JP2018535696A5 - - Google Patents

Download PDF

Info

Publication number
JP2018535696A5
JP2018535696A5 JP2018540229A JP2018540229A JP2018535696A5 JP 2018535696 A5 JP2018535696 A5 JP 2018535696A5 JP 2018540229 A JP2018540229 A JP 2018540229A JP 2018540229 A JP2018540229 A JP 2018540229A JP 2018535696 A5 JP2018535696 A5 JP 2018535696A5
Authority
JP
Japan
Prior art keywords
seq
sequence
represented
fragment
optionally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2018540229A
Other languages
English (en)
Japanese (ja)
Other versions
JP7073264B2 (ja
JP2018535696A (ja
Filing date
Publication date
Priority claimed from GB1518911.1A external-priority patent/GB2547179A/en
Application filed filed Critical
Publication of JP2018535696A publication Critical patent/JP2018535696A/ja
Publication of JP2018535696A5 publication Critical patent/JP2018535696A5/ja
Priority to JP2022078299A priority Critical patent/JP7503590B2/ja
Application granted granted Critical
Publication of JP7073264B2 publication Critical patent/JP7073264B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2018540229A 2015-10-26 2016-10-25 遺伝子構築物 Active JP7073264B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022078299A JP7503590B2 (ja) 2015-10-26 2022-05-11 遺伝子構築物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1518911.1 2015-10-26
GB1518911.1A GB2547179A (en) 2015-10-26 2015-10-26 Genetic construct
PCT/GB2016/053319 WO2017072498A1 (en) 2015-10-26 2016-10-25 Genetic construct

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022078299A Division JP7503590B2 (ja) 2015-10-26 2022-05-11 遺伝子構築物

Publications (3)

Publication Number Publication Date
JP2018535696A JP2018535696A (ja) 2018-12-06
JP2018535696A5 true JP2018535696A5 (https=) 2019-11-21
JP7073264B2 JP7073264B2 (ja) 2022-05-23

Family

ID=55130230

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2018540229A Active JP7073264B2 (ja) 2015-10-26 2016-10-25 遺伝子構築物
JP2022078299A Active JP7503590B2 (ja) 2015-10-26 2022-05-11 遺伝子構築物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2022078299A Active JP7503590B2 (ja) 2015-10-26 2022-05-11 遺伝子構築物

Country Status (21)

