JP2018534946A - キメラ転写後調節要素 - Google Patents

キメラ転写後調節要素 Download PDF

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Publication number
JP2018534946A
JP2018534946A JP2018542687A JP2018542687A JP2018534946A JP 2018534946 A JP2018534946 A JP 2018534946A JP 2018542687 A JP2018542687 A JP 2018542687A JP 2018542687 A JP2018542687 A JP 2018542687A JP 2018534946 A JP2018534946 A JP 2018534946A
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JP
Japan
Prior art keywords
seq
nucleic acid
acid sequence
sequence
fragment
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Pending
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JP2018542687A
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English (en)
Japanese (ja)
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JP2018534946A5 (cg-RX-API-DMAC7.html
Inventor
ゴエル、ニヒル
ゴエル、アミタ
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セルテオン コーポレイション
セルテオン コーポレイション
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Publication of JP2018534946A publication Critical patent/JP2018534946A/ja
Publication of JP2018534946A5 publication Critical patent/JP2018534946A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
    • C12N2800/107—Plasmid DNA for vertebrates for mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/30—Vector systems having a special element relevant for transcription being an enhancer not forming part of the promoter region
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/48—Vector systems having a special element relevant for transcription regulating transport or export of RNA, e.g. RRE, PRE, WPRE, CTE
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/60—Vector systems having a special element relevant for transcription from viruses

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2018542687A 2015-10-27 2016-10-27 キメラ転写後調節要素 Pending JP2018534946A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562246841P 2015-10-27 2015-10-27
US62/246,841 2015-10-27
PCT/US2016/059151 WO2017075237A2 (en) 2015-10-27 2016-10-27 Chimeric post-transcriptional regulatory element

Publications (2)

Publication Number Publication Date
JP2018534946A true JP2018534946A (ja) 2018-11-29
JP2018534946A5 JP2018534946A5 (cg-RX-API-DMAC7.html) 2019-12-05

Family

ID=58561919

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018542687A Pending JP2018534946A (ja) 2015-10-27 2016-10-27 キメラ転写後調節要素

Country Status (6)

Country Link
US (2) US10190135B2 (cg-RX-API-DMAC7.html)
EP (1) EP3368672B1 (cg-RX-API-DMAC7.html)
JP (1) JP2018534946A (cg-RX-API-DMAC7.html)
CN (1) CN108291238A (cg-RX-API-DMAC7.html)
IL (1) IL259010A (cg-RX-API-DMAC7.html)
WO (1) WO2017075237A2 (cg-RX-API-DMAC7.html)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11713468B2 (en) 2017-08-02 2023-08-01 Dna Twopointo Inc. DNA vectors and elements for sustained gene expression in eukaryotic cells
EP3891288B1 (en) * 2018-12-07 2024-10-09 Celltheon Corporation Matrix attachment regions and uses in promoting gene expression
EP3983449A1 (en) 2019-06-11 2022-04-20 Shire Human Genetic Therapies, Inc. Adeno associated viral vector delivery of antibodies for the treatment of disease mediated dysregulated plasma kallikrein
JP7659550B2 (ja) 2019-10-23 2025-04-09 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド アデノ随伴ウイルスベクターに基づく遺伝性血管浮腫のための遺伝子治療
EP4263614A1 (en) 2020-12-16 2023-10-25 Takeda Pharmaceutical Company Limited Adeno associated viral vector delivery of antibodies for the treatment of disease mediated by dysregulated plasma kallikrein

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6136597A (en) * 1997-09-18 2000-10-24 The Salk Institute For Biological Studies RNA export element

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005056057A1 (en) * 2003-12-04 2005-06-23 Childrens Hospital Los Angeles Research Institute Minimal lentiviral vector system
EP2914731B1 (en) * 2012-11-01 2019-09-11 California Institute of Technology Reversible gene expression
CA3246595A1 (en) * 2014-04-09 2025-07-08 Dna Twopointo Inc. Enhanced polynucleotide constructs for eukaryotic gene expression
SMT202000203T1 (it) * 2014-04-25 2020-05-08 Bluebird Bio Inc Recettori antigenici chimerici con promotore mnd

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6136597A (en) * 1997-09-18 2000-10-24 The Salk Institute For Biological Studies RNA export element

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J VIROL, 1998 JUN, VOL. 72, NO. 6, PP. 5085-5092, JPN6020043190, ISSN: 0004384760 *

Also Published As

Publication number Publication date
WO2017075237A2 (en) 2017-05-04
IL259010A (en) 2018-06-28
EP3368672A4 (en) 2019-03-27
WO2017075237A3 (en) 2017-06-22
US20190309322A1 (en) 2019-10-10
CN108291238A (zh) 2018-07-17
US20170114363A1 (en) 2017-04-27
EP3368672A2 (en) 2018-09-05
US10190135B2 (en) 2019-01-29
EP3368672B1 (en) 2020-11-25

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