JP2019047804A5 - - Google Patents
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- Publication number
- JP2019047804A5 JP2019047804A5 JP2018208031A JP2018208031A JP2019047804A5 JP 2019047804 A5 JP2019047804 A5 JP 2019047804A5 JP 2018208031 A JP2018208031 A JP 2018208031A JP 2018208031 A JP2018208031 A JP 2018208031A JP 2019047804 A5 JP2019047804 A5 JP 2019047804A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- seq
- promoter
- poi
- host cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 150000007523 nucleic acids Chemical class 0.000 claims 25
- 108020004707 nucleic acids Proteins 0.000 claims 19
- 102000039446 nucleic acids Human genes 0.000 claims 19
- 210000004027 cell Anatomy 0.000 claims 16
- 238000000034 method Methods 0.000 claims 8
- 101100028900 Caenorhabditis elegans pcs-1 gene Proteins 0.000 claims 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 6
- 239000002773 nucleotide Substances 0.000 claims 5
- 125000003729 nucleotide group Chemical group 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 238000012258 culturing Methods 0.000 claims 4
- 108090000790 Enzymes Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000013612 plasmid Substances 0.000 claims 2
- 238000013518 transcription Methods 0.000 claims 2
- 230000035897 transcription Effects 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 241000235058 Komagataella pastoris Species 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 241000235648 Pichia Species 0.000 claims 1
- 241000235070 Saccharomyces Species 0.000 claims 1
- 101710172711 Structural protein Proteins 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 239000013611 chromosomal DNA Substances 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000034356 gene-regulatory proteins Human genes 0.000 claims 1
- 108091006104 gene-regulatory proteins Proteins 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 239000000122 growth hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 238000012545 processing Methods 0.000 claims 1
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/835,589 US9150870B2 (en) | 2013-03-15 | 2013-03-15 | Constitutive promoter |
| US13/835,589 | 2013-03-15 | ||
| EP13159527.4 | 2013-03-15 | ||
| EP13159527 | 2013-03-15 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015561962A Division JP6698352B2 (ja) | 2013-03-15 | 2013-12-18 | 構成的プロモーター |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019047804A JP2019047804A (ja) | 2019-03-28 |
| JP2019047804A5 true JP2019047804A5 (enExample) | 2019-08-08 |
Family
ID=49841670
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015561962A Active JP6698352B2 (ja) | 2013-03-15 | 2013-12-18 | 構成的プロモーター |
| JP2018208031A Withdrawn JP2019047804A (ja) | 2013-03-15 | 2018-11-05 | 構成的プロモーター |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015561962A Active JP6698352B2 (ja) | 2013-03-15 | 2013-12-18 | 構成的プロモーター |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US11168117B2 (enExample) |
| EP (2) | EP2970994B1 (enExample) |
| JP (2) | JP6698352B2 (enExample) |
| KR (1) | KR102128959B1 (enExample) |
| CN (1) | CN105229154B (enExample) |
| AU (1) | AU2013382370B2 (enExample) |
| BR (1) | BR112015022558A2 (enExample) |
| CA (1) | CA2903568C (enExample) |
| DK (1) | DK2970994T3 (enExample) |
| ES (2) | ES3013464T3 (enExample) |
| HK (1) | HK1213292A1 (enExample) |
| IL (1) | IL241340B (enExample) |
| PL (1) | PL2970994T3 (enExample) |
| SG (2) | SG10201804002PA (enExample) |
| WO (1) | WO2014139608A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105229154B (zh) * | 2013-03-15 | 2026-03-03 | 龙沙有限公司 | 组成型启动子 |
| US11377677B2 (en) | 2016-03-02 | 2022-07-05 | Lonza Ltd | Fermentation process |
| US12404309B2 (en) | 2018-02-12 | 2025-09-02 | Lonza Ltd | Host cell for producing a protein of interest |
| EP3536784A1 (en) | 2018-03-05 | 2019-09-11 | ACIB GmbH | Host cell engineered for improved metabolite production |
| SI3802820T1 (sl) * | 2018-06-07 | 2023-05-31 | Basf Se | Postopek za prepoznavanje promotorjev za proizvodnjo proteinov v kvasovkah |
| JP2020146308A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146304A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146313A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146302A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146307A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146297A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146314A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146316A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146311A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146317A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146299A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146306A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146298A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146301A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146318A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146303A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146305A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146315A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146309A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146312A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146300A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| WO2020200415A1 (en) | 2019-04-01 | 2020-10-08 | Lonza Ltd | Mut- methylotrophic yeast |
