JP2018536849A5 - - Google Patents
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- Publication number
- JP2018536849A5 JP2018536849A5 JP2018520476A JP2018520476A JP2018536849A5 JP 2018536849 A5 JP2018536849 A5 JP 2018536849A5 JP 2018520476 A JP2018520476 A JP 2018520476A JP 2018520476 A JP2018520476 A JP 2018520476A JP 2018536849 A5 JP2018536849 A5 JP 2018536849A5
- Authority
- JP
- Japan
- Prior art keywords
- histone
- modification
- isoform
- variant
- nucleosome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010033040 Histones Proteins 0.000 claims description 154
- 102000006947 Histones Human genes 0.000 claims description 154
- 108010047956 Nucleosomes Proteins 0.000 claims description 88
- 210000001623 nucleosome Anatomy 0.000 claims description 88
- 102000001708 Protein Isoforms Human genes 0.000 claims description 74
- 108010029485 Protein Isoforms Proteins 0.000 claims description 74
- 238000012986 modification Methods 0.000 claims description 72
- 230000004048 modification Effects 0.000 claims description 72
- 238000000034 method Methods 0.000 claims description 40
- 239000011230 binding agent Substances 0.000 claims description 20
- 239000000090 biomarker Substances 0.000 claims description 16
- 206010028980 Neoplasm Diseases 0.000 claims description 15
- 201000011510 cancer Diseases 0.000 claims description 15
- 210000001124 body fluid Anatomy 0.000 claims description 12
- 239000010839 body fluid Substances 0.000 claims description 12
- 208000031229 Cardiomyopathies Diseases 0.000 claims description 10
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 10
- 208000011231 Crohn disease Diseases 0.000 claims description 10
- 206010009887 colitis Diseases 0.000 claims description 10
- 238000003745 diagnosis Methods 0.000 claims description 10
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 10
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 10
- 201000010099 disease Diseases 0.000 claims description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 9
- 241001465754 Metazoa Species 0.000 claims description 8
- 208000023275 Autoimmune disease Diseases 0.000 claims description 7
- 201000009273 Endometriosis Diseases 0.000 claims description 7
- 208000027866 inflammatory disease Diseases 0.000 claims description 7
- 210000004369 blood Anatomy 0.000 claims description 6
- 239000008280 blood Substances 0.000 claims description 6
- 206010009944 Colon cancer Diseases 0.000 claims description 5
- 210000001072 colon Anatomy 0.000 claims description 5
- 208000029742 colonic neoplasm Diseases 0.000 claims description 5
- 108010077544 Chromatin Proteins 0.000 claims description 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 4
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 4
- 210000004027 cell Anatomy 0.000 claims description 4
- 210000003483 chromatin Anatomy 0.000 claims description 4
- 238000001514 detection method Methods 0.000 claims description 4
- 210000004072 lung Anatomy 0.000 claims description 4
- 201000005202 lung cancer Diseases 0.000 claims description 4
- 208000020816 lung neoplasm Diseases 0.000 claims description 4
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 4
- 238000005259 measurement Methods 0.000 claims description 4
- 210000000214 mouth Anatomy 0.000 claims description 4
- 201000005443 oral cavity cancer Diseases 0.000 claims description 4
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 4
- 210000002381 plasma Anatomy 0.000 claims description 4
- 210000002966 serum Anatomy 0.000 claims description 4
- 206010005003 Bladder cancer Diseases 0.000 claims description 2
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 208000026310 Breast neoplasm Diseases 0.000 claims description 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 2
- 206010033128 Ovarian cancer Diseases 0.000 claims description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
- 208000015634 Rectal Neoplasms Diseases 0.000 claims description 2
- 206010038389 Renal cancer Diseases 0.000 claims description 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 2
- 239000013060 biological fluid Substances 0.000 claims description 2
- 210000000481 breast Anatomy 0.000 claims description 2
- 201000010881 cervical cancer Diseases 0.000 claims description 2
- 210000003679 cervix uteri Anatomy 0.000 claims description 2
- 230000000593 degrading effect Effects 0.000 claims description 2
- 201000004101 esophageal cancer Diseases 0.000 claims description 2
- 210000003238 esophagus Anatomy 0.000 claims description 2
- 238000011156 evaluation Methods 0.000 claims description 2
- 206010017758 gastric cancer Diseases 0.000 claims description 2
- 210000003734 kidney Anatomy 0.000 claims description 2
- 201000010982 kidney cancer Diseases 0.000 claims description 2
- 239000003446 ligand Substances 0.000 claims description 2
- 230000003278 mimic effect Effects 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 claims description 2
- 210000001672 ovary Anatomy 0.000 claims description 2
- 210000000496 pancreas Anatomy 0.000 claims description 2
- 201000002528 pancreatic cancer Diseases 0.000 claims description 2
