JP2018536152A5 - - Google Patents
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- Publication number
- JP2018536152A5 JP2018536152A5 JP2018517730A JP2018517730A JP2018536152A5 JP 2018536152 A5 JP2018536152 A5 JP 2018536152A5 JP 2018517730 A JP2018517730 A JP 2018517730A JP 2018517730 A JP2018517730 A JP 2018517730A JP 2018536152 A5 JP2018536152 A5 JP 2018536152A5
- Authority
- JP
- Japan
- Prior art keywords
- subject
- mcp
- mmr
- ptsd
- normal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 39
- 208000028173 post-traumatic stress disease Diseases 0.000 claims 30
- 102100023702 C-C motif chemokine 13 Human genes 0.000 claims 22
- 101710112613 C-C motif chemokine 13 Proteins 0.000 claims 22
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims 20
- 101710155857 C-C motif chemokine 2 Proteins 0.000 claims 20
- 208000020401 Depressive disease Diseases 0.000 claims 11
- 210000004369 blood Anatomy 0.000 claims 11
- 239000008280 blood Substances 0.000 claims 11
- 239000003550 marker Substances 0.000 claims 11
- 102000001326 Chemokine CCL4 Human genes 0.000 claims 10
- 108010055165 Chemokine CCL4 Proteins 0.000 claims 10
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 claims 9
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 claims 9
- AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 claims 3
- WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 claims 3
- RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 claims 3
- AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 claims 3
- 229960001653 citalopram Drugs 0.000 claims 3
- USRHYDPUVLEVMC-FQEVSTJZSA-N dapoxetine Chemical compound C1([C@H](CCOC=2C3=CC=CC=C3C=CC=2)N(C)C)=CC=CC=C1 USRHYDPUVLEVMC-FQEVSTJZSA-N 0.000 claims 3
- 229960005217 dapoxetine Drugs 0.000 claims 3
- 229960004341 escitalopram Drugs 0.000 claims 3
- WSEQXVZVJXJVFP-FQEVSTJZSA-N escitalopram Chemical compound C1([C@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-FQEVSTJZSA-N 0.000 claims 3
- 229960002464 fluoxetine Drugs 0.000 claims 3
- 229960004038 fluvoxamine Drugs 0.000 claims 3
- CJOFXWAVKWHTFT-XSFVSMFZSA-N fluvoxamine Chemical compound COCCCC\C(=N/OCCN)C1=CC=C(C(F)(F)F)C=C1 CJOFXWAVKWHTFT-XSFVSMFZSA-N 0.000 claims 3
- -1 indalpin Chemical compound 0.000 claims 3
- 229960002296 paroxetine Drugs 0.000 claims 3
- 229960002073 sertraline Drugs 0.000 claims 3
- VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 claims 3
- 102000019034 Chemokines Human genes 0.000 claims 2
- 108010012236 Chemokines Proteins 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 210000001616 monocyte Anatomy 0.000 claims 2
- 230000002250 progressing effect Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 210000001541 thymus gland Anatomy 0.000 claims 2
- 101100504320 Caenorhabditis elegans mcp-1 gene Proteins 0.000 claims 1
- 102000014962 Monocyte Chemoattractant Proteins Human genes 0.000 claims 1
- 108010064136 Monocyte Chemoattractant Proteins Proteins 0.000 claims 1
- 230000001276 controlling effect Effects 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562239004P | 2015-10-08 | 2015-10-08 | |
| US62/239,004 | 2015-10-08 | ||
| PCT/US2016/055675 WO2017062568A1 (en) | 2015-10-08 | 2016-10-06 | Biomarkers for diagnosing post traumatic stress disorder |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018536152A JP2018536152A (ja) | 2018-12-06 |
| JP2018536152A5 true JP2018536152A5 (enExample) | 2019-11-14 |
Family
ID=58488666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018517730A Pending JP2018536152A (ja) | 2015-10-08 | 2016-10-06 | 心的外傷後ストレス障害を診断するためのバイオマーカー |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11085934B2 (enExample) |
| EP (1) | EP3359969A4 (enExample) |
| JP (1) | JP2018536152A (enExample) |
| AU (1) | AU2016334027A1 (enExample) |
| CA (1) | CA2998533A1 (enExample) |
| WO (1) | WO2017062568A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11529054B2 (en) * | 2018-07-25 | 2022-12-20 | The Charles Stark Draper Laboratory, Inc. | Method and system for post-traumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI) diagnosis using magnetic resonance spectroscopy |
| WO2025154785A1 (ja) * | 2024-01-18 | 2025-07-24 | 国立研究開発法人産業技術総合研究所 | 心的外傷後ストレス障害（ｐｔｓｄ）または急性ストレス障害（ａｓｄ）の客観的評価方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5069213B2 (ja) * | 2006-02-17 | 2012-11-07 | 敦生 関山 | 生体負荷の指標剤および生体負荷の測定方法 |
| JP2013537415A (ja) * | 2010-08-03 | 2013-10-03 | アッヴィ・インコーポレイテッド | 二重可変ドメイン免疫グロブリンおよびその使用 |
| CA2846625A1 (en) * | 2011-09-14 | 2013-03-21 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Processes and kits to detect and monitor for diagnostic biomarkers for post traumatic stress disorder (ptsd) and to differentiate between suicidal and non-suicidal form of the disorder |
| WO2016057775A1 (en) | 2014-10-08 | 2016-04-14 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Biomarkers for diagnosing post traumatic stress disorder |
-
2016
- 2016-10-06 EP EP16854290.0A patent/EP3359969A4/en not_active Withdrawn
- 2016-10-06 AU AU2016334027A patent/AU2016334027A1/en not_active Abandoned
- 2016-10-06 WO PCT/US2016/055675 patent/WO2017062568A1/en not_active Ceased
- 2016-10-06 CA CA2998533A patent/CA2998533A1/en not_active Abandoned
- 2016-10-06 JP JP2018517730A patent/JP2018536152A/ja active Pending
- 2016-10-06 US US15/759,507 patent/US11085934B2/en not_active Expired - Fee Related
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