三共ヘルスケア株式会社 | ロキソプロフェン配合皮膚用外用剤 |
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