| JP7570346B2 (ja) | 2019-04-01 | 2024-10-21 | ウニヴェルズィテート・フューア・ボーデンクルトゥーア・ウィーン | Ｍｕｔ－メチロトローフ酵母 |
| WO2020200414A1 (en) | 2019-04-01 | 2020-10-08 | Lonza Ltd | Protein production in mut-methylotrophic yeast |
| CN114341358B (zh) * | 2019-07-25 | 2024-06-14 | 科学与工业研究委员会 | 用于在酵母中高表达蛋白质的重组载体 |
| WO2021198431A1 (en) | 2020-04-01 | 2021-10-07 | Lonza Ltd | Helper factors for expressing proteins in yeast |
| US12486525B2 (en) | 2020-09-22 | 2025-12-02 | Bristol-Myers Squibb Company | Methods for increasing productivity of therapeutic proteins |
| IL301312A (en) | 2020-09-30 | 2023-05-01 | Lonza Ag | Host cells overexpressing translational factors |
| US20250277248A1 (en) * | 2020-12-14 | 2025-09-04 | Indian Institute Of Science | Nucleotide sequence, expression vectors, recombinant yeast cells and applications thereof |
| KR20230144629A (ko) | 2021-02-12 | 2023-10-16 | 베링거 인겔하임 에르체파우 게엠베하 운트 코 카게 | 단백질 분비 증가를 위한 신호 펩타이드 |
| EP4638756A1 (en) | 2022-12-20 | 2025-10-29 | Lonza Ltd. | Host cells with pat1 knockout for increased specific protein productivity |
| CN118308361B (zh) * | 2024-06-07 | 2024-09-17 | 中国人民解放军军事科学院军事医学研究院 | 表达人血清白蛋白的重组序列、生物材料及其应用与方法 |
| WO2026027251A1 (en) | 2024-08-01 | 2026-02-05 | Boehringer Ingelheim Rcv Gmbh & Co Kg | Signal peptides for increased protein secretion |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU577259B2 (en) | 1982-08-13 | 1988-09-22 | Zymogenetics Inc. | Glycolytic promters for regulated protein expression protease inhibitor |
| US4808537A (en) | 1984-10-30 | 1989-02-28 | Phillips Petroleum Company | Methanol inducible genes obtained from pichia and methods of use |
| US4855231A (en) | 1984-10-30 | 1989-08-08 | Phillips Petroleum Company | Regulatory region for heterologous gene expression in yeast |
| WO1997044470A1 (en) | 1996-05-21 | 1997-11-27 | Novo Nordisk A/S | Novel yeast promoters suitable for expression cloning in yeast and heterologous expression of proteins in yeast |
| US6730499B1 (en) | 1998-07-03 | 2004-05-04 | Research Corporation Technologies, Inc. | Promoter for the Pichia pastoris formaldehyde dehydrogenase gene FLD1 |
| US7259255B2 (en) | 2003-06-25 | 2007-08-21 | E. I. Du Pont De Nemours And Company | Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast |
| AT501955B1 (de) | 2005-02-23 | 2007-08-15 | Univ Graz Tech | Mutierte aox1-promotoren |
| KR20070009269A (ko) * | 2005-07-15 | 2007-01-18 | 한국생명공학연구원 | 재조합단백질 생산용 단백질융합인자 라이브러리 및이로부터 획득된 단백질융합인자 |
| WO2007058407A1 (en) | 2005-11-16 | 2007-05-24 | Korea Research Institute Of Bioscience & Biotechnology | Translational elongation factor promoter from pichia pastoris and method for producing recombinant protein using the same |
| US8440456B2 (en) | 2009-05-22 | 2013-05-14 | Vib, Vzw | Nucleic acids of Pichia pastoris and use thereof for recombinant production of proteins |
| CN102180954B (zh) * | 2011-03-01 | 2013-04-17 | 华南理工大学 | 一种毕赤酵母壁蛋白及其构建的表面展示系统和构建方法 |
| CN102994501B (zh) | 2012-10-15 | 2018-04-27 | 华南理工大学 | 具有组成型启动子活性的dna及其应用和巴斯德毕赤酵母表达载体 |
| US20150293076A1 (en) * | 2012-10-22 | 2015-10-15 | Bolt Threads, Inc. | Cellular Reprogramming for Product Optimization |
| US10619164B2 (en) * | 2013-03-08 | 2020-04-14 | Keck Graduate Institute Of Applied Life Sciences | Yeast promoters from Pichia pastoris |
| CN105229154B (zh) * | 2013-03-15 | 2026-03-03 | 龙沙有限公司 | 组成型启动子 |
-
2013
- 2013-12-18 CN CN201380076047.XA patent/CN105229154B/zh active Active
- 2013-12-18 EP EP13811203.2A patent/EP2970994B1/en active Active
- 2013-12-18 ES ES19186013T patent/ES3013464T3/es active Active
- 2013-12-18 KR KR1020157028747A patent/KR102128959B1/ko active Active
- 2013-12-18 AU AU2013382370A patent/AU2013382370B2/en not_active Ceased
- 2013-12-18 BR BR112015022558A patent/BR112015022558A2/pt not_active Application Discontinuation
- 2013-12-18 SG SG10201804002PA patent/SG10201804002PA/en unknown
- 2013-12-18 HK HK16101211.3A patent/HK1213292A1/zh unknown
- 2013-12-18 PL PL13811203T patent/PL2970994T3/pl unknown
- 2013-12-18 DK DK13811203T patent/DK2970994T3/da active
- 2013-12-18 CA CA2903568A patent/CA2903568C/en active Active
- 2013-12-18 ES ES13811203T patent/ES2751336T3/es active Active
- 2013-12-18 EP EP19186013.9A patent/EP3584322B1/en active Active
- 2013-12-18 SG SG11201507557UA patent/SG11201507557UA/en unknown
- 2013-12-18 JP JP2015561962A patent/JP6698352B2/ja active Active
- 2013-12-18 WO PCT/EP2013/077144 patent/WO2014139608A1/en not_active Ceased
-
2015
- 2015-09-08 IL IL241340A patent/IL241340B/en unknown
-
2018
- 2018-11-05 JP JP2018208031A patent/JP2019047804A/ja not_active Withdrawn
-
2019
- 2019-07-16 US US16/513,022 patent/US11168117B2/en active Active
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