JP2018529931A5 - - Google Patents
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- Publication number
- JP2018529931A5 JP2018529931A5 JP2017568274A JP2017568274A JP2018529931A5 JP 2018529931 A5 JP2018529931 A5 JP 2018529931A5 JP 2017568274 A JP2017568274 A JP 2017568274A JP 2017568274 A JP2017568274 A JP 2017568274A JP 2018529931 A5 JP2018529931 A5 JP 2018529931A5
- Authority
- JP
- Japan
- Prior art keywords
- extracellular free
- epigenetic
- subject
- cancer
- nucleosome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010047956 Nucleosomes Proteins 0.000 claims description 70
- 210000001623 nucleosome Anatomy 0.000 claims description 70
- 230000001973 epigenetic effect Effects 0.000 claims description 48
- 206010036790 Productive cough Diseases 0.000 claims description 46
- 210000003802 sputum Anatomy 0.000 claims description 46
- 208000024794 sputum Diseases 0.000 claims description 46
- 238000000034 method Methods 0.000 claims description 40
- 206010028980 Neoplasm Diseases 0.000 claims description 24
- 201000011510 cancer Diseases 0.000 claims description 24
- 208000003200 Adenoma Diseases 0.000 claims description 20
- 208000023275 Autoimmune disease Diseases 0.000 claims description 20
- 108010033040 Histones Proteins 0.000 claims description 20
- 208000037979 autoimmune inflammatory disease Diseases 0.000 claims description 20
- 206010001233 Adenoma benign Diseases 0.000 claims description 17
- 241001465754 Metazoa Species 0.000 claims description 15
- 239000011230 binding agent Substances 0.000 claims description 14
- 239000000090 biomarker Substances 0.000 claims description 10
- 230000004048 modification Effects 0.000 claims description 10
- 238000012986 modification Methods 0.000 claims description 10
- 230000008836 DNA modification Effects 0.000 claims description 8
- 238000001514 detection method Methods 0.000 claims description 8
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 8
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 8
- 210000004027 cell Anatomy 0.000 claims description 7
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 6
- 102000001708 Protein Isoforms Human genes 0.000 claims description 6
- 108010029485 Protein Isoforms Proteins 0.000 claims description 6
- 238000003745 diagnosis Methods 0.000 claims description 6
- 201000005202 lung cancer Diseases 0.000 claims description 6
- 208000020816 lung neoplasm Diseases 0.000 claims description 6
- 230000001323 posttranslational effect Effects 0.000 claims description 6
- LRSASMSXMSNRBT-UHFFFAOYSA-N 5-methylcytosine Chemical compound CC1=CNC(=O)N=C1N LRSASMSXMSNRBT-UHFFFAOYSA-N 0.000 claims description 4
- -1 DNA modifications Proteins 0.000 claims description 4
- 102100023919 Histone H2A.Z Human genes 0.000 claims description 4
- 101000905054 Homo sapiens Histone H2A.Z Proteins 0.000 claims description 4
- BDJRBEYXGGNYIS-UHFFFAOYSA-N Nonanedioid acid Natural products OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 238000005259 measurement Methods 0.000 claims description 4
- 238000004393 prognosis Methods 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 230000001413 cellular effect Effects 0.000 claims description 2
- 238000002487 chromatin immunoprecipitation Methods 0.000 claims description 2
- 238000004587 chromatography analysis Methods 0.000 claims description 2
- 230000002759 chromosomal effect Effects 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 238000003018 immunoassay Methods 0.000 claims description 2
- 230000000984 immunochemical effect Effects 0.000 claims description 2
- 210000005265 lung cell Anatomy 0.000 claims description 2
