JP2018537495A5 - - Google Patents
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- Publication number
- JP2018537495A5 JP2018537495A5 JP2018531343A JP2018531343A JP2018537495A5 JP 2018537495 A5 JP2018537495 A5 JP 2018537495A5 JP 2018531343 A JP2018531343 A JP 2018531343A JP 2018531343 A JP2018531343 A JP 2018531343A JP 2018537495 A5 JP2018537495 A5 JP 2018537495A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- slurry
- acetone
- mixture
- polymorph
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 **CCc1cc(NC(*)=N)ccc1 Chemical compound **CCc1cc(NC(*)=N)ccc1 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021142864A JP2021191782A (ja) | 2015-12-17 | 2021-09-02 | 置換５，６−ジヒドロ−６−フェニルベンゾ［ｆ］イソキノリン−２−アミンを調製するための方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562268758P | 2015-12-17 | 2015-12-17 | |
| US62/268,758 | 2015-12-17 | ||
| PCT/US2016/067161 WO2017106639A1 (en) | 2015-12-17 | 2016-12-16 | Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021142864A Division JP2021191782A (ja) | 2015-12-17 | 2021-09-02 | 置換５，６−ジヒドロ−６−フェニルベンゾ［ｆ］イソキノリン−２−アミンを調製するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018537495A JP2018537495A (ja) | 2018-12-20 |
| JP2018537495A5 true JP2018537495A5 (cg-RX-API-DMAC7.html) | 2020-01-23 |
| JP6940504B2 JP6940504B2 (ja) | 2021-09-29 |
Family
ID=59057623
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018531343A Expired - Fee Related JP6940504B2 (ja) | 2015-12-17 | 2016-12-16 | 置換５，６−ジヒドロ−６−フェニルベンゾ［ｆ］イソキノリン−２−アミンを調製するための方法 |
| JP2021142864A Ceased JP2021191782A (ja) | 2015-12-17 | 2021-09-02 | 置換５，６−ジヒドロ−６−フェニルベンゾ［ｆ］イソキノリン−２−アミンを調製するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021142864A Ceased JP2021191782A (ja) | 2015-12-17 | 2021-09-02 | 置換５，６−ジヒドロ−６−フェニルベンゾ［ｆ］イソキノリン−２−アミンを調製するための方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US9834519B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP4015508A1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6940504B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20180085814A (cg-RX-API-DMAC7.html) |
| CN (2) | CN108602779A (cg-RX-API-DMAC7.html) |
| AU (2) | AU2016369520B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112018012325A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3006077A1 (cg-RX-API-DMAC7.html) |
| EA (1) | EA201891431A1 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1255014A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL259557A (cg-RX-API-DMAC7.html) |
| MX (2) | MX385672B (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ742785A (cg-RX-API-DMAC7.html) |
| SG (1) | SG11201804601TA (cg-RX-API-DMAC7.html) |
| TW (1) | TWI748972B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017106639A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112018012095A2 (pt) | 2015-12-17 | 2018-11-27 | Arqule Inc | formas sólidas de compostos substituidos de 5,6-di-hidro-6-fenilbenzo[f]isoquinolin-2-amina |
| EP4015508A1 (en) * | 2015-12-17 | 2022-06-22 | ArQule, Inc. | Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine |
| CN110669015A (zh) * | 2018-07-03 | 2020-01-10 | 上海喀露蓝科技有限公司 | 一种fgfr抑制剂的制备方法 |
| US10878412B2 (en) * | 2019-05-13 | 2020-12-29 | Truist Bank | In-line verification of transactions |
