DK3368678T3 - Genetisk konstrukt - Google Patents

Genetisk konstrukt Download PDF

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Publication number
DK3368678T3
DK3368678T3 DK16788748.8T DK16788748T DK3368678T3 DK 3368678 T3 DK3368678 T3 DK 3368678T3 DK 16788748 T DK16788748 T DK 16788748T DK 3368678 T3 DK3368678 T3 DK 3368678T3
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genetic construct
genetic
construct
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DK16788748.8T
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English (en)
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Peter Widdowson
Keith Martin
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Quethera Ltd
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C07K14/475—Growth factors; Growth regulators
    • C07K14/48—Nerve growth factor [NGF]
    • A—HUMAN NECESSITIES
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
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    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/86—Viral vectors
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    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • A—HUMAN NECESSITIES
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    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
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  • Genetics & Genomics (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
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  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
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  • Crystallography & Structural Chemistry (AREA)
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DK16788748.8T 2015-10-26 2016-10-25 Genetisk konstrukt DK3368678T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1518911.1A GB2547179A (en) 2015-10-26 2015-10-26 Genetic construct
PCT/GB2016/053319 WO2017072498A1 (en) 2015-10-26 2016-10-25 Genetic construct

Publications (1)

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DK3368678T3 true DK3368678T3 (da) 2021-09-13

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DK16788748.8T DK3368678T3 (da) 2015-10-26 2016-10-25 Genetisk konstrukt

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US (2) US10342880B2 (da)
EP (2) EP3985119A1 (da)
JP (2) JP7073264B2 (da)
KR (1) KR20180081503A (da)
CN (1) CN108350467B (da)
AU (1) AU2016344508B2 (da)
CA (1) CA3001036A1 (da)
CY (1) CY1124588T1 (da)
DK (1) DK3368678T3 (da)
ES (1) ES2886009T3 (da)
GB (1) GB2547179A (da)
HK (1) HK1252168A1 (da)
HR (1) HRP20211407T1 (da)
HU (1) HUE056911T2 (da)
LT (1) LT3368678T (da)
MX (1) MX2018005286A (da)
PL (1) PL3368678T3 (da)
PT (1) PT3368678T (da)
RS (1) RS62460B1 (da)
RU (1) RU2734678C2 (da)
SI (1) SI3368678T1 (da)
WO (1) WO2017072498A1 (da)

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GB201705484D0 (en) * 2017-04-05 2017-05-17 Quethera Ltd Genetic construct
CA3079416A1 (en) 2017-10-20 2019-04-25 Research Institute At Nationwide Children's Hospital Methods and materials for nt-3 gene therapy
JP2021507723A (ja) * 2017-12-05 2021-02-25 ユニバーシティ オブ ワシントンＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｗａｓｈｉｎｇｔｏｎ 視細胞における治療遺伝子の機能的発現を増強するための組成物および方法
CN108250288A (zh) * 2018-01-17 2018-07-06 吉林省农业科学院 一种叶绿体表达的脑源性神经营养因子hBDNFb蛋白及其制备方法
CN109022487A (zh) * 2018-08-15 2018-12-18 上海市第人民医院 一种表达p65的基因载体及其用于治疗视网膜神经节细胞变性的基因治疗药物
CN113365603A (zh) * 2018-10-11 2021-09-07 分贝治疗公司 Aav1载体及其用于治疗耳部适应症的用途
MA54503A (fr) * 2018-12-19 2021-10-27 Versameb Ag Arn codant pour une protéine
JP7524158B2 (ja) * 2019-03-04 2024-07-29 公益財団法人東京都医学総合研究所 Ｔｒｋ断片をコードする核酸構築物、及びその利用
WO2020181182A1 (en) * 2019-03-06 2020-09-10 Generation Bio Co. Closed-ended dna (cedna) and immune modulating compounds
WO2020252136A1 (en) 2019-06-11 2020-12-17 Shire Human Genetic Therapies, Inc. Adeno associated viral vector delivery of antibodies for the treatment of disease mediated dysregulated plasma kallikrein
US20230124994A1 (en) * 2019-07-18 2023-04-20 Lysogene Compositions and methods for the treatment of sanfilippo disease and other disorders
RU2719013C1 (ru) * 2019-09-25 2020-04-16 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Генно-инженерная конструкция для стимуляции посттравматической регенерации периферических нервов
JP2022553083A (ja) 2019-10-23 2022-12-21 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド アデノ随伴ウイルスベクターに基づく遺伝性血管浮腫のための遺伝子治療
US20220186252A1 (en) 2020-12-16 2022-06-16 Takeda Pharmaceutical Company Limited Adeno associated viral vector delivery of antibodies for the treatment of disease mediated by dysregulated plasma kallikrein
WO2022182983A1 (en) * 2021-02-26 2022-09-01 Icahn School Of Medicine At Mount Sinai Method for decreasing degeneration of retinal ganglion cells
CN116179495A (zh) * 2022-11-28 2023-05-30 上海恩凯细胞技术有限公司 转基因免疫细胞及其应用
CN118256562A (zh) * 2022-12-26 2024-06-28 科辉智药(深圳)新药研究中心有限公司 一种用于中枢神经系统疾病治疗的基因序列构建体及其应用
WO2024161142A1 (en) 2023-02-02 2024-08-08 Quethera Limited Recombinant adeno-associated virus vector

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