JP2018537975A5 - - Google Patents
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- JP2018537975A5 JP2018537975A5 JP2018527739A JP2018527739A JP2018537975A5 JP 2018537975 A5 JP2018537975 A5 JP 2018537975A5 JP 2018527739 A JP2018527739 A JP 2018527739A JP 2018527739 A JP2018527739 A JP 2018527739A JP 2018537975 A5 JP2018537975 A5 JP 2018537975A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- heavy chain
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562260854P | 2015-11-30 | 2015-11-30 | |
| US62/260,854 | 2015-11-30 | ||
| US201662289744P | 2016-02-01 | 2016-02-01 | |
| US201662289727P | 2016-02-01 | 2016-02-01 | |
| US62/289,744 | 2016-02-01 | ||
| US62/289,727 | 2016-02-01 | ||
| US201662409105P | 2016-10-17 | 2016-10-17 | |
| US62/409,105 | 2016-10-17 | ||
| PCT/IB2016/057017 WO2017093844A1 (en) | 2015-11-30 | 2016-11-22 | Site specific her2 antibody drug conjugates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018537975A JP2018537975A (ja) | 2018-12-27 |
| JP2018537975A5 true JP2018537975A5 (OSRAM) | 2020-01-16 |
| JP6979950B2 JP6979950B2 (ja) | 2021-12-15 |
Family
ID=57485830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018527739A Expired - Fee Related JP6979950B2 (ja) | 2015-11-30 | 2016-11-22 | 部位特異的her2抗体薬物コンジュゲート |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US10689458B2 (OSRAM) |
| EP (1) | EP3383918A1 (OSRAM) |
| JP (1) | JP6979950B2 (OSRAM) |
| KR (2) | KR102208317B1 (OSRAM) |
| CN (1) | CN108473591B (OSRAM) |
| AU (1) | AU2016363373A1 (OSRAM) |
| BR (1) | BR112018010102A2 (OSRAM) |
| CA (1) | CA2949032A1 (OSRAM) |
| CO (1) | CO2018005433A2 (OSRAM) |
| IL (1) | IL259651B2 (OSRAM) |
| MX (1) | MX2018006582A (OSRAM) |
| PH (1) | PH12018501043A1 (OSRAM) |
| RU (1) | RU2745565C2 (OSRAM) |
| SG (2) | SG11201803676PA (OSRAM) |
| TW (3) | TWI778491B (OSRAM) |
| WO (1) | WO2017093844A1 (OSRAM) |
| ZA (1) | ZA201803205B (OSRAM) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3111357A1 (en) | 2011-12-23 | 2013-06-27 | Pfizer Inc. | Engineered antibody constant regions for site-specific conjugation and methods and uses therefor |
| IL310865A (en) * | 2016-10-17 | 2024-04-01 | Pfizer | Antibodies against EDB and antibody-drug conjugates |
| CN111163809B (zh) | 2017-09-19 | 2024-07-02 | 保罗·谢勒学院 | 转谷氨酰胺酶缀合方法和接头 |
| US11364303B2 (en) | 2017-09-29 | 2022-06-21 | Pfizer Inc. | Cysteine engineered antibody drug conjugates |
| US20220370606A1 (en) | 2018-12-21 | 2022-11-24 | Pfizer Inc. | Combination Treatments Of Cancer Comprising A TLR Agonist |
| CN114901308A (zh) * | 2019-10-29 | 2022-08-12 | 石药集团巨石生物制药有限公司 | 使用抗her2抗体药物缀合物治疗癌症的组合物和方法 |
| CA3165135A1 (en) * | 2019-12-20 | 2021-06-24 | Pfizer Inc. | Treatment with site specific her2 antibody-drug conjugates |
| WO2021143741A1 (zh) * | 2020-01-15 | 2021-07-22 | 北京海步医药科技有限公司 | 靶向多肽-药物缀合物及其用途 |
| BR112023002154A2 (pt) | 2020-08-04 | 2023-03-14 | Pfizer | Tratamento com conjugados anticorpo-fármaco anti-her2 de local específico |
| CN112202628B (zh) * | 2020-09-08 | 2022-09-02 | 杭州涂鸦信息技术有限公司 | 一种WiFi模块串口协议自动化测试系统及方法 |
| CN112285361B (zh) * | 2020-09-27 | 2023-12-05 | 中国人民解放军空军军医大学 | 排除抗-cd38单克隆抗体药物对抗人球蛋白检测干扰的试剂 |
| WO2022084560A1 (en) | 2020-10-25 | 2022-04-28 | Araris Biotech Ag | Means and methods for producing antibody-linker conjugates |
| AU2022222937A1 (en) * | 2021-02-18 | 2023-08-17 | Remegen Co., Ltd. | Use of antibody-drug conjugate targeting her2 in treatment of specific breast cancer |
| CN118434759A (zh) * | 2021-10-10 | 2024-08-02 | 安立玺荣生医(香港)有限公司 | 用抗-pd-l1/il-10融合蛋白治疗疾病的方法 |