| WO2022053708A1 (en) | 2020-09-14 | 2022-03-17 | Basilea Pharmaceutica International AG | Pharmaceutical combinations for use in the treatment of gastric adenocarcinoma |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| EP0946523A1 (en) * | 1996-12-23 | 1999-10-06 | Celltech Therapeutics Limited | Fused polycyclic 2-aminopyrimidine derivatives, their preparation and their use as protein tyrosine kinase inhibitors |
| GB9713087D0 (en) * | 1997-06-20 | 1997-08-27 | Celltech Therapeutics Ltd | Chemical compounds |
| WO2006066172A1 (en) | 2004-12-17 | 2006-06-22 | Amgen, Inc. | Aminopyrimidine compounds and methods of use |
| AU2007342007A1 (en) | 2006-12-29 | 2008-07-10 | Rigel Pharmaceuticals, Inc. | Substituted triazoles useful as Axl inhibitors |
| GB2449293A (en) * | 2007-05-17 | 2008-11-19 | Evotec | Compounds having Hsp90 inhibitory activity |
| KR101714799B1 (ko) * | 2008-12-30 | 2017-03-09 | 아르퀼 인코포레이티드 | 치환된 5,6-디히드로-6-페닐벤조［ｆ］이소퀴놀린-2-아민 화합물 |
| CN103476770B (zh) | 2010-11-25 | 2017-02-15 | 拉蒂欧制药有限责任公司 | 阿法替尼盐和多晶型物 |
| US8815854B2 (en) * | 2011-06-24 | 2014-08-26 | Arqule, Inc. | Substituted imidazopyridinyl compounds |
| CN106459993A (zh) * | 2014-03-31 | 2017-02-22 | 德彪药业国际股份公司 | Fgfr融合体 |
| BR112018012095A2 (pt) | 2015-12-17 | 2018-11-27 | Arqule Inc | formas sólidas de compostos substituidos de 5,6-di-hidro-6-fenilbenzo[f]isoquinolin-2-amina |
| EP4015508A1 (en) | 2015-12-17 | 2022-06-22 | ArQule, Inc. | Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine |
-
2016
- 2016-12-16 EP EP21216064.2A patent/EP4015508A1/en active Pending
- 2016-12-16 KR KR1020187020433A patent/KR20180085814A/ko not_active Ceased
- 2016-12-16 BR BR112018012325A patent/BR112018012325A2/pt not_active Application Discontinuation
- 2016-12-16 CN CN201680081965.5A patent/CN108602779A/zh active Pending
- 2016-12-16 SG SG11201804601TA patent/SG11201804601TA/en unknown
- 2016-12-16 TW TW105141874A patent/TWI748972B/zh not_active IP Right Cessation
- 2016-12-16 WO PCT/US2016/067161 patent/WO2017106639A1/en not_active Ceased
- 2016-12-16 CA CA3006077A patent/CA3006077A1/en active Pending
- 2016-12-16 US US15/381,418 patent/US9834519B2/en active Active
- 2016-12-16 HK HK18114135.7A patent/HK1255014A1/zh unknown
- 2016-12-16 CN CN202210565751.2A patent/CN114874149A/zh active Pending
- 2016-12-16 MX MX2018007415A patent/MX385672B/es unknown
- 2016-12-16 JP JP2018531343A patent/JP6940504B2/ja not_active Expired - Fee Related
- 2016-12-16 MX MX2020012771A patent/MX2020012771A/es unknown
- 2016-12-16 AU AU2016369520A patent/AU2016369520B2/en not_active Ceased
- 2016-12-16 NZ NZ742785A patent/NZ742785A/en not_active IP Right Cessation
- 2016-12-16 EP EP16876767.1A patent/EP3390368A4/en not_active Withdrawn
- 2016-12-16 EA EA201891431A patent/EA201891431A1/ru unknown
-
2017
- 2017-11-01 US US15/800,648 patent/US10093632B2/en active Active
-
2018
- 2018-05-23 IL IL259557A patent/IL259557A/en unknown
-
2019
- 2019-04-22 US US16/390,205 patent/US10766868B2/en not_active Expired - Fee Related
- 2019-10-03 US US16/592,003 patent/US11279679B2/en active Active
-
2021
- 2021-04-28 AU AU2021202610A patent/AU2021202610B2/en not_active Ceased
- 2021-09-02 JP JP2021142864A patent/JP2021191782A/ja not_active Ceased
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