- 238000004949 mass spectrometry Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1511512.4A GB201511512D0 (en) | 2015-07-01 | 2015-07-01 | Use of cell-free nucleosomes as biomarkers |
| GB1511512.4 | 2015-07-01 | ||
| PCT/GB2016/051994 WO2017001863A1 (en) | 2015-07-01 | 2016-07-01 | Use of cell-free nucleosomes as biomarkers in sputum samples |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018529931A JP2018529931A (ja) | 2018-10-11 |
| JP2018529931A5 true JP2018529931A5 (OSRAM) | 2019-08-15 |
| JP7094700B2 JP7094700B2 (ja) | 2022-07-04 |
Family
ID=53872486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017568274A Active JP7094700B2 (ja) | 2015-07-01 | 2016-07-01 | 喀痰試料中のバイオマーカーとしての細胞外遊離ヌクレオソームの使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20180306804A1 (OSRAM) |
| EP (1) | EP3317671B1 (OSRAM) |
| JP (1) | JP7094700B2 (OSRAM) |
| CN (1) | CN108450000A (OSRAM) |
| ES (1) | ES2772701T3 (OSRAM) |
| GB (1) | GB201511512D0 (OSRAM) |
| WO (1) | WO2017001863A1 (OSRAM) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019228625B2 (en) * | 2018-03-01 | 2024-11-07 | Epicypher, Inc. | Quantification of nucleosome modifications using chemically-defined recombinant nucleosomes |
| US11154240B2 (en) | 2019-04-02 | 2021-10-26 | Kpn Innovations Llc | Methods and systems for utilizing diagnostics for informed vibrant constitutional guidance |
| GB201906199D0 (en) * | 2019-05-02 | 2019-06-19 | Belgian Volition Sprl | Method for the detection of cancer |
| JP7693670B2 (ja) * | 2019-12-02 | 2025-06-17 | ベルジアン ボリション エスアールエル | バイオマーカーとしての細胞外遊離ヌクレオソームの使用 |
| US11289206B2 (en) | 2020-06-02 | 2022-03-29 | Kpn Innovations, Llc. | Artificial intelligence methods and systems for constitutional analysis using objective functions |
| US12176108B2 (en) | 2020-06-02 | 2024-12-24 | Kpn Innovations Llc | Artificial intelligence methods and systems for constitutional analysis using objective functions |
| US11211158B1 (en) | 2020-08-31 | 2021-12-28 | Kpn Innovations, Llc. | System and method for representing an arranged list of provider aliment possibilities |
| GB202310137D0 (en) * | 2023-07-03 | 2023-08-16 | Belgian Volition Srl | Method for the detection of cancer |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7229772B1 (en) * | 1998-03-18 | 2007-06-12 | Roche Diagnostics Gmbh | Detection of apoptotic products |
| GB201012662D0 (en) | 2010-07-28 | 2010-09-15 | Valirx Plc | Method for detecting the presence of a gynaecological growth |
| GB201115098D0 (en) | 2011-09-01 | 2011-10-19 | Belgian Volition Sa | Method for detecting nucleosomes containing histone variants |
| GB201115095D0 (en) * | 2011-09-01 | 2011-10-19 | Singapore Volition Pte Ltd | Method for detecting nucleosomes containing nucleotides |
| PT2788767T (pt) * | 2011-12-07 | 2017-12-06 | Belgian Volition Sprl | Método de detecção de adutos de nucleosoma |
| GB201303575D0 (en) | 2013-02-28 | 2013-04-10 | Singapore Volition Pte Ltd | Method for detecting histone modifications in nucleosomes |
| US9499870B2 (en) * | 2013-09-27 | 2016-11-22 | Natera, Inc. | Cell free DNA diagnostic testing standards |
-
2015
- 2015-07-01 GB GBGB1511512.4A patent/GB201511512D0/en not_active Ceased
-
2016
- 2016-07-01 EP EP16736594.9A patent/EP3317671B1/en active Active
- 2016-07-01 JP JP2017568274A patent/JP7094700B2/ja active Active
- 2016-07-01 US US15/738,082 patent/US20180306804A1/en not_active Abandoned
- 2016-07-01 CN CN201680050736.7A patent/CN108450000A/zh active Pending
- 2016-07-01 ES ES16736594T patent/ES2772701T3/es active Active
- 2016-07-01 WO PCT/GB2016/051994 patent/WO2017001863A1/en not_active Ceased
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