JP2018537103A5 - - Google Patents
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- Publication number
- JP2018537103A5 JP2018537103A5 JP2018530502A JP2018530502A JP2018537103A5 JP 2018537103 A5 JP2018537103 A5 JP 2018537103A5 JP 2018530502 A JP2018530502 A JP 2018530502A JP 2018530502 A JP2018530502 A JP 2018530502A JP 2018537103 A5 JP2018537103 A5 JP 2018537103A5
- Authority
- JP
- Japan
- Prior art keywords
- rsv
- gene
- seq
- recombinant rsv
- recombinant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000725643 Respiratory syncytial virus Species 0.000 claims description 101
- 238000012986 modification Methods 0.000 claims description 24
- 230000004048 modification Effects 0.000 claims description 24
- 108090000623 proteins and genes Proteins 0.000 claims description 14
- 101150033828 NS1 gene Proteins 0.000 claims description 13
- 101150036080 at gene Proteins 0.000 claims description 12
- 239000002773 nucleotide Substances 0.000 claims description 12
- 125000003729 nucleotide group Chemical group 0.000 claims description 12
- 101150095629 NS2 gene Proteins 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- 108700008625 Reporter Genes Proteins 0.000 claims description 6
- 108091033319 polynucleotide Proteins 0.000 claims description 6
- 239000002157 polynucleotide Substances 0.000 claims description 6
- 102000040430 polynucleotide Human genes 0.000 claims description 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 4
- 108010043121 Green Fluorescent Proteins Proteins 0.000 claims description 4
- 102000004144 Green Fluorescent Proteins Human genes 0.000 claims description 4
- 102000014150 Interferons Human genes 0.000 claims description 4
- 108010050904 Interferons Proteins 0.000 claims description 4
- 208000036142 Viral infection Diseases 0.000 claims description 4
- 230000002238 attenuated effect Effects 0.000 claims description 4
- 238000004113 cell culture Methods 0.000 claims description 4
- 210000004748 cultured cell Anatomy 0.000 claims description 4
- 238000012217 deletion Methods 0.000 claims description 4
- 230000037430 deletion Effects 0.000 claims description 4
- 239000005090 green fluorescent protein Substances 0.000 claims description 4
- 229940079322 interferon Drugs 0.000 claims description 4
- 230000010076 replication Effects 0.000 claims description 4
- 230000004044 response Effects 0.000 claims description 4
- 230000009385 viral infection Effects 0.000 claims description 4
- 101150066838 12 gene Proteins 0.000 claims description 3
- 230000028993 immune response Effects 0.000 claims description 3
- 101150103632 M2-2 gene Proteins 0.000 claims description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 2
- 241000700605 Viruses Species 0.000 claims description 2
- 239000000443 aerosol Substances 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims description 2
- 239000002299 complementary DNA Substances 0.000 claims description 2
- 230000003247 decreasing effect Effects 0.000 claims description 2
- 230000002163 immunogen Effects 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 230000002458 infectious effect Effects 0.000 claims description 2
- 230000005764 inhibitory process Effects 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims description 2
- 230000010468 interferon response Effects 0.000 claims description 2
- 239000007923 nasal drop Substances 0.000 claims description 2
- 229940100662 nasal drops Drugs 0.000 claims description 2
- 239000007922 nasal spray Substances 0.000 claims description 2
- 229940097496 nasal spray Drugs 0.000 claims description 2
- 238000013518 transcription Methods 0.000 claims description 2
- 230000035897 transcription Effects 0.000 claims description 2
- 241000724205 Rice stripe tenuivirus Species 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562266206P | 2015-12-11 | 2015-12-11 | |
| US62/266,206 | 2015-12-11 | ||
| PCT/US2016/066142 WO2017100756A1 (en) | 2015-12-11 | 2016-12-12 | Recombinant respiratory syncytial virus strains comprising ns1 and ns2 gene shifts |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2018537103A JP2018537103A (ja) | 2018-12-20 |
| JP2018537103A5 true JP2018537103A5 (OSRAM) | 2020-01-23 |
| JP7063808B2 JP7063808B2 (ja) | 2022-05-09 |
| JP7063808B6 JP7063808B6 (ja) | 2022-06-07 |
Family
ID=58108722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018530502A Active JP7063808B6 (ja) | 2015-12-11 | 2016-12-12 | Ｎｓ１およびｎｓ２遺伝子シフトを含む組換えｒｓウイルス株 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10953083B2 (OSRAM) |
| EP (1) | EP3387120B1 (OSRAM) |
| JP (1) | JP7063808B6 (OSRAM) |
| KR (1) | KR20180085802A (OSRAM) |
| CN (1) | CN108699535B (OSRAM) |
| AU (1) | AU2016366768A1 (OSRAM) |
| CA (1) | CA3007474A1 (OSRAM) |
| WO (1) | WO2017100756A1 (OSRAM) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2022009099A (es) * | 2020-01-28 | 2022-10-20 | Codagenix Inc | Sars-cov-2 desoptimizados y metodos y usos de los mismos. |
| KR20230107609A (ko) * | 2020-11-12 | 2023-07-17 | 머크 샤프 앤드 돔 엘엘씨 | 항-호흡기 세포융합 바이러스 (rsv) 항체 세포-기반 역가 검정 |
| TW202535439A (zh) | 2023-11-17 | 2025-09-16 | 美商賽諾菲巴斯德公司 | 海藻糖疫苗調配物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3224404A1 (de) | 1982-06-30 | 1984-01-05 | LuK Lamellen und Kupplungsbau GmbH, 7580 Bühl | Reibungskupplung sowie verfahren zu deren montage |
| CA2230033C (en) | 1995-09-27 | 2010-01-26 | Peter L. Collins | Production of infectious respiratory syncytial virus from cloned nucleotide sequences |
| US6596529B1 (en) | 1997-05-02 | 2003-07-22 | Uab Research Foundation | Manipulation of negative stranded RNA viruses by rearrangement of their genes and uses thereof |
| US7820182B2 (en) * | 1999-07-09 | 2010-10-26 | The United States Of America As Represented By The Department Of Health And Human Services | Production of attenuated, human-bovine chimeric respiratory syncytial viruses for use in immunogenic compositions |
| IL147436A0 (en) * | 1999-07-13 | 2002-08-14 | Us Gov Health & Human Serv | Respiratory syncytial viruses expressing immune modulatory molecules |
| JP2004515218A (ja) * | 2000-06-23 | 2004-05-27 | アメリカ合衆国 | プロモータへ隣接する遺伝子から保護抗原を発現する呼吸器系合胞体ウイルスワクチン |
| WO2017030997A1 (en) | 2015-08-14 | 2017-02-23 | Research Institute At Nationwide Children's Hospital | Respiratory syncytial virus having altered ns1 protein function and related materials and methods |
-
2016
- 2016-12-12 US US16/061,316 patent/US10953083B2/en active Active
- 2016-12-12 AU AU2016366768A patent/AU2016366768A1/en not_active Abandoned
- 2016-12-12 JP JP2018530502A patent/JP7063808B6/ja active Active
- 2016-12-12 KR KR1020187019755A patent/KR20180085802A/ko not_active Ceased
- 2016-12-12 EP EP16838103.6A patent/EP3387120B1/en active Active
- 2016-12-12 WO PCT/US2016/066142 patent/WO2017100756A1/en not_active Ceased
- 2016-12-12 CN CN201680081929.9A patent/CN108699535B/zh active Active
- 2016-12-12 CA CA3007474A patent/CA3007474A1/en active Pending
-
2021
- 2021-02-23 US US17/183,227 patent/US11918638B2/en active Active
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