JP2018535647A5 - - Google Patents
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- JP2018535647A5 JP2018535647A5 JP2018513423A JP2018513423A JP2018535647A5 JP 2018535647 A5 JP2018535647 A5 JP 2018535647A5 JP 2018513423 A JP2018513423 A JP 2018513423A JP 2018513423 A JP2018513423 A JP 2018513423A JP 2018535647 A5 JP2018535647 A5 JP 2018535647A5
- Authority
- JP
- Japan
- Prior art keywords
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- amino acid
- acid sequence
- ile
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 28
- 108091008874 T cell receptors Proteins 0.000 claims 19
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 19
- 229920001184 polypeptide Polymers 0.000 claims 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims 19
- 102000004196 processed proteins & peptides Human genes 0.000 claims 19
- 102000004169 proteins and genes Human genes 0.000 claims 13
- 108090000623 proteins and genes Proteins 0.000 claims 13
- 210000004027 cell Anatomy 0.000 claims 10
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 239000013604 expression vector Substances 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 238000003259 recombinant expression Methods 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 210000000265 leukocyte Anatomy 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 102100028971 HLA class I histocompatibility antigen, C alpha chain Human genes 0.000 claims 1
- 108010037618 HLA-C*08 antigen Proteins 0.000 claims 1
- 101000986084 Homo sapiens HLA class I histocompatibility antigen, C alpha chain Proteins 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 108700020796 Oncogene Proteins 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 241000713810 Rat sarcoma virus Species 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002357 endometrial effect Effects 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 230000002611 ovarian Effects 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022188263A JP7461445B2 (ja) | 2015-09-15 | 2022-11-25 | Ｈｌａ－ｃｗ８拘束性の変異ｋｒａｓを認識するｔ細胞受容体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562218688P | 2015-09-15 | 2015-09-15 | |
| US62/218,688 | 2015-09-15 | ||
| PCT/US2016/050875 WO2017048593A1 (en) | 2015-09-15 | 2016-09-09 | T cell receptors recognizing hla-cw8 restricted mutated kras |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022188263A Division JP7461445B2 (ja) | 2015-09-15 | 2022-11-25 | Ｈｌａ－ｃｗ８拘束性の変異ｋｒａｓを認識するｔ細胞受容体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018535647A JP2018535647A (ja) | 2018-12-06 |
| JP2018535647A5 true JP2018535647A5 (OSRAM) | 2019-10-17 |
| JP7185524B2 JP7185524B2 (ja) | 2022-12-07 |
Family
ID=56985686
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018513423A Active JP7185524B2 (ja) | 2015-09-15 | 2016-09-09 | Ｈｌａ－ｃｗ８拘束性の変異ｋｒａｓを認識するｔ細胞受容体 |
| JP2022188263A Active JP7461445B2 (ja) | 2015-09-15 | 2022-11-25 | Ｈｌａ－ｃｗ８拘束性の変異ｋｒａｓを認識するｔ細胞受容体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022188263A Active JP7461445B2 (ja) | 2015-09-15 | 2022-11-25 | Ｈｌａ－ｃｗ８拘束性の変異ｋｒａｓを認識するｔ細胞受容体 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10556940B2 (OSRAM) |
| EP (2) | EP3901169A1 (OSRAM) |
| JP (2) | JP7185524B2 (OSRAM) |
| KR (2) | KR102841067B1 (OSRAM) |
| CN (2) | CN108350059B (OSRAM) |
| AU (3) | AU2016323017B2 (OSRAM) |
