JP2019052145A5 - - Google Patents
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- JP2019052145A5 JP2019052145A5 JP2018165218A JP2018165218A JP2019052145A5 JP 2019052145 A5 JP2019052145 A5 JP 2019052145A5 JP 2018165218 A JP2018165218 A JP 2018165218A JP 2018165218 A JP2018165218 A JP 2018165218A JP 2019052145 A5 JP2019052145 A5 JP 2019052145A5
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- 102100040877 E3 ubiquitin-protein ligase MARCHF5 Human genes 0.000 claims description 14
- 101001039881 Homo sapiens E3 ubiquitin-protein ligase MARCHF5 Proteins 0.000 claims description 14
- 230000001737 promoting effect Effects 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 11
- 210000004027 cell Anatomy 0.000 claims description 8
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims description 6
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 6
- RIUPLDUFZCXCHM-UHFFFAOYSA-N Urolithin A Chemical compound OC1=CC=C2C3=CC=C(O)C=C3OC(=O)C2=C1 RIUPLDUFZCXCHM-UHFFFAOYSA-N 0.000 claims description 6
- 230000002500 effect on skin Effects 0.000 claims description 6
- 210000002950 fibroblast Anatomy 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 238000012216 screening Methods 0.000 claims description 6
- 235000006040 Prunus persica var persica Nutrition 0.000 claims description 4
- 239000003112 inhibitor Substances 0.000 claims description 4
- 244000144730 Amygdalus persica Species 0.000 claims description 3
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 3
- FZAQROFXYZPAKI-UHFFFAOYSA-N anthracene-2-sulfonyl chloride Chemical compound C1=CC=CC2=CC3=CC(S(=O)(=O)Cl)=CC=C3C=C21 FZAQROFXYZPAKI-UHFFFAOYSA-N 0.000 claims description 3
- 229960005309 estradiol Drugs 0.000 claims description 3
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims description 3
- 229960003105 metformin Drugs 0.000 claims description 3
- 229960002477 riboflavin Drugs 0.000 claims description 3
- 235000019192 riboflavin Nutrition 0.000 claims description 3
- 239000002151 riboflavin Substances 0.000 claims description 3
- SHWIJIJNPFXOFS-UHFFFAOYSA-N thiotaurine Chemical compound NCCS(O)(=O)=S SHWIJIJNPFXOFS-UHFFFAOYSA-N 0.000 claims description 3
- ZGXJTSGNIOSYLO-UHFFFAOYSA-N 88755TAZ87 Chemical compound NCC(=O)CCC(O)=O ZGXJTSGNIOSYLO-UHFFFAOYSA-N 0.000 claims description 2
- 240000007594 Oryza sativa Species 0.000 claims description 2
- 235000007164 Oryza sativa Nutrition 0.000 claims description 2
- 150000001408 amides Chemical class 0.000 claims description 2
- 229960002749 aminolevulinic acid Drugs 0.000 claims description 2
- 235000009566 rice Nutrition 0.000 claims description 2
- 210000003780 hair follicle Anatomy 0.000 claims 4
- 210000000130 stem cell Anatomy 0.000 claims 4
- 229940007062 eucalyptus extract Drugs 0.000 claims 3
- RHXPDNGQJSXOMW-OIIXUNCGSA-N (2r,3r,4s,5s,6r)-2-[(2r,3s,4r,5r,6r)-6-(2-cyclohexylethoxy)-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)O[C@@H](OCCC2CCCCC2)[C@H](O)[C@H]1O RHXPDNGQJSXOMW-OIIXUNCGSA-N 0.000 claims 2