| JP2024539989A (ja) * | 2021-10-25 | 2024-10-31 | アラリス バイオテック アーゲー | 抗体-リンカーコンジュゲートを生成する方法 |
| MX2024009292A (es) * | 2022-01-26 | 2024-08-06 | Biocytogen Pharmaceuticals Beijing Co Ltd | Anticuerpos anti-her2/trop2 y usos de los mismos. |
| WO2024162772A1 (ko) * | 2023-02-01 | 2024-08-08 | 주식회사 에이티지씨 | 생체 내 지속성이 증가된 생리활성물질의 결합체 |
| CN120738196B (zh) * | 2025-09-03 | 2025-12-16 | 浙江博锐生物制药有限公司 | 编码抗her2抗体的核酸分子及其应用 |
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| CN104998273A (zh) | 2003-11-06 | 2015-10-28 | 西雅图基因公司 | 能够与配体偶联的单甲基缬氨酸化合物 |
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| RS53594B1 (sr) | 2004-07-22 | 2015-02-27 | Genentech, Inc. | Preparat her2 antitela |
| EP3088004B1 (en) | 2004-09-23 | 2018-03-28 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
| CA2598833A1 (en) | 2005-03-03 | 2006-09-08 | Curt W. Bradshaw | Anti-angiogenic compounds |
| CN101312748A (zh) | 2005-09-26 | 2008-11-26 | 梅达莱克斯公司 | 抗体-药物轭合物和使用方法 |
| JPWO2008032833A1 (ja) | 2006-09-14 | 2010-01-28 | 株式会社医学生物学研究所 | Adcc活性を増強させた抗体及びその製造方法 |
| US20090098115A1 (en) * | 2006-10-20 | 2009-04-16 | Lisa Michele Crocker | Cell lines and animal models of HER2 expressing tumors |
| JP5606916B2 (ja) | 2007-10-19 | 2014-10-15 | ジェネンテック, インコーポレイテッド | システイン操作抗tenb2抗体および抗体薬物結合体 |
| ES2613963T3 (es) | 2008-01-18 | 2017-05-29 | Medimmune, Llc | Anticuerpos manipulados con cisteína para conjugación específica de sitio |
| IL287292B (en) | 2008-01-31 | 2022-09-01 | Genentech Inc | Cycteine engineering anti-cd79b antibodies and antibody-drug conjugates |
| EP2711018A1 (en) | 2009-06-22 | 2014-03-26 | MedImmune, LLC | Engineered Fc regions for site-specific conjugation |
| CA2799540A1 (en) | 2010-06-08 | 2011-12-15 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
| ME02637B (me) | 2010-08-20 | 2017-06-20 | Novartis Ag | Antitela za receptor 3 faktora rasta epiderma (her3) |
| TW201302793A (zh) | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
| US9676871B2 (en) | 2010-11-05 | 2017-06-13 | Pfizer Inc. | Engineered polypeptide conjugates and methods for making thereof using transglutaminase |
| CA2818635C (en) | 2010-12-06 | 2021-06-15 | National Reseach Council Of Canada | Antibodies selective for cells presenting erbb2 at high density |
| US8852599B2 (en) | 2011-05-26 | 2014-10-07 | Bristol-Myers Squibb Company | Immunoconjugates, compositions for making them, and methods of making and use |
| CN104053672A (zh) | 2011-11-11 | 2014-09-17 | 瑞纳神经科学公司 | Trop-2特异性抗体及其用途 |
| WO2013072813A2 (en) * | 2011-11-17 | 2013-05-23 | Pfizer Inc. | Cytotoxic peptides and antibody drug conjugates thereof |
| CA3111357A1 (en) | 2011-12-23 | 2013-06-27 | Pfizer Inc. | Engineered antibody constant regions for site-specific conjugation and methods and uses therefor |
| EP2844289B1 (en) | 2012-04-30 | 2019-07-17 | MedImmune, LLC | Molecules with reduced effector function and extended half-lives, compositions, and uses thereof |
| KR102557309B1 (ko) | 2012-05-15 | 2023-07-20 | 씨젠 인크. | 자가-안정화 링커 접합체 |
| US9540442B2 (en) | 2012-08-02 | 2017-01-10 | Jn Biosciences Llc | Antibodies or fusion proteins multimerized via cysteine mutation and a mu tailpiece |
| WO2014022846A1 (en) | 2012-08-03 | 2014-02-06 | Board Of Regents Of The University Of Nebraska | Cancer biomarkers and methods of use thereof |
| KR20150083856A (ko) | 2012-10-12 | 2015-07-20 | 에이디씨 테라퓨틱스 에스에이알엘 | 피롤로벤조디아제핀-항-her2 항체 컨주게이트 |
| CN110256469B (zh) | 2012-10-12 | 2022-05-17 | 麦迪穆有限责任公司 | 吡咯并苯并二氮杂卓及其结合物 |