- 210000002307 prostate Anatomy 0.000 claims description 2
- 206010038038 rectal cancer Diseases 0.000 claims description 2
- 210000000664 rectum Anatomy 0.000 claims description 2
- 201000001275 rectum cancer Diseases 0.000 claims description 2
- 210000003491 skin Anatomy 0.000 claims description 2
- 201000000849 skin cancer Diseases 0.000 claims description 2
- 201000011549 stomach cancer Diseases 0.000 claims description 2
- 210000003932 urinary bladder Anatomy 0.000 claims description 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 2
- 210000002429 large intestine Anatomy 0.000 claims 1
- 201000011061 large intestine cancer Diseases 0.000 claims 1
- -1 variants Proteins 0.000 claims 1
- 239000000470 constituent Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1518674.5A GB201518674D0 (en) | 2015-10-21 | 2015-10-21 | Method for detecting nuleosomes containing histone modifications and variants |
| GB1518674.5 | 2015-10-21 | ||
| PCT/GB2016/053288 WO2017068359A1 (en) | 2015-10-21 | 2016-10-21 | Method for detecting nucleosomes containing histone modifications and variants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018536849A JP2018536849A (ja) | 2018-12-13 |
| JP2018536849A5 true JP2018536849A5 (OSRAM) | 2019-12-05 |
| JP6925328B2 JP6925328B2 (ja) | 2021-08-25 |
Family
ID=55131420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018520476A Active JP6925328B2 (ja) | 2015-10-21 | 2016-10-21 | ヒストン修飾及びバリアントを含むヌクレオソームを検出するための方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10768182B2 (OSRAM) |
| EP (1) | EP3365681B1 (OSRAM) |
| JP (1) | JP6925328B2 (OSRAM) |
| CN (1) | CN108496083A (OSRAM) |
| GB (1) | GB201518674D0 (OSRAM) |
| WO (1) | WO2017068359A1 (OSRAM) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11391742B2 (en) | 2015-02-10 | 2022-07-19 | B.R.A.H.M.S. Gmbh | Free histone proteins as biomarkers |
| JP7693670B2 (ja) * | 2019-12-02 | 2025-06-17 | ベルジアン ボリション エスアールエル | バイオマーカーとしての細胞外遊離ヌクレオソームの使用 |
| GB202108185D0 (en) | 2021-06-08 | 2021-07-21 | Belgian Volition Sprl | Standardisation of nucleosome assays using biologically derived calibrants |
| CN113480646B (zh) * | 2021-07-01 | 2022-03-15 | 中国科学院生物物理研究所 | 特异性结合h1.4移码突变蛋白的单克隆抗体制备及其应用 |
| GB202117799D0 (en) | 2021-12-09 | 2022-01-26 | Belgian Volition Srl | Method for the detection of blood cancer |
| EP4490323A1 (en) | 2022-03-11 | 2025-01-15 | Belgian Volition SRL | Differential diagnosis method |
| GB202205212D0 (en) | 2022-04-08 | 2022-05-25 | Belgian Volition Sprl | Method for transplant organ health assessment |
| WO2024133225A1 (en) | 2022-12-19 | 2024-06-27 | Belgian Volition Srl | Calibration |
| WO2024213795A1 (en) | 2023-04-14 | 2024-10-17 | Belgian Volition Srl | Diagnosis method using cell free nucleosome levels |
| WO2024223947A1 (en) | 2023-04-28 | 2024-10-31 | Belgian Volition Srl | Use of cell free nucleosomes as biomarkers of carcinomas |
| GB202307768D0 (en) | 2023-05-24 | 2023-07-05 | Belgian Volition Srl | Use of cell free nucleosomes as biomarkers |
| GB202310137D0 (en) | 2023-07-03 | 2023-08-16 | Belgian Volition Srl | Method for the detection of cancer |
| WO2025061853A1 (en) | 2023-09-19 | 2025-03-27 | Belgian Volition Srl | Lateral flow test device |
| WO2025094148A1 (en) * | 2023-11-03 | 2025-05-08 | Onchilles Pharma, Inc. | Histone h1 levels as biomarkers for cancer therapy |
| CN117904196B (zh) * | 2024-01-05 | 2024-07-12 | 安徽大学 | 一种非小细胞肺癌组蛋白h1.4赖氨酸乙酰化点突变细胞模型的构建及其应用 |
| WO2025181348A1 (en) | 2024-03-01 | 2025-09-04 | Belgian Volition Srl | Method for determining the origin of circulating dna |
| WO2025253002A1 (en) | 2024-06-07 | 2025-12-11 | Belgian Volition Srl | Sample collection for liquid biopsy |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0319376D0 (en) * | 2003-08-18 | 2003-09-17 | Chroma Therapeutics Ltd | Histone modification detection |
| WO2011150974A1 (en) * | 2010-06-03 | 2011-12-08 | Porto Conte Ricerche S.R.L. | Biomarkers for lung neuroendocrine tumors |
| GB201115098D0 (en) | 2011-09-01 | 2011-10-19 | Belgian Volition Sa | Method for detecting nucleosomes containing histone variants |
| GB201115095D0 (en) | 2011-09-01 | 2011-10-19 | Singapore Volition Pte Ltd | Method for detecting nucleosomes containing nucleotides |
| PT2788767T (pt) * | 2011-12-07 | 2017-12-06 | Belgian Volition Sprl | Método de detecção de adutos de nucleosoma |
| EP3401399B1 (en) * | 2012-03-02 | 2020-04-22 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| GB201303575D0 (en) | 2013-02-28 | 2013-04-10 | Singapore Volition Pte Ltd | Method for detecting histone modifications in nucleosomes |
-
2015
- 2015-10-21 GB GBGB1518674.5A patent/GB201518674D0/en not_active Ceased
-
2016
- 2016-10-21 EP EP16787535.0A patent/EP3365681B1/en active Active
- 2016-10-21 JP JP2018520476A patent/JP6925328B2/ja active Active
- 2016-10-21 CN CN201680074822.1A patent/CN108496083A/zh active Pending
- 2016-10-21 US US15/768,981 patent/US10768182B2/en active Active
- 2016-10-21 WO PCT/GB2016/053288 patent/WO2017068359A1/en not_active Ceased
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