- 102100022206 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Human genes 0.000 claims 2
- 241000208690 Hamamelis Species 0.000 claims 2
- 101000900394 Homo sapiens Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Proteins 0.000 claims 2
- 101000680020 Homo sapiens Troponin I, slow skeletal muscle Proteins 0.000 claims 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 2
- 102100032891 Superoxide dismutase [Mn], mitochondrial Human genes 0.000 claims 2
- 102100022171 Troponin I, slow skeletal muscle Human genes 0.000 claims 2
- 210000003205 muscle Anatomy 0.000 claims 2
- 229960003966 nicotinamide Drugs 0.000 claims 2
- 239000011570 nicotinamide Substances 0.000 claims 2
- 235000005152 nicotinamide Nutrition 0.000 claims 2
- 239000000049 pigment Substances 0.000 claims 2
- 108010045815 superoxide dismutase 2 Proteins 0.000 claims 2
- 241000208680 Hamamelis mollis Species 0.000 claims 1
- 244000061458 Solanum melongena Species 0.000 claims 1
- NEZDQSKPNPRYAW-UHFFFAOYSA-N Urolithin D Chemical compound OC1=C(O)C=C2C(=O)OC3=C(O)C(O)=CC=C3C2=C1 NEZDQSKPNPRYAW-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 210000005175 epidermal keratinocyte Anatomy 0.000 claims 1
- 210000004209 hair Anatomy 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 229940118846 witch hazel Drugs 0.000 claims 1
- 230000014509 gene expression Effects 0.000 description 15
- 238000012360 testing method Methods 0.000 description 10
- 108020004999 messenger RNA Proteins 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 6
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 6
- 239000002299 complementary DNA Substances 0.000 description 4
- 239000013589 supplement Substances 0.000 description 4
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 2
- 238000011530 RNeasy Mini Kit Methods 0.000 description 2
- 239000013592 cell lysate Substances 0.000 description 2
- 230000001461 cytolytic effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000006166 lysate Substances 0.000 description 2
- 238000003753 real-time PCR Methods 0.000 description 2
- 238000010839 reverse transcription Methods 0.000 description 2
- BOKQALWNGNLTOC-UHFFFAOYSA-N 4-(2,4-difluorophenyl)-2-(1h-indol-3-yl)-4-oxobutanoic acid Chemical compound C=1NC2=CC=CC=C2C=1C(C(=O)O)CC(=O)C1=CC=C(F)C=C1F BOKQALWNGNLTOC-UHFFFAOYSA-N 0.000 description 1
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 1
- 239000011703 D-panthenol Substances 0.000 description 1
- 235000004866 D-panthenol Nutrition 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- 241000222351 Pleurotus cornucopiae Species 0.000 description 1
- 240000005809 Prunus persica Species 0.000 description 1
- ATANIONNQLTUND-CKYFFXLPSA-N Riboflavin reduced Chemical compound OC[C@@H](O)[C@H](O)[C@H](O)CN1C2=CC=CC=C2N=C2C1=NC(=O)NC2=O ATANIONNQLTUND-CKYFFXLPSA-N 0.000 description 1
