JP2019026646A5 - - Google Patents
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- Publication number
- JP2019026646A5 JP2019026646A5 JP2018145568A JP2018145568A JP2019026646A5 JP 2019026646 A5 JP2019026646 A5 JP 2019026646A5 JP 2018145568 A JP2018145568 A JP 2018145568A JP 2018145568 A JP2018145568 A JP 2018145568A JP 2019026646 A5 JP2019026646 A5 JP 2019026646A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- aromatic heterocyclic
- formula
- aromatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 35
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 32
- 125000000217 alkyl group Chemical group 0.000 claims 31
- 125000003118 aryl group Chemical group 0.000 claims 26
- 125000002837 carbocyclic group Chemical group 0.000 claims 24
- 150000001875 compounds Chemical class 0.000 claims 19
- 239000008194 pharmaceutical composition Substances 0.000 claims 19
- 150000003839 salts Chemical class 0.000 claims 18
- 125000003545 alkoxy group Chemical group 0.000 claims 16
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 14
- 229910052736 halogen Inorganic materials 0.000 claims 14
- 150000002367 halogens Chemical class 0.000 claims 14
- 125000002619 bicyclic group Chemical group 0.000 claims 12
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 12
- 125000003342 alkenyl group Chemical group 0.000 claims 11
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 10
- 125000000304 alkynyl group Chemical group 0.000 claims 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims 9
- 125000005137 alkenylsulfonyl group Chemical group 0.000 claims 7
- 125000003302 alkenyloxy group Chemical group 0.000 claims 5
- 125000005092 alkenyloxycarbonyl group Chemical group 0.000 claims 5
- 125000005133 alkynyloxy group Chemical group 0.000 claims 5
- 125000005225 alkynyloxycarbonyl group Chemical group 0.000 claims 5
- 125000005139 alkynylsulfonyl group Chemical group 0.000 claims 5
- -1 cyano, carboxy Chemical group 0.000 claims 5
- 125000001424 substituent group Chemical group 0.000 claims 5
- 125000002252 acyl group Chemical group 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 101150111783 NTRK1 gene Proteins 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 0 CC(*)=*c1c(*)[n](*)nc1* Chemical compound CC(*)=*c1c(*)[n](*)nc1* 0.000 description 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017150341 | 2017-08-03 | ||
| JP2017150341 | 2017-08-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019026646A JP2019026646A (ja) | 2019-02-21 |
| JP2019026646A5 true JP2019026646A5 (enExample) | 2021-08-19 |
Family
ID=65477645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018145568A Pending JP2019026646A (ja) | 2017-08-03 | 2018-08-02 | 含窒素複素環および炭素環誘導体を含有する、疼痛の治療および／または予防用医薬組成物 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2019026646A (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4323353A4 (en) * | 2021-04-12 | 2025-04-02 | Cullgen (Shanghai), Inc. | TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE |
| JP2023085798A (ja) * | 2021-12-09 | 2023-06-21 | ヘンケルジャパン株式会社 | ホットメルト接着剤 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102001364B1 (ko) * | 2011-05-13 | 2019-07-22 | 어레이 바이오파마 인크. | Trka 키나제 저해제로서의 피롤리디닐 유레아 및 피롤리디닐 티오유레아 화합물 |
| UA116455C2 (uk) * | 2012-11-13 | 2018-03-26 | Еррей Біофарма Інк. | Сполуки n-піролідинілсечовини, n'-піразолілсечовини, тіосечовини, гуанідину та ціаногуанідину як інгібітори кінази trka |
| MY191956A (en) * | 2014-05-15 | 2022-07-20 | Array Biopharma Inc | 1-((3s,4r)-4-(3-fluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1h-pyrazol-5-yl)urea as a trka kinase inhibitor |
| WO2016021629A1 (ja) * | 2014-08-06 | 2016-02-11 | 塩野義製薬株式会社 | ＴｒｋＡ阻害活性を有する複素環および炭素環誘導体 |
-
2018
- 2018-08-02 JP JP2018145568A patent/JP2019026646A/ja active Pending
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