Country Link
US (2) US10342880B2 (https=)
EP (2) EP3368678B1 (https=)
JP (2) JP7073264B2 (https=)
KR (1) KR102819739B1 (https=)
CN (1) CN108350467B (https=)
AU (1) AU2016344508B2 (https=)
CY (1) CY1124588T1 (https=)
DK (1) DK3368678T3 (https=)
ES (1) ES2886009T3 (https=)
GB (1) GB2547179A (https=)
HR (1) HRP20211407T1 (https=)
HU (1) HUE056911T2 (https=)
LT (1) LT3368678T (https=)
MX (1) MX2018005286A (https=)
PL (1) PL3368678T3 (https=)
PT (1) PT3368678T (https=)
RS (1) RS62460B1 (https=)
RU (1) RU2734678C2 (https=)
SI (1) SI3368678T1 (https=)
SM (1) SMT202100520T1 (https=)
WO (1) WO2017072498A1 (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7097070B2 (ja) 2015-10-01 2022-07-07 ゴレイニ インコーポレイテッド クロライドチャネルの標的発現及びその使用方法
GB201705484D0 (en) * 2017-04-05 2017-05-17 Quethera Ltd Genetic construct
EP3687580A1 (en) * 2017-09-27 2020-08-05 Sigilon Therapeutics, Inc. Methods, compositions, and implantable elements comprising active cells
US11926653B2 (en) 2017-10-20 2024-03-12 Research Institute At Nationwide Children's Hospital Methods and materials for NT-3 gene therapy
US20200399656A1 (en) * 2017-12-05 2020-12-24 University Of Washington Compositions and methods for enhancing functional expression of therapeutic genes in photoreceptors
CN108250288A (zh) * 2018-01-17 2018-07-06 吉林省农业科学院 一种叶绿体表达的脑源性神经营养因子hBDNFb蛋白及其制备方法
CN109022487A (zh) * 2018-08-15 2018-12-18 上海市第人民医院 一种表达p65的基因载体及其用于治疗视网膜神经节细胞变性的基因治疗药物
WO2020077295A1 (en) * 2018-10-11 2020-04-16 Decibel Therapeutics, Inc. Aav1 vectors and uses thereof for treatment of otic indications
AU2019407921A1 (en) * 2018-12-19 2021-06-10 Versameb Ag RNA encoding a protein
JP7524158B2 (ja) * 2019-03-04 2024-07-29 公益財団法人東京都医学総合研究所 Trk断片をコードする核酸構築物、及びその利用
MA55223A (fr) * 2019-03-06 2022-01-12 Generation Bio Co Adn à extrémité fermée (cedna) et composés de modulation immunitaire
US20230123802A1 (en) * 2019-03-27 2023-04-20 Sigilon Therapeutics, Inc. Compositions, devices, and methods for factor vii therapy
CN114207135A (zh) 2019-06-11 2022-03-18 夏尔人类遗传性治疗公司 用于治疗由失调的血浆激肽释放酶介导的疾病的抗体的腺相关病毒载体递送
EP3999647A1 (en) * 2019-07-18 2022-05-25 Lysogene Compositions and methods for the treatment of sanfilippo disease and other disorders
RU2719013C1 (ru) * 2019-09-25 2020-04-16 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Генно-инженерная конструкция для стимуляции посттравматической регенерации периферических нервов
WO2021067448A1 (en) 2019-09-30 2021-04-08 Applied Genetic Technologies Corporation Adeno-associated virus (aav) systems for treatment of genetic hearing loss
WO2021081280A1 (en) 2019-10-23 2021-04-29 Shire Human Genetic Therapies, Inc. Adeno-associated virus vectors based gene therapy for hereditary angioedema
WO2022130014A1 (en) 2020-12-16 2022-06-23 Takeda Pharmaceutical Company Limited Adeno associated viral vector delivery of antibodies for the treatment of disease mediated by dysregulated plasma kallikrein
MX2023009922A (es) * 2021-02-26 2023-10-25 Icahn School Med Mount Sinai Método para reducir la degeneración de células ganglionares retinianas.
CN116179495B (zh) * 2022-11-28 2025-06-06 上海恩凯细胞技术有限公司 转基因免疫细胞及其应用
CN118256562A (zh) * 2022-12-26 2024-06-28 科辉智药(深圳)新药研究中心有限公司 一种用于中枢神经系统疾病治疗的基因序列构建体及其应用
AU2024214634A1 (en) 2023-02-02 2025-06-26 Quethera Limited Recombinant adeno-associated virus vector
CN118534135A (zh) * 2024-06-07 2024-08-23 中国人民解放军联勤保障部队第九二四医院 一种中枢性肥胖抵抗标志物及其检测方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229500A (en) 1989-08-30 1993-07-20 Regeneron Pharmaceuticals, Inc. Brain derived neurotrophic factor
US6225282B1 (en) * 1996-01-05 2001-05-01 Genentech, Inc. Treatment of hearing impairments
JP2001502323A (ja) * 1996-10-16 2001-02-20 リジェネロン ファーマシューティカルズ,インコーポレイテッド 成長因子の送達を増強する方法
AU3418199A (en) * 1998-04-20 1999-11-08 Koninklijke Nederlandse Akademie Van Wetenschappen Use of viral vectors for treatment of the injured peripheral and central nervoussystem
CN100591359C (zh) * 2000-12-19 2010-02-24 研究发展基金会 慢病毒载体介导的基因转移及其用途
US7060429B2 (en) * 2001-02-22 2006-06-13 University Of Maryland, Baltimore Treatment of neurodegenerative diseases by altering levels of TrkB isoforms and/or TrkC isoforms
FR2906533B1 (fr) * 2006-09-28 2013-02-22 Pf Medicament Procede de generation d'anticorps actifs contre un antigene de resistance,anticorps obtenus par ledit procede et leurs utilisations
WO2009048605A1 (en) * 2007-10-11 2009-04-16 Biogen Idec Ma Inc. Methods for treating pressure induced optic neuropathy, preventing neuronal degeneration and promoting neuronal cell, survival via administration of lingo-1 antagonists and trkb agonists
US9265843B2 (en) * 2008-03-27 2016-02-23 The Ohio State University Treatment of metabolic-related disorders using hypothalamic gene transfer of BDNF and compositions therefor
CN103614416B (zh) * 2013-09-30 2016-09-07 中国人民解放军第二军医大学东方肝胆外科医院 一种携带人穿膜肽p53与GM-CSF基因的重组溶瘤腺病毒及其用途

Similar Documents

Publication Publication Date Title
JP2018535696A5 (https=)
RU2018115760A (ru) Генетическая конструкция
US20220331409A1 (en) Factor ix gene therapy
JP2019089787A5 (https=)
JP2025039615A (ja) 変異体キャプシドを有するアデノ関連ウイルスビリオンおよびその使用方法
EP3448437B1 (en) Evasion of neutralizing antibodies by a recombinant adeno-associated virus
IL273776B1 (en) Gene therapies for lysosomal disorders
MX2023012410A (es) Metodos para tratar enfermedades oculares usando variantes de aav2 que codifican aflibercept.
RU2019126509A (ru) Выделенный модифицированный белок VP1 капсида аденоассоциированного вируса 5 серотипа (AAV5), капсид и вектор на его основе
UY38881A (es) Métodos de tratamiento de enfermedades neovasculares oculares utilizando variantes de aav2 que codifican aflibercept
JP2023503850A5 (https=)
MX2024010002A (es) Metodo para reducir la fluctuacion del cst en amd neovascular mediante un virus adenoasociado recombinante
TW202033768A (zh) 腺相關病毒對cln6聚核苷酸的遞送
CN112029773B (zh) 编码bdnf的核酸及其应用
JP2023526892A (ja) バルデー・ビードル症候群の遺伝子治療
EP4198047A1 (en) Fukutin related protein gene transfer increase using modified itr sequences
JP2022522004A5 (https=)
BR112022003206A2 (pt) Métodos para tratar doenças neovasculares oculares usando variantes de aav2 que codificam aflibercepte
WO2025010334A3 (en) Methods of treating ocular neovascular diseases using aav2 variants encoding aflibercept
HK40119673A (en) Adeno-associated virus virions with variant capsid and methods of use thereof
NZ748736B2 (en) Treatment of complement-mediated disorders
HK40077196A (en) Evasion of neutralizing antibodies by a recombinant adeno-associated virus
KR20240137067A (ko) 개선된 심장 형질도입 및 간의 탈표적화를 위한 aav 캡시드
JP2024511851A (ja) 改変血漿凝固第viii因子およびその使用方法
HK40035863B (en) Adeno-associated virus virions with variant capsid and methods of use thereof