- 229960003949 dexpanthenol Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022124223A JP7452586B2 (ja) | 2017-09-13 | 2022-08-03 | Ｍｉｔｏｌ産生を促進する成分を有効成分として含有する種々因子の産生調節用組成物、ｍｉｔｏｌ産生促進剤及びｍｉｔｏｌ産生促進作用を指標とする種々因子の産生調節剤のスクリーニング方法 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017175660 | 2017-09-13 | ||
| JP2017175660 | 2017-09-13 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022124223A Division JP7452586B2 (ja) | 2017-09-13 | 2022-08-03 | Ｍｉｔｏｌ産生を促進する成分を有効成分として含有する種々因子の産生調節用組成物、ｍｉｔｏｌ産生促進剤及びｍｉｔｏｌ産生促進作用を指標とする種々因子の産生調節剤のスクリーニング方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019052145A JP2019052145A (ja) | 2019-04-04 |
| JP2019052145A5 true JP2019052145A5 (https=) | 2021-10-07 |
Family
ID=66014244
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018165218A Pending JP2019052145A (ja) | 2017-09-13 | 2018-09-04 | Ｍｉｔｏｌ産生を促進する成分を有効成分として含有する種々因子の産生調節用組成物、ｍｉｔｏｌ産生促進剤及びｍｉｔｏｌ産生促進作用を指標とする種々因子の産生調節剤のスクリーニング方法 |
| JP2022124223A Active JP7452586B2 (ja) | 2017-09-13 | 2022-08-03 | Ｍｉｔｏｌ産生を促進する成分を有効成分として含有する種々因子の産生調節用組成物、ｍｉｔｏｌ産生促進剤及びｍｉｔｏｌ産生促進作用を指標とする種々因子の産生調節剤のスクリーニング方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022124223A Active JP7452586B2 (ja) | 2017-09-13 | 2022-08-03 | Ｍｉｔｏｌ産生を促進する成分を有効成分として含有する種々因子の産生調節用組成物、ｍｉｔｏｌ産生促進剤及びｍｉｔｏｌ産生促進作用を指標とする種々因子の産生調節剤のスクリーニング方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (2) | JP2019052145A (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7630764B2 (ja) * | 2019-06-26 | 2025-02-18 | 大正製薬株式会社 | 毛髪抗老化剤 |
| JP7803649B2 (ja) * | 2019-11-28 | 2026-01-21 | 株式会社ノエビア | 抗老化剤 |
| JP2022024400A (ja) * | 2020-07-28 | 2022-02-09 | エリジオンサイエンス株式会社 | 発育毛剤 |
| CN112263495B (zh) * | 2020-10-22 | 2023-06-27 | 广州善合化工有限公司 | 一种植物抗敏剂及其制备方法和应用 |
| JP7828033B2 (ja) * | 2021-03-04 | 2026-03-11 | 大正製薬株式会社 | 組成物 |
| JP7782167B2 (ja) * | 2021-08-19 | 2025-12-09 | 大正製薬株式会社 | 肌の透明感、くすみ、キメ、又は毛穴目立ちの改善剤 |
| JP7843656B2 (ja) * | 2022-06-30 | 2026-04-10 | ライオン株式会社 | コラーゲン産生促進方法 |
| JP7287587B1 (ja) | 2023-01-18 | 2023-06-06 | 大正製薬株式会社 | 固形組成物 |
| CN119564677A (zh) * | 2025-01-19 | 2025-03-07 | 湖北科技学院 | 植物激素线粒体酸5在制备治疗糖尿病引起的心肌损伤药物中的用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0686369B2 (ja) * | 1992-12-03 | 1994-11-02 | 和策 西郷 | 美男葛を主原料とする白髪防止を兼ねた発毛剤 |
| JPH11335235A (ja) * | 1998-05-22 | 1999-12-07 | Shiseido Co Ltd | 抗老化剤 |
| KR100443588B1 (ko) * | 2002-01-25 | 2004-08-09 | 나드리화장품주식회사 | 목단피추출물과 자귀나무추출물을 함유하는 노화방지화장료 조성물 |
| JP4460361B2 (ja) * | 2003-06-02 | 2010-05-12 | 日本メナード化粧品株式会社 | メラニン産生促進剤 |
| JP5860577B2 (ja) * | 2008-04-17 | 2016-02-16 | 丸善製薬株式会社 | クローディン産生促進剤及びオクルディン産生促進剤 |
| JP6358809B2 (ja) * | 2014-02-06 | 2018-07-18 | ピアス株式会社 | 生存期間延長剤、生存期間延長用飲食品組成物 |
| JP6910751B2 (ja) * | 2014-02-18 | 2021-07-28 | 共栄化学工業株式会社 | 保湿剤、抗炎症剤、抗酸化剤、皮膚のターンオーバー改善剤、細胞活性化剤及び美白剤 |
| EP4205750B1 (en) * | 2016-01-12 | 2025-04-09 | Eaderm Co., Ltd. | Nadph oxidase inhibitor for suppressing or improving hair loss or treating alopecia |
-
2018
- 2018-09-04 JP JP2018165218A patent/JP2019052145A/ja active Pending
-
2022
- 2022-08-03 JP JP2022124223A patent/JP7452586B2/ja active Active
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