JP2019073507A5 - - Google Patents
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- Publication number
- JP2019073507A5 JP2019073507A5 JP2018195550A JP2018195550A JP2019073507A5 JP 2019073507 A5 JP2019073507 A5 JP 2019073507A5 JP 2018195550 A JP2018195550 A JP 2018195550A JP 2018195550 A JP2018195550 A JP 2018195550A JP 2019073507 A5 JP2019073507 A5 JP 2019073507A5
- Authority
- JP
- Japan
- Prior art keywords
- carbonyl
- pharmaceutically acceptable
- oral
- active ingredient
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000004480 active ingredient Substances 0.000 claims 5
- 239000000825 pharmaceutical preparation Substances 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- -1 3,4-difluorophenyl group Chemical group 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 3
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 2
- 206010008118 cerebral infarction Diseases 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- 201000006474 Brain Ischemia Diseases 0.000 claims 1
- 206010048962 Brain oedema Diseases 0.000 claims 1
- 206010008120 Cerebral ischaemia Diseases 0.000 claims 1
- 208000012239 Developmental disease Diseases 0.000 claims 1
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 1
- 206010019196 Head injury Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000019022 Mood disease Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- KPNFHMCCBRGOKU-UHFFFAOYSA-N bicyclo[3.1.0]hexane-6-carboxylic acid Chemical compound C1CCC2C(C(=O)O)C21 KPNFHMCCBRGOKU-UHFFFAOYSA-N 0.000 claims 1
- 208000006752 brain edema Diseases 0.000 claims 1
- 208000026106 cerebrovascular disease Diseases 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010013663 drug dependence Diseases 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- MNWFXJYAOYHMED-UHFFFAOYSA-N heptanoic acid Chemical compound CCCCCCC(O)=O MNWFXJYAOYHMED-UHFFFAOYSA-N 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000011117 substance-related disease Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017200722 | 2017-10-17 | ||
| JP2017200722 | 2017-10-17 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019073507A JP2019073507A (ja) | 2019-05-16 |
| JP2019073507A5 true JP2019073507A5 (https=) | 2021-11-25 |
| JP7314494B2 JP7314494B2 (ja) | 2023-07-26 |
Family
ID=66543765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018195550A Active JP7314494B2 (ja) | 2017-10-17 | 2018-10-17 | アミノ酸誘導体のプロドラッグを含有する医薬 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP7314494B2 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2024004505A (ja) * | 2020-11-26 | 2024-01-17 | 大正製薬株式会社 | アミノ酸誘導体の製造方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2471642C (en) * | 2001-12-27 | 2011-05-24 | Taisho Pharmaceutical Co., Ltd. | 6-fluorobicyclo[3.1.0]hexane derivatives |
| JP4461865B2 (ja) * | 2003-04-23 | 2010-05-12 | 大正製薬株式会社 | グループｉｉメタボトロピックグルタミン酸受容体拮抗薬 |
| US9428483B2 (en) * | 2012-06-01 | 2016-08-30 | Taisho Pharmaceutical Co., Ltd. | Prodrug of fluorine-containing amino acid |
| JP5983713B2 (ja) * | 2013-11-29 | 2016-09-06 | 大正製薬株式会社 | 含フッ素アミノ酸のプロドラッグを含有する医薬 |
| EP3445743B1 (en) * | 2016-04-18 | 2021-08-04 | Taisho Pharmaceutical Co., Ltd. | Prodrug of amino acid derivative |
-
2018
- 2018-10-17 JP JP2018195550A patent/JP7314494B2/ja active Active
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