| DK (1) | DK3350213T3 (OSRAM) |
| ES (1) | ES2879287T3 (OSRAM) |
| IL (1) | IL257840B2 (OSRAM) |
| MX (1) | MX2018003062A (OSRAM) |
| SA (1) | SA518391109B1 (OSRAM) |
| SG (1) | SG10201913868XA (OSRAM) |
| WO (1) | WO2017048593A1 (OSRAM) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL257105B (en) | 2015-07-31 | 2022-09-01 | Univ Minnesota | Modified cells and methods of therapy |
| AU2017306038B2 (en) | 2016-08-02 | 2023-06-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-KRAS-G12D T cell receptors |
| GB201700621D0 (en) | 2017-01-13 | 2017-03-01 | Guest Ryan Dominic | Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue |
| EP3602053B1 (en) * | 2017-03-31 | 2023-06-28 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Methods of isolating neoantigen-specific t cell receptor sequences |
| WO2018213467A1 (en) | 2017-05-16 | 2018-11-22 | The Johns Hopkins University | Manabodies and methods of using |
| JP2020530307A (ja) | 2017-06-30 | 2020-10-22 | インティマ・バイオサイエンス，インコーポレーテッド | 遺伝子治療のためのアデノ随伴ウイルスベクター |
| EA202090652A1 (ru) * | 2017-09-20 | 2020-08-21 | Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез | T-клеточные рецепторы, рестриктированные по антигену лейкоцитов человека класса ii, против мутантного ras |
| IL273698B2 (en) | 2017-10-05 | 2025-07-01 | Us Health | Methods for selectively expanding cells expressing a tcr with a murine constant region |
| CN119162251A (zh) * | 2017-12-04 | 2024-12-20 | 美国卫生和人力服务部 | 针对突变的ras的hla i类限制性t细胞受体 |
| TW202015719A (zh) | 2018-06-19 | 2020-05-01 | 美商尼恩醫療公司 | 新抗原及其用途 |
| BR112021002826A2 (pt) * | 2018-08-16 | 2021-05-04 | Biontech Us Inc. | construtos de receptor de célula t e usos dos mesmos |
| JP7672979B2 (ja) * | 2019-01-22 | 2025-05-08 | アメリカ合衆国 | Ｇ１２ｒ変異を有するｒａｓに対するｈｌａクラスｉｉ拘束性ｔ細胞受容体 |
| EP3927727A1 (en) | 2019-02-20 | 2021-12-29 | Fred Hutchinson Cancer Research Center | Binding proteins specific for ras neoantigens and uses thereof |
| WO2020210202A1 (en) * | 2019-04-11 | 2020-10-15 | The Board Of Trustees Of The Leland Stanford Junior University | Cytotoxic t lymphocytes specific for mutated forms of epidermal growth factor receptor for use in treating cancer |
| CN110172089B (zh) * | 2019-06-11 | 2020-01-07 | 北京鼎成肽源生物技术有限公司 | 一种kras突变多抗原组合、靶向kras突变肿瘤ctl及其应用 |
| CN112110995A (zh) * | 2019-06-19 | 2020-12-22 | 上海交通大学医学院 | 肿瘤新抗原多肽及其用途 |
| CN114175087A (zh) * | 2019-08-14 | 2022-03-11 | 日本电气株式会社 | 信息处理装置、信息处理方法和记录介质 |
| CN112759641B (zh) * | 2019-11-01 | 2023-01-20 | 香雪生命科学技术（广东）有限公司 | 一种识别Kras G12V的高亲和力TCR |
| JP2023507432A (ja) | 2019-12-20 | 2023-02-22 | インスティル バイオ （ユーケイ） リミテッド | 腫瘍浸潤リンパ球を単離するためのデバイスおよび方法ならびにそれらの使用 |
| CA3167382A1 (en) * | 2020-02-14 | 2021-08-19 | Steven A. Rosenberg | Hla class i-restricted t cell receptors against ras with g12v mutation |
| CN111574616B (zh) * | 2020-06-17 | 2021-02-02 | 深圳豪石生物科技有限公司 | 分离的t细胞受体和应用 |
| WO2022015922A1 (en) * | 2020-07-16 | 2022-01-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Hla class ii-restricted drb t cell receptors against ras with g12v mutation |
| US20230365649A1 (en) * | 2020-10-02 | 2023-11-16 | The Usa, As Represented By The Secretary, Department Of Health And Human Services | Hla class ii-restricted dq t cell receptors against ras with g13d mutation |