| AU2013343111A1 (en) | 2012-11-07 | 2015-05-14 | Pfizer Inc. | Anti-IL-13 receptor alpha 2 antibodies and antibody-drug conjugates |
| SI2953976T1 (sl) * | 2013-02-08 | 2021-08-31 | Novartis Ag | Specifična mesta z modificiranje protiteles za izdelavo imunokonjugatov |
| NZ710745A (en) | 2013-03-13 | 2019-03-29 | Genentech Inc | Pyrrolobenzodiazepines and conjugates thereof |
| KR101899306B1 (ko) | 2013-07-03 | 2018-10-04 | 서울대학교산학협력단 | 시스테인으로 변형된 닭의 항체 및 이를 이용한 부위-특이적 접합 |
| BR112016002829A2 (pt) | 2013-08-12 | 2017-09-19 | Genentech Inc | Composto e processo para preparar o composto de conjugado anticorpo-¿droga, composição farmacêutica, método de tratamento do câncer, kit para o tratamento do câncer, intermediário ligante¿-droga, porção e composto de porção droga de dímero cbi |
| WO2015038426A1 (en) | 2013-09-13 | 2015-03-19 | Asana Biosciences, Llc | Self-immolative linkers containing mandelic acid derivatives, drug-ligand conjugates for targeted therapies and uses thereof |
| US9239324B2 (en) | 2013-12-06 | 2016-01-19 | Gang Chen | Antibody-binding protein-drug conjugate and methods of use |
| PL3086814T3 (pl) | 2013-12-23 | 2020-12-28 | Bayer Pharma Aktiengesellschaft | Koniugaty środka wiążącego (ADC) z inhibitorami KSP |
| PE20161031A1 (es) | 2014-01-27 | 2016-10-26 | Pfizer | Agentes citotoxicos bifuncionales |
| RS66392B1 (sr) * | 2014-02-28 | 2025-02-28 | Merus Nv | Antitelo koje vezuje erbb-2 i erbb-3 |
| HK1232127A1 (zh) | 2014-04-11 | 2018-01-05 | Medimmune, Llc | 双特异性her2抗体 |
| CN106456608B (zh) * | 2014-06-06 | 2020-08-28 | 雷德伍德生物科技股份有限公司 | 抗her2抗体-美登木素缀合物及其使用方法 |
| WO2016151432A1 (en) | 2015-03-20 | 2016-09-29 | Pfizer Inc. | Bifunctional cytotoxic agents containing the cti pharmacophore |
| CA2949033C (en) | 2015-11-30 | 2025-05-06 | Pfizer Inc. | ANTIBODIES AND ANTIBODY FRAGMENTS FOR SITE-SPECIFIC CONJUGATION |
-
2016
- 2016-11-21 TW TW110100847A patent/TWI778491B/zh not_active IP Right Cessation
- 2016-11-21 US US15/356,750 patent/US10689458B2/en active Active
- 2016-11-21 TW TW105138129A patent/TWI726942B/zh not_active IP Right Cessation
- 2016-11-21 TW TW108126399A patent/TWI727380B/zh not_active IP Right Cessation
- 2016-11-21 CA CA2949032A patent/CA2949032A1/en not_active Abandoned
- 2016-11-22 MX MX2018006582A patent/MX2018006582A/es unknown
- 2016-11-22 EP EP16806285.9A patent/EP3383918A1/en not_active Withdrawn
- 2016-11-22 KR KR1020187018244A patent/KR102208317B1/ko not_active Expired - Fee Related
- 2016-11-22 AU AU2016363373A patent/AU2016363373A1/en not_active Abandoned
- 2016-11-22 KR KR1020207030005A patent/KR102312149B1/ko not_active Expired - Fee Related
- 2016-11-22 RU RU2018119683A patent/RU2745565C2/ru active
- 2016-11-22 BR BR112018010102-8A patent/BR112018010102A2/pt not_active IP Right Cessation
- 2016-11-22 SG SG11201803676PA patent/SG11201803676PA/en unknown
- 2016-11-22 JP JP2018527739A patent/JP6979950B2/ja not_active Expired - Fee Related
- 2016-11-22 SG SG10202005102YA patent/SG10202005102YA/en unknown
- 2016-11-22 CN CN201680072749.4A patent/CN108473591B/zh not_active Expired - Fee Related
- 2016-11-22 WO PCT/IB2016/057017 patent/WO2017093844A1/en not_active Ceased
-
2018
- 2018-05-15 ZA ZA2018/03205A patent/ZA201803205B/en unknown
- 2018-05-16 PH PH12018501043A patent/PH12018501043A1/en unknown
- 2018-05-24 CO CONC2018/0005433A patent/CO2018005433A2/es unknown
- 2018-05-28 IL IL259651A patent/IL259651B2/en unknown
-
2020
- 2020-06-03 US US16/891,460 patent/US20200377615A1/en not_active Abandoned
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