| EP4298121A1 (en) | 2021-02-25 | 2024-01-03 | Alaunos Therapeutics, Inc. | Recombinant vectors comprising polycistronic expression cassettes and methods of use thereof |
| WO2023150562A1 (en) | 2022-02-01 | 2023-08-10 | Alaunos Therapeutics, Inc. | Methods for activation and expansion of t cells |
| CN114920824B (zh) * | 2022-05-27 | 2023-12-05 | 重庆医科大学 | Tcr或其抗原结合片段及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7301017B2 (en) * | 2002-05-30 | 2007-11-27 | Kolesnick Richard N | Kinase suppressor of Ras inactivation for therapy of Ras mediated tumorigenesis |
| CA2497552C (en) | 2002-09-06 | 2014-05-27 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Immunotherapy with in vitro-selected antigen-specific lymphocytes after nonmyeloablative lymphodepleting chemotherapy |
| PT2327763T (pt) * | 2005-08-05 | 2018-05-11 | Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Gesundheit & Umwelt Gmbh | Geração de células t específicas de antigénios |
| US8383099B2 (en) | 2009-08-28 | 2013-02-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adoptive cell therapy with young T cells |
| EP3213765B1 (en) | 2010-09-20 | 2019-08-28 | BioNTech Cell & Gene Therapies GmbH | Antigen-specific t cell receptors and t cell epitopes |
| US20120244133A1 (en) | 2011-03-22 | 2012-09-27 | The United States of America, as represented by the Secretary, Department of Health and | Methods of growing tumor infiltrating lymphocytes in gas-permeable containers |
| SI3392270T1 (sl) * | 2011-09-15 | 2020-12-31 | The United States Of America, As Represented By The Secretary Department Of Health And Human Services | T-celični receptorji, ki prepoznajo HLA-A1- ali HLA-CW7-omejeni MAGE |
| GB201314404D0 (en) | 2013-08-12 | 2013-09-25 | Immunocore Ltd | T Cell Receptors |
| SI3223850T1 (sl) | 2014-11-26 | 2020-09-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-mutiran kras T-celični receptorji |
-
2016
- 2016-09-09 DK DK16770408.9T patent/DK3350213T3/da active
- 2016-09-09 CN CN201680058891.3A patent/CN108350059B/zh active Active
- 2016-09-09 WO PCT/US2016/050875 patent/WO2017048593A1/en not_active Ceased
- 2016-09-09 AU AU2016323017A patent/AU2016323017B2/en active Active
- 2016-09-09 MX MX2018003062A patent/MX2018003062A/es unknown
- 2016-09-09 KR KR1020187010326A patent/KR102841067B1/ko active Active
- 2016-09-09 CN CN202111083392.9A patent/CN115073583A/zh active Pending
- 2016-09-09 EP EP21162567.8A patent/EP3901169A1/en active Pending
- 2016-09-09 SG SG10201913868XA patent/SG10201913868XA/en unknown
- 2016-09-09 ES ES16770408T patent/ES2879287T3/es active Active
- 2016-09-09 KR KR1020257025325A patent/KR20250117744A/ko active Pending
- 2016-09-09 JP JP2018513423A patent/JP7185524B2/ja active Active
- 2016-09-09 IL IL257840A patent/IL257840B2/en unknown
- 2016-09-09 EP EP16770408.9A patent/EP3350213B1/en active Active
- 2016-09-09 US US15/758,954 patent/US10556940B2/en active Active
-
2018
- 2018-03-13 SA SA518391109A patent/SA518391109B1/ar unknown
-
2020
- 2020-01-10 US US16/739,310 patent/US11667692B2/en active Active
-
2021
- 2021-02-10 AU AU2021200833A patent/AU2021200833B2/en active Active
-
2022
- 2022-07-26 AU AU2022209229A patent/AU2022209229B2/en active Active
- 2022-11-25 JP JP2022188263A patent/JP7461445B2/ja active Active
-
2023
- 2023-05-01 US US18/310,141 patent/US20230406904A1/en active Pending
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